The Changing Phenotype of Inflammatory Bowel Disease

It is widely known that there have been improvements in patient care and an increased incidence of Inflammatory Bowel Disease (IBD) worldwide in recent decades. However, less well known are the phenotypic changes that have occurred; these are discussed in this review. Namely, we discuss the emergence of obesity in patients with IBD, elderly onset disease, mortality rates, colorectal cancer risk, the burden of medications and comorbidities, and the improvement in surgical treatment with a decrease in surgical rates in recent decades.

• Publication year

  2016

• Venue

  Gastroenterology Research and Practice

• Publication date

  2016-12-06

• Fields of study

  Medicine

• Identifiers
  DOI 10.1155/2016/1619053PMID 28050166PMCID 5168455
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Duration of Inflammatory Bowel Disease Is Associated With Increased Risk of Cholangiocarcinoma in Patients With Primary Sclerosing Cholangitis and IBD

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• Incidence and Predictors of Nonalcoholic Fatty Liver Disease by Serum Biomarkers in Patients with Inflammatory Bowel Disease

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• Higher Risk for Hematological Malignancies in Inflammatory Bowel Disease: A Nationwide Population-based Study in Taiwan

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• Increased risk of colorectal neoplasia in patients with primary sclerosing cholangitis and inflammatory bowel disease: a meta-analysis of 16 observational studies

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• Cancer in Elderly Onset Inflammatory Bowel Disease: A Population-Based Study

  2016cited by this paper
• Prevalence of Sclerosing Cholangitis Detected by Magnetic Resonance Cholangiography in Patients With Long-term Inflammatory Bowel Disease.

  2016cited by this paper
• Systematic Review and Meta-analysis: Phenotype and Clinical Outcomes of Older-onset Inflammatory Bowel Disease.

  2016cited by this paper
• Early Course of Inflammatory Bowel Disease in a Population-Based Inception Cohort Study From 8 Countries in Asia and Australia.

  2016cited by this paper
• The microbiota in inflammatory bowel disease

  2015cited by this paper
• Metabolic Inflammation in Inflammatory Bowel Disease: Crosstalk Between Adipose Tissue and Bowel

  2015cited by this paper
• Risk of lymphoma in patients with inflammatory bowel disease treated with azathioprine and 6-mercaptopurine: a meta-analysis.

  2015cited by this paper
• Risk of Lymphoma

  2015cited by this paper
• Cancers complicating inflammatory bowel disease.

  2015cited by this paper
• Body Image Dissatisfaction: Clinical Features, and Psychosocial Disability in Inflammatory Bowel Disease

  2015cited by this paper
• Effect of intestinal resection on quality of life in Crohn's disease.

  2015cited by this paper
• Appearance of hepatobiliary diseases in a population‐based cohort with inflammatory bowel diseases (Inflammatory Bowel Disease Cohort of the Uppsala Region)

  2015cited by this paper
• Colonoscopy is associated with a reduced risk for colon cancer and mortality in patients with inflammatory bowel diseases.

  2015cited by this paper
• Measures of Obesity and Risk of Crohn's Disease and Ulcerative Colitis

  2015cited by this paper
• Older Age and Steroid Use Are Associated with Increasing Polypharmacy and Potential Medication Interactions Among Patients with Inflammatory Bowel Disease

  2015cited by this paper
• Health Care Utilization in Elderly Onset Inflammatory Bowel Disease: A Population-based Study

  2015cited by this paper
• Obesity in Inflammatory Bowel Disease: A Marker of Less Severe Disease

  2015cited by this paper
• Risk of Lymphoma, Colorectal and Skin Cancer in Patients with IBD Treated with Immunomodulators and Biologics: A Quebec Claims Database Study

  2015cited by this paper
• Inflammatory Bowel Disease Is Associated With an Increased Risk of Hospitalization for Heart Failure: A Danish Nationwide Cohort Study

  2014cited by this paper
• Systematic review with meta‐analysis: the declining risk of colorectal cancer in ulcerative colitis

  2014cited by this paper
• Clinical characteristics and treatment of inflammatory bowel disease: a comparison of Eastern and Western perspectives.

  2014cited by this paper
• Systematic review: the epidemiology of the hepatobiliary manifestations in patients with inflammatory bowel disease

  2014cited by this paper
• Incidence and clinical course of Crohn's disease during the first year - results from the IBD Cohort of the Uppsala Region (ICURE) of Sweden 2005-2009.

  2014cited by this paper
• Mortality in inflammatory bowel disease patients under 65 years of age

  2014cited by this paper
• Increased risk of atrial fibrillation and stroke during active stages of inflammatory bowel disease: a nationwide study.

  2014cited by this paper
• Randomized efficacy trial of two psychotherapies for depression in youth with inflammatory bowel disease.

  2014cited by this paper
• Risk of cancer in patients with inflammatory bowel diseases: a nationwide population-based cohort study with 30 years of follow-up evaluation.

