Human glioma cells and undifferentiated primary astrocytes that express aberrant EAAT2 mRNA inhibit normal EAAT2 protein expression and prevent cell death.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Molecular and cellular neurosciences

• Publication date

  2002-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1006/MCNE.2002.1198PMID 12504589
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2001influential reference
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  1998influential reference
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  1995cited by this paper
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  1994cited by this paper
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  1992cited by this paper
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  1992cited by this paper
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  1992cited by this paper
• Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate transporter from rat brain.

  1992cited by this paper
• Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis

  1990cited by this paper
• Most studied single cell

  1976cited by this paper

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  2024cites this paper
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  2020cites this paper
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  2019cites this paper
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  2017cites this paper
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