Bisphenol A stimulates adrenal cortical cell proliferation via ERβ-mediated activation of the sonic hedgehog signalling pathway.

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Journal of Steroid Biochemistry and Molecular Biology

• Publication date

  2018-04-01

• Fields of study

  Biology, Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1016/j.jsbmb.2018.01.004PMID 29307715
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Pervasive translational regulation of the cell signalling circuitry underlies mammalian development

  2017cited by this paper
• Bisphenol A activates EGFR and ERK promoting proliferation, tumor spheroid formation and resistance to EGFR pathway inhibition in estrogen receptor-negative inflammatory breast cancer cells

  2017cited by this paper
• Evaluation of the isoflavones and estrogen effects on the rat adrenal

  2017cited by this paper
• An integrative transcriptomic analysis reveals bisphenol A exposure-induced dysregulation of microRNA expression in human endometrial cells.

  2017cited by this paper
• Prenatal exposure to bisphenol A disrupts adrenal steroidogenesis in adult mouse offspring.

  2016cited by this paper
• Hedgehog signalling

  2016cited by this paper
• Prenatal Exposure to Bisphenol A Disrupts Mouse Fetal Liver Maturation in a Sex‐Specific Manner

  2016cited by this paper
• Maternal Exposure to Bisphenol-A During Pregnancy Increases Pancreatic β-Cell Growth During Early Life in Male Mice Offspring.

  2016cited by this paper
• Prenatal exposure to bisphenol A alters mouse fetal pancreatic morphology and islet composition

  2016cited by this paper
• Urinary bisphenol A is associated with dysregulation of HPA-axis function in pregnant women: Findings from the APrON cohort study.

  2016cited by this paper
• Effects of bisphenol A on decreasing the percentage and promoting the growth of stem cell-like cells from SK-N-SH human neuroblastoma cells.

  2015cited by this paper
• Prenatal exposure to bisphenol A disrupts mouse fetal lung development

  2015cited by this paper
• Bisphenol A disrupts gene expression in human placental trophoblast cells.

  2015cited by this paper
• Estrogen promotes stemness and invasiveness of ER-positive breast cancer cells through Gli1 activation

  2014cited by this paper
• Maternal Bisphenol A Exposure Impacts the Fetal Heart Transcriptome

  2014cited by this paper
• Estrogen receptor-β regulates mechanical signaling in primary osteoblasts.

  2014cited by this paper
• Sonic hedgehog signaling is active in human adrenal cortex development and deregulated in adrenocortical tumors.

  2014cited by this paper
• Bisphenol A and Reproductive Health: Update of Experimental and Human Evidence, 2007–2013

  2014cited by this paper
• Involvement of activating ERK1/2 through G protein coupled receptor 30 and estrogen receptor α/β in low doses of bisphenol A promoting growth of Sertoli TM4 cells.

  2014cited by this paper
• Signaling related with biphasic effects of bisphenol A (BPA) on Sertoli cell proliferation: a comparative proteomic analysis.

  2014cited by this paper
• Perinatal exposure to low-dose bisphenol A affects the neuroendocrine stress response in rats.

  2014cited by this paper
• Inhibitory Effects of Bisphenol-A on Neural Stem Cells Proliferation and Differentiation in the Rat Brain Are Dependent on Wnt/β-Catenin Pathway

  2014cited by this paper
• Hedgehog-signaling is upregulated in non-producing human adrenal adenomas and antagonism of hedgehog-signaling inhibits proliferation of NCI-H295R cells and an immortalized primary human adrenal cell line.

  2014cited by this paper
• Bisphenol A and human health: a review of the literature.

  2013cited by this paper
• Metallothionein-I- and -II-deficient mice display increased susceptibility to cadmium-induced fetal growth restriction.

  2013cited by this paper
• Low-Dose BPA Exposure Alters the Mesenchymal and Epithelial Transcriptomes of the Mouse Fetal Mammary Gland

  2013cited by this paper
• Prenatal exposure to bisphenol A impacts midbrain dopamine neurons and hippocampal spine synapses in non-human primates.

  2013cited by this paper
• Prenatal Exposure to Low Doses of Bisphenol A Increases Pituitary Proliferation and Gonadotroph Number in Female Mice Offspring at Birth1

  2012cited by this paper
• Bisphenol A alters the development of the rhesus monkey mammary gland

  2012cited by this paper
• Bisphenol-A acts as a potent estrogen via non-classical estrogen triggered pathways.

