The closing and opening of TRPC channels by Homer1 and STIM1

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Acta Physiologica

• Publication date

  2012-02-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1111/j.1748-1716.2011.02319.xPMID 21518270PMCID PMC3639315
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Polarized but Differential Localization and Recruitment of STIM1, Orai1 and TRPC Channels in Secretory Cells

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• Functional interactions among STIM1, Orai1 and TRPC1 on the activation of SOCs in HL-7702 cells

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• STIM1-dependent and STIM1-independent Function of Transient Receptor Potential Canonical (TRPC) Channels Tunes Their Store-operated Mode*

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• STIM1 translocation to the plasma membrane enhances intestinal epithelial restitution by inducing TRPC1-mediated Ca2+ signaling after wounding.

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• S-glutathionylation activates STIM1 and alters mitochondrial homeostasis

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• A minimal regulatory domain in the C terminus of STIM1 binds to and activates ORAI1 CRAC channels.

  2009cited by this paper
• Stromal Interaction Molecule (STIM) 1 and STIM2 Calcium Sensing Regions Exhibit Distinct Unfolding and Oligomerization Kinetics*

  2009influential reference
• Recent progress on STIM1 domains controlling Orai activation.

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• Interaction Between TRPC1/TRPC4 Assembly and STIM1 Contributes to Store-Operated Ca2+ Entry in Mesangial Cells

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• Phosphorylation of STIM1 underlies suppression of store-operated calcium entry during mitosis

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• A Ca2+ Release-activated Ca2+ (CRAC) Modulatory Domain (CMD) within STIM1 Mediates Fast Ca2+-dependent Inactivation of ORAI1 Channels*♦

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• SOAR and the polybasic STIM1 domains gate and regulate the Orai channels

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• Deletion of TRPC3 in mice reduces store-operated Ca2+ influx and the severity of acute pancreatitis.

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• STIM1 and calmodulin interact with Orai1 to induce Ca2+-dependent inactivation of CRAC channels

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• Coordinating speed and amplitude in G-protein signaling.

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• Dynamic Assembly of TRPC1-STIM1-Orai1 Ternary Complex Is Involved in Store-operated Calcium Influx

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• CRACM1, CRACM2, and CRACM3 are store-operated Ca2+ channels with distinct functional properties.

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• Molecular basis of the CRAC channel.

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• Live-cell imaging reveals sequential oligomerization and local plasma membrane targeting of stromal interaction molecule 1 after Ca2+ store depletion

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• Attenuation of store-operated Ca2+ current impairs salivary gland fluid secretion in TRPC1(−/−) mice

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• TRPC channels as STIM1-regulated store-operated channels.

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• Ca2+ Signaling in Microdomains

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• TRPC channels: interacting proteins.

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• STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels

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• Homer proteins in Ca2+ signaling by excitable and non-excitable cells.

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• Mechanism and functional significance of TRPC channel multimerization.

  2006cited by this paper
• Calcium microdomains: organization and function.

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• Large Store-operated Calcium Selective Currents Due to Co-expression of Orai1 or Orai2 with the Intracellular Calcium Sensor, Stim1*

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• Stored Ca 2 Depletion-induced Oligomerization of Stromal Interaction Molecule 1 ( STIM 1 ) via the EF-SAM Region AN INITIATION MECHANISM FOR CAPACITIVE Ca 2 ENTRY *

  2006cited by this paper
• Tetrameric Hub Structure of Postsynaptic Scaffolding Protein Homer

  2006influential reference
• STIM1 carboxyl-terminus activates native SOC, Icrac and TRPC1 channels

  2006cited by this paper
• Calcium signaling complexes in microdomains of polarized secretory cells.

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• E3-targeted anti-TRPC5 antibody inhibits store-operated calcium entry in freshly isolated pial arterioles.

  2006cited by this paper
• Stored Ca2+ Depletion-induced Oligomerization of Stromal Interaction Molecule 1 (STIM1) via the EF-SAM Region

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• Homer 1 Mediates Store- and Inositol 1,4,5-Trisphosphate Receptor-dependent Translocation and Retrieval of TRPC3 to the Plasma Membrane*

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• The Interaction of Phospholipase C-β3 with Shank2 Regulates mGluR-mediated Calcium Signal*

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• STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx.

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• Homer2 Is Necessary for EtOH-Induced Neuroplasticity

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• Homer: a link between neural activity and glutamate receptor function.

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• Homer 1b Regulates the Trafficking of Group I Metabotropic Glutamate Receptors*

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• Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins.

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