VEGF receptor protein-tyrosine kinases: structure and regulation.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Biochemical and Biophysical Research Communications - BBRC

• Publication date

  2008-10-24

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.bbrc.2008.07.121PMID 18680722
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Neuropilins: structure, function and role in disease.

  2008cited by this paper
• Discovery of novel benzimidazoles as potent inhibitors of TIE-2 and VEGFR-2 tyrosine kinase receptors.

  2007cited by this paper
• Sunitinib: a VEGF and PDGF receptor protein kinase and angiogenesis inhibitor.

  2007cited by this paper
• Discovery and development of sorafenib: a multikinase inhibitor for treating cancer

  2007cited by this paper
• Vascular endothelial growth factor (VEGF) signaling in tumor progression.

  2007cited by this paper
• VEGF receptor signalling ? in control of vascular function

  2006cited by this paper
• Corneal avascularity is due to soluble VEGF receptor-1

  2006cited by this paper
• A Single Amino Acid Substitution in the Activation Loop Defines the Decoy Characteristic of VEGFR-1/FLT-1*

  2006cited by this paper
• Discovery and development of sorafenib: a multikinase inhibitor for treating cancer

  2006cited by this paper
• Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism

  2006cited by this paper
• VEGF receptor‐2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis

  2005cited by this paper
• Membrane Fixation of Vascular Endothelial Growth Factor Receptor 1 Ligand-Binding Domain Is Important for Vasculogenesis and Angiogenesis in Mice

  2005cited by this paper
• The Crystal Structure of Placental Growth Factor in Complex with Domain 2 of Vascular Endothelial Growth Factor Receptor-1*

  2004cited by this paper
• Ligand-induced Vascular Endothelial Growth Factor Receptor-3 (VEGFR-3) Heterodimerization with VEGFR-2 in Primary Lymphatic Endothelial Cells Regulates Tyrosine Phosphorylation Sites*

  2003cited by this paper
• Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1

  2003cited by this paper
• Protein Explorer: easy yet powerful macromolecular visualization.

  2002cited by this paper
• Alternative Splicing of the Human VEGFGR-3/FLT4 Gene as a Consequence of an Integrated Human Endogenous Retrovirus

  2001cited by this paper
• Cell signaling by receptor tyrosine kinases.

  2000cited by this paper
• Cell signaling by receptor tyrosine kinases.

  2000cited by this paper
• Vascular Endothelial Growth Factor Receptor KDR Tyrosine Kinase Activity Is Increased by Autophosphorylation of Two Activation Loop Tyrosine Residues*

  1999cited by this paper
• Characterization and kinetic mechanism of catalytic domain of human vascular endothelial growth factor receptor-2 tyrosine kinase (VEGFR2 TK), a key enzyme in angiogenesis.

  1998cited by this paper
• Cardiovascular failure in mouse embryos deficient in VEGF receptor-3.

  1998cited by this paper
• Requirements for Binding and Signaling of the Kinase Domain Receptor for Vascular Endothelial Growth Factor*

  1998cited by this paper
• Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice.

  1998cited by this paper
• Crystal structure at 1.7 A resolution of VEGF in complex with domain 2 of the Flt-1 receptor.

  1997cited by this paper
• Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development.

  1995cited by this paper
• Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

  1995cited by this paper
• Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

  1995cited by this paper
• Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor.

  1994cited by this paper
• Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor.

  1993cited by this paper
• The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.

  1988cited by this paper

• GlycoRNA complexed with heparan sulfate regulates VEGF-A signalling.

  2026cites this paper
• Strategies for the vascular patterning of engineered tissues for organ repair

  2025cites this paper
• Impact of Endothelial Cell Repair Mechanisms on Doxorubicin-Induced Cardiomyopathy: Exploring Molecular Docking and Simulation of Angiogenic Factors

  2025cites this paper
• Sulfonamides a Promising Hit for Cancer Therapy Through VEGFR-2 Inhibition

  2025cites this paper
• Antiangiogenic Potential of Beneficial Sterols from Parotoid Gland Secretion of Indian Common Toads (Duttaphrynus melanostictus) in the Coastal Region of the Indian Subcontinent: An In Vivo to In Silico Approach

  2025cites this paper
• Vascular endothelial cells and angiogenesis.

  2025cites this paper
• Serotonin, a downstream effector of GLP-2, enhances lacteal contractility and lymph flow.

