Bone morphogenetic protein-4 inhibitor gremlin is overexpressed in idiopathic pulmonary fibrosis.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  American Journal of Pathology

• Publication date

  2006-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.2353/AJPATH.2006.051263PMID 16816361PMCID PMC1698771
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• TGF-beta and epithelial-to-mesenchymal transitions.

  2005cited by this paper
• Bone Morphogenic Protein-7 Induces Mesenchymal to Epithelial Transition in Adult Renal Fibroblasts and Facilitates Regeneration of Injured Kidney*

  2005influential reference
• Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosis.

  2005cited by this paper
• Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease

  2005cited by this paper
• Up-Regulation and Profibrotic Role of Osteopontin in Human Idiopathic Pulmonary Fibrosis

  2005cited by this paper
• Expression of gremlin, a bone morphogenetic protein antagonist, in human diabetic nephropathy.

  2005cited by this paper
• TGF-β and epithelial-to-mesenchymal transitions

  2005cited by this paper
• Connective tissue growth factor expression and induction by transforming growth factor-beta is abrogated by simvastatin via a Rho signaling mechanism.

  2004cited by this paper
• Disruption of LTBP-4 function reduces TGF-β activation and enhances BMP-4 signaling in the lung

  2004cited by this paper
• Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis

  2004cited by this paper
• Bone marrow-derived progenitor cells in pulmonary fibrosis.

  2004cited by this paper
• Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis.

  2004cited by this paper
• Epithelial-mesenchymal interactions in the developing lung.

  2004cited by this paper
• Imatinib mesylate inhibits the profibrogenic activity of TGF-beta and prevents bleomycin-mediated lung fibrosis.

  2004cited by this paper
• Cutting Edge: Bone Morphogenetic Protein Antagonists Drm/Gremlin and Dan Interact with Slits and Act as Negative Regulators of Monocyte Chemotaxis12

  2004cited by this paper
• Gremlin – a putative pathogenic player in progressive renal disease

  2003cited by this paper
• BMP-7 counteracts TGF-β1–induced epithelial-to-mesenchymal transition and reverses chronic renal injury

  2003influential reference
• Idiopathic pulmonary fibrosis--a disorder of alveolar wound repair?

  2003influential reference
• Matrilysin (matrix metalloproteinase-7) mediates E-cadherin ectodomain shedding in injured lung epithelium.

  2003influential reference
• Defect of hepatocyte growth factor secretion by fibroblasts in idiopathic pulmonary fibrosis.

  2003cited by this paper
• Complex Regulation of Transforming Growth Factor 13, 12, and 13 mRNA Expression in Mouse Fibroblasts and Keratinocytes by Transforming Growth Factors 13 and 12

  2003cited by this paper
• Bone morphogenic protein-7 inhibits progression of chronic renal fibrosis associated with two genetic mouse models.

  2003cited by this paper
• Matrix metalloproteinase-9 in lung remodeling.

  2003influential reference
• Secretion of human latent TGF-β-binding protein-3 (LTBP-3) is dependent on co-expression of TGF-β

  2002cited by this paper
• Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans

  2002influential reference
• ATS/ERS international multidisciplinary consensus classification of the idiopathic interstitial pneumonias

  2002cited by this paper
• Identification and Functional Characterization of Distinct Critically Important Bone Morphogenetic Protein-specific Response Elements in the Id1 Promoter*

  2002cited by this paper
• American thoracic society/European respiratory society international multidisciplinary consensus classification of the idiopathic interstitial pneumonias

  2002cited by this paper
• Secretion of human latent TGF-beta-binding protein-3 (LTBP-3) is dependent on co-expression of TGF-beta.

  2002cited by this paper
• Molecular aspects of scleroderma.

  2002cited by this paper
• American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias. This joint statement of the American Thoracic Society (ATS), and the European Respiratory Society (ERS) was adopted by the ATS board of directors

  2002cited by this paper
• Triggering the induction of myofibroblast and fibrogenesis by airway epithelial shedding.

