Hunger states switch a flip-flop memory circuit via a synaptic AMPK-dependent positive feedback loop.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Cell

• Publication date

  2011-09-16

• Fields of study

  Biology, Medicine, Physics

• Identifiers
  DOI 10.1016/j.cell.2011.07.039PMID 21925320PMCID PMC3209501
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training

  2010influential reference
• Generation of Digital Responses in Stress Sensors*

  2009cited by this paper
• UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals

  2009influential reference
• Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators

  2009cited by this paper
• A positive feedback signal transduction loop determines timing of cerebellar long-term depression.

  2008cited by this paper
• Ghrelin raises [Ca2+]i via AMPK in hypothalamic arcuate nucleus NPY neurons.

  2008cited by this paper
• UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals

  2008cited by this paper
• Hypothalamic CaMKK2 contributes to the regulation of energy balance.

  2008cited by this paper
• A FLEX Switch Targets Channelrhodopsin-2 to Multiple Cell Types for Imaging and Long-Range Circuit Mapping

  2008cited by this paper
• Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin.

  2008cited by this paper
• NPY/AgRP neurons are not essential for feeding responses to glucoprivation.

  2007cited by this paper
• Expression of ghrelin receptor mRNA in the rat and the mouse brain

  2006cited by this paper
• Vasodilation by the calcium-mobilizing messenger cyclic ADP-ribose. VOLUME 278 (2003) PAGES 9602-9608

  2006cited by this paper
• Can homeostatic circuits learn and remember?

  2006cited by this paper
• Differential effects of leptin and refeeding on the fasting-induced decrease of pituitary type 2 deiodinase and thyroid hormone receptor beta2 mRNA expression in mice.

  2006cited by this paper
• Does AMP-activated Protein Kinase Couple Inhibition of Mitochondrial Oxidative Phosphorylation by Hypoxia to Calcium Signaling in O2-sensing Cells?*

  2005cited by this paper
• Millisecond-timescale, genetically targeted optical control of neural activity

  2005cited by this paper
• Development of growth hormone secretagogues.

  2005cited by this paper
• NPY-induced feeding: pharmacological characterization using selective opioid antagonists and antisense probes in rats.

  2005cited by this paper
• The Ca2+/Calmodulin-dependent Protein Kinase Kinases Are AMP-activated Protein Kinase Kinases*

  2005cited by this paper
• Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase.

  2005cited by this paper
• Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells.

  2005cited by this paper
• Topographic mapping of VMH → arcuate nucleus microcircuits and their reorganization by fasting

  2005influential reference
• Fasting induces a large, leptin-dependent increase in the intrinsic action potential frequency of orexigenic arcuate nucleus neuropeptide Y/Agouti-related protein neurons.

  2005cited by this paper
• Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis.

  2004cited by this paper
• AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus

  2004cited by this paper
• Transcriptional regulation of agouti-related protein (Agrp) in transgenic mice.

  2004cited by this paper
• Rapid Rewiring of Arcuate Nucleus Feeding Circuits by Leptin

  2004influential reference
• A role for the endogenous opioid beta-endorphin in energy homeostasis.

  2003cited by this paper
• High constitutive signaling of the ghrelin receptor--identification of a potent inverse agonist.

  2003cited by this paper
• A Role for the Endogenous Opioid -Endorphin in Energy Homeostasis

  2003cited by this paper
• The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis.

  2003influential reference
• Self-perpetuating states in signal transduction: positive feedback, double-negative feedback and bistability.

  2002cited by this paper
• Dynorphin A(1-17)-induced feeding: pharmacological characterization using selective opioid antagonists and antisense probes in rats.

  2002cited by this paper
• A role for ghrelin in the central regulation of feeding

  2001cited by this paper
• Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

  2001influential reference
• Beta-endorphin-induced feeding: pharmacological characterization using selective opioid antagonists and antisense probes in rats.

  2001cited by this paper
• Virus-Assisted Mapping of Neural Inputs to a Feeding Center in the Hypothalamus

  2001cited by this paper
• Calcium stores in hippocampal synaptic boutons mediate short-term plasticity, store-operated Ca2+ entry, and spontaneous transmitter release.

