UDP-sugar substrates of HAS3 regulate its O-GlcNAcylation, intracellular traffic, extracellular shedding and correlate with melanoma progression

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Cellular and Molecular Life Sciences

• Publication date

  2016-02-16

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s00018-016-2158-5PMID 26883802PMCID PMC11108457
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Diabetes-associated dysregulation of O-GlcNAcylation in rat cardiac mitochondria

  2015cited by this paper
• Hyaluronan synthase 3 (HAS3) overexpression downregulates MV3 melanoma cell proliferation, migration and adhesion.

  2015cited by this paper
• Interleukin-1β-induced Reduction of CD44 Ser-325 Phosphorylation in Human Epidermal Keratinocytes Promotes CD44 Homomeric Complexes, Binding to Ezrin, and Extended, Monocyte-adhesive Hyaluronan Coats*

  2015cited by this paper
• A novel role of low molecular weight hyaluronan in breast cancer metastasis

  2015cited by this paper
• Interactions between Hyaluronan and Its Receptors (CD44, RHAMM) Regulate the Activities of Inflammation and Cancer

  2015cited by this paper
• Hyaluronan regulation of endothelial barrier function in cancer.

  2014cited by this paper
• Accumulation of small hyaluronan oligosaccharides in tumour interstitial fluid correlates with lymphatic invasion and lymph node metastasis

  2014cited by this paper
• Bladder cancer exosomes contain EDIL-3/Del1 and facilitate cancer progression.

  2014cited by this paper
• Accumulation of Extracellular Hyaluronan by Hyaluronan Synthase 3 Promotes Tumor Growth and Modulates the Pancreatic Cancer Microenvironment

  2014cited by this paper
• Natural Antisense Transcript for Hyaluronan Synthase 2 (HAS2-AS1) Induces Transcription of HAS2 via Protein O-GlcNAcylation*

  2014cited by this paper
• STIM1- and Orai1-mediated Ca2+ oscillation orchestrates invadopodium formation and melanoma invasion

  2014cited by this paper
• Borate-aided anion exchange high-performance liquid chromatography of uridine diphosphate-sugars in brain, heart, adipose and liver tissues.

  2014cited by this paper
• Rab10-mediated Endocytosis of the Hyaluronan Synthase HAS3 Regulates Hyaluronan Synthesis and Cell Adhesion to Collagen*

  2014cited by this paper
• The dynamic metabolism of hyaluronan regulates the cytosolic concentration of UDP-GlcNAc.

  2014cited by this paper
• Inverse expression of hyaluronidase 2 and hyaluronan synthases 1-3 is associated with reduced hyaluronan content in malignant cutaneous melanoma.

  2013cited by this paper
• Inverse expression of hyaluronidase 2 and hyaluronan synthases 1–3 is associated with reduced hyaluronan content in malignant cutaneous melanoma

  2013cited by this paper
• High molecular weight hyaluronan mediates the cancer resistance of the naked mole-rat

  2013cited by this paper
• Hyaluronan production enhances shedding of plasma membrane-derived microvesicles.

  2013cited by this paper
• Deregulation of hyaluronan synthesis, degradation and binding promotes breast cancer.

  2013cited by this paper
• Bladder cancer cell-derived exosomes inhibit tumor cell apoptosis and induce cell proliferation in vitro.

  2013cited by this paper
• Hyaluronan Synthase 1 (HAS1) Requires Higher Cellular UDP-GlcNAc Concentration than HAS2 and HAS3*

  2013cited by this paper
• The hyaluronan synthase catalyzes the synthesis and membrane translocation of hyaluronan.

  2012cited by this paper
• Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

  2012cited by this paper
• Hyaluronan and versican in the control of human T-lymphocyte adhesion and migration.

