Rho as a mediator of G protein-coupled receptor signaling.

Heterotrimeric GTP-binding proteins (G proteins) contain α subunits that switch between an inactive GDP-bound state and an active GTP-bound state in response to agonist binding to heptahelical receptors. The low-molecular-weight or small G proteins are also GTPases that serve as molecular switches

• Publication year

  1999

• Venue

  Molecular Pharmacology

• Publication date

  1999-06-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1124/MOL.55.6.949PMID 10347235
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Regulation of the small GTP‐binding protein Rho by cell adhesion and the cytoskeleton

  1999cited by this paper
• Rho and Rho kinase mediate thrombin-stimulated vascular smooth muscle cell DNA synthesis and migration.

  1999influential reference
• A Novel PDZ Domain Containing Guanine Nucleotide Exchange Factor Links Heterotrimeric G Proteins to Rho*

  1999cited by this paper
• Activation of G12/G13 Results in Shape Change and Rho/Rho-Kinase–mediated Myosin Light Chain Phosphorylation in Mouse Platelets

  1999cited by this paper
• Carbachol-induced actin reorganization involves Gi activation of Rho in human airway smooth muscle cells.

  1998cited by this paper
• Characterization of Graf, the GTPase-activating Protein for Rho Associated with Focal Adhesion Kinase

  1998cited by this paper
• RhoA effector mutants reveal distinct effector pathways for cytoskeletal reorganization, SRF activation and transformation

  1998cited by this paper
• p160ROCK mediates RhoA activation of Na–H exchange

  1998cited by this paper
• Constitutively active Galpha12, Galpha13, and Galphaq induce Rho-dependent neurite retraction through different signaling pathways.

  1998cited by this paper
• A family of cAMP-binding proteins that directly activate Rap1.

  1998cited by this paper
• Regulation of phospholipase C-delta by GTP-binding proteins-rhoA as an inhibitory modulator.

  1998cited by this paper
• Requirement for Rho-mediated Myosin Light Chain Phosphorylation in Thrombin-stimulated Cell Rounding and Its Dissociation from Mitogenesis*

  1998influential reference
• Role of G proteins in agonist-induced Ca2+ sensitization of tracheal smooth muscle.

  1998cited by this paper
• Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

  1998cited by this paper
• Gα12 and Gα13 Stimulate Rho-dependent Tyrosine Phosphorylation of Focal Adhesion Kinase, Paxillin, and p130 Crk-associated Substrate*

  1998cited by this paper
• Rhodopsin-family receptors associate with small G proteins to activate phospholipase D

  1998cited by this paper
• Gβγ-independent Coupling of α2-Adrenergic Receptor to p21 rhoA in Preadipocytes*

  1998influential reference
• Gbeta gamma-independent coupling of alpha2-adrenergic receptor to p21(rhoA) in preadipocytes.

  1998cited by this paper
• Thrombin Inactivates Myosin Light Chain Phosphatase via Rho and Its Target Rho Kinase in Human Endothelial Cells*

  1998cited by this paper
• Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13.

  1998influential reference
• RhoA Signaling via Serum Response Factor Plays an Obligatory Role in Myogenic Differentiation*

  1998cited by this paper
• p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13.

  1998cited by this paper
• Angiotensin II activates RhoA in cardiac myocytes: a critical role of RhoA in angiotensin II-induced premyofibril formation.

  1998influential reference
• Halothane Attenuates Calcium Sensitization in Airway Smooth Muscle by Inhibiting G‐proteins

  1998cited by this paper
• Association of the Myosin-binding Subunit of Myosin Phosphatase and Moesin: Dual Regulation of Moesin Phosphorylation by Rho-associated Kinase and Myosin Phosphatase

  1998cited by this paper
• Molecular Dissection of the Rho-associated Protein Kinase (p160ROCK)-regulated Neurite Remodeling in Neuroblastoma N1E-115 Cells

  1998cited by this paper
• Small GTP-binding Protein Rho Stimulates the Actomyosin System, Leading to Invasion of Tumor Cells*

  1998cited by this paper
• The Rho small G protein family-Rho GDI system as a temporal and spatial determinant for cytoskeletal control.