  2012cited by this paper
• A review of dietary and non-dietary exposure to bisphenol-A.

  2012cited by this paper
• Gestational exposure to bisphenol a produces transgenerational changes in behaviors and gene expression.

  2012cited by this paper
• Effect of bisphenol-A on the expression of selected genes involved in cell cycle and apoptosis in the OVCAR-3 cell line.

  2011cited by this paper
• Tocotrienols activity in MCF-7 breast cancer cells: involvement of ERbeta signal transduction.

  2010cited by this paper
• Frequent Deregulations in the Hedgehog Signaling Network and Cross-Talks with the Epidermal Growth Factor Receptor Pathway Involved in Cancer Progression and Targeted Therapies

  2010cited by this paper
• Oestrogen receptor-α contributes to the regulation of the hedgehog signalling pathway in ERα-positive gastric cancer

  2010cited by this paper
• Progenitor cell expansion and organ size of mouse adrenal is regulated by sonic hedgehog.

  2010cited by this paper
• A novel mechanism of natural vitamin E tocotrienol activity: involvement of ERbeta signal transduction.

  2009cited by this paper
• Shh signaling regulates adrenocortical development and identifies progenitors of steroidogenic lineages

  2009cited by this paper
• Low Doses of Bisphenol A Promote Human Seminoma Cell Proliferation by Activating PKA and PKG via a Membrane G-Protein–Coupled Estrogen Receptor

  2009cited by this paper
• Cell growth of ovarian cancer cells is stimulated by xenoestrogens through an estrogen-dependent pathway, but their stimulation of cell growth appears not to be involved in the activation of the mitogen-activated protein kinases ERK-1 and p38.

  2009cited by this paper
• Effect of bisphenol A with or without enzyme treatment on the proliferation and viability of MCF-7 cells.

  2009cited by this paper
• Targeted disruption of Sonic Hedgehog in the mouse adrenal leads to adrenocortical hypoplasia

  2009cited by this paper
• Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation.

  2009cited by this paper
• Novel link between estrogen receptor alpha and hedgehog pathway in breast cancer.

  2008cited by this paper
• Maternal bisphenol-A levels at delivery: a looming problem?

  2008cited by this paper
• Hedgehog: functions and mechanisms.

  2008cited by this paper
• Novel link between estrogen receptor α and hedgehog pathway in breast cancer

  2008cited by this paper
• Laccase treatment impairs bisphenol A‐induced cancer cell proliferation affecting estrogen receptor α‐dependent rapid signals

  2008cited by this paper
• Human exposure to bisphenol A (BPA).

  2007cited by this paper
• Bisphenol A Exposure In Utero Disrupts Early Oogenesis in the Mouse

  2007cited by this paper
• Estrogen signaling multiple pathways to impact gene transcription.

  2006cited by this paper
• Large effects from small exposures. III. Endocrine mechanisms mediating effects of bisphenol A at levels of human exposure.

  2006cited by this paper
• Antiestrogens upregulate estrogen receptor beta expression and inhibit adrenocortical H295R cell proliferation.

  2005cited by this paper
• Sonic hedgehog regulates the proliferation, differentiation, and migration of enteric neural crest cells in gut

  2004cited by this paper
• Effects of the environmental oestrogens bisphenol A, tetrachlorobisphenol A, tetrabromobisphenol A, 4-hydroxybiphenyl and 4,4'-dihydroxybiphenyl on oestrogen receptor binding, cell proliferation and regulation of oestrogen sensitive proteins in the human breast cancer cell line MCF-7.

  2003cited by this paper
• Bisphenol a induces both transient and permanent histofunctional alterations of the hypothalamic-pituitary-gonadal axis in prenatally exposed male rats.

  2003cited by this paper
• Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo

  2003cited by this paper
• Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo

  2003cited by this paper
• The xenoestrogen bisphenol A induces inappropriate androgen receptor activation and mitogenesis in prostatic adenocarcinoma cells.

  2002cited by this paper
• The Hedgehog and Wnt signalling pathways in cancer

  2001cited by this paper
• In vitro and in vivo interactions of bisphenol A and its metabolite, bisphenol A glucuronide, with estrogen receptors alpha and beta.