  2025cites this paper
• Physiological and tumor-associated angiogenesis: Key factors and therapy targeting VEGF/VEGFR pathway.

  2024cites this paper
• Synthesis, docking study, and antitumor evaluation of benzamides and oxadiazole derivatives of 3‐phenoxybenzoic acid as VEGFR‐2 inhibitors

  2024cites this paper
• Molecular Characterization and Interaction between Human VEGF-D and VEGFR-3

  2024cites this paper
• Discovery of bioactive peptides as therapeutic agents for skin wound repair

  2024cites this paper
• New Gliobastoma Cell Lines: Analysis of Genetic Changes, and Assessment of Sensitivity to Radiotherapy and Immunotherapy

  2024cites this paper
• Assessment of Inhibition of the Growth of Breast and Colon Tumors when Blocking VEGFR-1 with Monoclonal Antibodies

  2024cites this paper
• VEGF as a Key Actor in Recurrent Respiratory Papillomatosis: A Narrative Review

  2024cites this paper
• Cell surface ribonucleoproteins cluster with heparan sulfate to regulate growth factor signaling

  2024cites this paper
• Recent advances and future directions on small molecule VEGFR inhibitors in oncological conditions.

  2024cites this paper
• VEGFB ameliorates insulin resistance in NAFLD via the PI3K/AKT signal pathway

  2024cites this paper
• Exploring the Spectrum of VEGF Inhibitors’ Toxicities from Systemic to Intra-Vitreal Usage in Medical Practice

  2024cites this paper
• Small molecule protein kinase inhibitors approved by regulatory agencies outside of the United States

  2023cites this paper
• Dietary supplementation with L-citrulline improves placental angiogenesis and embryonic survival in gilts

  2023cites this paper
• Inhibition of VEGFR‐2 by SU5416 increases neonatally glutamate‐induced neuronal damage in the cerebral motor cortex and hippocampus

  2023cites this paper
• Aggressive PitNETs and Potential Target Therapies: A Systematic Review of Molecular and Genetic Pathways

  2023cites this paper
• Cost in the United States of FDA-approved small molecule protein kinase inhibitors used in the treatment of neoplastic and non-neoplastic diseases.

  2023cites this paper
• VEGFR endocytosis: Implications for angiogenesis.

  2023cites this paper
• Transcriptional Regulation of the Human 5-HT1A Receptor Gene by Lithium: Role of Deaf1 and GSK3β

  2023cites this paper
• Synthesis and Molecular Docking of Some Novel 3-Thiazolyl-Coumarins as Inhibitors of VEGFR-2 Kinase

  2023cites this paper
• Therapeutic effects of a novel venom abstract (ZK002) solution in an alkali-burned corneal wound-healing model

  2023cites this paper
• Physico-mechanical and biological evaluation of heparin/VEGF-loaded electrospun polycaprolactone/decellularized rat aorta extracellular matrix for small-diameter vascular grafts

  2022cites this paper
• Establishment of an oral squamous cell carcinoma cell line expressing vascular endothelial growth factor a and its two receptors

  2022influential citation
• Targeted Codelivery of Prodigiosin and Simvastatin Using Smart BioMOF: Functionalization by Recombinant Anti-VEGFR1 scFv

  2022cites this paper
• Effects of plant-based medicinal food on postoperative recurrence and lung metastasis of gastric cancer regulated by Wnt/β-catenin-EMT signaling pathway and VEGF-C/D-VEGFR-3 cascade in a mouse model

  2022cites this paper
• Discovery of octahydropyrrolo [3,2‐b] pyridin derivative as a highly selective Type I inhibitor of FGFR3 over VEGFR2 by high‐throughput virtual screening

  2022cites this paper
• Molecular Docking Studies and in silico ADMET Screening of Indazole Scaffolds as VEGFR and Enoyl-ACP (CoA) Reductase Inhibitors

  2022cites this paper
• The thiophene α-terthienylmethanol isolated from Tagetes minuta inhibits angiogenesis by targeting protein kinase C isozymes α and β2

  2022cites this paper
• Dietary supplementation with 0.4% L-arginine between days 14 and 30 of gestation enhances NO and polyamine syntheses and water transport in porcine placentae

  2022cites this paper
• Brain endothelial cells acquire blood-brain barrier properties in the absence of Vegf-dependent CNS angiogenesis.

