Nuclear architecture dictates HIV-1 integration site selection

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Nature

• Publication date

  2015-03-02

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/nature14226PMID 25731161
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• B-108 Specific HIV integration sites are linked to clonal expansion and persistence of infected cells

  2016cited by this paper
• Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection

  2014cited by this paper
• Specific HIV integration sites are linked to clonal expansion and persistence of infected cells

  2014cited by this paper
• Proximity to PML nuclear bodies regulates HIV-1 latency in CD4+ T cells.

  2013cited by this paper
• Nucleoporin NUP153 Phenylalanine-Glycine Motifs Engage a Common Binding Pocket within the HIV-1 Capsid Protein to Mediate Lentiviral Infectivity

  2013cited by this paper
• Functional implications of genome topology

  2013cited by this paper
• HIV latency and integration site placement in five cell-based models

  2013cited by this paper
• A Conserved Role for Human Nup98 in Altering Chromatin Structure and Promoting Epigenetic Transcriptional Memory

  2013cited by this paper
• Dynamic Association of NUP98 with the Human Genome

  2013cited by this paper
• Concerted action of cellular JNK and Pin1 restricts HIV-1 genome integration to activated CD4+ T lymphocytes

  2010cited by this paper
• 3D-FISH on cultured cells combined with immunostaining.

  2010cited by this paper
• Nucleoporins directly stimulate expression of developmental and cell-cycle genes inside the nucleoplasm.

  2010cited by this paper
• High-Definition Mapping of Retroviral Integration Sites Defines the Fate of Allogeneic T Cells After Donor Lymphocyte Infusion

  2010cited by this paper
• Chromatin-bound nuclear pore components regulate gene expression in higher eukaryotes.

  2010cited by this paper
• BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources

  2009cited by this paper
• HIV integration site distributions in resting and activated CD4+ T cells infected in culture

  2009cited by this paper
• Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes.

  2009cited by this paper
• Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions

  2008cited by this paper
• Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication.

  2008cited by this paper
• Identification of Host Proteins Required for HIV Infection Through a Functional Genomic Screen

  2008cited by this paper
• Functional Targeting of DNA Damage to a Nuclear Pore-Associated SUMO-Dependent Ubiquitin Ligase

  2008cited by this paper
• Experimental approaches to the study of HIV-1 latency

  2007cited by this paper
• Idiographica: a general-purpose web application to build idiograms on-demand for human, mouse and rat

  2007cited by this paper
• Hot spots of retroviral integration in human CD34+ hematopoietic cells.

  2007cited by this paper
• Successful immunization with a single injection of non-integrating lentiviral vector.

  2007cited by this paper
• Recurrent HIV-1 integration at the BACH2 locus in resting CD4+ T cell populations during effective highly active antiretroviral therapy.

  2007cited by this paper
• HIV integration site selection: analysis by massively parallel pyrosequencing reveals association with epigenetic modifications.

  2007cited by this paper
• High-resolution profiling of histone methylations in the human genome.

  2007cited by this paper
• LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration.

  2007cited by this paper
• Integration of Human Immunodeficiency Virus Type 1 in Untreated Infection Occurs Preferentially within Genes

  2006cited by this paper
• Supplementary Material and Methods

  2006cited by this paper
• Genetic Analyses of DNA-Binding Mutants in the Catalytic Core Domain of Human Immunodeficiency Virus Type 1 Integrase

  2005cited by this paper
• A gene atlas of the mouse and human protein-encoding transcriptomes.

  2004cited by this paper
• Conditional Suppression of Cellular Genes: Lentivirus Vector-Mediated Drug-Inducible RNA Interference

  2003cited by this paper
• Simple and cost-effective isolation of monocytes from buffy coats.

  2003cited by this paper
• HIV reproducibly establishes a latent infection after acute infection of T cells in vitro

  2003cited by this paper
• Regulatory Sequence Analysis Tools

  2003cited by this paper
• Live imaging of telomeres: yKu and Sir proteins define redundant telomere-anchoring pathways in yeast.

  2002cited by this paper
• HIV-1 integration in the human genome favors active genes and local hotspots.

