Total Synthesis of Dixiamycin B by Electrochemical Oxidation

N–N-linked dimeric indole alkaloids represent an unexplored class of natural products for which chemical synthesis has no practical solution. To meet this challenge, an electrochemical oxidative dimerization method was developed, which was applied as the pivotal step of the first total synthesis of dixiamycin B. This method is also general for N–N dimerization of substituted carbazoles and β-carbolines, providing entry into seldom explored chemical space.

• Publication year

  2014

• Venue

  Journal of the American Chemical Society

• Publication date

  2014-04-03

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/ja5013323PMID 24697810PMCID 4004216
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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