  2001cited by this paper
• Ghrelin induces adiposity in rodents

  2000influential reference
• μ‐Opioid receptor inhibits N‐type Ca2+ channels in the calyx presynaptic terminal of the embryonic chick ciliary ganglion

  2000influential reference
• Identification of neuronal input to the arcuate nucleus (ARH) activated during lactation: implications in the activation of neuropeptide Y neurons.

  1999cited by this paper
• Emergent properties of networks of biological signaling pathways.

  1999cited by this paper
• Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons

  1998cited by this paper
• Heterogeneity of release probability, facilitation, and depletion at central synapses.

  1997cited by this paper
• A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release

  1996cited by this paper
• 5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?

  1995influential reference
• The Art of Electronics

  1990cited by this paper
• The art of electronics - Second edition

  1989cited by this paper
• Amplification and adaptation in regulatory and sensory systems.

  1982cited by this paper
• A Simple Sequentially Rejective Multiple Test Procedure

  1979cited by this paper
• Stimulation of food intake by muscimol and beta endorphin.

  1977cited by this paper
• Spontaneous subthreshold activity at motor nerve endings

  1952cited by this paper
• ORGANIZATION FOR PHYSIOLOGICAL HOMEOSTASIS

  1929cited by this paper

• AMPK at the interface of nutrient sensing, metabolic flux and energy homeostasis

  2026cites this paper
• Prefrontal cortex-to-hypothalamic outputs orchestrate cue-potentiated palatable food consumption via AMPKβ2 signaling

  2026cites this paper
• Emerging role of AgRP neurons as integrators of metabolic, sensory and environmental cues in the control of energy homeostasis.

  2025cites this paper
• Fructose-induced synaptic and neuronal adaptations at neuropeptide Y/agouti-related peptide neurons

  2025cites this paper
• The (dys)regulation of energy storage in obesity.

  2025cites this paper
• The ARCCRABP1 neurons play a crucial role in the regulation of energy homeostasis

  2025cites this paper
• The management of hypothalamic obesity in craniopharyngioma.

  2025cites this paper
• Brain control of energy homeostasis: Implications for anti-obesity pharmacotherapy.

  2025cites this paper
• VGluT3 BNST neurons transmit GABA and restrict sucrose consumption

  2025cites this paper
• Hunger Games: A Role for cAMP.

  2025cites this paper
• The liver talks back: NPY orchestrates attraction of cancer cells and CHK2-dependent clonogenicity in the metastatic niche.

  2025cites this paper
• VGluT3 BNST neurons transmit GABA and restrict feeding without affecting rewarding or aversive processing

  2025cites this paper
• Sustained Weight Loss With Combined LEAP2 and Semaglutide Treatment in Mice

  2025cites this paper
• An Analysis of AMPK and Ferroptosis in Cancer: A Potential Regulatory Axis.

  2025cites this paper
• Cell-type-resolved RNA-seq reveals molecular engrams of sexual experience in Drosophila neuromodulatory neurons

  2025cites this paper
• Canonical transient receptor potential channels and hypothalamic control of homeostatic functions

  2024cites this paper
• Paraventricular hypothalamic RUVBL2 neurons suppress appetite by enhancing excitatory synaptic transmission in distinct neurocircuits

  2024cites this paper
• Medial hypothalamic MC3R signalling regulates energy rheostasis in adult mice

  2024cites this paper
• Neuroanatomical dissection of the MC3R circuitry regulating energy rheostasis

  2024cites this paper
• Integrating Genetic and Transcriptomic Data to Identify Genes Underlying Obesity Risk Loci

  2024cites this paper
• Glycation-lowering compounds inhibit ghrelin signaling to reduce food intake, lower insulin resistance, and extend lifespan

  2024cites this paper
• Hypothalamic AMP-Activated Protein Kinase as a Whole-Body Energy Sensor and Regulator

  2024cites this paper
• Acute and circadian feedforward regulation of agouti-related peptide hunger neurons.

  2024cites this paper
• Stochastic neuropeptide signals compete to calibrate the rate of satiation

  2024cites this paper
• Opposing GPCR signaling programs protein intake setpoint in Drosophila.

  2024cites this paper
• Hypothalamic AgRP neurons regulate the hyperphagia of lactation

  2024cites this paper
• The Role of BDNF and TrkB in the Central Control of Energy and Glucose Balance: An Update

  2024cites this paper
• Low resting metabolic rate and increased hunger due to β-MSH and β-endorphin deletion in a canine model

  2024cites this paper
• From Mammals to Insects: Exploring the Genetic and Neural Basis of Eating Behavior.

