Signaling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampus.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Cell Stem Cell

• Publication date

  2010-07-02

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.stem.2010.04.016PMID 20621052
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Primate-specific alterations in neural stem/progenitor cells in the aged hippocampus.

  2011cited by this paper
• Coexistence of Quiescent and Active Adult Stem Cells in Mammals

  2010cited by this paper
• Stem cells and the niche: a dynamic duo.

  2010cited by this paper
• Noggin and BMP4 co-modulate adult hippocampal neurogenesis in the APP(swe)/PS1(DeltaE9) transgenic mouse model of Alzheimer's disease.

  2009cited by this paper
• Home at last: neural stem cell niches defined.

  2009cited by this paper
• BMP Signaling Mediates Effects of Exercise on Hippocampal Neurogenesis and Cognition in Mice

  2009cited by this paper
• Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh

  2009cited by this paper
• Aging does not alter the number or phenotype of putative stem/progenitor cells in the neurogenic region of the hippocampus.

  2008cited by this paper
• Mechanisms and functional implications of adult neurogenesis.

  2008cited by this paper
• Stem cells and niches: mechanisms that promote stem cell maintenance throughout life.

  2008cited by this paper
• Noggin Expands Neural Stem Cells in the Adult Hippocampus

  2008influential reference
• Control of the Reversibility of Cellular Quiescence by the Transcriptional Repressor HES1

  2008influential reference
• Adult Neurogenesis Requires Smad4-Mediated Bone Morphogenic Protein Signaling in Stem Cells

  2008cited by this paper
• Concise Review: Bone Morphogenetic Protein Pleiotropism in Neural Stem Cells and Their Derivatives—Alternative Pathways, Convergent Signals

  2007cited by this paper
• Distinct Modes of Neuron Addition in Adult Mouse Neurogenesis

  2007cited by this paper
• In vivo fate analysis reveals the multipotent and self-renewal capacities of Sox2+ neural stem cells in the adult hippocampus.

  2007influential reference
• Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss.

  2007cited by this paper
• Adult neurogenesis in the mammalian central nervous system.

  2005cited by this paper
• p21 loss compromises the relative quiescence of forebrain stem cell proliferation leading to exhaustion of their proliferation capacity.

  2005cited by this paper
• The disparate role of BMP in stem cell biology

  2005cited by this paper
• Wnt signalling regulates adult hippocampal neurogenesis

  2005cited by this paper
• Cell types, lineage, and architecture of the germinal zone in the adult dentate gyrus

  2004cited by this paper
• Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation

  2004cited by this paper
• Emerging roles for bone morphogenetic proteins in central nervous system glial biology

  2004cited by this paper
• Two Distinct Subpopulations of Nestin-Positive Cells in Adult Mouse Dentate Gyrus

  2003cited by this paper
• Subpopulation of nestin-expressing progenitor cells in the adult murine hippocampus shows electrophysiological and morphological characteristics of astrocytes.

  2003cited by this paper
• Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction.

  2003cited by this paper
• Subpopulations of proliferating cells of the adult hippocampus respond differently to physiologic neurogenic stimuli

  2003cited by this paper
• The control of neural stem cells by morphogenic signals.

  2002cited by this paper
• Roles of the Basic Helix-Loop-Helix Genes Hes1 and Hes5 in Expansion of Neural Stem Cells of the Developing Brain*

  2001cited by this paper
• BMP2-mediated alteration in the developmental pathway of fetal mouse brain cells from neurogenesis to astrocytogenesis

  2001cited by this paper
• Retroviral manipulation of the expression of bone morphogenetic protein receptor Ia by SVZa progenitor cells leads to changes in their p19INK4d expression but not in their neuronal commitment

  2001cited by this paper
• Astrocytes Give Rise to New Neurons in the Adult Mammalian Hippocampus

  2001cited by this paper
• Hematopoietic stem cell quiescence maintained by p21cip1/waf1.

  2000cited by this paper
• Distribution of bone morphogenetic protein and bone morphogenetic protein receptor transcripts in the rodent nervous system and up-regulation of bone morphogenetic protein receptor type II in hippocampal dentate gyrus in a rat model of global cerebral ischemia.

  2000cited by this paper
• Noggin antagonizes BMP signaling to create a niche for adult neurogenesis.

