Regulation of toxin production in the pathogenic clostridia

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Molecular Microbiology

• Publication date

  2014-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/mmi.12469PMID 24563915
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Correction for Chen et al., Epsilon-Toxin Production by Clostridium perfringens Type D Strain CN3718 Is Dependent upon the agr Operon but Not the VirS/VirR Two-Component Regulatory System

  2015cited by this paper
• The agr Locus Regulates Virulence and Colonization Genes in Clostridium difficile 027

  2013cited by this paper
• Unique Regulatory Mechanism of Sporulation and Enterotoxin Production in Clostridium perfringens

  2013influential reference
• Regulatory RNAs and target mRNA decay in prokaryotes.

  2013cited by this paper
• Two-Component Signal Transduction System CBO0787/CBO0786 Represses Transcription from Botulinum Neurotoxin Promoters in Clostridium botulinum ATCC 3502

  2013influential reference
• A genomic update on clostridial phylogeny: Gram-negative spore formers and other misplaced clostridia.

  2013influential reference
• Genome-Wide Identification of Regulatory RNAs in the Human Pathogen Clostridium difficile

  2013cited by this paper
• Effects of ciprofloxacin on the expression and production of exotoxins by Clostridium difficile.

  2013cited by this paper
• Spo0A Differentially Regulates Toxin Production in Evolutionarily Diverse Strains of Clostridium difficile

  2013cited by this paper
• Life-threatening clostridial infections.

  2012cited by this paper
• C. difficile 630Δerm Spo0A Regulates Sporulation, but Does Not Contribute to Toxin Production, by Direct High-Affinity Binding to Target DNA

  2012cited by this paper
• TcdC Does Not Significantly Repress Toxin Expression in Clostridium difficile 630ΔErm

  2012cited by this paper
• Global transcriptional control by glucose and carbon regulator CcpA in Clostridium difficile

  2012cited by this paper
• The role of toxin A and toxin B in the virulence of Clostridium difficile.

  2012cited by this paper
• Botulinum toxin: therapeutic agent to cosmetic enhancement to lethal biothreat.

  2012cited by this paper
• Secretion of Clostridium difficile Toxins A and B Requires the Holin-like Protein TcdE

  2012cited by this paper
• Co-amoxiclav induces proliferation and cytotoxin production of Clostridium difficile ribotype 027 in a human gut model.

  2012cited by this paper
• Evidence that the Agr‐like quorum sensing system regulates the toxin production, cytotoxicity and pathogenicity of Clostridium perfringens type C isolate CN3685

  2012influential reference
• Evolution of two-component signal transduction systems.

  2012cited by this paper
• Sugar inhibits the production of the toxins that trigger clostridial gas gangrene.

  2012influential reference
• Precise Manipulation of the Clostridium difficile Chromosome Reveals a Lack of Association between the tcdC Genotype and Toxin Production

  2012cited by this paper
• The Clostridium difficile spo0A Gene Is a Persistence and Transmission Factor

  2012cited by this paper
• Two-Component Systems Are Involved in the Regulation of Botulinum Neurotoxin Synthesis in Clostridium botulinum Type A Strain Hall

  2012cited by this paper
• Clostridium perfringens tpeL is expressed during sporulation.

  2011cited by this paper
• TcsL Is an Essential Virulence Factor in Clostridium sordellii ATCC 9714

  2011cited by this paper
• Epsilon-Toxin Production by Clostridium perfringens Type D Strain CN3718 Is Dependent upon the agr Operon but Not the VirS/VirR Two-Component Regulatory System

  2011cited by this paper
• The Anti-Sigma Factor TcdC Modulates Hypervirulence in an Epidemic BI/NAP1/027 Clinical Isolate of Clostridium difficile

  2011cited by this paper
• Regulation by small RNAs in bacteria: expanding frontiers.

  2011cited by this paper
• Recent progress in understanding the pathogenesis of Clostridium perfringens type C infections.

