Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice

See Mercado and Hetz (doi:10.1093/brain/awx107) for a scientific commentary on this article. Signalling through the PERK/eIF2α-P branch of the Unfolded Protein Response is increased in many neurodegenerative diseases. Halliday et al. identify two safe compounds – one licensed – that act on this pathway and are neuroprotective in mice with neurodegeneration. These drugs can now be repurposed in clinical trials for the treatment of dementia.

• Publication year

  2017

• Venue

  Brain : a journal of neurology

• Publication date

  2017-04-19

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/brain/awx074PMID 28430857PMCID 5445255
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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