Meta-Analysis of TNF 308 G/A Polymorphism and Type 2 Diabetes Mellitus

Background and Objectives Many investigations have focused the association between TNF 308 G/A polymorphism and risk for type 2 diabetes mellitus (T2DM). However, the sample sizes of most of the studies were small. The aim of this study is to evaluate the precise association between this variant and risk for T2DM in a large-scale meta-analysis. Methods All publications were searched on the association between TNF 308 G/A polymorphism and T2DM. The key words were as follows: diabetes, tumor necrosis factor and polymorphism/variant/genotype. This meta-analysis was assessed by Review manager 5.0. Results There were 18 studies identified. The odd ritos (ORs) and 95% confidence intervals (CI) for GA+AA versus GG genotype of TNF 308 G/A polymorphism were 1.03 (0.95–1.12), 1.03 (0.94–1.13) and 1.03 (0.78–1.36) in overall, Caucasian and Asian populations, respectively. The sensitivity analysis further strengthened the validity of this association. No publication bias or heterogeneity was observed in this study. Conclusion In summary, there was no significant association detected between the TNF 308 G/A polymorphism and risk for T2DM.

• Publication year

  2011

• Venue

  PLoS ONE

• Publication date

  2011-04-08

• Fields of study

  Medicine

• Identifiers
  DOI 10.1371/journal.pone.0018480PMID 21494616PMCID 3072982
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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