  1998influential reference
• Guanine nucleotide exchange factor GEF115 specifically mediates activation of Rho and serum response factor by the G protein alpha subunit Galpha13.

  1998influential reference
• The small GTP-binding protein RhoA regulates a delayed rectifier potassium channel.

  1998cited by this paper
• p115 RhoGEF, a GTPase activating protein for Gα12 and Gα13

  1998influential reference
• Constitutively Active Gα12, Gα13, and Gαq Induce Rho-dependent Neurite Retraction through Different Signaling Pathways*

  1998influential reference
• The Low Molecular Weight GTPase Rho Regulates Myofibril Formation and Organization in Neonatal Rat Ventricular Myocytes

  1998cited by this paper
• Galpha12 and Galpha13 stimulate Rho-dependent tyrosine phosphorylation of focal adhesion kinase, paxillin, and p130 Crk-associated substrate.

  1998cited by this paper
• The G-protein G13 but Not G12 Mediates Signaling from Lysophosphatidic Acid Receptor via Epidermal Growth Factor Receptor to Rho*

  1998influential reference
• cAMP-induced Morphological Changes Are Counteracted by the Activated RhoA Small GTPase and the Rho Kinase ROKα*

  1998influential reference
• The small GTP-binding protein Rho links G protein-coupled receptors and Galpha12 to the serum response element and to cellular transformation.

  1997cited by this paper
• Growth Factor Activity of Endothelin-1 in Primary Astrocytes Mediated by Adhesion-Dependent and -Independent Pathways

  1997cited by this paper
• Gln 63 of Rho is deamidated by Escherichia coli cytotoxic necrotizing factor-1

  1997cited by this paper
• Toxin-induced activation of the G protein p21 Rho by deamidation of glutamine

  1997cited by this paper
• Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

  1997cited by this paper
• Direct stimulation of Bruton's tyrosine kinase by Gq-protein α-subunit

  1997cited by this paper
• Reconstitution of Receptors and GTP-binding Regulatory Proteins (G Proteins) in Sf9 Cells

  1997cited by this paper
• The Rho GTPase and a putative RhoGEF mediate a signaling pathway for the cell shape changes in Drosophila gastrulation.

  1997cited by this paper
• Thrombin Induces Apoptosis in Cultured Neurons and Astrocytes via a Pathway Requiring Tyrosine Kinase and RhoA Activities

  1997cited by this paper
• Muscarinic receptor‐stimulated cytosol‐membrane translocation of RhoA

  1997cited by this paper
• Direct stimulation of Bruton's tyrosine kinase by G(q)-protein alpha-subunit.

  1997cited by this paper
• Escherichia coli Cytotoxic Necrotizing Factor 1 (CNF1), a Toxin That Activates the Rho GTPase*

  1997cited by this paper
• Lysophosphatidic Acid Induces Threonine Phosphorylation of Tiam1 in Swiss 3T3 Fibroblasts via Activation of Protein Kinase C*

  1997cited by this paper
• Studies on the function of Rho A protein in cardiac myofibrillogenesis

  1997influential reference
• Role of Rho GTPase in the endothelin-1-induced nuclear signaling.

  1997cited by this paper
• Rho-associated Kinase Directly Induces Smooth Muscle Contraction through Myosin Light Chain Phosphorylation*

  1997cited by this paper
• Sphingosine 1-phosphate stimulates rho-mediated tyrosine phosphorylation of focal adhesion kinase and paxillin in Swiss 3T3 fibroblasts.

