Insulin-Like Growth Factor-I Is Necessary for Neural Stem Cell Proliferation and Demonstrates Distinct Actions of Epidermal Growth Factor and Fibroblast Growth Factor-2

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Journal of Neuroscience

• Publication date

  2001-09-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1523/JNEUROSCI.21-18-07194.2001PMID 11549730PMCID PMC6762999
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Retinal stem cells in the adult mammalian eye.

  2000cited by this paper
• In vivo induction of massive proliferation, directed migration, and differentiation of neural cells in the adult mammalian brain.

  2000cited by this paper
• Noggin antagonizes BMP signaling to create a niche for adult neurogenesis.

  2000cited by this paper
• Timing of CNS cell generation: a programmed sequence of neuron and glial cell production from isolated murine cortical stem cells.

  2000cited by this paper
• FGF-2-responsive neural stem cell proliferation requires CCg, a novel autocrine/paracrine cofactor.

  2000cited by this paper
• Peripheral Infusion of IGF-I Selectively Induces Neurogenesis in the Adult Rat Hippocampus

  2000cited by this paper
• BMP and FGF regulate the development of EGF-responsive neural progenitor cells.

  2000influential reference
• Disruption of Eph/ephrin signaling affects migration and proliferation in the adult subventricular zone

  2000cited by this paper
• Epidermal and Fibroblast Growth Factors Behave as Mitogenic Regulators for a Single Multipotent Stem Cell-Like Population from the Subventricular Region of the Adult Mouse Forebrain

  1999cited by this paper
• Developmental changes in progenitor cell responsiveness to cytokines

  1999cited by this paper
• Expression of EGF receptor and FGF receptor isoforms during neuroepithelial stem cell differentiation.

  1999cited by this paper
• Distinct neural stem cells proliferate in response to EGF and FGF in the developing mouse telencephalon.

  1999influential reference
• A role for the POU‐III transcription factor Brn‐4 in the regulation of striatal neuron precursor differentiation

  1999cited by this paper
• Transforming growth factor‐β mediates the neurotrophic effect of fibroblast growth factor‐2 on midbrain dopaminergic neurons

  1998cited by this paper
• Self‐renewing canine oligodendroglial progenitor expanded as oligospheres

  1998cited by this paper
• Insulin-Like Growth Factor-I Is a Differentiation Factor for Postmitotic CNS Stem Cell-Derived Neuronal Precursors: Distinct Actions from Those of Brain-Derived Neurotrophic Factor

  1998cited by this paper
• A strain‐independent postnatal neurodegeneration in mice lacking the EGF receptor

  1998cited by this paper
• Survival of Purified Rat Photoreceptors In Vitro Is Stimulated Directly by Fibroblast Growth Factor-2

  1998cited by this paper
• Growth and Fate of PSA-NCAM+ Precursors of the Postnatal Brain

  1998cited by this paper
• Insulin-like growth factor-binding proteins: functional diversity or redundancy?

  1998cited by this paper
• Differentiation of Oligodendroglial Progenitors Derived from Cortical Multipotent Cells Requires Extrinsic Signals Including Activation of gp130/LIFβ Receptors

  1998cited by this paper
• Fibroblast Growth Factor 2 (FGF-2) Promotes Acquisition of Epidermal Growth Factor (EGF) Responsiveness in Mouse Striatal Precursor Cells: Identification of Neural Precursors Responding to both EGF and FGF-2

  1998influential reference
• Short communication: transforming growth factor-beta mediates the neurotrophic effect of fibroblast growth factor-2 on midbrain dopaminergic neurons.

  1998cited by this paper
• Neuroepithelial stem cells from the embryonic spinal cord: isolation, characterization, and clonal analysis.

  1997influential reference
• Myelination following transplantation of EGF-responsive neural stem cells into a myelin-deficient environment.

  1997cited by this paper
• Epidermal Growth Factor and Fibroblast Growth Factor-2 Have Different Effects on Neural Progenitors in the Adult Rat Brain

  1997cited by this paper
• Hematolymphopoietic and inflammatory cytokines in neural development.

  1997cited by this paper
• Transforming Growth Factor-α Null and Senescent Mice Show Decreased Neural Progenitor Cell Proliferation in the Forebrain Subependyma

  1997influential reference
• Induction of Cell Proliferation by Fibroblast and Insulin-Like Growth Factors in Pure Rat Inner Ear Epithelial Cell Cultures

  1997cited by this paper
• The adult rat hippocampus contains primordial neural stem cells.

  1997influential reference
• FGF2 concentration regulates the generation of neurons and glia from multipotent cortical stem cells.