  2012cited by this paper
• Multiple post-translational modifications regulate E-cadherin transport during apoptosis

  2012cited by this paper
• Role of UDP-N-Acetylglucosamine (GlcNAc) and O-GlcNAcylation of Hyaluronan Synthase 2 in the Control of Chondroitin Sulfate and Hyaluronan Synthesis*

  2012cited by this paper
• Cellular Content of UDP-N-acetylhexosamines Controls Hyaluronan Synthase 2 Expression and Correlates with O-Linked N-Acetylglucosamine Modification of Transcription Factors YY1 and SP1*

  2011cited by this paper
• Hyaluronan in human malignancies.

  2011cited by this paper
• Hyaluronan as an immune regulator in human diseases.

  2011cited by this paper
• Glycosaminoglycans and Glucose Prevent Apoptosis in 4-Methylumbelliferone-treated Human Aortic Smooth Muscle Cells*

  2011cited by this paper
• HAS3-induced accumulation of hyaluronan in 3D MDCK cultures results in mitotic spindle misorientation and disturbed organization of epithelium

  2011cited by this paper
• Transcriptional and post‐translational regulation of hyaluronan synthesis

  2011cited by this paper
• Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma

  2010cited by this paper
• Hyaluronan Stabilizes Focal Adhesions, Filopodia, and the Proliferative Phenotype in Esophageal Squamous Carcinoma Cells*

  2010cited by this paper
• Radiotherapy to the chest wall following mastectomy for node-negative breast cancer: a systematic review.

  2009cited by this paper
• Hyaluronan-CD44 Interactions in Cancer: Paradoxes and Possibilities

  2009cited by this paper
• Local Relapse after Breast-Conserving Surgery and Radiotherapy

  2009cited by this paper
• Impact of the boost dose of 10 Gy versus 26 Gy in patients with early stage breast cancer after a microscopically incomplete lumpectomy: 10-year results of the randomised EORTC boost trial.

  2009cited by this paper
• Expression of Hyaluronan Synthases (HAS1–3) and Hyaluronidases (HYAL1–2) in Serous Ovarian Carcinomas: Inverse Correlation between HYAL1 and Hyaluronan Content

  2009cited by this paper
• Immediate Reconstruction with an Expander/Implant Following Ablatio Mammae because of Breast Cancer

  2009cited by this paper
• The Effect of Adjuvant Radiotherapy on Mortality Differs According to Primary Tumor Location in Women with Node-Positive Breast Cancer

  2009cited by this paper
• Survival Benefit with Radiation Therapy in Node-Positive Breast Carcinoma Patients

  2009cited by this paper
• 4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3.

  2009cited by this paper
• Incidence of severe capsular contracture following implant-based immediate breast reconstruction with or without postoperative chest wall radiotherapy using 40 Gray in 15 fractions.

  2009cited by this paper
• Radiation Therapy and Breast Reconstruction: A Critical Review of the Literature

  2009cited by this paper
• Clinical outcomes of postmastectomy radiation therapy after immediate breast reconstruction.

  2008cited by this paper
• Mannose Inhibits Hyaluronan Synthesis by Down-regulation of the Cellular Pool of UDP-N-acetylhexosamines*

  2008cited by this paper
• A Retrospective Analysis of Outcomes Using Three Common Methods for Immediate Breast Reconstruction

  2008cited by this paper
• Effects of an Autologous Flap Combined with an Implant for Breast Reconstruction: An Evaluation of 1000 Consecutive Reconstructions of Previously Irradiated Breasts

  2008cited by this paper
• Hyaluronan in cancer biology.

  2008cited by this paper
• Hyaluronan in human tumors: pathobiological and prognostic messages from cell-associated and stromal hyaluronan.

  2008cited by this paper
• Hyaluronan: a constitutive regulator of chemoresistance and malignancy in cancer cells.

  2008cited by this paper
• Cycling of O-linked β-N-acetylglucosamine on nucleocytoplasmic proteins

  2007cited by this paper
• [On the interaction of adjuvant radiotherapy and tamoxifen treatment for breast cancer].

