The journey of resveratrol from yeast to human

The natural polyphenolic compound resveratrol was first discovered in the 1940s. In the recent years, this compound received renewed interest as several findings implicated resveratrol as a potent SIRT1 activator capable of mimicking the effects of calorie restriction, and regulating longevity in lower organisms. Given the worldwide increase in age-related metabolic diseases the beneficial effects of resveratrol on metabolism and healthy aging in humans are currently a topic of intense investigation.

• Publication year

  2012

• Venue

  Aging

• Publication date

  2012-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.18632/AGING.100445PMID 22436213PMCID 3348475
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients.

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• Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation.

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• Resveratrol stimulates glucose transport in C2C12 myotubes by activating AMP-activated protein kinase

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• New enlightenment of French paradox: Resveratrol's potential for cancer chemoprevention and anti-cancer therapy

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• Diagnostic performance of urinary resveratrol metabolites as a biomarker of moderate wine consumption.

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  2005cited by this paper
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  2005influential reference
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• Identification of the major metabolites of resveratrol in rat urine by HPLC-MS/MS.

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• Sirtuin activators mimic caloric restriction and delay ageing in metazoans

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• Urinary and plasma levels of resveratrol and quercetin in humans, mice, and rats after ingestion of pure compounds and grape juice.

  2004influential reference
• HIGH ABSORPTION BUT VERY LOW BIOAVAILABILITY OF ORAL RESVERATROL IN HUMANS

  2004influential reference
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  2003influential reference
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  2003influential reference
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  2025cites this paper
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  2024cites this paper
• Resveratrol: Protective Agent Against Alzheimer's Disease.

  2024cites this paper
• Effects of resveratrol on rheumatic symptoms and hepatic metabolism of arthritic rats

  2024cites this paper
• Comparative Neuroprotective Potential of Nanoformulated and Free Resveratrol Against Cuprizone-Induced Demyelination in Rats

  2024cites this paper
• Retaining Resveratrol Content in Berries and Berry Products with Agricultural and Processing Techniques: Review

  2024cites this paper
• Characterization of Some Stilbenoids Extracted from Two Cultivars of Lambrusco—Vitis vinifera Species: An Opportunity to Valorize Pruning Canes for a More Sustainable Viticulture

  2023cites this paper
• Low-Dose Trans-Resveratrol Ameliorates Diabetes-Induced Retinal Ganglion Cell Degeneration via TyrRS/c-Jun Pathway

  2023cites this paper
• Effect of resveratrol and combination of resveratrol and donepezil on the expression of microglial cells and astrocytes in Wistar albino rats of colchicine-induced Alzheimer’s disease

  2023cites this paper
• Pterostilbene Promotes Mean Lifespan in Both Male and Female Drosophila Melanogaster Modulating Different Proteins in the Two Sexes

  2022cites this paper
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  2022cites this paper
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  2022cites this paper
• UV Protection in the Cornea: Failure and Rescue

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• Resveratrol: A Phenolic Prodigy

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• Treating Neurodegenerative Disease with Antioxidants: Efficacy of the Bioactive Phenol Resveratrol and Mitochondrial-Targeted MitoQ and SkQ

  2021cites this paper
• From genoprotection to rejuvenation.

  2021cites this paper
• The Potential of Calorie Restriction and Calorie Restriction Mimetics in Delaying Aging: Focus on Experimental Models

  2021cites this paper
• Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer

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• Comparison of malondialdehyde levels and superoxide dismutase activity in resveratrol and resveratrol/donepezil combination treatment groups in Alzheimer’s disease induced rat model

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• Neuroprotective effects of resveratrol in Alzheimer's disease.

  2020influential citation
• Healthy Lifestyle Recommendations: Do the Beneficial Effects Originate from NAD+ Amount at the Cellular Level?

  2020cites this paper
• Role of Dietary Polyphenols in adipose tissue browning: A narrative review.

  2020cites this paper
• Oral resveratrol supplementation improves Metabolic Syndrome features in obese patients submitted to a lifestyle-changing program.

  2020cites this paper
• RESVERATROL DIFFERENTLY MODULATES GROUP I METABOTROPIC GLUTAMATE RECEPTORS DEPENDING ON AGE IN SAMP8 MICE.

  2020cites this paper
• Stability testing of resveratrol and viniferin obtained from Vitis vinifera L. by various extraction methods considering the industrial viewpoint

  2020cites this paper
• Resveratrol treatment during maturation enhances developmental competence of oocytes after prolonged ovary storage at 4 °C in the domestic cat model.