  1997cited by this paper
• Translocation of rhoA Associated with Ca2+ Sensitization of Smooth Muscle*

  1997cited by this paper
• Cytoskeletal Rearrangements and Transcriptional Activation of c-fos Serum Response Element by Rho-kinase*

  1997cited by this paper
• Elevation of Intracellular cAMP Inhibits RhoA Activation and Integrin-dependent Leukocyte Adhesion Induced by Chemoattractants*

  1997cited by this paper
• The Role of RNA Editing in Controlling Glutamate Receptor Channel Properties

  1996cited by this paper
• Lfc and Lsc Oncoproteins Represent Two New Guanine Nucleotide Exchange Factors for the Rho GTP-binding Protein*

  1996cited by this paper
• Gα12 and Gα13 Are Phosphorylated during Platelet Activation*

  1996influential reference
• Evidence for Rho-mediated Agonist Stimulation of Phospholipase D in Rat1 Fibroblasts

  1996cited by this paper
• Protein kinase A phosphorylation of RhoA mediates the morphological and functional effects of cyclic AMP in cytotoxic lymphocytes.

  1996cited by this paper
• Differential Translocation of Rho Family GTPases by Lysophosphatidic Acid, Endothelin-1, and Platelet-derived Growth Factor*

  1996cited by this paper
• Rho Is Required for Gαq and α1-Adrenergic Receptor Signaling in Cardiomyocytes

  1996cited by this paper
• Lysophosphatidic Acid‐Induced Neurite Retraction in PC12 Cells: Neurite‐Protective Effects of Cyclic AMP Signaling

  1996cited by this paper
• G alpha 13 stimulates Na+-H+ exchange through distinct Cdc42-dependent and RhoA-dependent pathways.

  1996cited by this paper
• Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

  1996cited by this paper
• Rho is required for Galphaq and alpha1-adrenergic receptor signaling in cardiomyocytes. Dissociation of Ras and Rho pathways.

  1996influential reference
• Endothelin‐induced cytoskeletal actin re‐organization in cultured astrocytes: Inhibition by C3 ADP‐ribosyltransferase

  1996cited by this paper
• Interaction of G protein Gbetagamma dimers with small GTP-binding proteins of the Rho family.

  1996cited by this paper
• Protein kinase C phosphorylates G12 alpha and inhibits its interaction with G beta gamma.

  1996cited by this paper
• Lysophosphatidic Acid‐Induced Neurite Retraction in PC12 Cells: Control by Phosphoinositide‐Ca2+ Signaling and Rho

  1996cited by this paper
• Rho-stimulated contractility drives the formation of stress fibers and focal adhesions

  1996cited by this paper
• Prostaglandin E Receptor EP3 Subtype Induces Neurite Retraction via Small GTPase Rho*

  1996cited by this paper
• Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase)*

  1996influential reference
• Identification of a Novel Guanine Nucleotide Exchange Factor for the Rho GTPase*

  1996cited by this paper
• Gα12 Differentially Regulates Na+-H+ Exchanger Isoforms*

  1996cited by this paper
• Galpha12 differentially regulates Na+-H+ exchanger isoforms.

  1996cited by this paper
• Role of Rho in Chemoattractant-Activated Leukocyte Adhesion Through Integrins

  1996cited by this paper
• Ga12 Differentially Regulates Na-H Exchanger Isoforms*

  1996cited by this paper
• G13 Stimulates Na-H Exchange through Distinct Cdc42-dependent and RhoA-dependent Pathways (*)

  1996cited by this paper
• Interaction of G protein Gβγ dimers with small GTP‐binding proteins of the Rho family

  1996cited by this paper
• Protein Kinase C Phosphorylates G12α and Inhibits Its Interaction with Gβγ(*)

  1996influential reference
• Sphingosine‐1‐phosphate rapidly induces Rho‐dependent neurite retraction: action through a specific cell surface receptor.

  1996cited by this paper
• G alpha 12 and G alpha 13 stimulate Rho-dependent stress fiber formation and focal adhesion assembly.

  1995cited by this paper
• Direct Involvement of the Small GTP-binding Protein Rho in lbc Oncogene Function (*)

  1995cited by this paper
• Transcriptional regulation by extracellular signals: mechanisms and specificity.

  1995cited by this paper
• A dual functional signal mediator showing RhoGAP and phospholipase C‐delta stimulating activities.

  1995influential reference
• Activation of the small GTP-binding proteins rho and rac by growth factor receptors.

