NADPH oxidase is involved in post-ischemic brain inflammation.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Neurobiology of Disease

• Publication date

  2011-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.nbd.2011.01.027PMID 21303700PMCID PMC3079796
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Inflammatory mechanisms in ischemic stroke: role of inflammatory cells

  2010cited by this paper
• Post-Stroke Inhibition of Induced NADPH Oxidase Type 4 Prevents Oxidative Stress and Neurodegeneration

  2010cited by this paper
• Role of Chemokines in CNS Health and Pathology: A Focus on the CCL2/CCR2 and CXCL8/CXCR2 Networks

  2010cited by this paper
• Endosomal Nox2 Facilitates Redox-Dependent Induction of NF-κB by TNF-α

  2009cited by this paper
• Inhibition of NADPH Oxidase is Neuroprotective after Ischemia—Reperfusion

  2009influential reference
• Therapeutic targets and limits of minocycline neuroprotection in experimental ischemic stroke

  2009cited by this paper
• Post‐ischemic brain damage: pathophysiology and role of inflammatory mediators

  2009cited by this paper
• Zinc Triggers Microglial Activation

  2008cited by this paper
• Free Radical Production in CA1 Neurons Induces MIP-1α Expression, Microglia Recruitment, and Delayed Neuronal Death after Transient Forebrain Ischemia

  2008cited by this paper
• Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

  2007cited by this paper
• The inflammatory response in stroke.

  2007cited by this paper
• The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology.

  2007cited by this paper
• Nox2 and Rac1 Regulate H2O2-Dependent Recruitment of TRAF6 to Endosomal Interleukin-1 Receptor Complexes

  2006influential reference
• Microglia Biology in Health and Disease

  2006cited by this paper
• Delayed minocycline inhibits ischemia-activated matrix metalloproteinases 2 and 9 after experimental stroke

  2006cited by this paper
• Microglia Potentiate Damage to Blood–Brain Barrier Constituents: Improvement by Minocycline In Vivo and In Vitro

  2006cited by this paper
• Microglia Proliferation Is Regulated by Hydrogen Peroxide from NADPH Oxidase1

  2006influential reference
• Cell signaling. H2O2, a necessary evil for cell signaling.

  2006cited by this paper
• H2O2, a Necessary Evil for Cell Signaling

  2006cited by this paper
• Superoxide Dismutase 1 Overexpression Reduces MCP-1 and MIP-1α Expression after Transient Focal Cerebral Ischemia

  2005influential reference
• The Potential of Minocycline for Neuroprotection in Human Neurologic Disease

  2004cited by this paper
• Overexpression of Monocyte Chemoattractant Protein 1 in the Brain Exacerbates Ischemic Brain Injury and is Associated with Recruitment of Inflammatory Cells

  2003cited by this paper
• Interleukin-1 Influences Ischemic Brain Damage in the Mouse Independently of the Interleukin-1 Type I Receptor

  2002cited by this paper
• Monocyte Chemoattractant Protein-1 Deficiency is Protective in a Murine Stroke Model

  2002cited by this paper
• Macrophage/Microglia-specific Protein Iba1 Enhances Membrane Ruffling and Rac Activation via Phospholipase C-γ-dependent Pathway*

  2002cited by this paper
• Cytokines and acute neurodegeneration

  2001cited by this paper
• Reactive Oxygen Radicals in Signaling and Damage in the Ischemic Brain

  2001cited by this paper
• Cytochrome c Release and Caspase Activation in Traumatic Axonal Injury

  2000cited by this paper
• Interleukin 1 in the brain: biology, pathology and therapeutic target.

  2000cited by this paper
• Inflammatory Mediators and Stroke: New Opportunities for Novel Therapeutics

  1999cited by this paper
• A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window.

  1999cited by this paper
• Potential mechanisms of interleukin-1 involvement in cerebral ischaemia.

  1999cited by this paper
• Ischemic cell death in brain neurons.