  2000cited by this paper
• Stem cells in the adult mammalian central nervous system.

  1999cited by this paper
• Expression of serine/threonine kinase receptors including the bone morphogenetic factor type II receptor in the developing and adult rat brain

  1996cited by this paper
• Persistent expression of helix‐loop‐helix factor HES‐1 prevents mammalian neural differentiation in the central nervous system.

  1994cited by this paper
• Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4.

  1994cited by this paper

• Application of Lentivirus Vectors to Adult Neurogenesis and Manipulation of Neural Stem Cells.

  2026cites this paper
• Brain aging and rejuvenation at single-cell resolution.

  2025cites this paper
• Generation and Pharmacological Manipulation of 3D‐Spheroid Cultures Derived From Zebrafish Adult Neural Stem Cells in a Droplet‐Based Microfluidic Platform

  2025cites this paper
• PRDM16 functions as a co-repressor in the BMP pathway to suppress neural stem cell proliferation

  2025cites this paper
• Neuronal Primary Cilia Mediate Noggin Release to Enable Extracellular Signaling

  2025cites this paper
• Bike-Riding Training may Improve Communication Skills and Stereotyped Behavior in Adolescents With Autism.

  2025cites this paper
• Endothelial PD‐1 Regulates Vascular Homeostasis and Oligodendrogenesis during Brain Development

  2025cites this paper
• OLIG2 mediates a rare targetable stem cell fate transition in sonic hedgehog medulloblastoma

  2025cites this paper
• Quiescence Multiverse

  2025cites this paper
• Adult hippocampal neurogenesis: New avenues for treatment of brain disorders

  2025cites this paper
• Neural stem cell secretome: a secret key to unlocking the power of regeneration in the adult and aging brain

  2025cites this paper
• Neural stem cell heterogeneity in adult hippocampus

  2025cites this paper
• YAP/TAZ create a physical niche for the maintenance of adult neural stem cell quiescence

  2025cites this paper
• The Critical Balance Between Quiescence and Reactivation of Neural Stem Cells

  2025influential citation
• Vegfr3 activation of Pkd2l1+ CSF-cNs triggers the neural stem cell response in spinal cord injury.

  2025cites this paper
• Sequential transcriptional programs underpin activation of hippocampal stem cells

  2025cites this paper
• A cholinergic signaling pathway underlying cortical circuit activation of quiescent neural stem cells in the lateral ventricle

  2024cites this paper
• A Reversible Neural Stem Cell Quiescence and Activation Culture System for Metabolic Study

  2024cites this paper
• Modelling quiescence exit of neural stem cells reveals a FOXG1-FOXO6 axis

  2024cites this paper
• Generating neurons in the embryonic and adult brain: compared principles and mechanisms.

  2024cites this paper
• Lrig1 regulates cell fate specification of glutamatergic neurons via FGF-driven Jak2/Stat3 signaling in cortical progenitors.

  2024cites this paper
• Dynamics of Neurogenic Signals as Biological Switchers of Brain Plasticity

  2024cites this paper
• BMP Antagonist Gremlin 2 Regulates Hippocampal Neurogenesis and Is Associated with Seizure Susceptibility and Anxiety

  2024influential citation
• Epigenetic maintenance of adult neural stem cell quiescence in the mouse hippocampus via Setd1a

  2024cites this paper
• The Derlin-1-Stat5b axis maintains homeostasis of adult hippocampal neurogenesis

  2024cites this paper
• The Principle of Cortical Development and Evolution

  2024cites this paper
• Tools to study neural and glioma stem cell quiescence.

  2024cites this paper
• Autofluorescence lifetime flow cytometry with time-correlated single photon counting

  2024cites this paper
• Quiescent Adult Neural Stem Cells: Developmental Origin and Regulatory Mechanisms

  2024cites this paper
• Transcriptional control of neural stem cell activity.

  2024cites this paper
• CRISPR–Cas9 screens reveal regulators of ageing in neural stem cells

  2024cites this paper
• RSPO/LGR signaling regulates proliferation of adult hippocampal neural stem cells.

  2024cites this paper
• m6A/YTHDF2-mediated mRNA decay targets TGF-β signaling to suppress the quiescence acquisition of early postnatal mouse hippocampal NSCs.