  2001cited by this paper
• In Vitro and in Vivo Interactions of Bisphenol A and Its Metabolite, Bisphenol A Glucuronide, with Estrogen Receptors α and β

  2001cited by this paper
• Post-transcriptional Regulation of the GLI1 Oncogene by the Expression of Alternative 5′ Untranslated Regions*

  2001cited by this paper
• Transcription of the human genes for cytochrome P450scc and P450c17 is regulated differently in human adrenal NCI-H295 cells than in mouse adrenal Y1 cells.

  1997cited by this paper
• Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta.

  1997cited by this paper
• Comparison of the Ligand Binding Specificity and Transcript Tissue Distribution of Estrogen Receptors a and b

  1997cited by this paper
• Regulation of steroidogenesis in NCI-H295 cells: a cellular model of the human fetal adrenal.

  1993cited by this paper
• Establishment and characterization of a human adrenocortical carcinoma cell line that expresses multiple pathways of steroid biosynthesis.

  1990cited by this paper

• Brain under siege: the role of micro and nanoplastics in neuroinflammation and oxidative stress

  2026cites this paper
• Environmental endocrine disruptors and endometrial cancer: a systematic review of epidemiological studies.

  2026cites this paper
• Endocrine Toxicity of Micro- and Nanoplastics, and Advances in Detection Techniques for Human Tissues: A Comprehensive Review

  2025cites this paper
• Bisphenol A (BPA) Modifies Cancer Signaling Pathways: A Neglected Global Health Threat

  2025cites this paper
• The Toxicity-Dynamic Effects of Dioxydiphenylsulfone (BPS) on Particular Human Targets: An In Silico Investigation

  2025cites this paper
• Understanding the Xenoestrogenic Activity of BPA Involves Molecular Docking Study with a few Chosen Nuclear Receptors and Toxicodynamics Analysis: An In Silico Research

  2024cites this paper
• Estrogenic actions of alkaloids: Structural characteristics and molecular mechanisms.

  2024cites this paper
• Detrimental consequences of micropolymers associated plasticizers on endocrinal disruption

  2024cites this paper
• Exploring novel insights into the molecular mechanisms underlying Bisphenol A-induced toxicity: A persistent threat to human health.

  2024cites this paper
• A Brief Look at Hashimoto’s Disease, Adrenal Incidentalomas, Obesity and Insulin Resistance—Could Endocrine Disruptors Be the Other Side of the Same Coin?

  2023cites this paper
• A review of the endocrine disrupting effects of micro and nano plastic and their associated chemicals in mammals

  2023cites this paper
• Toxicity of bisphenol A (BPA) and its derivatives in divers biological models with the assessment of molecular mechanisms of toxicity

  2023cites this paper
• Endocrine Disruptors: Focus on the Adrenal Cortex

  2023cites this paper
• Dual effects of bisphenol A on wound healing, involvement of estrogen receptor β.

  2022cites this paper
• Oestrogen ameliorates blood-brain barrier damage after experimental subarachnoid haemorrhage via the SHH pathway in male rats

  2022cites this paper
• Cytotoxic Effect of Progesterone, Tamoxifen and Their Combination in Experimental Cell Models of Human Adrenocortical Cancer

  2021cites this paper
• A comprehensive review on the carcinogenic potential of bisphenol A: clues and evidence

  2021cites this paper
• Neural stem cell–specific ITPA deficiency causes neural depolarization and epilepsy

  2020cites this paper
• Evaluation of the effects of low nanomolar bisphenol A-like compounds' levels on early human embryonic development and lipid metabolism with human embryonic stem cell in vitro differentiation models.

  2020cites this paper
• Update on the health effects of bisphenol A: Overwhelming evidence of harm.

  2020cites this paper
• Nonfunctional adrenal incidentalomas may be related to bisphenol-A

  2020cites this paper
• Gestational exposure to bisphenol A and bisphenol S leads to fetal skeletal muscle hypertrophy independent of sex.

  2019cites this paper
• Melatonin attenuates bisphenol A-induced toxicity of the adrenal gland of Wistar rats

  2019cites this paper
• Effects of Prenatal Bisphenol A Exposure on Adrenal Gland Development and Steroidogenic Function

  2017cites this paper
• Hormone and Metabolic Research Endocrine Disruptors: Focus on the Adrenal Cortex

  year unknowncites this paper