  2020cites this paper
• Resveratrol as an active ingredient for cosmetic and dermatological applications: a review

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  2019cites this paper
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• Resveratrol-Loaded Lipid Nanocarriers Are Internalized By Endocytosis in Yeast.

  2019cites this paper
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• Effects of Supplementation and Training on Ameliorating Lipid Profiles and Protection against Coronary Artery Disease; an Experimental Study

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• Influence of trans-resveratrol on macrophage and lymphocyte activity in rainbow trout (Oncorhynchus mykiss) – in vitro study

  2018cites this paper
• Pharmaceutical Intervention of Aging.

  2018cites this paper
• PKA-GSK3β and β-Catenin Signaling Play a Critical Role in Trans-Resveratrol Mediated Neuronal Differentiation in Human Cord Blood Stem Cells

  2018cites this paper
• Protective Activity of Resveratrol in Cardio- and Cerebrovascular Diseases

  2018cites this paper
• Evaluation of Resveratrol Supplementation on Laboratory Animals, Cats, Pigs, Horses, Dogs, Cattle, and Birds

  2018cites this paper
• Breaking down the Contradictory Roles of Histone Deacetylase SIRT1 in Human Breast Cancer

  2018cites this paper
• Sirt3-Mediated Autophagy Contributes to Resveratrol-Induced Protection against ER Stress in HT22 Cells

  2018cites this paper
• Aging and Aging-Related Diseases: Mechanisms and Interventions

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• Repairing Mitochondrial Dysfunction in Disease.

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• Resveratrol eliminates cancer stem cells of osteosarcoma by STAT3 pathway inhibition

  2018cites this paper
• Dihydrocapsiate improved age-associated impairments in mice by increasing energy expenditure.

  2017cites this paper
• Inhaled resveratrol treatments slow ageing-related degenerative changes in mouse lung

  2017cites this paper
• Effects of Resveratrol on pharmacokinetics and pharmacodynamics of Pioglitazone in Diabetic rats

  2017cites this paper
• Distribution of trans-resveratrol and its metabolites after acute or sustained administration in mouse heart, brain, and liver.

  2017cites this paper
• Resveratrol attenuates hepatic complications associated with insulin resistance: Implications on hepatic HAIR, LAIR, cell energy and DNA fragmentation. -

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• Roles of AMP, ADP, ATP, and AMPK in Healthy Energy Boosting and Prolonged Life Span

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• Evaluation of resveratrol organogels prepared by micro-irradiation: fibroblast proliferation through in vitro wound healing

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  2017cites this paper
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• Célia de Jesus Sousa Barbosa

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• The protective effects of Resveratrol against radiation-induced intestinal injury

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  2016cites this paper
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  2016cites this paper
• The endocannabinoid system and NGF are involved in the mechanism of action of resveratrol: a multi-target nutraceutical with therapeutic potential in neuropsychiatric disorders

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  2016cites this paper
• Novel nutraceutic therapies for the treatment of metabolic syndrome.

  2016cites this paper
• Calorie restriction-induced SIRT6 activation delays aging by suppressing NF-κB signaling

  2016cites this paper
• The combination of resveratrol and quercetin enhances the individual effects of these molecules on triacylglycerol metabolism in white adipose tissue

  2016cites this paper
• Therapeutic Potential of Resveratrol in Lymphoid Malignancies

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• Amendment effect of resveratrol on diclofenac idiosyncratic toxicity: Augmentation of the anti-inflammatory effect by assessment of Arachidonic acid and IL-1beta levels.

  2016cites this paper
• Effect of resveratrol, Metformin and Eucalyptus Oil on Visceral Fat Deposition, Serum glucose, Lipid Profiles and Liver Function Tests of Swiss Albino Mice Fed a High-fat diet

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  2016cites this paper
• Does SIRT1 or cytostasis underlie the anti-ageing activity of trans-stilbenes?

  2016cites this paper
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  2015cites this paper
• Resveratrol: A Sirtuin Activator and The Fountain of Youth

  2015influential citation
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• The Acute And Chronic Effects Of Resveratrol On Renal Function And Blood Pressure

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  2015cites this paper
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  2015influential citation
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  2015cites this paper
• O resveratol como uma molécula anti-envelhecimento

  2015cites this paper
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  2014cites this paper
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