  1999cited by this paper
• Signal transduction pathways activated by the IL‐1 receptor family: ancient signaling machinery in mammals, insects, and plants

  1998cited by this paper
• Mitochondrial Susceptibility to Oxidative Stress Exacerbates Cerebral Infarction That Follows Permanent Focal Cerebral Ischemia in Mutant Mice with Manganese Superoxide Dismutase Deficiency

  1998cited by this paper
• Microglia-specific localisation of a novel calcium binding protein, Iba1.

  1998cited by this paper
• Inflammation and glial responses in ischemic brain lesions.

  1998cited by this paper
• Exacerbation of Ischemic Brain Damage by Localized Striatal Injection of Interleukin-1β in the Rat

  1998cited by this paper
• Temporal profile of microglial response following transient (2 h) middle cerebral artery occlusion.

  1997influential reference
• Ischemic stroke injury is reduced in mice lacking a functional NADPH oxidase.

  1997cited by this paper
• Role of oxidants in ischemic brain damage.

  1996cited by this paper
• Mouse model of X–linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production

  1995influential reference
• Expression of monocyte chemoattractant protein-1 and macrophage inflammatory protein-1 after focal cerebral ischemia in the rat.

  1995cited by this paper
• Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant.

  1994cited by this paper
• Brain macrophages: evaluation of microglia and their functions.

  1992cited by this paper
• Macrophage inflammatory protein 1 modulates macrophage function.

  1992cited by this paper
• Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

  1990cited by this paper
• Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties

  1988cited by this paper

• The ADMA–NO–NOX2 axis and its association with leptomeningeal collateral impairment in acute ischemic stroke

  2025cites this paper
• Dexmedetomidine activates mitophagy and protects against pyroptosis in oxygen-glucose deprivation/reperfusion-induced brain damage via PINK1/Parkin pathway activation

  2025cites this paper
• Mechanisms of Action of Propofol in Modulating Microglial Activation in Ischemic Stroke

  2025cites this paper
• Therapeutic potential of berries in age-related neurological disorders

  2024cites this paper
• Insight into the pathophysiological advances and molecular mechanisms underlying cerebral stroke: current status

  2024cites this paper
• The underlying mechanism of calcium toxicity-induced autophagic cell death and lysosomal degradation in early stage of cerebral ischemia

  2024cites this paper
• Gene Expression Changes in Cultured Reactive Rat Astrocyte Models and Comparison to Device-Associated Effects in the Brain

  2023cites this paper
• Inhibition of NADPH oxidase 2 improves cognitive abilities by modulating aquaporin-4 after traumatic brain injury in mice

  2023cites this paper
• Crebanine ameliorates ischemia-reperfusion brain damage by inhibiting oxidative stress and neuroinflammation mediated by NADPH oxidase 2 in microglia.

  2023cites this paper
• Therapeutic potential of NOX inhibitors in neuropsychiatric disorders

  2023cites this paper
• Fatty Acids: An Insight into the Pathogenesis of Neurodegenerative Diseases and Therapeutic Potential

  2022cites this paper
• Disengaging the COVID-19 Clutch as a Discerning Eye Over the Inflammatory Circuit During SARS-CoV-2 Infection

  2022cites this paper
• Endothelial NOX4 Oxidase Negatively Regulates Inflammation and Improves Morbidity During Influenza A Virus Lung Infection in Mice

  2022cites this paper
• Treadmill exercise training alleviates diabetes-induced depressive-like behavior and cognitive impairment by improving hippocampal CA1 neurons injury in db/db mice.

  2022cites this paper
• Inhibition of NADPH oxidase 2 (NOX2) reverses cognitive deficits by modulating excitability and excitatory transmission in the hippocampus after traumatic brain injury.