  2007cited by this paper
• Subcompartments of the macrophage recycling endosome direct the differential secretion of IL-6 and TNFα

  2007cited by this paper
• Cycling of O-linked beta-N-acetylglucosamine on nucleocytoplasmic proteins.

  2007cited by this paper
• Hyaluronan Synthases: A Decade-plus of Novel Glycosyltransferases*

  2007cited by this paper
• Extracellular matrix of the cumulus-oocyte complex.

  2006cited by this paper
• Hexosamines, insulin resistance, and the complications of diabetes: current status.

  2006cited by this paper
• Biosynthesis of hyaluronan: direction of chain elongation.

  2006cited by this paper
• Is Grading of Breast Fibrosis with Mammography Feasible?

  2005cited by this paper
• Biosynthesis of Hyaluronan

  2005cited by this paper
• A Role for the Phagosome in Cytokine Secretion

  2005cited by this paper
• Hyaluronan metabolism: a major paradox in cancer biology.

  2005cited by this paper
• Plasma Membrane Residence of Hyaluronan Synthase Is Coupled to Its Enzymatic Activity*[boxs]

  2005cited by this paper
• Has2 is required upstream of Rac1 to govern dorsal migration of lateral cells during zebrafish gastrulation

  2004cited by this paper
• Hyaluronan: from extracellular glue to pericellular cue

  2004cited by this paper
• Concomitant use of tamoxifen with radiotherapy enhances subcutaneous breast fibrosis in hypersensitive patients

  2004cited by this paper
• A Novel Mechanism for the Inhibition of Hyaluronan Biosynthesis by 4-Methylumbelliferone*

  2004cited by this paper
• Irradiation after Immediate Tissue Expander/Implant Breast Reconstruction: Outcomes, Complications, Aesthetic Results, and Satisfaction among 156 Patients

  2004cited by this paper
• Radiotherapy and breast reconstruction: complications and cosmesis with TRAM versus tissue expander/implant.

  2002cited by this paper
• Elevated hyaluronan concentration without hyaluronidase activation in malignant epithelial ovarian tumors.

  2002cited by this paper
• Complications and patient satisfaction following expander/implant breast reconstruction with and without radiotherapy.

  2001cited by this paper
• Cytoplasmic O‐glycosylation prevents cell surface transport of E‐cadherin during apoptosis

  2001cited by this paper
• Comparison of Immediate and Delayed Free TRAM Flap Breast Reconstruction in Patients Receiving Postmastectomy Radiation Therapy

  2001cited by this paper
• [Radiation therapy after mastectomy--interdisciplinary consensus puts and end to a controversy. German Society of Senology].

  2001cited by this paper
• Morbidity of immediate breast reconstruction (IBR) after mastectomy by a subpectorally placed silicone prosthesis: the adverse effect of radiotherapy.

  2000cited by this paper
• Favourable and unfavourable effects on long-term survival of radiotherapy for early breast cancer: an overview of the randomised trials. Early Breast Cancer Trialists' Collaborative Group.

  2000cited by this paper
• Reduced level of CD44 and hyaluronan associated with unfavorable prognosis in clinical stage I cutaneous melanoma.

  2000cited by this paper
• Adjuvant radiotherapy for breast cancer significantly improves overall survival: the missing link.

  2000cited by this paper
• Does locoregional radiation therapy improve survival in breast cancer? A meta-analysis.

  2000cited by this paper
• Glycosylation Sites Flank Phosphorylation Sites on Synapsin I

  1999cited by this paper
• Cell lines with reduced UDP-N-acetylhexosamine pool in the presence of ammonium.

  1999cited by this paper
• Three Isoforms of Mammalian Hyaluronan Synthases Have Distinct Enzymatic Properties*

  1999cited by this paper
• Treatment outcome with radiation therapy after breast augmentation or reconstruction in patients with primary breast carcinoma

  1998cited by this paper
• Radiotherapy-related lung fibrosis enhanced by tamoxifen.

  1996cited by this paper
• Expression of local hepatocyte growth factor system in vascular tissues.

