A "vascular normalization index" as potential mechanistic biomarker to predict survival after a single dose of cediranib in recurrent glioblastoma patients.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Cancer Research

• Publication date

  2009-07-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1158/0008-5472.CAN-09-0814PMID 19549889PMCID PMC2824172
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1993cited by this paper

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