  2002cited by this paper
• A quantitative assay for HIV DNA integration in vivo

  2001cited by this paper
• Nuclear pore complexes form immobile networks and have a very low turnover in live mammalian cells

  2001cited by this paper
• A Third-Generation Lentivirus Vector with a Conditional Packaging System

  1998cited by this paper
• Vpr is required for efficient replication of human immunodeficiency virus type-1 in mononuclear phagocytes.

  1995cited by this paper

• Topological Catenation Induced Pore Size in 2D Olympic Network

  2026cites this paper
• Neuroinflammation, Blood–Brain Barrier, and HIV Reservoirs in the CNS: An In-Depth Exploration of Latency Mechanisms and Emerging Therapeutic Strategies

  2025cites this paper
• Early pandemic HIV-1 integration site preferences differ across anatomical reservoirs

  2025cites this paper
• The transmembrane nucleoporin Nup210 weakens HIV-1 infection via modulating late events of viral nuclear import

  2025cites this paper
• The Complex Interactions Between HIV-1 and Human Host Cell Genome: From Molecular Mechanisms to Clinical Practice

  2025cites this paper
• Retroviral Vector Technology for Gene Therapy: History, Current Landscape, and Future Prospects.

  2025cites this paper
• Evolutionary interplay between viruses and R‐loops

  2025cites this paper
• Ex Vivo Gene and Cell Therapy in Hematopoietic Stem Cells

  2025cites this paper
• Impact of chromatin on HIV-1 latency: a multi-dimensional perspective

  2025influential citation
• Aquarius helicase facilitates HIV-1 integration into R-loop enriched genomic regions

  2025cites this paper
• HIV capsids: orchestrators of innate immune evasion, pathogenesis and pandemicity

  2025cites this paper
• LEDGF Binds H3R17me2a Promoting De Novo Nucleotide Biosynthesis in SETD2 Mutant Clear Cell Renal Cell Carcinoma

  2025cites this paper
• Early pandemic HIV-1 integration site preferences differ across anatomical sites

  2025cites this paper
• Dynamic interactions of retroviral Gag condensates with nascent viral RNA at transcriptional burst sites: implications for genomic RNA packaging

  2025cites this paper
• HIV-1 Integration Site Determines the Transcriptional Fate and Persistence of Integrated Proviruses

  2025cites this paper
• A comprehensive review of neurotransmitter modulation via artificial intelligence: A new frontier in personalized neurobiochemistry

  2025cites this paper
• Chronic Neuroplasticity Changes Following Neurotropic Viral Infection: Mechanisms and Implications

  2025cites this paper
• HIV reservoirs in lymphomagenesis: hidden driver in the era of viral suppression?

  2025cites this paper
• Lentiviral Vectors: From Wild-Type Viruses to Efficient Multi-Functional Delivery Vectors

  2025cites this paper
• The role of chromatin in retroviral preintegration complex function

  2025cites this paper
• Imaging Flow Cytometry in HIV Infection Research: Advantages and Opportunities

  2025cites this paper
• Dynamic interactions of retroviral Gag condensates with nascent viral RNA at transcriptional burst sites: implications for genomic RNA packaging

  2025cites this paper
• Synergistic Activity of Second Mitochondrial-Derived Activator of Caspases Mimetic with Toll-like Receptor 8 Agonist Reverses HIV-1-Latency and Enhances Antiviral Immunity

  2025cites this paper
• Impacts of immune checkpoint inhibitors use on the HIV reservoir are linked to provirus sequences but not integration sites

  2025cites this paper
• Identification of Reliable Housekeeping Genes for qRT-PCR Normalization in Neuroblastoma and Glioblastoma Cell Lines Infected with Lentivirus

  2025cites this paper
• HIV-1 usurps mixed-charge domain-dependent CPSF6 phase separation for higher-order capsid binding, nuclear entry and viral DNA integration

  2024cites this paper
• A macrophage-cell model of HIV latency reveals the unusual importance of the bromodomain axis

  2024cites this paper
• Novel role of host protein SLC25A42 in the HIV‐1 reactivation of latent HIV‐1 provirus

  2024cites this paper
• The influencers' era: how the environment shapes chromatin in 3D.

