Brainstem nutrient sensing in the nucleus of the solitary tract inhibits feeding.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Cell Metabolism

• Publication date

  2012-11-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.CMET.2012.10.003PMID 23123165PMCID PMC3537851
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• AMPK: a nutrient and energy sensor that maintains energy homeostasis

  2012cited by this paper
• CCK-induced reduction of food intake and hindbrain MAPK signaling are mediated by NMDA receptor activation.

  2012influential reference
• p70S6 kinase phosphorylates AMPK on serine 491 to mediate leptin's effect on food intake.

  2012cited by this paper
• The Glucagon-Like Peptide 1 (GLP-1) Analogue, Exendin-4, Decreases the Rewarding Value of Food: A New Role for Mesolimbic GLP-1 Receptors

  2012cited by this paper
• Ghrelin directly targets the ventral tegmental area to increase food motivation.

  2011cited by this paper
• Hindbrain leptin and glucagon-like-peptide-1 receptor signaling interact to suppress food intake in an additive fashion

  2011cited by this paper
• Hindbrain noradrenergic A2 neurons: diverse roles in autonomic, endocrine, cognitive, and behavioral functions.

  2011cited by this paper
• Metabolic sensing and the brain: who, what, where, and how?

  2011cited by this paper
• Ghrelin Inhibits Visceral Afferent Activation of Catecholamine Neurons in the Solitary Tract Nucleus

  2011cited by this paper
• Intracellular signals mediating the food intake-suppressive effects of hindbrain glucagon-like peptide-1 receptor activation.

  2011cited by this paper
• Endogenous leptin signaling in the caudal nucleus tractus solitarius and area postrema is required for energy balance regulation.

  2010cited by this paper
• Pro-opiomelanocortin gene transfer to the nucleus of the solitary track but not arcuate nucleus ameliorates chronic diet-induced obesity.

  2010cited by this paper
• Control of energy homeostasis by insulin and leptin: targeting the arcuate nucleus and beyond.

  2009cited by this paper
• The control of food intake: behavioral versus molecular perspectives.

  2009cited by this paper
• Endogenous hindbrain glucagon-like peptide-1 receptor activation contributes to the control of food intake by mediating gastric satiation signaling.

  2009influential reference
• Forebrain melanocortin signaling enhances the hindbrain satiety response to CCK-8.

  2009cited by this paper
• Opioids inhibit visceral afferent activation of catecholamine neurons in the solitary tract nucleus.

  2009cited by this paper
• Phenotype of neurons in the nucleus of the solitary tract that express CCK-induced activation of the ERK signaling pathway.

  2009cited by this paper
• Oleic acid directly regulates POMC neuron excitability in the hypothalamus.

  2009cited by this paper
• Mediobasal Hypothalamic Leucine Sensing Regulates Food Intake through Activation of a Hypothalamus–Brainstem Circuit

  2009cited by this paper
• The nucleus tractus solitarius: a portal for visceral afferent signal processing, energy status assessment and integration of their combined effects on food intake

  2009cited by this paper
• A Central Role for Neuronal AMP-Activated Protein Kinase (AMPK) and Mammalian Target of Rapamycin (mTOR) in High-Protein Diet–Induced Weight Loss

  2008cited by this paper
• Regulation of food intake through hypothalamic signaling networks involving mTOR.

  2008cited by this paper
• Central Nervous System Regulation of Energy Metabolism

  2008cited by this paper
• Mediobasal hypothalamic p70 S6 kinase 1 modulates the control of energy homeostasis.

  2008cited by this paper
• Behavioral / Systems / Cognitive Presynaptic Melanocortin-4 Receptors on Vagal Afferent Fibers Modulate the Excitability of Rat Nucleus Tractus Solitarius Neurons

  2008influential reference
• Ionic currents underlying the response of rat dorsal vagal neurones to hypoglycaemia and chemical anoxia

  2007cited by this paper
• Leptin and the control of food intake: neurons in the nucleus of the solitary tract are activated by both gastric distension and leptin.