  2001cited by this paper
• The bone morphogenic protein antagonist gremlin regulates proximal‐distal patterning of the lung

  2001cited by this paper
• Morphological and Biochemical Properties of Alveolar Fibroblasts in Interstitial Lung Diseases

  2001cited by this paper
• Latency, activation, and binding proteins of TGF‐β

  2001cited by this paper
• Growth factors in idiopathic pulmonary fibrosis: relative roles

  2001influential reference
• Idiopathic pulmonary fibrosis: Diagnosis and treatment: International Consensus Statement

  2000cited by this paper
• IHG-2, a Mesangial Cell Gene Induced by High Glucose, Is Human gremlin

  2000cited by this paper
• Signaling of transforming growth factor-beta family members through Smad proteins.

  2000cited by this paper
• TIMP-1, -2, -3, and -4 in idiopathic pulmonary fibrosis. A prevailing nondegradative lung microenvironment?

  2000cited by this paper
• Signaling of transforming growth factor‐β family members through Smad proteins

  2000cited by this paper
• American Thoracic Society. Idiopathic pulmonary fibrosis: diagnosis and treatment. International consensus statement. American Thoracic Society (ATS), and the European Respiratory Society (ERS).

  2000cited by this paper
• Transient effect of epidermal growth factor on the motility of an immortalized mammary epithelial cell line

  1999cited by this paper
• The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis.

  1999cited by this paper
• The integrin αvβ6 binds and activates latent TGFβ1 : A mechanism for regulating pulmonary inflammation and fibrosis

  1999cited by this paper
• The L45 loop in type I receptors for TGF‐β family members is a critical determinant in specifying Smad isoform activation

  1998cited by this paper
• Thrombospondin-1 Is a Major Activator of TGF-β1 In Vivo

  1998cited by this paper
• Thrombospondin-1 is a major activator of TGF-beta1 in vivo.

  1998cited by this paper
• Identification of drm, a novel gene whose expression is suppressed in transformed cells and which can inhibit growth of normal but not transformed cells in culture

  1997influential reference
• Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis.

  1996cited by this paper
• A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene.

  1996cited by this paper
• Increased procoagulant and antifibrinolytic activities in the lungs with idiopathic pulmonary fibrosis.

  1995cited by this paper
• An assay for transforming growth factor-beta using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct.

  1994cited by this paper
• Growth Factors in the Regulation of Plasminogen-Plasmin System in Tumor Cells

  1991cited by this paper
• Increased production and immunohistochemical localization of transforming growth factor-beta in idiopathic pulmonary fibrosis.

  1991influential reference
• Physicochemical activation of recombinant latent transforming growth factor-beta's 1, 2, and 3.

  1990cited by this paper
• Complex regulation of transforming growth factor beta 1, beta 2, and beta 3 mRNA expression in mouse fibroblasts and keratinocytes by transforming growth factors beta 1 and beta 2

  1989cited by this paper
• Stimulation of the chemotactic migration of human fibroblasts by transforming growth factor beta

  1987cited by this paper
• Transforming growth factor-beta increases steady state levels of type I procollagen and fibronectin messenger RNAs posttranscriptionally in cultured human dermal fibroblasts.

  1987cited by this paper
• Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix.

  1986cited by this paper
• Enhanced production and extracellular deposition of the endothelial- type plasminogen activator inhibitor in cultured human lung fibroblasts by transforming growth factor-beta

  1986cited by this paper

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• Mechanisms and markers of lung ageing in health and disease

  2025cites this paper
• Role of BMPR2 Mutation in Lung Organoid Differentiation

  2025cites this paper
• Penile remodeling, Sonic hedgehog, and fibrosis.

  2025cites this paper
• Demethyleneberberine Alleviates Pulmonary Fibrosis through Disruption of USP11 Deubiquitinating GREM1

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• Gremlin1: a BMP antagonist with therapeutic potential in Oncology

  2024cites this paper
• Emerging role of BMPs/BMPR2 signaling pathway in treatment for pulmonary fibrosis

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  2023cites this paper
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  2022cites this paper
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  2022cites this paper
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  2022cites this paper
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  2021cites this paper
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  2021influential citation
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  2021cites this paper
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  2021cites this paper
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• Gremlin-1 for the Differential Diagnosis of Idiopathic Pulmonary Fibrosis Versus Other Interstitial Lung Diseases: A Clinical and Pathophysiological Analysis

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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
• FOXL1 Regulates Lung Fibroblast Function via Multiple Mechanisms.

  2020cites this paper
• OPTH_A_245915 1391..1402

  2020cites this paper
• More than a Genetic Code: Epigenetics of Lung Fibrosis

  2020cites this paper
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