  2024cites this paper
• Sox5 controls the establishment of quiescence in neural stem cells during postnatal development

  2024influential citation
• Characteristics of quiescent adult neural stem cells induced by the bFGF/BMP4 combination or BMP4 alone in vitro

  2024cites this paper
• Dephosphorylation of 4EBP1/2 Induces Prenatal Neural Stem Cell Quiescence

  2023cites this paper
• Regulation of adult stem cell quiescence and its functions in the maintenance of tissue integrity

  2023cites this paper
• The transcriptional co‐activator Yap1 promotes adult hippocampal neural stem cell activation

  2023cites this paper
• ErbB3 binding protein 1 contributes to adult hippocampal neurogenesis by modulating Bmp4 and Ascl1 signaling

  2023cites this paper
• Homeostatic Regulation of Seizure Susceptibility and Cognitive Function by Derlin-1 through Maintenance of Adult Neurogenesis

  2023cites this paper
• Chromatin accessibility dynamics of neurogenic niche cells reveal defects in neural stem cell adhesion and migration during aging

  2023cites this paper
• Epigenetic memory of drug exposure history controls neural stem cell quiescence in the adult brain

  2023cites this paper
• Cell type-specific NRBF2 orchestrates autophagic flux and adult hippocampal neurogenesis in chronic stress-induced depression

  2023cites this paper
• Autophagy drives the conversion of developmental neural stem cells to the adult quiescent state

  2023influential citation
• Elevated FOXG1 in glioblastoma stem cells cooperates with Wnt/β-catenin to induce exit from quiescence.

  2023cites this paper
• Fine-tuned rest: unveiling the regulatory landscape of adult quiescent neural stem cells.

  2023cites this paper
• Overexpression of NT-3 in the hippocampus suppresses the early phase of the adult neurogenic process

  2023cites this paper
• Adult neurogenesis: a real hope or a delusion?

  2023cites this paper
• Autophagy is a cell-intrinsic driver of neural stem cell quiescence in hippocampal dentate gyrus development

  2023cites this paper
• Single-cell analysis of the postnatal dorsal V-SVZ reveals a role for Bmpr1a signaling in silencing pallial germinal activity

  2023cites this paper
• MuSK-BMP signaling in adult muscle stem cells maintains quiescence and regulates myofiber size

  2023cites this paper
• Stem Cell Scaffolds for the Treatment of Spinal Cord Injury—A Review

  2023cites this paper
• Autofluorescence is a biomarker of neural stem cell activation state

  2022cites this paper
• Wif1 Mediates Coordination of Bone Morphogenetic Protein and Wnt Signaling in Neural and Glioma Stem Cells

  2022cites this paper
• Lrig1 regulates the balance between proliferation and quiescence in glioblastoma stem cells

  2022cites this paper
• Could a Different View of Quiescence Help Us Understand How Neurogenesis Is Regulated?

  2022cites this paper
• Copper Modulates Adult Neurogenesis in Brain Subventricular Zone

  2022cites this paper
• HYPOTHESIS: Do LRIG Proteins Regulate Stem Cell Quiescence by Promoting BMP Signaling?

  2022cites this paper
• Effects of cannabis on congenital limb anomalies in 14 European nations: A geospatiotemporal and causal inferential study

  2022cites this paper
• Optogenetic Instruction of Cell Fate by Temporal Patterning of Mechanobiological Signals

  2022cites this paper
• The transcription factor LEF1 interacts with NFIX and switches isoforms during adult hippocampal neural stem cell quiescence

  2022influential citation
• Mitochondrial pyruvate metabolism regulates the activation of quiescent adult neural stem cells

  2022cites this paper
• From cradle to grave: neurogenesis, neuroregeneration and neurodegeneration in Alzheimer’s and Parkinson’s diseases

  2022cites this paper
• Astrogenesis in the murine dentate gyrus is a life‐long and dynamic process

  2022cites this paper
• Interaction of Neural Stem Cells (NSCs) and Mesenchymal Stem Cells (MSCs) as a Promising Approach in Brain Study and Nerve Regeneration

  2022cites this paper
• Resident Neural Stem Cell Niches and Regeneration: The Splendors and Miseries of Adult Neurogenesis

  2022cites this paper
• Single cell analysis of the dorsal V-SVZ reveals differential quiescence of postnatal pallial and subpallial neural stem cells driven by TGFbeta/BMP-signalling

  2022cites this paper
• SoxD genes are required for adult neural stem cell activation

  2022cites this paper
• Metabolic control of adult neural stem cell self-renewal by the mitochondrial protease YME1L.