  2022cites this paper
• Functional antibody characterization via direct structural analysis and information‐driven protein–protein docking

  2021cites this paper
• VEGFR-Mediated Cytotoxic Activity of Pulicaria undulata Isolated Metabolites: A Biological Evaluation and In Silico Study

  2021cites this paper
• Role of Vascular Endothelial Growth Factor Receptor 2 Pathway Due to Preeclampsia: A Review

  2021cites this paper
• VEGF and VEGFR2 bind to similar pH-sensitive sites on fibronectin, exposed by heparin-mediated conformational changes

  2021cites this paper
• Properties of FDA-approved small molecule phosphatidylinositol 3-kinase inhibitors prescribed for the treatment of malignancies.

  2021cites this paper
• VEGFR1 signaling in retinal angiogenesis and microinflammation

  2021cites this paper
• Disabling VEGF-Response of Purkinje Cells by Downregulation of KDR via miRNA-204-5p

  2021cites this paper
• Rare variants in KDR, encoding VEGF Receptor 2, are associated with tetralogy of Fallot

  2021cites this paper
• Circulating vascular endothelial growth factor receptor 2 levels and their association with lipid abnormalities in patients on hemodialysis

  2021cites this paper
• Recombinant fusion protein by lysozyme and antibacterial peptide enhances ischemic wound healing via angiogenesis and reduction of inflammation in diabetic db/db mice

  2021cites this paper
• US FDA‐Approved Small‐Molecule Kinase Inhibitors for Cancer Therapy

  2021cites this paper
• Decreased angiogenesis as a possible pathomechanism in cervical degenerative myelopathy

  2021cites this paper
• Reveal the interaction mechanism of five old drugs targeting VEGFR2 through computational simulations.

  2020cites this paper
• Novel pyrazolopyrimidine urea derivatives: Synthesis, antiproliferative activity, VEGFR‐2 inhibition, and effects on the cell cycle profile

  2020cites this paper
• VEGF-A splice variants bind VEGFRs with differential affinities

  2020cites this paper
• Case Study on Receptor Tyrosine Kinases EGFR, VEGFR, and PDGFR

  2020cites this paper
• Structural Basis for Vascular Endothelial Growth Factor Receptor Activation and Implications for Disease Therapy

  2020cites this paper
• Dermatological Side-Effects Developing in Patients Using Targeted Chemotherapy Drugs: A Review of the Literature

  2020cites this paper
• Differential expression of several factors involved in placental development in normal and abnormal condition.

  2020cites this paper
• Methods | Ligand Binding to Receptor Tyrosine Kinases: Thermodynamic Cycles and Experimental Approaches

  2020cites this paper
• An Insight into the Angiogenic and Lymphatic Interplay in Pre-eclampsia Comorbid with HIV Infection

  2020cites this paper
• Creation of different bioluminescence resonance energy transfer based biosensors with high affinity to VEGF

  2020cites this paper
• Role of VEGFs in metabolic disorders

  2019cites this paper
• SELECTING PROTEIN STRUCTURE/S FOR DOCKING-BASED VIRTUAL SCREENING: A CASE STUDY ON TYPE II INHIBITORS OF VEGFR-2 KINASE

  2019cites this paper
• A cross sectional study to assess the sFlt-1:PlGF ratio in pregnant women with and without preeclampsia

  2019cites this paper
• VEGF and FGF signaling during head regeneration in hydra

  2019cites this paper
• New 2,4‐disubstituted‐2‐thiopyrimidines as VEGFR‐2 inhibitors: Design, synthesis, and biological evaluation

  2019cites this paper
• Design, synthesis, biological evaluation of benzoyl amide derivatives containing nitrogen heterocyclic ring as potential VEGFR-2 inhibitors.

  2019cites this paper
• Biomarkers of Prognosis and Efficacy of Anti-angiogenic Therapy in Metastatic Clear Cell Renal Cancer

  2019cites this paper
• Targeting Cancer from a Structural Biology Perspective

  2019cites this paper
• Corosolic acid impairs human lung adenocarcinoma A549 cells proliferation by inhibiting cell migration.

  2019cites this paper
• Genomic signatures of high-altitude adaptation in Ethiopian sheep populations

  2019cites this paper
• Changes in the Expression Profile of VEGF-A, VEGF-B, VEGFR-1, VEGFR-2 in Different Grades of Endometrial Cancer

  2019cites this paper
• In Vitro Study of Combined Application of Bevacizumab and 5-Fluorouracil or Bevacizumab and Mitomycin C to Inhibit Scar Formation in Glaucoma Filtration Surgery

  2019cites this paper
• Naturally occurring and synthetic constitutive-active cytokine receptors in disease and therapy.