  1995cited by this paper
• Radiotherapy and breast reconstruction: clinical results and dosimetry.

  1991cited by this paper
• Results of Closed Compression Capsulotomy for Treatment of Contracted Breast Implant Capsules

  1980cited by this paper
• Über den Stoffwechsel der Carcinomzelle

  1924cited by this paper

• UGDH Promotes 5-Fluorouracil Resistance in Colorectal Cancer via the ROS-Activated PI3K/AKT-EEF1A2-PRDX1 Pathway.

  2025cites this paper
• O-GlcNAcylation: Sagacious Orchestrator of Bone-, Joint-, and Spine-Related Diseases

  2025cites this paper
• Glutamine: fructose-6-phosphate amidotransferase (GFAT) in the pathology of diseases: a review

  2025cites this paper
• Hyaluronan accumulation is associated with reduced hyaluronidase expression in renal cell carcinoma, with CD44, HAS1, and HYAL2 emerging as prognostic markers

  2025cites this paper
• Silencing of O‐GlcNAc Transferase Attenuated O‐GlcNAcylation and Metastatic Potentials of Melanoma Cells Through Suppression of Akt‐NFκB Signaling Pathway

  2025cites this paper
• Impacts of Hyaluronan on Extracellular Vesicle Production and Signaling

  2025cites this paper
• Hyaluronic acid metabolism and chemotherapy resistance: recent advances and therapeutic potential

  2023cites this paper
• Glucose metabolism in B cell malignancies: a focus on glycolysis branching pathways

  2023cites this paper
• O-GlcNAc Dynamics: The Sweet Side of Protein Trafficking Regulation in Mammalian Cells

  2023cites this paper
• Context-specific regulation of extracellular vesicle biogenesis and cargo selection

  2023cites this paper
• Improved antitumor activity against prostate cancer via synergistic targeting of Myc and GFAT-1

  2023cites this paper
• UDP-glucose dehydrogenase (UGDH) in clinical oncology and cancer biology

  2023cites this paper
• O-GlcNAcylation in cancer development and immunotherapy.

  2023cites this paper
• Microscopic characterization reveals the diversity of EVs secreted by GFP-HAS3 expressing MCF7 cells.

  2022cites this paper
• Mechanisms of coordinating hyaluronan and glycosaminoglycan production by nucleotide sugars.

  2022cites this paper
• Absorption, metabolism, and functions of hyaluronic acid and its therapeutic prospects in combination with microorganisms: A review.

  2022cites this paper
• Connections between metabolism and epigenetic modifications in cancer

  2021cites this paper
• 1-Ethyl-β-N-acetylglucosaminide increases hyaluronan production in human keratinocytes by being converted to N-acetylglucosamine via β-N-acetylglucosaminidase-dependent manner.

  2021cites this paper
• Initial Identification of UDP-Glucose Dehydrogenase as a Prognostic Marker in Breast Cancer Patients, Which Facilitates Epirubicin Resistance and Regulates Hyaluronan Synthesis in MDA-MB-231 Cells

  2021cites this paper
• Initial Identification of UDP-Glucose Dehydrogenase as a Prognostic Marker in Breast Cancer Patients, Which Facilitates Epirubicin Resistance and Regulates Hyaluronan Synthesis in MDA-MB-231 Cells

  2021cites this paper
• Diverse plasma membrane protrusions act as platforms for extracellular vesicle shedding

  2021cites this paper
• Salicylate suppresses the oncogenic hyaluronan network in metastatic breast cancer cells

  2020cites this paper
• Intracellular hyaluronan: Importance for cellular functions.

  2020cites this paper
• Revisiting the hallmarks of cancer: the role of hyaluronan.

  2020cites this paper
• The regulation of HAS3 by miR-10b and miR-29a in neuroendocrine transdifferentiated LNCaP prostate cancer cells.