  2011cited by this paper
• Small RNAs in the Genus Clostridium

  2011cited by this paper
• CcpA‐mediated repression of Clostridium difficile toxin gene expression

  2011influential reference
• The Agr-Like Quorum-Sensing System Regulates Sporulation and Production of Enterotoxin and Beta2 Toxin by Clostridium perfringens Type A Non-Food-Borne Human Gastrointestinal Disease Strain F5603

  2011influential reference
• The Key Sigma Factor of Transition Phase, SigH, Controls Sporulation, Metabolism, and Virulence Factor Expression in Clostridium difficile

  2011cited by this paper
• The VirS/VirR Two-Component System Regulates the Anaerobic Cytotoxicity, Intestinal Pathogenicity, and Enterotoxemic Lethality of Clostridium perfringens Type C Isolate CN3685

  2011cited by this paper
• Integration of Metabolism and Virulence by Clostridium difficile CodY

  2010cited by this paper
• Regulation of Neurotoxin Production and Sporulation by a Putative agrBD Signaling System in Proteolytic Clostridium botulinum

  2010influential reference
• The VirSR Two-Component Signal Transduction System Regulates NetB Toxin Production in Clostridium perfringens

  2010cited by this paper
• Identification of a two-component VirR/VirS regulon in Clostridium perfringens.

  2010influential reference
• Evaluating the Involvement of Alternative Sigma Factors SigF and SigG in Clostridium perfringens Sporulation and Enterotoxin Synthesis

  2010cited by this paper
• Stabilization of Clostridium perfringens collagenase mRNA by VR‐RNA‐dependent cleavage in 5′ leader sequence

  2010cited by this paper
• Clostridia as agents of zoonotic disease.

  2010cited by this paper
• Functional Analysis of the VirSR Phosphorelay from Clostridium perfringens

  2009cited by this paper
• Contact with enterocyte‐like Caco‐2 cells induces rapid upregulation of toxin production by Clostridium perfringens type C isolates

  2009influential reference
• Characterization of the Sporulation Initiation Pathway of Clostridium difficile and Its Role in Toxin Production

  2009cited by this paper
• Construction of a Nontoxigenic Clostridium botulinum Strain for Food Challenge Studies

  2009cited by this paper
• Use of an EZ-Tn5-Based Random Mutagenesis System to Identify a Novel Toxin Regulatory Locus in Clostridium perfringens Strain 13

  2009influential reference
• Sporulation and Enterotoxin (CPE) Synthesis Are Controlled by the Sporulation-Specific Sigma Factors SigE and SigK in Clostridium perfringens

  2009cited by this paper
• Virulence Gene Regulation by the agr System in Clostridium perfringens

  2009influential reference
• Characterization of Genes Regulated Directly by the VirR/VirS System in Clostridium perfringens

  2008influential reference
• Clostridium difficile toxin synthesis is negatively regulated by TcdC.

  2008cited by this paper
• A novel toxin homologous to large clostridial cytotoxins found in culture supernatant of Clostridium perfringens type C.

  2007cited by this paper
• Binary Toxin Production in Clostridium difficile Is Regulated by CdtR, a LytTR Family Response Regulator

  2007cited by this paper
• Repression of Clostridium difficile toxin gene expression by CodY

  2007cited by this paper
• Clostridium difficile toxin expression is inhibited by the novel regulator TcdC

  2007cited by this paper
• Both Epsilon-Toxin and Beta-Toxin Are Important for the Lethal Properties of Clostridium perfringens Type B Isolates in the Mouse Intravenous Injection Model

  2007cited by this paper
• The ClosTron: a universal gene knock-out system for the genus Clostridium.

  2007cited by this paper
• The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome

  2006cited by this paper
• Construction and analysis of chromosomal Clostridium difficile mutants

  2006cited by this paper
• Regulation of toxin and bacteriocin gene expression in Clostridium by interchangeable RNA polymerase sigma factors

  2006influential reference
• Expression of botulinum neurotoxins A and E, and associated non-toxin genes, during the transition phase and stability at high temperature: analysis by quantitative reverse transcription-PCR.

  2006cited by this paper
• Toxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe disease in North America and Europe.

  2005influential reference
• Construction of an Alpha Toxin Gene Knockout Mutant of Clostridium perfringens Type A by Use of a Mobile Group II Intron

  2005cited by this paper
• The CcpA Protein Is Necessary for Efficient Sporulation and Enterotoxin Gene (cpe) Regulation in Clostridium perfringens

  2004cited by this paper
• The Spatial Organization of the VirR Boxes Is Critical for VirR-Mediated Expression of the Perfringolysin O Gene, pfoA, from Clostridium perfringens

  2004cited by this paper
• Disruption of the gene (spo0A) encoding sporulation transcription factor blocks endospore formation and enterotoxin production in enterotoxigenic Clostridium perfringens type A.