  2022cites this paper
• MicroRNA-126a-5p Exerts Neuroprotective Effects on Ischemic Stroke via Targeting NADPH Oxidase 2

  2021cites this paper
• Pathophysiology and Therapeutic Potential of NADPH Oxidases in Ischemic Stroke-Induced Oxidative Stress

  2021cites this paper
• NDT_A_293611 2089..2103

  2021cites this paper
• In vivo dynamics of acidosis and oxidative stress in the acute phase of an ischemic stroke in a rodent model

  2021cites this paper
• NADPH Oxidases in the Central Nervous System: Regional and Cellular Localization and the Possible Link to Brain Diseases

  2021cites this paper
• The Role of NADPH Oxidase in Neuronal Death and Neurogenesis after Acute Neurological Disorders

  2021cites this paper
• Wound Healing After Alkali Burn Injury of the Cornea Involves Nox4-Type NADPH Oxidase

  2020cites this paper
• Glaucoma causes redox imbalance in the primary visual cortex by modulating NADPH oxidase-4, iNOS, and Nrf2 pathway in a rat experimental model.

  2020cites this paper
• Dynamic Alterations of Brain Injury, Functional Recovery, and Metabolites Profile after Cerebral Ischemia/Reperfusion in Rats Contributes to Potential Biomarkers

  2020cites this paper
• Nox2 and Nox4 Participate in ROS-Induced Neuronal Apoptosis and Brain Injury During Ischemia-Reperfusion in Rats.

  2020cites this paper
• Nicotinamide adenine dinucleotide phosphate oxidase activation and neuronal death after ischemic stroke

  2019cites this paper
• Acacetin protects against cerebral ischemia-reperfusion injury via the NLRP3 signaling pathway

  2019cites this paper
• Neuroinflammation, oxidative stress, and blood-brain barrier (BBB) disruption in acute Utah electrode array implants and the effect of deferoxamine as an iron chelator on acute foreign body response.

  2019cites this paper
• Modulating neuroinflammation and oxidative stress to prevent epilepsy and improve outcomes after traumatic brain injury.

  2019cites this paper
• Potential Neuroprotective Treatment of Stroke: Targeting Excitotoxicity, Oxidative Stress, and Inflammation

  2019cites this paper
• RvD1binding with FPR2 attenuates inflammation via Rac1/NOX2 pathway after neonatal hypoxic-ischemic injury in rats.

  2019cites this paper
• Inhibition of NOX2 signaling limits pain-related behavior and improves motor function in male mice after spinal cord injury: Participation of IL-10/miR-155 pathways.

  2019influential citation
• Attenuation of stroke damage by angiotensin II type 2 receptor stimulation via peroxisome proliferator-activated receptor-gamma activation

  2018cites this paper
• Reactive Oxygen Species in Metabolic and Inflammatory Signaling.

  2018cites this paper
• ptimization for extraction of an oil recipe consisting of white epper , long pepper , cinnamon , saffron , and myrrh by supercritical arbon dioxide and the protective effects against oxygen – glucose eprivation in PC 12 cells

  2018cites this paper
• Discovery of Neuroprotective Antioxidants for the Management of Ischemic Brain Stroke

  2018cites this paper
• Glutathione Reduction of Patulin-Evoked Cytotoxicity in HEK293 Cells by the Prevention of Oxidative Damage and the Mitochondrial Apoptotic Pathway.

  2018cites this paper
• NADPH oxidases in traumatic brain injury – Promising therapeutic targets?

  2018cites this paper
• Gp91phox (NOX2) in Activated Microglia Exacerbates Neuronal Damage Induced by Oxygen Glucose Deprivation and Hyperglycemia in an in Vitro Model

  2018cites this paper
• Optimization for extraction of an oil recipe consisting of white pepper, long pepper, cinnamon, saffron, and myrrh by supercritical carbon dioxide and the protective effects against oxygen-glucose deprivation in PC12 cells

  2018cites this paper
• NADPH oxidase in brain injury and neurodegenerative disorders

  2017cites this paper
• NOX2 deficiency alters macrophage phenotype through an IL-10/STAT3 dependent mechanism: implications for traumatic brain injury

  2017cites this paper
• Phospholipase A2 of Peroxiredoxin 6 Plays a Critical Role in Cerebral Ischemia/Reperfusion Inflammatory Injury

  2017cites this paper
• Allelopathic effects of volatile organic compounds from Eucalyptus grandis rhizosphere soil on Eisenia fetida assessed using avoidance bioassays, enzyme activity, and comet assays.