  1997cited by this paper
• Response diversity and the timing of progenitor cell maturation are regulated by developmental changes in EGFR expression in the cortex.

  1997cited by this paper
• Glial-restricted precursors are derived from multipotent neuroepithelial stem cells.

  1997cited by this paper
• FGF-2 is sufficient to isolate progenitors found in the adult mammalian spinal cord.

  1997cited by this paper
• IGF-I increases bFGF-induced mitogenesis and upregulates FGFR-1 in rabbit vascular smooth muscle cells.

  1996cited by this paper
• Bone morphogenetic proteins promote astroglial lineage commitment by mammalian subventricular zone progenitor cells.

  1996cited by this paper
• Clonal and population analyses demonstrate that an EGF-responsive mammalian embryonic CNS precursor is a stem cell.

  1996cited by this paper
• In vivo growth factor expansion of endogenous subependymal neural precursor cell populations in the adult mouse brain

  1996cited by this paper
• Single factors direct the differentiation of stem cells from the fetal and adult central nervous system.

  1996cited by this paper
• Stimulation of C2C12 myoblast growth by basic fibroblast growth factor and insulin-like growth factor 1 can occur via mitogen-activated protein kinase-dependent and -independent pathways

  1996cited by this paper
• BDNF enhances the differentiation but not the survival of CNS stem cell- derived neuronal precursors

  1995cited by this paper
• The developing CNS: a scenario for the action of proinsulin, insulin and insulin-like growth factors.

  1995influential reference
• Igf1 gene disruption results in reduced brain size, CNS hypomyelination, and loss of hippocampal granule and striatal parvalbumin-containing neurons.

  1995influential reference
• Implication of insulin-like growth factors in the pathogenesis of diabetic neuropathy.

  1995cited by this paper
• Murine FGFR-1 is required for early postimplantation growth and axial organization.

  1994cited by this paper
• Genesis of olfactory receptor neurons in vitro: regulation of progenitor cell divisions by fibroblast growth factors.

  1994cited by this paper
• Distinct expression patterns of insulin-like growth factor binding proteins 2 and 5 during fetal and postnatal development.

  1994cited by this paper
• Neural stem cells in the adult mammalian forebrain: a relatively quiescent subpopulation of subependymal cells.

  1994cited by this paper
• fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation.

  1994cited by this paper
• A Neurologist's Overview of Developmental Dyslexia

  1993cited by this paper
• Insulin‐like Growth Factor Receptors: Implications for Nervous System Function

  1993cited by this paper
• Correlation between insulin-like growth factor (IGF)-binding protein 5 and IGF-I gene expression during brain development

  1993cited by this paper
• Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r).

  1993influential reference
• Quantitative autoradiographic localization of [125I]insulin‐like growth factor I, [125I]insulin‐like growth factor II, and [125I]insulin receptor binding sites in developing and adult rat brain

  1993cited by this paper
• Role of insulin-like growth factors in embryonic and postnatal growth.

  1993influential reference
• Insulin II gene expression in rat central nervous system.

  1993cited by this paper
• bFGF regulates the proliferative fate of unipotent (neuronal) and bipotent (neuronal/astroglial) EGF-generated CNS progenitor cells.

  1993cited by this paper
• A multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes

  1992cited by this paper
• Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system.

  1992cited by this paper
• Fibroblast growth factor-mediated proliferation of central nervous system precursors depends on endogenous production of insulin-like growth factor I.

  1991cited by this paper
• Transient IGF-I gene expression during the maturation of functionally related central projection neurons

  1991cited by this paper
• Localization of insulin-like growth factor I (IGF-I)-like immunoreactivity in the developing and adult rat brain.

  1991cited by this paper
• Localization of insulin-like growth factor-1 mRNA in murine central nervous system during postnatal development.

  1991cited by this paper
• Cellular pattern of insulin-like growth factor-I (IGF-I) and type I IGF receptor gene expression in early organogenesis: comparison with IGF-II gene expression.

  1990cited by this paper
• Development of receptors for insulin and insulin-like growth factor-I in head and brain of chick embryos: autoradiographic localization.

  1989cited by this paper
• Expression of the insulin-like growth factor II gene in the choroid plexus and the leptomeninges of the adult rat central nervous system.

  1988cited by this paper
• Tissue localization of Drosophila melanogaster insulin receptor transcripts during development

  1988cited by this paper
• Basic and acidic fibroblast growth factors have trophic effects on neurons from multiple CNS regions

  1988cited by this paper
• Development of brain insulin receptors.