  2019cites this paper
• A marine sponge associated fungal metabolite monacolin X suppresses angiogenesis by down regulating VEGFR2 signaling

  2019cites this paper
• Effect of Chlorpyrifos on human extravillous-like trophoblast cells.

  2019cites this paper
• Dissecting the role of novel EZH2 inhibitors in primary glioblastoma cell cultures: effects on proliferation, epithelial-mesenchymal transition, migration, and on the pro-inflammatory phenotype

  2019cites this paper
• Hydrogen sulfide improves vessel formation of the ischemic adductor muscle and wound healing in diabetic db/db mice

  2019cites this paper
• Direct measurements of VEGF–VEGFR2 binding affinities reveal the coupling between ligand binding and receptor dimerization

  2019cites this paper
• The Anti–Vascular Endothelial Growth Factor Receptor-1 Monoclonal Antibody D16F7 Inhibits Glioma Growth and Angiogenesis In Vivo

  2018cites this paper
• Tumor necrosis factor-α regulates angiogenesis of BeWo cells via synergy of PlGF/VEGFR1 and VEGF-A/VEGFR2 axes.

  2018cites this paper
• Therapeutic implication of vascular endothelial growth factor receptor‐1 (VEGFR‐1) targeting in cancer cells and tumor microenvironment by competitive and non‐competitive inhibitors

  2018cites this paper
• The Developing Regorafenib Eye drops for neovascular Age‐related Macular degeneration (DREAM) study: an open‐label phase II trial

  2018cites this paper
• Omics-Based Approach Reveals Complement-Mediated Inflammation in Chronic Lymphocytic Inflammation With Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS)

  2018cites this paper
• Cyclooxygenase-2 deficiency causes delayed ossification of lumbar vertebral endplates.

  2018cites this paper
• Lysozyme-Antimicrobial Peptide Fusion Protein Promotes the Diabetic Wound Size Reduction in Streptozotocin (STZ)-Induced Diabetic Rats

  2018cites this paper
• New insights in the structure-activity relationships of 2-phenylamino-substituted benzothiopyrano[4,3-d]pyrimidines as kinase inhibitors.

  2018cites this paper
• Altered Long Noncoding RNA and Messenger RNA Expression in Experimental Intracerebral Hemorrhage - a Preliminary Study

  2018cites this paper
• Molecular Pharmacology of VEGF-A Isoforms: Binding and Signalling at VEGFR2

  2018cites this paper
• VEGF Upregulation in Viral Infections and Its Possible Therapeutic Implications

  2018cites this paper
• Topical administration of regorafenib eye drops: phase I dose‐escalation study in healthy volunteers

  2018cites this paper
• Morphometric study of the porcine placental vascularization

  2018cites this paper
• Structure and function of vascular endothelial growth factor and its receptor system

  2018cites this paper
• 99mTc labeled D(LPR): A novel retro-inverso peptide for VEGF receptor-1 targeted tumor imaging.

  2018cites this paper
• Relationship of Angiogenesis and Oral Squamous Cell Carcinoma.

  2017cites this paper
• Reprogramming Bone Marrow Stem Cells to Functional Endothelial Cells in a Mini Pig Animal Model

  2017cites this paper
• Vascular endothelial growth factor (VEGF) and VEGF receptor inhibitors in the treatment of renal cell carcinomas.

  2017cites this paper
• VEGF and VEGFR1 levels in different regions of the normal and preeclampsia placentae

  2017cites this paper
• The anti-vascular endothelial growth factor receptor-1 monoclonal antibody D16F7 inhibits invasiveness of human glioblastoma and glioblastoma stem cells

  2017cites this paper
• Cooperative interactions between VEGFR2 extracellular Ig-like subdomains ensure VEGFR2 dimerization.

  2017cites this paper
• Help‐me signaling: Non‐cell autonomous mechanisms of neuroprotection and neurorecovery

  2017cites this paper
• Pharmacophore and Docking Guided Virtual Screening Study for Discovery of Type I Inhibitors of VEGFR-2 Kinase.

  2017cites this paper
• Cabozantinib As Salvage Therapy for Patients With Tyrosine Kinase Inhibitor-Refractory Differentiated Thyroid Cancer: Results of a Multicenter Phase II International Thyroid Oncology Group Trial.

  2017cites this paper