  2024cites this paper
• Human immunodeficiency virus-1 induces host genomic R-loops and preferentially integrates its genome near the R-loop regions

  2024cites this paper
• Advances in HIV Gene Therapy

  2024cites this paper
• Brief Histories of Retroviral Integration Research and Associated International Conferences

  2024cites this paper
• The nuclear pore protein NUP98 impedes LTR-driven basal gene expression of HIV-1, viral propagation, and infectivity

  2024cites this paper
• SIV infection and ARV treatment reshape the transcriptional and epigenetic profile of naïve and memory T cells in vivo

  2024cites this paper
• Enhancers on the edge - how the nuclear envelope controls gene regulatory elements.

  2024cites this paper
• Role of LEDGF/p75 (PSIP1) in oncogenesis. Insights in molecular mechanism and therapeutic potential.

  2024cites this paper
• Immune targeting of HIV-1 reservoir cells: a path to elimination strategies and cure

  2024cites this paper
• The HIV-1 Capsid-Targeted Inhibitor GSK878 Alters Selection of Target Sites for HIV DNA Integration

  2023cites this paper
• HIV-induced CPSF6 condensates.

  2023cites this paper
• DNA double-strand break-capturing nuclear envelope tubules drive DNA repair

  2023cites this paper
• Understanding latent HIV-1 reservoirs through host genomics approaches

  2023cites this paper
• Role of gene therapy in treatment of cancer for craniofacial regeneration—current molecular strategies, future perspectives, and challenges: a narrative review

  2023cites this paper
• Integrome signatures of lentiviral gene therapy for SCID-X1 patients

  2023cites this paper
• InCliniGene enables high-throughput and comprehensive in vivo clonal tracking toward clinical genomics data integration

  2023cites this paper
• HIV-1 capsid and viral DNA integration

  2023cites this paper
• Genomic profiling of HIV-1 integration in microglia cells links viral integration to the topologically associated domains.

  2023cites this paper
• Biomolecular condensates: insights into early and late steps of the HIV-1 replication cycle

  2023influential citation
• HIV-1 Gag co-localizes with euchromatin histone marks at the nuclear periphery

  2023cites this paper
• Capsid–host interactions for HIV-1 ingress

  2023cites this paper
• Loops are geometric catalysts for DNA integration

  2023influential citation
• HIV Infection: Shaping the Complex, Dynamic, and Interconnected Network of the Cytoskeleton

  2023cites this paper
• HIV-1 Preintegration Complex Preferentially Integrates the Viral DNA into Nucleosomes Containing Trimethylated Histone 3-Lysine 36 Modification and Flanking Linker DNA

  2022cites this paper
• Characterizing mobile element insertions in 5675 genomes

  2022cites this paper
• Decoding Human Genome Regulatory Features That Influence HIV-1 Proviral Expression and Fate Through an Integrated Genomics Approach

  2022cites this paper
• Intranuclear Positions of HIV-1 Proviruses Are Dynamic and Do Not Correlate with Transcriptional Activity

  2022cites this paper
• Workshop on RanBP2/Nup358 and acute necrotizing encephalopathy

  2022cites this paper
• Spatial and Genomic Correlates of HIV-1 Integration Site Targeting

  2022influential citation
• Dynamics of Viral and Host 3D Genome Structure upon Infection

  2022cites this paper
• Activation of HIV-1 proviruses increases downstream chromatin accessibility

  2022cites this paper
• Design, Synthesis, and Mechanistic Study of 2-Pyridone-Bearing Phenylalanine Derivatives as Novel HIV Capsid Modulators

  2022cites this paper
• Tuning Rex rules HTLV-1 pathogenesis

  2022cites this paper
• Determinants of Retroviral Integration and Implications for Gene Therapeutic MLV—Based Vectors and for a Cure for HIV-1 Infection

  2022cites this paper
• Single-Cell Imaging Shows That the Transcriptional State of the HIV-1 Provirus and Its Reactivation Potential Depend on the Integration Site

  2022cites this paper
• Expansion microscopy allows high resolution single cell analysis of epigenetic readers

  2022cites this paper
• G-Quadruplex DNA and Other Non-Canonical B-Form DNA Motifs Influence Productive and Latent HIV-1 Integration and Reactivation Potential

  2022cites this paper
• Development and clinical translation of ex vivo gene therapy

  2022cites this paper
• CBX4 contributes to HIV‐1 latency by forming phase‐separated nuclear bodies and SUMOylating EZH2