  2007cited by this paper
• Leptin receptor signaling in midbrain dopamine neurons regulates feeding.

  2006cited by this paper
• Hypothalamic mTOR Signaling Regulates Food Intake

  2006cited by this paper
• Glutamate-dependent translational regulation in cultured Bergmann glia cells: involvement of p70S6K.

  2006cited by this paper
• Gut Peptide Signaling in the Controls of Food Intake

  2006cited by this paper
• Metabolic sensing neurons and the control of energy homeostasis.

  2006cited by this paper
• Distributed Neural Control of Energy Balance: Contributions from Hindbrain and Hypothalamus

  2006cited by this paper
• Melanocortinergic modulation of cholecystokinin-induced suppression of feeding through extracellular signal-regulated kinase signaling in rat solitary nucleus.

  2005influential reference
• Glutamatergic Regulation of the p70S6 Kinase in Primary Mouse Neurons*

  2005cited by this paper
• mTOR-mediated regulation of translation factors by amino acids.

  2004cited by this paper
• Evidence that paraventricular nucleus oxytocin neurons link hypothalamic leptin action to caudal brain stem nuclei controlling meal size.

  2004cited by this paper
• Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system

  2004cited by this paper
• Third ventricular alloxan reversibly impairs glucose counterregulatory responses.

  2004cited by this paper
• Extracellular Signal-Regulated Kinase 1/2 Signaling Pathway in Solitary Nucleus Mediates Cholecystokinin-Induced Suppression of Food Intake in Rats

  2004influential reference
• The regulation of glucose-excited neurons in the hypothalamic arcuate nucleus by glucose and feeding-relevant peptides.

  2004cited by this paper
• TSC2 mediates cellular energy response to control cell growth and survival.

  2003influential reference
• Hindbrain Noradrenergic Lesions Attenuate Anorexia and Alter Central cFos Expression in Rats after Gastric Viscerosensory Stimulation

  2003cited by this paper
• Hypothalamic proopiomelanocortin neurons are glucose responsive and express K(ATP) channels.

  2003cited by this paper
• Hyperphagic effects of brainstem ghrelin administration.

  2003influential reference
• Hepatic Akt activation induces marked hypoglycemia, hepatomegaly, and hypertriglyceridemia with sterol regulatory element binding protein involvement.

  2003cited by this paper
• Melanocortin receptor signaling through mitogen-activated protein kinase in vitro and in rat hypothalamus.

  2003cited by this paper
• Central melanocortin receptor agonist reduces spontaneous and scheduled meal size but does not augment duodenal preload-induced feeding inhibition.

  2002cited by this paper
• Leptin and neuropeptide y have opposing modulatory effects on nucleus of the solitary tract neurophysiological responses to gastric loads: implications for the control of food intake.

  2002cited by this paper
• Central administration of oleic acid inhibits glucose production and food intake.

  2002cited by this paper
• Evidence that the caudal brainstem is a target for the inhibitory effect of leptin on food intake.

  2002influential reference
• Central nervous system control of food intake

  2000cited by this paper
• Localization of hindbrain glucoreceptive sites controlling food intake and blood glucose.

  2000influential reference
• Central leptin modulates behavioral and neural responsivity to CCK.

  1999cited by this paper
• The direct and indirect controls of meal size.

  1996cited by this paper
• Distribution and neurochemical phenotypes of caudal medullary neurons activated to express cFos following peripheral administration of cholecystokinin

  1993cited by this paper
• The Rat Brain in Stereotaxic Coordinates

  1983cited by this paper
• Cellular and Molecular Life Sciences REVIEW Sensing the fuels: glucose and lipid signaling in the CNS controlling energy homeostasis

  year unknowncited by this paper

• Nutritional Management of Schizophrenia: Gut-Brain Axis Mechanisms and Dietary Interventions

  2026cites this paper
• Transcriptomic analysis reveals the effect of leucine deprivations and starvation on glucose and lipid metabolism on mice liver

  2025cites this paper
• Insights into the mechanisms of body weight control.