  2017cites this paper
• NOX Activation by Subunit Interaction and Underlying Mechanisms in Disease

  2017cites this paper
• NADPH Oxidase-Related Pathophysiology in Experimental Models of Stroke

  2017cites this paper
• Chronic cerebral hypoperfusion alters amyloid-β peptide pools leading to cerebral amyloid angiopathy, microinfarcts and haemorrhages in Tg-SwDI mice.

  2017influential citation
• Theraupeutic Effect of Small Molecular Entities

  2017cites this paper
• Targeting Oxidative Stress in Stroke

  2017cites this paper
• Myeloid differentiation protein 2‐dependent mechanisms in retinal ischemia‐reperfusion injury

  2017cites this paper
• Neuronal expression of the mitochondrial protein prohibitin confers profound neuroprotection in a mouse model of focal cerebral ischemia

  2017cites this paper
• Amyloid-β and chronic cerebral hypoperfusion in the early pathogenesis of Alzheimer’s disease

  2016influential citation
• Persistent systemic monocyte and neutrophil activation in neonatal encephalopathy

  2016cites this paper
• Nox4 contributes to the hypoxia-mediated regulation of actin cytoskeleton in cerebrovascular smooth muscle.

  2016cites this paper
• Dexmedetomidine Protects against Transient Global Cerebral Ischemia/Reperfusion Induced Oxidative Stress and Inflammation in Diabetic Rats

  2016cites this paper
• NADPH oxidase inhibitor improves outcome of mechanical reperfusion by suppressing hemorrhagic transformation

  2016cites this paper
• Method parameters’ impact on mortality and variability in mouse stroke experiments: a meta-analysis

  2016cites this paper
• Microglial/Macrophage Polarization Dynamics following Traumatic Brain Injury

  2016cites this paper
• Targeting specific cells in the brain with nanomedicines for CNS therapies.

  2016cites this paper
• Persistent systemic monocyte and neutrophil activation in neonatal encephalopathy

  2016cites this paper
• NOX2 drives M1-like microglial/macrophage activation and neurodegeneration following experimental traumatic brain injury.

  2016cites this paper
• [Salidroside protects PC12 cells from H2O2-induced apoptosis via suppressing NOX2-ROS-MAPKs signaling pathway].

  2016cites this paper
• The Role of NADPH oxidase 2 (NOX2) in High-Fat Diet-Induced Adiposopathy and Brain Dysfunction in a Mouse Model

  2016influential citation
• THE ROLE OF NADPH OXIDASE IN THE MODULATION OF PP 2 A By

  2016cites this paper
• Focal Ischemic Injury with Complex Middle Cerebral Artery in Stroke-Prone Spontaneously Hypertensive Rats with Loss-Of-Function in NADPH Oxidases

  2015cites this paper
• PPAR-γ Ameliorates Neuronal Apoptosis and Ischemic Brain Injury via Suppressing NF-κB-Driven p22phox Transcription

  2015cites this paper
• A combined pre-clinical meta-analysis and randomized confirmatory trial approach to improve data validity for therapeutic target validation

  2015cites this paper
• Inhibition of myosin light chain kinase reduces NADPH oxidase-mediated oxidative injury in rat brain following cerebral ischemia/reperfusion

  2015cites this paper
• NADPH Oxidase-2: Linking Glucose, Acidosis, and Excitotoxicity in Stroke

  2015cites this paper
• Alpha-Lipoic Acid Attenuates Cerebral Ischemia and Reperfusion Injury via Insulin Receptor and PI3K/Akt-Dependent Inhibition of NADPH Oxidase

  2015cites this paper
• Pathophysiology and Treatments of Oxidative Injury in Ischemic Stroke: Focus on the Phagocytic NADPH Oxidase 2

  2015cites this paper
• Phagocyte NADPH oxidase restrains the inflammasome in ANCA-induced GN.