  2022cites this paper
• Clade-Specific Alterations within the HIV-1 Capsid Protein with Implications for Nuclear Translocation

  2022cites this paper
• Position Effect Variegation: Role of the Local Chromatin Context in Gene Expression Regulation

  2022cites this paper
• Progressive transformation of the HIV-1 reservoir cell profile over two decades of antiviral therapy

  2022cites this paper
• HIV-1 preintegration complex preferentially integrates the viral DNA into nucleosomes containing trimethylated histone 3-lysine 36 modification

  2022cites this paper
• Biology and Model Predictions of the Dynamics and Heterogeneity of Chromatin-Nuclear Lamina Interactions

  2022cites this paper
• Harnessing nucleic acid technologies for human health on earth and in space.

  2022cites this paper
• HIV-1 preintegration complex preferentially integrates the viral DNA into 1 nucleosomes containing trimethylated histone 3-lysine 36 modification 2

  2022cites this paper
• Tough Way In, Tough Way Out: The Complex Interplay of Host and Viral Factors in Nucleocytoplasmic Trafficking during HIV-1 Infection

  2022influential citation
• T cell stimulation remodels the latently HIV-1 infected cell population by differential activation of proviral chromatin

  2021cites this paper
• Designing Lentiviral Vectors for Gene Therapy of Genetic Diseases

  2021cites this paper
• Transplantation of human embryonic stem cells alleviates motor dysfunction in AAV2-Htt171-82Q transfected rat model of Huntington’s disease

  2021cites this paper
• Epigenetic Mechanisms of HIV-1 Persistence

  2021cites this paper
• rigrag: high-resolution mapping of genic targeting preferences during HIV-1 integration in vitro and in vivo

  2021cites this paper
• Strategies for Targeting Retroviral Integration for Safer Gene Therapy: Advances and Challenges

  2021cites this paper
• LEDGINs, Inhibitors of the Interaction Between HIV-1 Integrase and LEDGF/p75, Are Potent Antivirals with a Potential to Cure HIV Infection.

  2021cites this paper
• HIV-1 Capsid Core: A Bullet to the Heart of the Target Cell

  2021cites this paper
• Membraneless organelles restructured and built by pandemic viruses: HIV-1 and SARS-CoV-2

  2021cites this paper
• 3D Immuno-DNA Fluorescence In Situ Hybridization (FISH) for Detection of HIV-1 and Cellular Genes in Primary CD4+ T Cells.

  2021cites this paper
• Capturing Chromosome Conformation: Methods and Protocols

  2021cites this paper
• Histone chaperone CAF‐1 promotes HIV‐1 latency by leading the formation of phase‐separated suppressive nuclear bodies

  2021cites this paper
• Viruses in the Nucleus.

  2021cites this paper
• Longitudinal clonal tracking in humanized mice reveals sustained polyclonal repopulation of gene-modified human-HSPC despite vector integration bias

  2021cites this paper
• Predicting Post-treatment HIV Remission: Does Size of the Viral Reservoir Matter?

  2021cites this paper
• GS-9822, a Preclinical LEDGIN Candidate, Displays a Block-and-Lock Phenotype in Cell Culture

  2021cites this paper
• The decreased exclusion of nuclear eccDNA: from molecular and subcellular levels to human aging and age-related diseases.

  2021cites this paper
• Light and shadow on the mechanisms of integration site selection in yeast Ty retrotransposon families

  2021cites this paper
• Imaging Viral Infection by Fluorescence Microscopy: Focus on HIV-1 Early Stage

  2021cites this paper
• The HIV-1 Capsid: From Structural Component to Key Factor for Host Nuclear Invasion

  2021cites this paper
• Longitudinal clonal tracking in humanized mice reveals sustained polyclonal repopulation of gene-2 modified human-HSPC despite vector integration bias 3 4

  2021cites this paper
• Investigating site-selection mechanisms of retroviral integration in supercoiled DNA braids

  2021cites this paper
• Genome-wide analysis of mobile element insertions in human genomes

  2021cites this paper
• Three-dimensional chromatin in infectious disease—A role for gene regulation and pathogenicity?

  2021cites this paper
• HIV Capsid and Integration Targeting

  2021influential citation