Loss of VEGFB and its signaling in the diabetic heart is associated with increased cell death signaling.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  American Journal of Physiology. Heart and Circulatory Physiology

• Publication date

  2017-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1152/ajpheart.00659.2016PMID 28314760
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Intracoronary Cytoprotective Gene Therapy: A Study of VEGF-B167 in a Pre-Clinical Animal Model of Dilated Cardiomyopathy.

  2015cited by this paper
• Diabetic cardiomyopathy and its mechanisms: Role of oxidative stress and damage

  2014cited by this paper
• Endothelial cell regulation of cardiac metabolism following diabetes.

  2014cited by this paper
• Vascular endothelial growth factor-B in physiology and disease.

  2014cited by this paper
• VEGF-B-induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart

  2014cited by this paper
• Endothelial Cell Heparanase Taken Up by Cardiomyocytes Regulates Lipoprotein Lipase Transfer to the Coronary Lumen After Diabetes

  2014cited by this paper
• Glycogen Synthase Kinase 3 Regulates Cell Death and Survival Signaling in Tumor Cells under Redox Stress1

  2014cited by this paper
• Assessment of cardiac inflammation and remodeling during the development of streptozotocin-induced diabetic cardiomyopathy in vivo: a time course analysis.

  2013cited by this paper
• Hyperglycemia-Induced Secretion of Endothelial Heparanase Stimulates a Vascular Endothelial Growth Factor Autocrine Network in Cardiomyocytes That Promotes Recruitment of Lipoprotein Lipase

  2013cited by this paper
• The endothelial cell: An “early responder” in the development of insulin resistance

  2013cited by this paper
• Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair

  2013cited by this paper
• Lipoprotein lipase mediated fatty acid delivery and its impact in diabetic cardiomyopathy.

  2012cited by this paper
• Complicated life, complicated VEGF-B.

  2012cited by this paper
• Severity of Diabetes Governs Vascular Lipoprotein Lipase by Affecting Enzyme Dimerization and Disassembly

  2011cited by this paper
• Cell Communications in the Heart

  2010cited by this paper
• Vascular Endothelial Growth Factor-B Acts as a Coronary Growth Factor in Transgenic Rats Without Inducing Angiogenesis, Vascular Leak, or Inflammation

  2010cited by this paper
• Intramyocardial VEGF-B167 Gene Delivery Delays the Progression Towards Congestive Failure in Dogs With Pacing-Induced Dilated Cardiomyopathy

  2010cited by this paper
• Myocardial fatty acid metabolism in health and disease.

  2010influential reference
• Glucose-induced endothelial heparanase secretion requires cortical and stress actin reorganization.

  2010cited by this paper
• Cardiomyocyte VEGFR‐1 activation by VEGF‐B induces compensatory hypertrophy and preserves cardiac function after myocardial infarction

  2010cited by this paper
• VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis

  2009cited by this paper
• Endothelial heparanase secretion after acute hypoinsulinemia is regulated by glucose and fatty acid.

  2009cited by this paper
• Rodent models of diabetic cardiomyopathy

  2009cited by this paper
• Glycogen synthase kinase-3β regulates etoposide-induced apoptosis via Bcl-2 mediated caspase-3 activation in C3H10T1/2 cells

  2009cited by this paper
• VEGF-B inhibits apoptosis via VEGFR-1-mediated suppression of the expression of BH3-only protein genes in mice and rats.

  2008cited by this paper
• Protein Kinase G-dependent Cardioprotective Mechanism of Phosphodiesterase-5 Inhibition Involves Phosphorylation of ERK and GSK3β*

  2008cited by this paper
• Phosphorylation of glycogen synthase kinase-3 beta at serine 9 confers cisplatin resistance in ovarian cancer cells.

  2007cited by this paper
• Cell death and diabetic cardiomyopathy

  2007cited by this paper
• Site-directed Mutagenesis, Proteolytic Cleavage, and Activation of Human Proheparanase*

  2005cited by this paper
• The vascular endothelial growth factor (VEGF) family: angiogenic factors in health and disease

  2005cited by this paper
• Lysophosphatidic acid-mediated augmentation of cardiomyocyte lipoprotein lipase involves actin cytoskeleton reorganization.

  2005cited by this paper
• Erk Associates with and Primes GSK-3β for Its Inactivation Resulting in Upregulation of β-Catenin

  2005cited by this paper
• Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin.

  2005influential reference
• Diabetic cardiomyopathy: evidence, mechanisms, and therapeutic implications.

  2004cited by this paper
• Heparanase Uptake Is Mediated by Cell Membrane Heparan Sulfate Proteoglycans*

  2004cited by this paper
• Lipoprotein lipase and its role in regulation of plasma lipoproteins and cardiac risk

  2004influential reference
• Heparanase affects adhesive and tumorigenic potential of human glioma cells.

  2003cited by this paper
• GSK-3: tricks of the trade for a multi-tasking kinase

  2003cited by this paper
• Diabetes, Hypertension, and Cardiovascular Disease: An Update

  2001cited by this paper
• Isoform-specific Expression of VEGF-B in Normal Tissues and Tumors

  2001cited by this paper
• An elevated bax/bcl-2 ratio corresponds with the onset of prostate epithelial cell apoptosis

  1999cited by this paper
• Processing of the Human Heparanase Precursor and Evidence That the Active Enzyme Is a Heterodimer*

  1999cited by this paper
• Localization of lipoprotein lipase in the diabetic heart: regulation by acute changes in insulin.

  1999cited by this paper
• Altered creatine kinase enzyme kinetics in diabetic cardiomyopathy. A(31)P NMR magnetization transfer study of the intact beating rat heart.