  2015cites this paper
• Inhibition of TNF-α protects in vitro brain barrier from ischaemic damage.

  2015cites this paper
• Two-Dimensional Zymography Differentiates Gelatinase Isoforms in Stimulated Microglial Cells and in Brain Tissues of Acute Brain Injuries

  2015cites this paper
• Alpha‐7 nicotinic acetylcholine receptor agonist treatment reduces neuroinflammation, oxidative stress, and brain injury in mice with ischemic stroke and bone fracture

  2014cites this paper
• NADPH oxidase inhibition improves neurological outcome in experimental traumatic brain injury.

  2014cites this paper
• Oxidative Stress and the Use of Antioxidants in Stroke

  2014cites this paper
• The Role of NADPH Oxidase in the Modulation of PP2A

  2014cites this paper
• Nox2 Knockout Delays Infarct Progression and Increases Vascular Recovery through Angiogenesis in Mice following Ischaemic Stroke with Reperfusion

  2014cites this paper
• Reactive Oxygen species and cerebrovascular diseases

  2014cites this paper
• Patient specific stem cell models: focus on glioblastoma and neuronal differentiation aspects of chronic granulomatous disease

  2014cites this paper
• NOXious oxidative stress : from head toe too and back

  2014cites this paper
• Attenuation of urokinase activity during experimental ischaemia protects the cerebral barrier from damage through regulation of matrix metalloproteinase‐2 and NAD(P)H oxidase

  2014cites this paper
• 15-Deoxy-∆12,14-PGJ2, by Activating Peroxisome Proliferator-Activated Receptor-Gamma, Suppresses p22phox Transcription to Protect Brain Endothelial Cells Against Hypoxia-Induced Apoptosis

  2014cites this paper
• Maternal Inflammation Contributes to Brain Overgrowth and Autism-Associated Behaviors through Altered Redox Signaling in Stem and Progenitor Cells

  2014cites this paper
• Mitochondrial reactive oxygen species: A double edged sword in ischemia/reperfusion vs preconditioning

  2014cites this paper
• Progressive neurodegeneration after experimental brain trauma: association with chronic microglial activation.

  2014cites this paper
• Dietary Sutherlandia and Elderberry Mitigate Cerebral Ischemia-Induced Neuronal Damage and Attenuate p47phox and Phospho-ERK1/2 Expression in Microglial Cells

  2014influential citation
• Protective Effects of Minocycline against Short-Term Ischemia-Reperfusion Injury in Rat Brain

  2014cites this paper
• Prohibitin Viral Gene Transfer Protects Hippocampal CA1 Neurons From Ischemia and Ameliorates Postischemic Hippocampal Dysfunction

  2014cites this paper
• New Insights on NOX Enzymes in the Central Nervous System

  2014cites this paper
• Activation of α-7 Nicotinic Acetylcholine Receptor Reduces Ischemic Stroke Injury through Reduction of Pro-Inflammatory Macrophages and Oxidative Stress

  2014cites this paper
• Activation of mGluR5 and Inhibition of NADPH Oxidase Improves Functional Recovery after Traumatic Brain Injury

  2013cites this paper
• Nucleotide excision repair in chronic neurodegenerative diseases.

  2013cites this paper
• NADPH Oxidase as a Therapeutic Target for Neuroprotection against Ischaemic Stroke: Future Perspectives

  2013cites this paper
• Which NADPH Oxidase Isoform Is Relevant for Ischemic Stroke? The Case for Nox 2

  2013cites this paper
• Antibiotics acting as neuroprotectants via mechanisms independent of their anti-infective activities.

  2013cites this paper
• The effect of NADPH-oxidase inhibitor apocynin on cognitive impairment induced by moderate lateral fluid percussion injury: role of inflammatory and oxidative brain damage.

  2013cites this paper
• NOX 2 deficiency attenuates markers of adiposopathy and brain injury induced by high-fat diet

  2013cites this paper
• NOX2 deficiency attenuates markers of adiposopathy and brain injury induced by high-fat diet.

  2013cites this paper