  2020cites this paper
• Tumor Microenvironment: Extracellular Matrix Components – Part A

  2020cites this paper
• ROCK2 mediates osteosarcoma progression and TRAIL resistance by modulating O-GlcNAc transferase degradation.

  2020cites this paper
• Hyaluronan in the Tumor Microenvironment.

  2020cites this paper
• Cell Energy Metabolism and Hyaluronan Synthesis

  2020cites this paper
• The Density and Length of Filopodia Associate with the Activity of Hyaluronan Synthesis in Tumor Cells

  2020cites this paper
• The Emerging Role of Galectins and O-GlcNAc Homeostasis in Processes of Cellular Differentiation

  2020cites this paper
• Integration of Sugar Metabolism and Proteoglycan Synthesis by UDP-glucose Dehydrogenase

  2020cites this paper
• Knockdown Of Udp-Glucose Dehydrogenase Facilitates Epirubicin-Resistance In MDA-MB-231 Breast Cancer Cells By Regulation Of Hyaluronan Synthesis.

  2020cites this paper
• Inhibition of the hyaluronan matrix enhances metabolic anticancer therapy by dichloroacetate in vitro and in vivo

  2019cites this paper
• Dissecting the role of hyaluronan synthases in the tumor microenvironment

  2019cites this paper
• Effects of mutations in the post-translational modification sites on the trafficking of hyaluronan synthase 2 (HAS2).

  2019cites this paper
• HAS3-induced extracellular vesicles from melanoma cells stimulate IHH mediated c-Myc upregulation via the hedgehog signaling pathway in target cells

  2019cites this paper
• DNA Methylation Module Network-Based Prognosis and Molecular Typing of Cancer

  2019cites this paper
• Activated hyaluronan metabolism in the tumor matrix - Causes and consequences.

  2019cites this paper
• Hexosamine Biosynthetic Pathway and Glycosylation Regulate Cell Migration in Melanoma Cells

  2019cites this paper
• UDP-sugar accumulation drives hyaluronan synthesis in breast cancer.

  2018cites this paper
• O-GlcNAc in cancer: An Oncometabolism-fueled vicious cycle

  2018cites this paper
• Physical biology of the cancer cell glycocalyx

  2018cites this paper
• A widely compatible expression system for the production of highly O-GlcNAcylated recombinant protein in Escherichia coli

  2018cites this paper
• The Many Ways by Which O-GlcNAcylation May Orchestrate the Diversity of Complex Glycosylations

  2018cites this paper
• Hyaluronan metabolism enhanced during epidermal differentiation is suppressed by vitamin C

  2018cites this paper
• Regulation of hyaluronan biosynthesis and clinical impact of excessive hyaluronan production.

  2018cites this paper
• Extracellular ATP activates hyaluronan synthase 2 (HAS2) in epidermal keratinocytes via P2Y2, Ca2+ signaling, and MAPK pathways.

  2018cites this paper
• Human mesenchymal stem cells secrete hyaluronan-coated extracellular vesicles.

  2017cites this paper
• Regulation of Hyaluronan Synthesis and Signaling via CD44 in Cancer

  2017cites this paper
• Human Keratinocytes Respond to Extracellular UTP by Induction of Hyaluronan Synthase 2 Expression and Increased Hyaluronan Synthesis*

  2017cites this paper
• High extent of O-GlcNAcylation in breast cancer cells correlates with the levels of HAS enzymes, accumulation of hyaluronan, and poor outcome

  2016cites this paper
• Hexosamine biosynthesis in keratinocytes: roles of GFAT and GNPDA enzymes in the maintenance of UDP-GlcNAc content and hyaluronan synthesis.

  2016cites this paper
• Hijacking the Hexosamine Biosynthetic Pathway to Promote EMT-Mediated Neoplastic Phenotypes

  2016cites this paper
• Hyaluronan metabolism enhanced during epidermal differentiation is suppressed by vitamin C Running head : Epidermal maturation , vitamin C and hyaluronan metabolism

  year unknowncites this paper