  2025cites this paper
• Semaglutide drives weight loss through cAMP-dependent mechanisms in GLP1R-expressing hindbrain neurons

  2025cites this paper
• Adaptive thermogenesis reprograms the behavioural and metabolic responses to protein restriction for successful amino acid homeostasis

  2025cites this paper
• Increased weight-bearing load reduces biological body weight while sodium and water balances are unaffected

  2025cites this paper
• Brain amino acid sensing for organismal amino acid homeostasis

  2025influential citation
• Characterization of NTS‐to‐VTA projection neurons reveals higher‐order synaptic organization and distinct responsiveness to cholecystokinin

  2025cites this paper
• Modulation of peripheral energy metabolism through central leucine administration in rainbow trout (Oncorhynchus mykiss).

  2025cites this paper
• The Cholinergic Amelioration of Sepsis-Induced Baroreflex Dysfunction and Brainstem Inflammation Is Negated by Central Adenosine A3 Receptors

  2025cites this paper
• Amino Acid‐Sensing Neurons in the Anterior Piriform Cortex Control Brown Adipose Tissue Thermogenesis

  2025cites this paper
• Regulation of Energy and Glucose Homeostasis by the Nucleus of the Solitary Tract and the Area Postrema

  2024influential citation
• Excess dietary Lys reduces feed intake, stimulates jejunal CCK secretion and alters essential and non-essential blood AA profile in pigs

  2024cites this paper
• IUPHAR Themed Review: The Gut Microbiome in Schizophrenia.

  2024cites this paper
• Microbiota-gut-brain axis drives overeating disorders.

  2023cites this paper
• Reduction of body weight by increased loading is associated with activation of norepinephrine neurones in the medial nucleus of the solitary tract

  2023cites this paper
• Adrenergic modulation of melanocortin pathway by hunger signals

  2023cites this paper
• Manipulating mitochondrial dynamics in the NTS prevents diet-induced deficits in brown fat morphology and activity

  2023cites this paper
• Branched-chain amino acids prevent obesity by inhibiting the cell cycle in an NADPH-FTO-m6A coordinated manner.

  2023cites this paper
• Time-dependent effects of endogenous hyperglucagonemia on glucose homeostasis and hepatic glucagon action

  2023cites this paper
• Manipulating mitochondrial dynamics in the NTS prevents diet-induced deficits in brown fat morphology and glucose uptake

  2023cites this paper
• The Neural Code for Taste in the Nucleus of the Solitary Tract of Rats with Obesity Following Roux-En-Y Gastric Bypass Surgery

  2022cites this paper
• Fibroblast Growth Factor 21 Facilitates the Homeostatic Control of Feeding Behavior

  2022cites this paper
• Towards understanding the neural origins of hibernation.

  2022cites this paper
• Acts of appetite: neural circuits governing the appetitive, consummatory, and terminating phases of feeding

  2022cites this paper
• Impacts of essential amino acids on energy balance

  2021cites this paper
• Neurological Manifestations Associated with SARS-CoV-2 Invasion of the Autonomous Nervous System

  2021cites this paper
• NTS Prlh overcomes orexigenic stimuli and ameliorates dietary and genetic forms of obesity

  2021cites this paper
• An inhibitory circuit from brainstem to GnRH neurons in male mice: a new role for the RFRP receptor.

  2021cites this paper
• Central Apolipoprotein A-IV Stimulates Thermogenesis in Brown Adipose Tissue

  2021cites this paper
• The role of glia in the physiology and pharmacology of glucagon‐like peptide‐1: implications for obesity, diabetes, neurodegeneration and glaucoma

  2021cites this paper
• Genetic analysis of dietary intake identifies new loci and functional links with metabolic traits

  2021cites this paper
• Effects of Oro-Sensory Exposure on Satiation and Underlying Neurophysiological Mechanisms—What Do We Know So Far?

  2021cites this paper
• Nutrient regulation of inflammatory signalling in obesity and vascular disease.