  1999cited by this paper
• Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells.

  1998cited by this paper
• Developmental and cell-type-specific expression of cell surface heparan sulfate proteoglycans in the rat heart.

  1997cited by this paper
• Differential Effects of Streptozotocin-Induced Diabetes on Cardiac Lipoprotein Lipase Activity

  1997cited by this paper
• Myocardial substrate metabolism: implications for diabetic cardiomyopathy.

  1995cited by this paper
• The diabetic heart: metabolic causes for the development of a cardiomyopathy.

  1992cited by this paper
• Cardiac function in spontaneously hypertensive diabetic rats.

  1986cited by this paper

• Global knockout of VEGFB improves lipoprotein lipase activity leading to an improved lipid profile during diabetes.

  2026cites this paper
• Gene Therapy for Heart Failure

  2026cites this paper
• Endothelial dysfunction as a driver of microvascular injury in diabetic cardiomyopathy

  2025cites this paper
• Heparanase Stimulation of Physiological Cardiac Hypertrophy is Suppressed Following Chronic Diabetes Resulting in Cardiac Remodeling and Dysfunction.

  2024cites this paper
• Ferroptosis in diabetic cardiomyopathy: Advances in cardiac fibroblast-cardiomyocyte interactions

  2024cites this paper
• Role of VEGFA in type 2 diabetes mellitus rats subjected to partial hepatectomy

  2024cites this paper
• Cardiomyocyte crosstalk with endothelium modulates cardiac structure, function, and ischemia-reperfusion injury susceptibility through erythropoietin

  2024cites this paper
• Application of anti-vascular endothelial growth factor antibody restores the function of saliva secretion in a type 2 diabetes mouse model.

  2024cites this paper
• Vascular endothelial growth factor B regulates insulin secretion in β cells of type 2 diabetes mellitus mice via PLCγ and the IP3R‑evoked Ca2+/CaMK2 signaling pathway

  2023cites this paper
• The Effect of Atorvastatin and Continuous Aerobic Exercise on the Expression of Vascular Endothelial Growth Factor Beta Gene in the Liver Tissue of Diabetic Rats

  2023cites this paper
• Nanoparticles as a Therapeutic Approach for Tumor Angiogenesis

  2022cites this paper
• Therapeutic Potential of VEGF-B in Coronary Heart Disease and Heart Failure: Dream or Vision?

  2022cites this paper
• Long non-coding RNA XIST promotes the malignant features of oral squamous cell carcinoma (OSCC) cells through regulating miR-133a-5p/VEGFB.

  2022cites this paper
• Changes in lipoprotein lipase in the heart following diabetes onset

  2022cites this paper
• Knockdown of VEGFB/VEGFR1 Signaling Promotes White Adipose Tissue Browning and Skeletal Muscle Development

  2022cites this paper
• Role of VEGFB in Electrical Pulse Stimulation Inhibits Apoptosis in C2C12 myotubes.

  2022cites this paper
• The Role of the VEGF Family in Atherosclerosis Development and Its Potential as Treatment Targets

  2022cites this paper
• Impact of prediabetes on cardiovascular disease risk in patients with acute myocardial infarctions

  2021cites this paper
• Role of Vascular Endothelial Growth Factor (VEGF) in Human Embryo Implantation: Clinical Implications

  2021cites this paper
• Trans-endothelial trafficking of metabolic substrates and its importance in cardio-metabolic disease.

  2021cites this paper
• Vascular growth factors as potential new treatment in cardiorenal syndrome in diabetes

  2021cites this paper
• Lipoprotein Lipase and Its Delivery of Fatty Acids to the Heart

  2021cites this paper
• Cardiac-specific VEGFB overexpression reduces lipoprotein lipase activity and improves insulin action in rat heart.

  2021cites this paper
• VEGF-B Gene Therapy for the Heart: Proceed with Caution.

  2020cites this paper
• Involvement of Heparanase in Endothelial Cell-Cardiomyocyte Crosstalk.

  2020cites this paper
• Hyperlipidemias and Obesity

  2019cites this paper
• Novel Concepts in Cardiac Energy Metabolism: From Biology to Disease

  2019cites this paper
• A biotechnological approach to understanding the interactions between endothelial cell integrins and neuropilin-2 in angiogenesis

  2019cites this paper
• Guidelines for experimental models of myocardial ischemia and infarction

  2018cites this paper
• Vascular Endothelial Growth Factor B and Its Signaling

  2018cites this paper
• VEGFB‐VEGFR1 ameliorates Ang II‐induced cardiomyocyte hypertrophy through Ca2+‐mediated PKG I pathway

  2018cites this paper
• L-Carnitine: An Antioxidant Remedy for the Survival of Cardiomyocytes under Hyperglycemic Condition

  2018cites this paper
• Statistical considerations in reporting cardiovascular research.

  2018cites this paper
• Title : The Role of Vascular Endothelial Growth Factor-B in Metabolic Homeostasis : Current Evidence Running Title : VEGF-B role in metabolic homeostasis

  2017cites this paper
• Vascular endothelial growth factors and placenta growth factor in retinal vasculopathies: Current research and future perspectives.

  2017cites this paper
• VEGF-B: friend or foe to the heart in times of nutrient excess?

  2017cites this paper
• Diabetes-Related Cardiac Dysfunction

  2017cites this paper
• Hemoglobin A1c is associated with severity of coronary artery stenosis but not with long term clinical outcomes in diabetic and nondiabetic patients with acute myocardial infarction undergoing primary angioplasty

  2017cites this paper
• The role of vascular endothelial growth factor-B in metabolic homoeostasis: current evidence

  2017cites this paper