  2024cites this paper
• Investigating the Impact of Fasting and Refeeding on Blood Biochemical Indicators and Transcriptional Profiles in the Hypothalamus and Subcutaneous Adipose Tissue in Geese

  2024cites this paper
• Revealing brain cell-stratified causality through dissecting causal variants according to their cell-type-specific effects on gene expression

  2024cites this paper
• RNA-sequencing Reveals Altered Gene Expression in the Ventromedial Hypothalamus Following Predator Odor Exposure

  2024cites this paper
• A Light-Responsive Neural Circuit Suppresses Feeding

  2024cites this paper
• Opioidergic signaling contributes to food-mediated suppression of AgRP neurons

  2024cites this paper
• Bisphenol A and its Analogues Alter Appetite Control in Zebrafish

  2024cites this paper
• Ghrelin-responsive mediobasal hypothalamic neurons mediate exercise-associated food intake and exercise endurance

  2023cites this paper
• Dynamic, sex‐ and diet‐specific pleiotropism in the PAC1 receptor‐mediated regulation of arcuate proopiomelanocortin and Neuropeptide Y/Agouti related peptide neuronal excitability by anorexigenic ventromedial nucleus PACAP neurons

  2023cites this paper
• Anti-inflammatory effects of hunger are transmitted to the periphery via projection-specific AgRP circuits

  2023cites this paper
• Subcellular localization and transcriptional regulation of brain ryanodine receptors. Functional implications.

  2023cites this paper
• Neurochemical Basis of Inter-Organ Crosstalk in Health and Obesity: Focus on the Hypothalamus and the Brainstem

  2023cites this paper
• High sucrose consumption decouples intrinsic and synaptic excitability of AgRP neurons without altering body weight

  2023cites this paper
• Competition between stochastic neuropeptide signals calibrates the rate of satiation

  2023cites this paper
• Maternal chronic caffeine intake impairs fertility, placental vascularization and fetal development in mice.

  2023cites this paper
• Fasting modulates GABAergic synaptic transmission to arcuate kisspeptin neurons in female mice.

  2023cites this paper
• Competition between stochastic neuropeptide signals calibrates the rate of satiation

  2023cites this paper
• Ghrelin Amplifies the Nicotine-Induced Release of Dopamine in the Bed Nucleus of Stria Terminalis (BNST)

  2023cites this paper
• Melanocortin-3 receptor expression in AgRP neurons is required for normal activation of the neurons in response to energy deficiency

  2023cites this paper
• CPT1A in AgRP neurons is required for sex-dependent regulation of feeding and thirst

  2023cites this paper
• The Complex Interplay between Imbalanced Mitochondrial Dynamics and Metabolic Disorders in Type 2 Diabetes

  2023cites this paper
• Hunger potentiated.

  2023cites this paper
• Asprosin promotes feeding through SK channel–dependent activation of AgRP neurons

  2023cites this paper
• Convergent Energy State–Dependent Antagonistic Signaling by Cocaine- and Amphetamine-Regulated Transcript (CART) and Neuropeptide Y (NPY) Modulates the Plasticity of Forebrain Neurons to Regulate Feeding in Zebrafish

  2023cites this paper
• Synaptic plasticity and the role of astrocytes in central metabolic circuits.

  2023cites this paper
• A synaptic amplifier of hunger for regaining body weight in the hypothalamus.

  2023cites this paper
• Emergence in complex networks of simple agents

  2023cites this paper
• Anxiolytic effect of antidiabetic metformin is mediated by AMPK activation in mPFC inhibitory neurons

  2023cites this paper
• RyR-mediated calcium release in hippocampal health and disease.

  2023cites this paper
• New insights into activation and function of the AMPK

  2022cites this paper
• Mechanistic insights on impact of Adenosine monophosphate-activated protein kinase (AMPK) mediated signalling pathways on cerebral ischemic injury.

  2022cites this paper
• Role of AMPK in autophagy

  2022cites this paper
• Transcriptomics reveals amygdala neuron regulation by fasting and ghrelin thereby promoting feeding

  2022cites this paper
• Olfactory chemosensation extends lifespan through TGF-β signaling and UPR activation

  2022cites this paper
• Fasting inhibits excitatory synaptic input on paraventricular oxytocin neurons via neuropeptide Y and Y1 receptor, inducing rebound hyperphagia, and weight gain

  2022cites this paper
• Development of "Hunger Neurons" and the Unanticipated Relationship Between Energy Metabolism and Mother-Infant Interactions.