  2021cites this paper
• Neuroendocrine Mechanisms Underlying Non-breeding Aggression: Common Strategies Between Birds and Fish

  2021cites this paper
• Very-low-protein diets lead to reduced food intake and weight loss, linked to inhibition of hypothalamic mTOR signaling, in mice.

  2021cites this paper
• Nutrient infusion in the dorsal vagal complex controls hepatic lipid and glucose metabolism in rats

  2021cites this paper
• Fetal programming of human energy homeostasis brain networks: Issues and considerations

  2021cites this paper
• Calcitonin Receptor Neurons in the Mouse Nucleus Tractus Solitarius Control Energy Balance via the Non-aversive Suppression of Feeding

  2020cites this paper
• Hypothalamic Obesity and Wasting Syndromes

  2020cites this paper
• Neuroendocrinology of the Hypothalamus and Pituitary Axes

  2020cites this paper
• A ventrolateral medulla-midline thalamic circuit for hypoglycemic feeding

  2020cites this paper
• Cellular, Molecular, and Physiological Adaptations of Hibernation: The Solution to Environmental Challenges.

  2020cites this paper
• A Vagal-NTS Neural Pathway that Stimulates Feeding.

  2020cites this paper
• Nutrient sensing in the nucleus of the solitary tract mediates non-aversive suppression of feeding via inhibition of AgRP neurons

  2020influential citation
• Neurochemical Characterization of Brainstem Pro-Opiomelanocortin Cells

  2020cites this paper
• Effects of intraduodenal co-administration of lauric acid and leucine on gut motility, plasma cholecystokinin and energy intake in healthy men.

  2020cites this paper
• Dorsal vagal complex and hypothalamic glia differentially respond to leptin and energy balance dysregulation

  2020cites this paper
• Estradiol treatment attenuates high fat diet-induced microgliosis in ovariectomized rats.

  2020cites this paper
• Defining the contribution of dorsal vagal complex astrocytes to the regulation of food intake

  2020cites this paper
• Neural Coding of Gustatory Information in the Nucleus of the Solitary Tract in Lean and Obese Awake Freely-licking Rats

  2019influential citation
• Nutrient Sensing by Hypothalamic Tanycytes

  2019cites this paper
• NTS Catecholamine Neurons Mediate Hypoglycemic Hunger via Medial Hypothalamic Feeding Pathways.

  2019cites this paper
• Eating for 3.8 × 1013: Examining the Impact of Diet and Nutrition on the Microbiota-Gut-Brain Axis Through the Lens of Microbial Endocrinology

  2019cites this paper
• Analysis of FAM19A2/TAFA-2 function.

  2019cites this paper
• Fibroblast Growth Factor-21 Controls Dietary Protein Intake in Male Mice.

  2019cites this paper
• Taste Responses in the Nucleus of the Solitary Tract of Awake Obese Rats Are Blunted Compared With Those in Lean Rats

  2019cites this paper
• Biomarkers of Insulin Resistance

  2019cites this paper
• Vagal Interoceptive Modulation of Motivated Behavior.

  2018cites this paper
• Central regulation of food intake in fish: an evolutionary perspective.

  2018cites this paper
• Intragastric preloads of l-tryptophan reduce ingestive behavior via oxytocinergic neural mechanisms in male mice.

  2018cites this paper
• Evidence for the presence in rainbow trout brain of amino acid-sensing systems involved in the control of food intake.

  2018cites this paper
• Feeding Stimulation Ability and Central Effects of Intraperitoneal Treatment of L-Leucine, L-Valine, and L-Proline on Amino Acid Sensing Systems in Rainbow Trout: Implication in Food Intake Control

  2018cites this paper
• Causes and solutions to "globesity": The new fa(s)t alarming global epidemic.

  2018cites this paper
• Reduction in voluntary food intake, but not fasting, stimulates hypothalamic gonadotropin-inhibitory hormone precursor mRNA expression in chicks under heat stress.