  2004cited by this paper
• BotR/A and TetR are alternative RNA polymerase sigma factors controlling the expression of the neurotoxin and associated protein genes in Clostridium botulinum type A and Clostridium tetani

  2004cited by this paper
• The VirR/VirS regulatory cascade affects transcription of plasmid-encoded putative virulence genes in Clostridium perfringens strain 13.

  2003influential reference
• Autoinduction and signal transduction in the regulation of staphylococcal virulence

  2003cited by this paper
• Expression of Clostridium difficile Toxins A and B and Their Sigma Factor TcdD Is Controlled by Temperature

  2003cited by this paper
• Clostridial VirR/VirS regulon involves a regulatory RNA molecule for expression of toxins

  2002influential reference
• Identification of a novel locus that regulates expression of toxin genes in Clostridium perfringens.

  2002cited by this paper
• Environmental Response and Autoregulation of Clostridium difficile TxeR, a Sigma Factor for Toxin Gene Expression

  2002cited by this paper
• Regulation of toxin synthesis in Clostridium difficile by an alternative RNA polymerase sigma factor

  2001cited by this paper
• Staphylococcus aureus and Staphylococcus epidermidis peptide pheromones produced by the accessory gene regulator agr system.

  2001cited by this paper
• Clostridium botulinum and its neurotoxins: a metabolic and cellular perspective.

  2001cited by this paper
• Extreme potency of botulinum toxin.

  2000cited by this paper
• Identification of novel VirR/VirS‐regulated genes in Clostridium perfringens

  2000cited by this paper
• The VirR Response Regulator from Clostridium perfringens Binds Independently to Two Imperfect Direct Repeats Located Upstream of the pfoA Promoter

  2000cited by this paper
• Toxins, Butyric Acid, and Other Short-Chain Fatty Acids Are Coordinately Expressed and Down-Regulated by Cysteine in Clostridium difficile

  2000cited by this paper
• Promoter upstream bent DNA activates the transcription of the Clostridium perfringens phospholipase C gene in a low temperature‐dependent manner

  1999cited by this paper
• Suppression of toxin production in Clostridium difficile VPI 10463 by amino acids.

  1999influential reference
• Virulence genes of Clostridium perfringens.

  1998cited by this paper
• Regulated transcription of Clostridium difficile toxin genes

  1998cited by this paper
• Clostridial diseases of small ruminants

  1998cited by this paper
• Clostridial diseases of small ruminants.

  1998cited by this paper
• Identification and Characterization of Sporulation-Dependent Promoters Upstream of the Enterotoxin Gene (cpe) of Clostridium perfringens

  1998cited by this paper
• Transcription analysis of the genes tcdA-E of the pathogenicity locus of Clostridium difficile.

  1997cited by this paper
• Definition of the single integration site of the pathogenicity locus in Clostridium difficile.

  1996influential reference
• Clostridial enteric diseases of domestic animals

  1996cited by this paper
• Regulation of extracellular toxin production in Clostridium perfringens.

  1995cited by this paper
• The mechanism of action of tetanus and botulinum neurotoxins.

  1995cited by this paper
• Mechanism of action of tetanus and botulinum neurotoxins

  1994cited by this paper
• Sporulation and primary sigma factor homologous genes in Clostridium acetobutylicum

  1994cited by this paper
• The virR gene, a member of a class of two-component response regulators, regulates the production of perfringolysin O, collagenase, and hemagglutinin in Clostridium perfringens

  1994influential reference
• Identification and molecular analysis of a locus that regulates extracellular toxin production in Clostridium perfringens

  1994influential reference
• A comparative biochemical, pharmacological and immunological study of Clostridium novyi alpha-toxin, C. difficile toxin B and C. sordellii lethal toxin.

  1991cited by this paper
• Purification and characterization of toxins A and B of Clostridium difficile

  1982influential reference
• How does tetanus toxin act?