  2022cites this paper
• Context-dependent transcriptional regulations of YAP/TAZ in stem cell and differentiation

  2022cites this paper
• Transcriptional regulation of neural stem cell expansion in the adult hippocampus

  2022cites this paper
• Regulating Endogenous Neural Stem Cell Activation to Promote Spinal Cord Injury Repair

  2022cites this paper
• Altered BMP2/4 Signaling in Stem Cells and Their Niche: Different Cancers but Similar Mechanisms, the Example of Myeloid Leukemia and Breast Cancer

  2022cites this paper
• Adult Neural Stem Cell Regulation by Small Non-coding RNAs: Physiological Significance and Pathological Implications

  2022cites this paper
• BuMPing Into Neurogenesis: How the Canonical BMP Pathway Regulates Neural Stem Cell Divisions Throughout Space and Time

  2022cites this paper
• Elevated FOXG1 supports exit from quiescence in neural stem cells through FoxO6

  2022cites this paper
• High BMP4 expression in low/intermediate risk BCP-ALL identifies children with poor outcomes

  2022cites this paper
• Neural stem cells-from quiescence to differentiation and potential clinical uses

  2021cites this paper
• Transcription Factors of Direct Neuronal Reprogramming in Ontogenesis and Ex Vivo

  2021cites this paper
• Signaling in the tumor microenvironment of therapy-resistant glioblastoma

  2021cites this paper
• Molecular diversity of diencephalic astrocytes reveals adult astrogenesis regulated by Smad4

  2021cites this paper
• Hippocampal BMP signaling as a common pathway for antidepressant action

  2021cites this paper
• Neuron-Radial Glial Cell Communication via BMP/Id1 Signaling Is Key to Long-Term Maintenance of the Regenerative Capacity of the Adult Zebrafish Telencephalon

  2021cites this paper
• Wnt/β-catenin signalling is dispensable for adult neural stem cell homeostasis and activation

  2021influential citation
• Chromatin accessibility dynamics of neurogenic niche cells reveal a reversible decline in neural stem cell migration during aging

  2021cites this paper
• Bone morphogenetic Proteins (BMPs) in the central regulation of energy balance and adult neural plasticity.

  2021cites this paper
• Targeting impaired adult hippocampal neurogenesis in ageing by leveraging intrinsic mechanisms regulating Neural Stem Cell activity.

  2021cites this paper
• Metabolic control of adult neural stem cell self-renewal by the mitochondrial protease YME1L

  2021influential citation
• c-Myc regulates neural stem cell quiescence and activation by coordinating the cell cycle and mitochondrial remodeling

  2021cites this paper
• Applications of Stem cells Technology in Livestock Production

  2021cites this paper
• Id proteins: emerging roles in CNS disease and targets for modifying neural stemcell behavior

  2021cites this paper
• Discrete limbal epithelial stem cell populations mediate corneal homeostasis and wound healing.

  2021cites this paper
• Regulation of Adult Mammalian Neural Stem Cells and Neurogenesis by Cell Extrinsic and Intrinsic Factors

  2021cites this paper
• LRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells

  2021cites this paper
• The Participation of Microglia in Neurogenesis: A Review

  2021cites this paper
• Formation and integration of new neurons in the adult hippocampus

  2021cites this paper
• Declining lamin B1 expression mediates age-dependent decreases of hippocampal stem cell activity.

  2021cites this paper
• Neuron-radial glial cell communication via BMP/Id1 signaling maintains the regenerative capacity of the adult zebrafish telencephalon

  2021cites this paper
• Single-cell transcriptional profiling of human thymic stroma uncovers novel cellular heterogeneity in the thymic medulla

  2021cites this paper
• REV-ERB Agonist SR9009 Regulates the Proliferation and Neurite Outgrowth/Suppression of Cultured Rat Adult Hippocampal Neural Stem/Progenitor Cells in a Concentration-Dependent Manner

  2021cites this paper