Preparation and Comprehensive Characterization of a Calcium Hydroxyapatite Reference Material

Numerous biological and chemical studies involve the use of calcium hydroxyapatite (HA), Ca10(PO4)6(OH)2. In this study detailed physicochemical characterization of HA, prepared from an aqueous solution, was carried out employing different methods and techniques: chemical and thermal analyses, x-ray diffraction, infrared and Raman spectroscopies, scanning and transmission microscopies, and Brunauer, Emmett, and Teller (BET) surface-area method. The contents of calcium (Ca2+), phosphate (PO43−), hydroxide (OH−), hydrogenphosphate (HPO42−), water (H2O), carbonate (CO32−), and trace constituents, the Ca/P molar ratio, crystal size and morphology, surface area, unit-cell parameters, crystallinity, and solubility of this HA were determined. This highly pure, homogeneous, and highly crystalline HA is certified as a National Institute of Standards and Technology (NIST) standard reference material, SRM 2910.

• Publication year

  2004

• Venue

  Journal of Research of the National Institute of Standards and Technology

• Publication date

  2004-11-01

• Fields of study

  Medicine, Materials Science

• Identifiers
  DOI 10.6028/jres.109.042PMID 27366634PMCID 4856200
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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