Overexpression of the p53 Tumor Suppressor Gene Product in Primary Lung Adenocarcinomas Is Associated with Cigarette Smoking

No abstract is available for this paper.

• Publication year

  1993

• Venue

  American Journal of Surgical Pathology

• Publication date

  1993-03-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1097/00000478-199303000-00001PMID 8434702
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1992cited by this paper
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  1992cited by this paper
• Clinicopathological Significance of Nuclear Accumulation of Tumor Suppressor Gene p53 Product in Primary Lung Cancer

  1992cited by this paper
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  1992cited by this paper
• Small subgroup of aggressive, highly proliferative prostatic carcinomas defined by p53 accumulation.

  1992cited by this paper
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  1992cited by this paper
• p53 mutations in non-small cell lung cancer in Japan: association between mutations and smoking.

  1992cited by this paper
• Oncogenic forms of p53 inhibit p53-regulated gene expression.

  1992cited by this paper
• Enhanced binding of a 95 kDa protein to p53 in cells undergoing p53‐mediated growth arrest.

  1992cited by this paper
• Aberrations of the p53 tumor suppressor gene in human non-small cell carcinomas of the lung.

  1992cited by this paper
• Expression of mutant p53 proteins in lung cancer correlates with the class of p53 gene mutation.

  1992cited by this paper
• p53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features.

  1992cited by this paper
• A mutant p53 protein is required for maintenance of the transformed phenotype in cells transformed with p53 plus ras cDNAs.

  1992cited by this paper
• Evidence for synergistic interactions between ras, myc and a mutant form of p53 in cellular transformation and tumor dissemination.

  1992cited by this paper
• The origin of point mutations in human tumor cells.

  1992cited by this paper
• Association of overexpression of tumor suppressor protein p53 with rapid cell proliferation and poor prognosis in node-negative breast cancer patients.

  1992cited by this paper
• p53 mutations in human lung tumors.

  1992cited by this paper
• Identification of p53 as a sequence-specific DNA-binding protein

  1991cited by this paper
• Tumor suppressor genes.

  1991cited by this paper
• Relationship between K-ras oncogene activation and smoking in adenocarcinoma of the human lung.

  1991cited by this paper
• Tumor suppressor genes.

  1991cited by this paper
• Detection of p53 in primary lung tumors and nonsmall cell lung carcinoma cell lines.

  1991cited by this paper
• Direct sequencing from touch preparations of human carcinomas: analysis of p53 mutations in breast carcinomas.

  1991cited by this paper
• p53 mutations in human cancers.

  1991cited by this paper
• Aberrant expression of the p53 oncoprotein is a common feature of a wide spectrum of human malignancies.

  1991cited by this paper
• Identification of p53 gene mutations in bladder cancers and urine samples.

  1991cited by this paper
• Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer. Lung Cancer Study Group.

  1990cited by this paper
• DNA base changes in benzo[a]pyrene diol epoxide-induced dihydrofolate reductase mutants of Chinese hamster ovary cells.

  1990cited by this paper
• Increased expression of mutant forms of p53 oncogene in primary lung cancer.

  1990cited by this paper
• Incidence and possible clinical significance of K-ras oncogene activation in adenocarcinoma of the human lung.

  1988cited by this paper
• Mutational activation of the K-ras oncogene. A possible pathogenetic factor in adenocarcinoma of the lung.

  1987cited by this paper
• Specific interaction between the p53 cellular tumour antigen and major heat shock proteins

  1986cited by this paper
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  1984cited by this paper
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  1982cited by this paper
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  1981cited by this paper
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  1979cited by this paper

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  2020cites this paper
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  2018cites this paper
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  2015cites this paper
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  2015cites this paper
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  2013cites this paper
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  2013cites this paper
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  2009cites this paper
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  2009cites this paper
• Impact and interactions between smoking and traditional prognostic factors in lung cancer progression.