  1988cited by this paper
• Astroglial and fibroblast growth factors have neurotrophic functions for cultured peripheral and central nervous system neurons.

  1987cited by this paper
• Isolation of a Drosophila genomic sequence homologous to the kinase domain of the human insulin receptor and detection of the phosphorylated Drosophila receptor with an anti-peptide antibody.

  1986cited by this paper

• Defective Neural Stem and Progenitor Cell Proliferation in Neurodevelopmental Disorders

  2025cites this paper
• The Effects of Exercise‐Associated Factors on Hippocampal Progenitor Cell Dynamics Are Mediated by Cannabinoid Type 2 Receptors

  2025cites this paper
• In vitro models of valproic acid to assess neurodevelopmental toxicity: A scoping review

  2025cites this paper
• Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1

  2025cites this paper
• Role of Fibroblast Growth Factors in Neurological Disorders: Insight into Therapeutic Approaches and Molecular Mechanisms

  2025cites this paper
• Neuroactive network tissue based on dual-factor neuroregenerative bioactive coating scaffolds and neural stem cells for spinal cord injury repair

  2025cites this paper
• Microproteins Simba1 and Simba2 activate Wingless signaling during the reactivation of neural stem cells in Drosophila

  2025cites this paper
• Microglia Colonization Associated with Angiogenesis and Neural Cell Development.

  2024cites this paper
• The role of IGF/IGF-1R signaling in the regulation of cancer stem cells

  2024cites this paper
• A Hybrid 2D‐to‐3D in vitro Differentiation Platform Improves Outcomes of Cerebral Cortical Organoid Generation in hiPSCs

  2024cites this paper
• Golgi-dependent reactivation and regeneration of Drosophila quiescent neural stem cells.

  2023cites this paper
• Critical points for optimizing long-term culture and neural differentiation capacity of rodent and human neural stem cells to facilitate translation into clinical settings.

  2023cites this paper
• Patronin/CAMSAP promotes reactivation and regeneration of Drosophila quiescent neural stem cells

  2023cites this paper
• Response to growth hormone therapy in ring chromosome 15: Review and evidence from a new case on possible beneficial effect in neurodevelopment.

  2023cites this paper
• Understanding Intra- and Inter-Species Variability in Neural Stem Cells’ Biology Is Key to Their Successful Cryopreservation, Culture, and Propagation

  2023cites this paper
• Brain IGF-I regulates LTP, spatial memory, and sexual dimorphic behavior

  2023cites this paper
• Effect of expansion of human umbilical cord blood CD34 + cells on neurotrophic and angiogenic factor expression and function

  2022cites this paper
• TNFα-Induced Oxidative Stress and Mitochondrial Dysfunction Alter Hypothalamic Neurogenesis and Promote Appetite Versus Satiety Neuropeptide Expression in Mice

  2022cites this paper
• Golgi-dependent Reactivation and Regeneration of Quiescent Neural Stem Cells

  2022cites this paper
• A role for insulin-like growth factor-1 in hippocampal plasticity following traumatic brain injury.

  2022cites this paper
• Postnatal serum IGF-1 levels associate with brain volumes at term in extremely preterm infants

  2022cites this paper
• Neural stem cells-from quiescence to differentiation and potential clinical uses

  2021cites this paper
• Heparin-mediated electrostatic immobilization of bFGF via functional polymer films for enhanced self-renewal of human neural stem cells.

  2021cites this paper
• Estrogen receptor α: a critical role in successful female cognitive aging

  2021cites this paper
• Preclinical and clinical evidence of IGF-1 as a prognostic marker and acute intervention with ischemic stroke

  2021cites this paper
• Hormonal Regulation of Oligodendrogenesis I: Effects across the Lifespan

  2021cites this paper
• Stimulation of the Migration and Expansion of Adult Mouse Neural Stem Cells by the FPR2-Specific Peptide WKYMVm

  2021cites this paper
• L’inflammation chronique perturbe la mobilisation et la migration des cellules souches, altérant le fonctionnement de notre système naturel de réparation et de renouvellement : nouvelle approche thérapeutique complémentaire et combinée dans la prise en charge de maladies chroniques inflammatoires ?

  2021cites this paper
• In vitro investigation of growth factors including MGF and IGF-1 in neural stem cell activation, proliferation, and migration.

  2021cites this paper
• Epidermal Growth Factor in the CNS: A Beguiling Journey from Integrated Cell Biology to Multiple Sclerosis. An Extensive Translational Overview

  2020cites this paper
• Combining growth factor and stem cell therapy for stroke rehabilitation, a review.