  2018cites this paper
• Characterisation of an acute anorexigenic action of l-tryptophan: a link with neural mechanisms regulating appetite

  2018influential citation
• Hypothalamic AgRP neurons and the regulation of appetite and body weight: A review

  2018cites this paper
• Discovery of Leptin and its Catabolic and Glucose-Lowering Action In 1994

  2017cites this paper
• Effects of leucine supplementation and resistance training on myopathy of diabetic rats

  2017cites this paper
• Impact of Dietary Fats on Brain Functions

  2017cites this paper
• mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice

  2017cites this paper
• Comparative effects of intraduodenal amino acid infusions on food intake and gut hormone release in healthy males

  2017cites this paper
• Amino acid sensing in hypothalamic tanycytes via umami taste receptors

  2017influential citation
• Neuronal connections of the central amygdalar nucleus with refeeding-activated brain areas in rats

  2017cites this paper
• CNS hormonal and nutritional regulation of glucose and energy homeostasis

  2017cites this paper
• Central Regulation of Glucose Homeostasis.

  2017cites this paper
• Nutrient Sensing Systems in Fish: Impact on Food Intake Regulation and Energy Homeostasis

  2017cites this paper
• The Fatty Acid β-Oxidation Pathway is Activated by Leucine Deprivation in HepG2 Cells: A Comparative Proteomics Study

  2017cites this paper
• Nutritional status‐dependent endocannabinoid signalling regulates the integration of rat visceral information

  2017cites this paper
• Efeitos da suplementação de leucina e do treinamento de força sobre a miopatia diabética em modelo experimental de diabetes mellitus induzido por estreptozotocina

  2016cites this paper
• Control of Food Intake by Dietary Amino Acids and Proteins

  2016cites this paper
• Impact of Dietary Proteins on Energy Balance, Insulin Sensitivity and Glucose Homeostasis: From Proteins to Peptides to Amino Acids

  2016cites this paper
• Steroidogenic factor 1 expressing neurons in the ventromedial hypothalamus regulate feeding, metabolism and risk-associated decision making

  2016influential citation
• Leucine in Obesity: Therapeutic Prospects.

  2016cites this paper
• Hepatic autophagy contributes to the metabolic response to dietary protein restriction.

  2016cites this paper
• Physiology, pathophysiology and therapeutic implications of enteroendocrine control of food intake

  2016cites this paper
• ole of the neural pathway from hindbrain to hypothalamus in the egulation of energy homeostasis in rats

  2016cites this paper
• Appetite controlled by a cholecystokinin nucleus of the solitary tract to hypothalamus neurocircuit

  2016cites this paper
• FATTY ACID SENSING IN THE DORSAL VAGAL COMPLEX AND REGULATION OF TRIGLYCERIDE-RICH VERY LOW-DENSITY LIPOPROTEIN SECRETION

  2016cites this paper
• Dietary Protein, Metabolism, and Aging.

  2016cites this paper
• The Gut as an Endocrine Organ: Role in the Regulation of Food Intake and Body Weight

  2016cites this paper
• Insights into the role of neuronal glucokinase

  2016cites this paper
• Central Amino Acid Sensing in the Control of Feeding Behavior

  2016cites this paper
• Comparative effects of intraduodenal protein and lipid on ghrelin, peptide YY, and leptin release in healthy men.

  2015cites this paper
• Investigating the physiological role of glucokinase in central glucose sensing

  2015cites this paper
• Reviewing the Effects of l-Leucine Supplementation in the Regulation of Food Intake, Energy Balance, and Glucose Homeostasis

  2015influential citation
• High Calorie Diet and the Human Brain

  2015cites this paper
• Does Nutrient Sensing Determine How We “See” Food?

  2015cites this paper
• Effects of Long Term Consumption of Animal Proteins in the High Calorie Diet

  2015cites this paper
• Acute heat stress up-regulates neuropeptide Y precursor mRNA expression and alters brain and plasma concentrations of free amino acids in chicks.

  2015cites this paper