  2009cites this paper
• Hepatocarcinogenic susceptibility of rasH2 mice to troglitazone in a two-stage hepatocarcinogenesis model

  2009cites this paper
• Histological Evaluation of the Effect of Smoking on Peripheral Small Adenocarcinomas of the Lung

  2008cites this paper
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  2008cites this paper
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  2008cites this paper
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  2007cites this paper
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  2006cites this paper
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  2006cites this paper
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  2005cites this paper
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  2005cites this paper
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  2005cites this paper
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  2004cites this paper
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  2004cites this paper
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  2004cites this paper
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  2004cites this paper
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  2004cites this paper
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  2003cites this paper
• Lung Adenocarcinoma With Mixed Bronchioloalveolar and Invasive Components: Clinicopathological Features, Subclassification by Extent of Invasive Foci, and Immunohistochemical Characterization

  2003cites this paper
• [2000 Standards, Options and Recommendations for prognostic value of oncogenes and tumor suppressor genes in non small cell lung cancer].

  2002cites this paper
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  2002cites this paper
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  2001cites this paper
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  2001cites this paper
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  2001cites this paper
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  2001cites this paper
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  2001cites this paper
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  2001cites this paper
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  2000cites this paper
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  2000cites this paper
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  2000cites this paper
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  2000cites this paper
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  1999cites this paper
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  1999cites this paper
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  1999cites this paper
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  1999cites this paper
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  1999cites this paper
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  1999cites this paper
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  1999cites this paper
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  1999cites this paper
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  1999cites this paper
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  1998cites this paper
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  1998cites this paper
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  1998cites this paper
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  1998cites this paper
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  1998cites this paper
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  1998cites this paper
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  1998cites this paper
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  1997cites this paper
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  1997cites this paper
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  1997cites this paper
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  1997cites this paper
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  1997cites this paper
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  1997cites this paper
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  1997cites this paper
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  1997cites this paper
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  1997cites this paper
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  1997cites this paper
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  1997cites this paper
• Correlation between the Human Papilloma Virus and the p53 Tumor Suppressor Gene in Cancer of the Tongue.

  1997cites this paper
• Antigen Retrieval Technique: A Novel Approach to Immunohistochemistry on Routinely Processed Tissue Sections

  1996cites this paper
• Genetic and molecular events in the pathogenesis of lung cancer

  1996cites this paper
• The Biology of Bronchial Premalignancy

  1996cites this paper
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  1996cites this paper
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  1996cites this paper
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  1996cites this paper
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  1996cites this paper
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  1996cites this paper
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  1996cites this paper
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  1996cites this paper
• Laboratory probing of oncogenes from human liquid and solid specimens as markers of exposure to toxicants.

  1996cites this paper
• p53 mutations in non-small cell lung carcinomas in Hong Kong.

  1996cites this paper
• DNA Ploidy and Proliferative Activity in bcl-2 Expressed Non-small Cell lung Cancer

  1996cites this paper
• A dose‐response relationship between the frequency of p53 mutations and tobacco consumption in lung cancer patients

  1996cites this paper
• Histological differentiation of oral squamous cell cancer in relation to tobacco smoking.

  1995cites this paper
• Comparative analysis of p53 gene mutations and protein accumulation in human non‐small‐cell lung cancer

  1995cites this paper
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  1995cites this paper
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  1995cites this paper
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  1995cites this paper
• The aberrant p53 protein (review).

  1995cites this paper
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  1995cites this paper
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  1995cites this paper
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  1995cites this paper
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  1995cites this paper
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  1995cites this paper
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  1995cites this paper
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  1995cites this paper
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  1995cites this paper
• [The tumor suppressor gene p53 (part one). Structure, function and mechanisms of inactivation].

  1995cites this paper
• p53 protein expression is correlated with benzo[a]pyrene-DNA adducts in carcinoma cell lines.

  1995cites this paper
• Lung Pathology: The molecular genetics of non‐small cell lung cancer

  1995cites this paper
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  1995cites this paper