  2020cites this paper
• Troxerutin flavonoid has neuroprotective properties and increases neurite outgrowth and migration of neural stem cells from the subventricular zone

  2020cites this paper
• NeuroCore formation during differentiation of neurospheres of mouse embryonic neural stem cells.

  2020cites this paper
• The role of exercise in the reversal of IGF-1 deficiencies in microvascular rarefaction and hypertension

  2019cites this paper
• STRIPAK Members Orchestrate Hippo and Insulin Receptor Signaling to Promote Neural Stem Cell Reactivation

  2019cites this paper
• IGFBP5 promotes angiogenic and neurogenic differentiation potential of dental pulp stem cells

  2019cites this paper
• Novel Approaches for the Treatment of Alzheimer’s and Parkinson’s Disease

  2019cites this paper
• A Novel Approach via Surface Modification of Degradable Polymers With Adhesive DOPA-IGF-1 for Neural Tissue Engineering.

  2019cites this paper
• Regulation of glioblastoma cell proliferation in dependence of cell density and growth factors in vitro

  2018cites this paper
• Neural Precursor Cell Galvanotaxis is Conserved Across Age and is Modulated by Resting Membrane Potential

  2018cites this paper
• Instructions for use Title Tricyclic Antidepressant Amitriptyline Indirectly Increases the Proliferation of Adult Dentate Gyrus-Derived NeuralPrecursors : An Involvement of Astrocytes

  2018cites this paper
• Hsp83/Hsp90 Physically Associates with Insulin Receptor to Promote Neural Stem Cell Reactivation

  2018cites this paper
• Transplantation of a bone marrow mesenchymal stem cell line increases neuronal progenitor cell migration in a cerebral ischemia animal model

  2018cites this paper
• Derivation of Neural Stem Cells from the Developing and Adult Human Brain.

  2018cites this paper
• Three‐Dimensional Models of the Human Brain Development and Diseases

  2018cites this paper
• Effect of crude venom from the spider Chilobrachys jingzhao on the proliferation and differentiation of C17.2 neural stem cells

  2018cites this paper
• Streptozotocin Impairs Proliferation and Differentiation of Adult Hippocampal Neural Stem Cells in Vitro-Correlation With Alterations in the Expression of Proteins Associated With the Insulin System

  2018cites this paper
• Cyclin‐Dependent Kinase 4 Regulates Adult Neural Stem Cell Proliferation and Differentiation in Response to Insulin

  2017cites this paper
• Cell density-dependent differential proliferation of neural stem cells on omnidirectional nanopore-arrayed surface

  2017cites this paper
• Acute Ethanol Increases IGF‐I‐Induced Phosphorylation of ERKs by Enhancing Recruitment of p52‐Shc to the Grb2/Shc Complex

  2017cites this paper
• Vascular Degeneration in Human Parkinson Disease: Novel Insights in the Pathologies, Functions and Mechanisms

  2017cites this paper
• Rapid Serum-Free Isolation of Oligodendrocyte Progenitor Cells from Adult Rat Spinal Cord

  2017cites this paper
• IGF-1 mediated Neurogenesis Involves a Novel RIT1/Akt/Sox2 Cascade

  2017cites this paper
• Emerging Molecular Pathways Governing Dietary Regulation of Neural Stem Cells during Aging

  2017cites this paper
• Effect of Metformin on Adult Hippocampal Neurogenesis: Comparison with Donepezil and Links to Cognition

  2017cites this paper
• IGF-1 in retinopathy of prematurity, a CNS neurovascular disease.

  2016cites this paper
• The role of small leucine-rich repeat proteoglycan Asporin in early eye development

  2016cites this paper
• Vascular regulation of embryonic neurogenesis

  2016cites this paper
• Future Targets for Female Sexual Dysfunction.

  2016cites this paper
• Mutant Ataxin-1 Inhibits Neural Progenitor Cell Proliferation in SCA1

  2016cites this paper
• Diabetes Impairs Wnt3 Protein-induced Neurogenesis in Olfactory Bulbs via Glutamate Transporter 1 Inhibition*

  2016cites this paper
• CXCR7 Participates in CXCL12-mediated Cell Cycle and Proliferation Regulation in Mouse Neural Progenitor Cells

  2016cites this paper
• Mimicking Neural Stem Cell Niche by Biocompatible Substrates

  2016cites this paper
• IGF-I: A Key Growth Factor that Regulates Neurogenesis and Synaptogenesis from Embryonic to Adult Stages of the Brain

  2016cites this paper
• Autophagy for the quality control of adult hippocampal neural stem cells.