  2014cited by this paper
• Predictors and risks for death in a population-based study of persons with IBD in Manitoba

  2014cited by this paper
• Venous Thromboembolism in Patients with Inflammatory Bowel Diseases: A Case-control Study of Risk Factors

  2014cited by this paper
• National trends and inpatient outcomes of inflammatory bowel disease patients with concomitant chronic liver disease

  2014cited by this paper
• Are Patients with Inflammatory Bowel Disease on Chronic Immunosuppressive Therapy at Increased Risk of Cervical High-grade Dysplasia/Cancer? A Meta-analysis

  2014cited by this paper
• Characteristics and Behavior of Elderly-onset Inflammatory Bowel Disease: A Multi-center US Study

  2014cited by this paper
• Tricyclic Antidepressants for Management of Residual Symptoms in Inflammatory Bowel Disease

  2014cited by this paper
• Thromboembolic events and cardiovascular mortality in inflammatory bowel diseases: a meta-analysis of observational studies.

  2014cited by this paper
• The Prevalence and Predictors of Opioid Use in Inflammatory Bowel Disease: A Population-Based Analysis

  2014cited by this paper
• Inflammatory bowel diseases increase future ischemic stroke risk: a Taiwanese population-based retrospective cohort study.

  2014cited by this paper
• The Increasing Weight of Crohn's Disease Subjects in Clinical Trials: A Hypothesis-generatings Time-trend Analysis

  2013cited by this paper
• Risk factors of non-alcoholic fatty liver disease in patients with inflammatory bowel disease.

  2013cited by this paper
• The Burden of Comedication Among Patients with Inflammatory Bowel Disease

  2013cited by this paper
• Incidence and natural history of ulcerative colitis in the Uppsala Region of Sweden 2005-2009 - results from the IBD cohort of the Uppsala Region (ICURE).

  2013cited by this paper
• Crohn’s Disease and Ulcerative Colitis Are Associated With Elevated Standardized Mortality Ratios: A Meta-Analysis

  2013cited by this paper
• Disease Activity in Inflammatory Bowel Disease Is Associated with Increased Risk of Myocardial Infarction, Stroke and Cardiovascular Death – A Danish Nationwide Cohort Study

  2013cited by this paper
• High prevalence of overweight and obesity in adults with Crohn's disease: associations with disease and lifestyle factors.

  2013cited by this paper
• Multiphasic analysis of the temporal development of the distal gut microbiota in patients following ileal pouch anal anastomosis

  2013cited by this paper
• Prognosis following emergency surgery for ulcerative colitis in elderly patients

  2013cited by this paper
• Incidence and phenotype of inflammatory bowel disease based on results from the Asia-pacific Crohn's and colitis epidemiology study.

  2013cited by this paper
• Trends in overall and cause-specific mortality among patients with inflammatory bowel disease from 1982 to 2010.

  2013cited by this paper
• Body Mass Index and the Risk for Crohn's Disease and Ulcerative Colitis: Data From a European Prospective Cohort Study (The IBD in EPIC Study)

  2013cited by this paper
• Declining Risk of Colorectal Cancer in Inflammatory Bowel Disease: An Updated Meta-analysis of Population-based Cohort Studies

  2013cited by this paper
• Modifiable Factors Associated with Nonadherence to Maintenance Medication for Inflammatory Bowel Disease

  2013cited by this paper
• Meta‐analysis: the risk of venous thromboembolism in patients with inflammatory bowel disease

  2013cited by this paper
• Changes in medical treatment and surgery rates in inflammatory bowel disease: a nationwide cohort study 1979–2011

  2013influential reference
• Does morbid obesity change outcomes after laparoscopic surgery for inflammatory bowel disease? Review of 626 consecutive cases.

  2013cited by this paper
• Phenotype of Inflammatory Bowel Disease at Diagnosis in the Netherlands: A Population-based Inception Cohort Study (the Delta Cohort)

  2013cited by this paper
• Increased Body Mass Index Is Associated with Earlier Time to Loss of Response to Infliximab in Patients with Inflammatory Bowel Disease

  2013cited by this paper
• Risk of surgery for inflammatory bowel diseases has decreased over time: a systematic review and meta-analysis of population-based studies.

  2013cited by this paper
• Natural history of elderly-onset inflammatory bowel disease: a population-based cohort study

  2013cited by this paper
• Does weight-adjusted anti-tumour necrosis factor treatment favour obese patients with Crohn’s disease?

  2013cited by this paper
• Outcomes of rescue therapy in acute severe ulcerative colitis: data from the United Kingdom inflammatory bowel disease audit

  2013cited by this paper
• Narcotic use for inflammatory bowel disease and risk factors during hospitalization

  2012cited by this paper
• An Integrated Model of Care for Inflammatory Bowel Disease Sufferers in Australia: Development and the Effects of Its Implementation

  2012cited by this paper
• Do Antidepressants Influence the Disease Course in Inflammatory Bowel Disease? A Retrospective Case‐Matched Observational Study

  2012cited by this paper
• Has There Been a Change in the Natural History of Crohn's Disease? Surgical Rates and Medical Management in a Population-Based Inception Cohort from Western Hungary Between 1977–2009

  2012cited by this paper
• Primary sclerosing cholangitis is associated with a distinct phenotype of inflammatory bowel disease

  2012cited by this paper
• I and J

  2012cited by this paper
• Mood disorders in inflammatory bowel disease: Relation to diagnosis, disease activity, perceived stress, and other factors

  2012cited by this paper
• Decreasing risk of colorectal cancer in patients with inflammatory bowel disease over 30 years.

