The Neuropeptide Oxytocin Facilitates Pro-Social Behavior and Prevents Social Avoidance in Rats and Mice

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Neuropsychopharmacology

• Publication date

  2011-10-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1038/npp.2011.95PMID 21677650PMCID PMC3176581
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Distinct correlations of vasopressin release within the lateral septum and the bed nucleus of the stria terminalis with the display of intermale aggression.

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  2010cited by this paper
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  2010cited by this paper
• Oxytocin Attenuates Amygdala Reactivity to Fear in Generalized Social Anxiety Disorder

  2010cited by this paper
• Chronic icv oxytocin attenuates the pathological high anxiety state of selectively bred Wistar rats.

  2010influential reference
• Maternal separation interferes with developmental changes in brain vasopressin and oxytocin receptor binding in male rats.

  2010cited by this paper
• The advantage of social living: brain neuropeptides mediate the beneficial consequences of sex and motherhood.

  2009influential reference
• Characterization of the oxytocin system regulating affiliative behavior in female prairie voles.

  2009cited by this paper
• Mesotocin and Nonapeptide Receptors Promote Estrildid Flocking Behavior

  2009cited by this paper
• Aggression and Anxiety: Social Context and Neurobiological Links

  2009cited by this paper
• A randomized controlled trial of intranasal oxytocin as an adjunct to exposure therapy for social anxiety disorder.

  2009cited by this paper
• Autism spectrum disorders: clinical and research frontiers

  2008cited by this paper
• Central vasopressin and oxytocin release: regulation of complex social behaviours.

  2008cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2007cited by this paper
• Differences in intermale aggression are accompanied by opposite vasopressin release patterns within the septum in rats bred for low and high anxiety

  2007cited by this paper
• Centrally released oxytocin mediates mating-induced anxiolysis in male rats

  2007influential reference
• Microparticle-based delivery of oxytocin receptor antisense DNA in the medial amygdala blocks social recognition in female mice

  2007cited by this paper
• Essential Role of BDNF in the Mesolimbic Dopamine Pathway in Social Defeat Stress

  2006cited by this paper
• Anxiolytic-like activity of oxytocin in male mice: behavioral and autonomic evidence, therapeutic implications

  2006cited by this paper
• The involvement of the vasopressin system in stress-related disorders.

  2006cited by this paper
• Dendritic peptide release and peptide-dependent behaviours

  2006cited by this paper
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  2005cited by this paper
• Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans

  2005cited by this paper
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  2005cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
• An estrogen-dependent four-gene micronet regulating social recognition: A study with oxytocin and estrogen receptor-α and -β knockout mice

  2003cited by this paper
• An estrogen-dependent four-gene micronet regulating social recognition: a study with oxytocin and estrogen receptor-alpha and -beta knockout mice.

  2003cited by this paper
• Involvement of the brain oxytocin system in stress coping: interactions with the hypothalamo-pituitary-adrenal axis.

  2002cited by this paper
• Stress-induced social avoidance: a new model of stress-induced anxiety?

  2002cited by this paper
• Oxytocin in the Medial Amygdala is Essential for Social Recognition in the Mouse

  2001cited by this paper
• CNS Region-Specific Oxytocin Receptor Expression: Importance in Regulation of Anxiety and Sex Behavior

  2001cited by this paper
• Oxytocin, motherhood and bonding

  2000cited by this paper
• Brain Oxytocin Inhibits Basal and Stress‐Induced Activity of the Hypothalamo‐Pituitary‐Adrenal Axis in Male and Female Rats: Partial Action Within the Paraventricular Nucleus

  2000cited by this paper
• Social amnesia in mice lacking the oxytocin gene

  2000cited by this paper
• A single social defeat experience selectively stimulates the release of oxytocin, but not vasopressin, within the septal brain area of male rats.

  2000cited by this paper
• The effects of oxytocin and vasopressin on partner preferences in male and female prairie voles (Microtus ochrogaster).

  1999cited by this paper
• Brain oxytocin: differential inhibition of neuroendocrine stress responses and anxiety-related behaviour in virgin, pregnant and lactating rats.

  1999cited by this paper
• Endogenous oxytocin is involved in short-term olfactory memory in female rats.

  1998cited by this paper
• Voles and vasopressin: a review of molecular, cellular, and behavioral studies of pair bonding and paternal behaviors.

  1998cited by this paper
• Changes in Behaviour and Body Weight Following a Single or Double Social Defeat in Rats.

  1996cited by this paper
• Species Differences in Central Oxytocin Receptor Gene Expression: Comparative Analysis of Promoter Sequences

  1996cited by this paper
• Vasopressin and oxytocin receptors in the central nervous system.

  1996influential reference
• Polymodal dose-response curve for oxytocin in the social recognition test.

  1995cited by this paper
• Oxytocin and vasopressin release in the olfactory bulb of parturient ewes: changes with maternal experience and effects on acetylcholine, gamma-aminobutyric acid, glutamate and noradrenaline release.

  1995cited by this paper
• Simultaneous Monitoring of Intracerebral Release and Behavior: Endogenous Vasopressin Improves Social Recognition

  1994cited by this paper
• Oxytocin Administered Centrally Facilitates Formation of a Partner Preference in Female Prairie Voles (Microtus ochrogaster)

  1994cited by this paper
• Oxytocin and vasopressin release within the supraoptic and paraventricular nuclei of pregnant, parturient and lactating rats: a microdialysis study.

  1993influential reference
• Enhanced social interactions in rats following chronic, centrally infused oxytocin.

  1992cited by this paper
• Oxytocin effects on lordosis frequency and lordosis duration following infusion into the medial pre-optic area and ventromedial hypothalamus of female rats.

  1991cited by this paper
• A selective oxytocin antagonist attenuates progesterone facilitation of female sexual behavior.

  1991cited by this paper
• Oxytocin but not vasopressin facilitates social recognition following injection into the medial preoptic area of the rat brain.

  1991cited by this paper
• Oxytocin inhibits infanticide in female house mice (Mus domesticus).

  1990cited by this paper
• Localization and pharmacological characterization of high affinity binding sites for vasopressin and oxytocin in the rat brain by light microscopic autoradiography.

  1988cited by this paper
• Inhibition of post-partum maternal behaviour in the rat by injecting an oxytocin antagonist into the cerebral ventricles.

  1987cited by this paper
• Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat.

  1985cited by this paper
• Oxytocin induces maternal behavior in virgin female rats.

  1982cited by this paper
• Printed in U.S.A. Copyright © 1997 by The Endocrine Society Central Oxytocin Administration Reduces Stress- Induced Corticosterone Release and Anxiety Behavior in Rats*

  year unknowncited by this paper

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