  2016cites this paper
• The Effects of Insulin Like Growth Factor -1 (IGF-1) on the Plasticity of Umbilical Cord Blood Derived Mesenchymal Stem Cells Colonies to In Vitro Neurogenic Differentiation

  2015cites this paper
• The Effect of Layer-by-Layer Assembly Coating on the Proliferation and Differentiation of Neural Stem Cells.

  2015cites this paper
• Energy Metabolism, Adult Neurogenesis and their Possible Roles in Alzheimer's Disease: A Brief Overview.

  2015cites this paper
• Insulin and IGF receptor signalling in neural-stem-cell homeostasis

  2015cites this paper
• Suppression of IGF-I signals in neural stem cells enhances neurogenesis and olfactory function during aging

  2015cites this paper
• Diabetes and Stem Cell Function

  2015cites this paper
• Neurosphere and adherent culture conditions are equivalent for malignant glioma stem cell lines

  2015cites this paper
• Strategies for regeneration of components of nervous system: scaffolds, cells and biomolecules

  2015cites this paper
• The regulation of stem cell aging by Wnt signaling.

  2015cites this paper
• Developing ovarian cancer stem cell models: laying the pipeline from discovery to clinical intervention

  2014cites this paper
• Physical Exercise Promotes Recovery of Neurological Function after Ischemic Stroke in Rats

  2014cites this paper
• Insulin-Like Growth Factor Receptor Signaling is Necessary for Epidermal Growth Factor Mediated Proliferation of SVZ Neural Precursors in vitro Following Neonatal Hypoxia–Ischemia

  2014cites this paper
• Chapter 1 – Early Development of the Vertebrate Inner Ear

  2014cites this paper
• New insights into signalling-pathway alterations in rhabdomyosarcoma

  2014cites this paper
• Targeting pleiotropic signaling pathways to control adult cardiac stem cell fate and function

  2014cites this paper
• Stem Cell Therapies for Age Associated Neurodegeneration

  2014cites this paper
• Hippocampal apoptosis involved in learning deficits in the offspring exposed to maternal high sucrose diets.

  2014cites this paper
• MicroRNA Profiling Reveals Unique miRNA Signatures in IGF-1 Treated Embryonic Striatal Stem Cell Fate Decisions in Striatal Neurogenesis In Vitro

  2014cites this paper
• Maternal exposure to bisphenol A may increase the risks of Parkinson's disease through down-regulation of fetal IGF-1 expression.

  2014cites this paper
• The role of FGF2 in spinal cord trauma and regeneration research

  2014cites this paper
• Effects of the KI-180 and KI-188 Calcium Formulae on the Growth and Development of Rats

  2014cites this paper
• Immobilization of insulin-like growth factor-1 onto thermosensitive hydrogels to enhance cardiac progenitor cell survival and differentiation under ischemic conditions

  2014cites this paper
• Programmed hyperphagia secondary to increased hypothalamic SIRT1.

  2014cites this paper
• IGF-1 Promotes Brn-4 Expression and Neuronal Differentiation of Neural Stem Cells via the PI3K/Akt Pathway

  2014cites this paper
• FGF2 and Insulin Signaling Converge to Regulate Cyclin D Expression in Multipotent Neural Stem Cells

  2014cites this paper
• Metabolic circuits in neural stem cells

  2014cites this paper
• Developmental Vascularization, Neurogenesis, Myelination, and Astrogliogenesis

  2014cites this paper
• INDUCTION OF NEURONAL DIFFERENTIATION OF EMBRYONIC RAT CORTICAL NEUROSPHERES BY NERVE GROWTH FACTOR AND FETAL BOVINE SERUM ON THE NONADHERENT AND ADHERENT SUBSTRATES

  2013cites this paper
• Neural stem cell survival factors.

  2013cites this paper
• Monitoring neurodegeneration in diabetes using adult neural stem cells derived from the olfactory bulb

  2013cites this paper
• Efectos neurotóxicos del timerosal, a dosis de vacuna, sobre el encéfalo y el desarrollo en hámsteres de 7 días de nacidos

  2013cites this paper
• IGF-1 Acts as Controlling Switch for Long-term Proliferation and Maintenance of EGF/FGF-responsive Striatal Neural Stem Cells

  2013cites this paper
• Evaluation of insulin-like growth factor-1 as a therapeutic approach for the treatment of traumatic brain injury

  2013cites this paper
• Functions of neurotrophins and growth factors in neurogenesis and brain repair

  2013cites this paper
• El timerosal y las enfermedades del neurodesarrollo infantil

  2013cites this paper