  1995cited by this paper
• Involvement of botulinum C3-sensitive GTP-binding proteins in alpha 1-adrenoceptor subtypes mediating Ca(2+)-sensitization.

  1995cited by this paper
• The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF

  1995cited by this paper
• Guanosine 5′-3-O-(Thio)triphosphate Stimulates Tyrosine Phosphorylation of p125FAK and Paxillin in Permeabilized Swiss 3T3 Cells

  1995cited by this paper
• Tyrosine kinase inhibition: an approach to drug development.

  1995cited by this paper
• Sphingosylphosphorylcholine Rapidly Induces Tyrosine Phosphorylation of p125FAK and Paxillin, Rearrangement of the Actin Cytoskeleton and Focal Contact Assembly

  1995cited by this paper
• Gα12 and Gα13 Stimulate Rho-dependent Stress Fiber Formation and Focal Adhesion Assembly (*)

  1995influential reference
• Novel human oncogene lbc detected by transfection with distinct homology regions to signal transduction products.

  1994cited by this paper
• The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells.

  1994cited by this paper
• Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho

  1994influential reference
• Botulinum C3 exoenzyme blocks the tyrosine phosphorylation of p125FAK and paxillin induced by bombesin and endothelin

  1994cited by this paper
• Signal transduction pathways regulating Rho‐mediated stress fibre formation: requirement for a tyrosine kinase.

  1994cited by this paper
• G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets.

  1994influential reference

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• ERα inhibits mesenchymal and amoeboidal movement of liver cancer cell via Gα12

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• NPFFR2 Contributes to the Malignancy of Hepatocellular Carcinoma Development by Activating RhoA/YAP Signaling

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• Thrombin induces IL-8/CXCL8 expression by DCLK1-dependent RhoA and YAP activation in human lung epithelial cells

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• Rho-Mancing to Sensitize Calcium Signaling for Contraction in the Vasculature: Role of Rho Kinase.

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  2016cites this paper
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  2015cites this paper
• Role of the heterotrimeric protein Gq and small GTPase RhoA in the cholinergic modulation of the slow afterhyperpolarizing current, sIAHP, in hippocampal pyramidal neurons

  2015influential citation
• The Chemerin Receptor GPR1 Signals Through a RhoA/ROCK Pathway and Contributes to Glucose Homeostasis in Obese Mice

  2015cites this paper
• CMKLR1 and GPR1 mediate chemerin signaling through the RhoA/ROCK pathway.

  2015cites this paper
• Role of ROCK expression in gallbladder smooth muscle contraction.

  2015cites this paper
• Label-free biosensor assays in GPCR screening.

  2015cites this paper
• Simvastatin Treatment Highlights a New Role for the Isoprenoid/Cholesterol Biosynthetic Pathway in the Modulation of Emotional Reactivity and Cognitive Performance in Rats

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• Targeting the Myofibroblast Genetic Switch: Inhibitors of Myocardin-Related Transcription Factor/Serum Response Factor–Regulated Gene Transcription Prevent Fibrosis in a Murine Model of Skin Injury

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• The Ras-related Protein, Rap1A, Mediates Thrombin-stimulated, Integrin-dependent Glioblastoma Cell Proliferation and Tumor Growth*

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  2014cites this paper
• Activation of Gαq subunits up-regulates the expression of the tumor suppressor Fhit.

  2013cites this paper
• Heparin inhibits angiotensin II-induced vasoconstriction on isolated mouse mesenteric resistance arteries through Rho-A- and PKA-dependent pathways.

  2013cites this paper
• The activation of proteinase-activated receptor-1 (PAR1) promotes gastric cancer cell alteration of cellular morphology related to cell motility and invasion.

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• A new mechanism of RhoA ubiquitination and degradation: roles of SCF(FBXL19) E3 ligase and Erk2.

  2013cites this paper
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  2012cites this paper
• Sphingosylphosphorylcholine induces stress fiber formation via activation of Fyn-RhoA-ROCK signaling pathway in fibroblasts.

  2012cites this paper
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