  1981cited by this paper
• Time of Enterotoxin Formation and Release During Sporulation of Clostridium perfringens Type A

  1973influential reference
• Identification and Characterization of Clostridium sordellii Toxin Gene Regulator

  year unknowninfluential reference

• Botulinum toxin in modern clinical and aesthetic medicine: history, applications, risks and future perspectives

  2025cites this paper
• CAMKK2-AMPK axis endows dietary calcium and phosphorus levels with regulatory effects on lipid metabolism in weaned piglets

  2024cites this paper
• Pantothenate kinase: A promising therapeutic target against pathogenic Clostridium species

  2024influential citation
• Alginate oligosaccharides enhance gut microbiota and intestinal barrier function, alleviating host damage induced by deoxynivalenol in mice.

  2024cites this paper
• Improvement of loperamide-hydrochloride-induced intestinal motility disturbance by Platycodon grandiflorum polysaccharides through effects on gut microbes and colonic serotonin

  2023cites this paper
• Detection of Clostridium perfringens types through genetic profiling and mouse neutralisation test.

  2023cites this paper
• Gut microbiota in a mouse model of obesity and peripheral neuropathy associated with plasma and nerve lipidomics and nerve transcriptomics

  2023cites this paper
• Mating Leads to a Decline in the Diversity of Symbiotic Microbiomes and Promiscuity Increased Pathogen Abundance in a Moth

  2022cites this paper
• A Sarcina bacterium linked to lethal disease in sanctuary chimpanzees in Sierra Leone

  2021cites this paper
• Vaccination against pathogenic clostridia in animals: a review

  2021cites this paper
• First Comparative Analysis of Clostridium septicum Genomes Provides Insights Into the Taxonomy, Species Genetic Diversity, and Virulence Related to Gas Gangrene

  2021cites this paper
• Fecal microbiota transplantation mitigates vaginal atrophy in ovariectomized mice

  2021cites this paper
• Time-course transcriptomics reveals that amino acids catabolism plays a key role in toxinogenesis and morphology in Clostridium tetani.

  2020cites this paper
• Molecular Biology Perspective of Susceptibility and Resistance in Main Target Pathogens in the Respective Species and Antimicrobials of Concern

  2020cites this paper
• Tetanus Toxin Synthesis is Under the Control of A Complex Network of Regulatory Genes in Clostridium tetani

  2020cites this paper
• Prevalence and characterization of Clostridium perfringens toxinotypes among patients with antibiotic-associated diarrhea in Iran

  2019cites this paper
• Vaccine Production to Protect Animals Against Pathogenic Clostridia

  2019influential citation
• Clostridium sordellii Pathogenicity Locus Plasmid pCS1-1 Encodes a Novel Clostridial Conjugation Locus

  2018cites this paper
• Developing Anti-virulence Chemotherapies by Exploiting the Diversity of Microbial Quorum Sensing Systems

  2018cites this paper
• Production and Evaluation of a New Recombinant Cloning Vector for the Clostridium novyi Type B Vaccine Strain Alpha Toxin Gene

  2017cites this paper
• Heat shock and prolonged heat stress attenuate neurotoxin and sporulation gene expression in group I Clostridium botulinum strain ATCC 3502

  2017cites this paper
• Growth temperature variation and heat stress response of Clostridium botulinum

  2017cites this paper
• Tetanus toxin production is triggered by the transition from amino acid consumption to peptides.

  2016cites this paper
• Gas Gangrene (Malignant Edema)

  2016cites this paper
• Phenotypic Characterisation of Clostridium difficile PCR Ribotype 078 and Comparison with PCR Ribotypes 027 and 002

  2016cites this paper
• The Mechanisms of Virulence Regulation by Small Noncoding RNAs in Low GC Gram-Positive Pathogens

  2015influential citation
• Mycoplasma iowae: relationships among oxygen, virulence, and protection from oxidative stress

  2015cites this paper
• Antibiotic resistance, virulence factors and genetics of Clostridium sordellii.

  2015cites this paper
• Updates on tetanus toxin: a fundamental approach

  2015cites this paper
• Inhibiting Microbial Toxins Using Plant-Derived Compounds and Plant Extracts

  2015cites this paper
• Towards an understanding of the role of Clostridium perfringens toxins in human and animal disease.

  2014cites this paper