  2012cited by this paper
• Adipose Tissue and Inflammatory Bowel Disease Pathogenesis

  2012cited by this paper
• Geriatric Inflammatory Bowel Disease: Phenotypic Presentation, Treatment Patterns, Nutritional Status, Outcomes, and Comorbidity

  2012cited by this paper
• Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review.

  2012cited by this paper
• Patients enrolled in randomized controlled trials do not represent the inflammatory bowel disease patient population.

  2012cited by this paper
• Risk of melanoma and nonmelanoma skin cancer among patients with inflammatory bowel disease.

  2012cited by this paper
• Incidence, disease phenotype at diagnosis, and early disease course in inflammatory bowel diseases in Western Hungary, 2002–2006

  2011cited by this paper
• Epidemiology and natural history of inflammatory bowel diseases.

  2011cited by this paper
• Protection From Colorectal Cancer After Colonoscopy

  2011cited by this paper
• Prevalence and epidemiology of overweight and obesity in children with inflammatory bowel disease 12

  2011cited by this paper
• Is Obesity a Risk Factor for Crohn’s Disease?

  2011cited by this paper
• Outcomes of patients with Crohn's disease improved from 1988 to 2008 and were associated with increased specialist care.

  2011cited by this paper
• Prevalence of high body mass index in US children and adolescents, 2007-2008.

  2010cited by this paper
• Trends in quality-adjusted life-years lost contributed by smoking and obesity.

  2010cited by this paper
• Natural history of Crohn's disease in a population-based cohort from Cardiff (1986–2003): a study of changes in medical treatment and surgical resection rates

  2010cited by this paper
• Protection from colorectal cancer after colonoscopy: Population-based case-control study

  2010cited by this paper
• Risk factors associated with progression to intestinal complications of Crohn's disease in a population-based cohort.

  2010cited by this paper
• Prevalence of ulcerative colitis and Crohn’s disease in Japan

  2009cited by this paper
• A Brief Report of the Epidemiology of Obesity in the Inflammatory Bowel Disease Population of Tayside, Scotland

  2009cited by this paper
• Overall and cause‐specific mortality in Crohn's disease: A meta‐analysis of population‐based studies

  2009cited by this paper
• Inflammatory bowel disease in the elderly is associated with worse outcomes: A national study of hospitalizations

  2008cited by this paper
• Retrospective analysis of old-age colitis in the Dutch inflammatory bowel disease population.

  2008cited by this paper
• The effect of smoking after surgery for Crohn’s disease: a meta-analysis of observational studies

  2008cited by this paper
• Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies.

  2008cited by this paper
• Crohn's disease initially diagnosed after age 60 years.

  2007cited by this paper
• Changes in Clinical Characteristics, Course, and Prognosis of Inflammatory Bowel Disease during the Last 5 Decades: A Population‐Based Study from Copenhagen, Denmark

  2007cited by this paper
• Overall and Cause-Specific Mortality in Ulcerative Colitis: Meta-analysis of Population-Based Inception Cohort Studies

  2007cited by this paper
• Long‐term clinical results of ileocecal resection for Crohn's disease

  2007cited by this paper
• Body mass index in children with newly diagnosed inflammatory bowel disease: observations from two multicenter North American inception cohorts.

  2007cited by this paper
• Influence of cultivation temperature on the ligninolytic activity of selected fungal strains

  2006cited by this paper

• Non-alcoholic fatty liver disease in patients with intestinal, pulmonary or skin diseases: Inflammatory cross-talk that needs a multidisciplinary approach

  2021cites this paper
• Real-world disease activity and sociodemographic, clinical and treatment characteristics of moderate-to-severe inflammatory bowel disease in Brazil

  2021cites this paper
• Changing phenotype of inflammatory bowel disease and neglected metabolic health

  2021cites this paper
• Ernährung bei chronisch-entzündlichen Darmerkrankungen

  2020cites this paper
• Ernährungstherapie bei chronisch-entzündlichen Darmerkrankungen

  2020cites this paper
• Stricturing ulcerative colitis: a case of rapid disease progression.

  2020cites this paper
• Stricturing ulcerative colitis: a case of rapid disease progression

  2020cites this paper
• Non-alcoholic fatty liver disease in inflammatory bowel disease patients.

  2020cites this paper
• Polymorphism at rs9264942 is associated with HLA-C expression and inflammatory bowel disease in the Japanese

  2020cites this paper
• Epidemiology of Inflammatory Bowel Disease in Southern Peninsular Malaysia

  2018cites this paper
• Non-alcoholic fatty liver disease in underweight patients with inflammatory bowel disease: A case-control study

  2018cites this paper
• Determinants of Reduced Genetic Capacity for Butyrate Synthesis by the Gut Microbiome in Crohn’s Disease and Ulcerative Colitis

  2018cites this paper