  2022cites this paper
• Gabra5 plays a sexually dimorphic role in POMC neuron activity and glucose balance

  2022cites this paper
• The PACAP Paradox: Dynamic and Surprisingly Pleiotropic Actions in the Central Regulation of Energy Homeostasis

  2022cites this paper
• Estrogenic regulation of reproduction and energy homeostasis by a triumvirate of hypothalamic arcuate neurons

  2022cites this paper
• AMPK and the Challenge of Treating Hypoxic Pulmonary Hypertension

  2022cites this paper
• Appetite to learn: an allostatic role of AgRP neurons in the maintenance of energy balance

  2022cites this paper
• “Sibling” battle or harmony: crosstalk between nesfatin-1 and ghrelin

  2022cites this paper
• Tamas Horvath: The hunger view on body, brain and behavior

  2022cites this paper
• AMPA Receptor Function in Hypothalamic Synapses

  2022cites this paper
• Brain circuits for promoting homeostatic and non-homeostatic appetites

  2022cites this paper
• Targeting the Gut in Obesity: Signals from the Inner Surface

  2022cites this paper
• Hypothalamic AMPK as a possible target for energy balance-related diseases.

  2022cites this paper
• Acute Fasting Modulates Food-Seeking Behavior and Neural Signaling in the Piriform Cortex

  2022cites this paper
• GHS-R1a activity suppresses synaptic function of primary cultured hippocampal neurons.

  2022cites this paper
• Reproductive neuronal circuitry in adaptive changes of energy balance

  2021cites this paper
• The Physiological Control of Eating: Signals, Neurons, and Networks.

  2021cites this paper
• A New Understanding of Metformin

  2021cites this paper
• Eating for hunger or pleasure: a Serotonin Model

  2021cites this paper
• AgRP neuronal activity across feeding‐related behaviours

  2021cites this paper
• Individuals Diagnosed with Binge-Eating Disorder Have DNA Hypomethylated Sites in Genes of the Metabolic System: A Pilot Study

  2021cites this paper
• Hunger-promoting AgRP neurons trigger an astrocyte-mediated feed-forward auto-activation loop in mice.

  2021influential citation
• High-fat diet induced loss of GABAergic inhibition decouples intrinsic and synaptic excitability in AgRP neurons

  2021influential citation
• Neural mechanisms underlying the role of fructose in overfeeding.

  2021cites this paper
• Neuroendocrine Peptides of the Gut and Their Role in the Regulation of Food Intake.

  2021cites this paper
• Metabolic sensing in AgRP neurons integrates homeostatic state with dopamine signalling in the striatum

  2021cites this paper
• Deficiency of ER Ca2+ sensor STIM1 in AgRP neurons confers protection against dietary obesity.

  2021cites this paper
• Network dynamics of hypothalamic feeding neurons

  2021cites this paper
• Ablation of Nampt in AgRP neurons leads to neurodegeneration and impairs fasting‐ and ghrelin‐mediated food intake

  2021cites this paper
• Ghrelin treatment induces rapid and delayed increments of food intake: a heuristic model to explain ghrelin’s orexigenic effects

  2021cites this paper
• AgRP neurons trigger long-term potentiation and facilitate food seeking

  2021cites this paper
• Weight gain and neuroadaptations elicited by high fat diet depend on fatty acid composition.

  2021cites this paper
• Targeting AMPK Signaling by Dietary Polyphenols in Cancer Prevention.

  2021cites this paper
• Comparison of the effects of intracerebroventricular administration of glucagon-like peptides 1 and 2 on hypothalamic appetite regulating factors and sleep-like behavior in chicks.

  2021cites this paper
• Adenosine Monophosphate-activated Protein Kinase (AMPK) in serotonin neurons mediates select behaviors during protracted withdrawal from morphine in mice.

  2021cites this paper
• Hunger‐driven adaptive prioritization of behavior

  2021cites this paper
• AgRP/NPY and POMC neurons in the arcuate nucleus and their potential role in treatment of obesity.

  2021cites this paper
• Motivational competition and the paraventricular thalamus.

  2021cites this paper