Mechanical regulation of cardiac fibroblast profibrotic phenotypes

K. Herum,Jonas Choppe,Aditya Kumar,A. Engler,A. McCulloch

Published 2017 in Molecular Biology of the Cell

ABSTRACT

Cardiac fibroblasts are essential for beneficial myocardial healing but also cause detrimental adverse remodeling following myocardial infarction. The mechanical properties of the infarcted myocardium and border regions display temporal and spatial characteristics that regulate different aspects of the profibrotic cardiac fibroblast phenotypes.

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