Epigenetic Alterations in Cellular Immunity: New Insights into Autoimmune Diseases

Epigenetic modification is an additional regulator in immune responses as the genome-wide profiling somehow fails to explain the sophisticated mechanisms in autoimmune diseases. The effect of epigenetic modifications on adaptive immunity derives from their regulations to induce a permissive or negative gene expression. Epigenetic events, such as DNA methylation, histone modifications and microRNAs (miRNAs) are often found in T cell activation, differentiation and commitment which are the major parts in cellular immunity. Recognizing the complexity of interactions between epigenetic mechanisms and immune disturbance in autoimmune diseases is essential for the exploration of efficient therapeutic targets. In this review, we summarize a list of studies that indicate the significance of dysregulated epigenetic modifications in autoimmune diseases while focusing on T cell immunity.

• Publication year

  2017

• Venue

  Cellular Physiology and Biochemistry

• Publication date

  2017-02-08

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1159/000457944PMID 28214857
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Stat3 promotes IL-10 expression in lupus T cells through trans-activation and chromatin remodeling

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• Critical role of all-trans retinoic acid in stabilizing human natural regulatory T cells under inflammatory conditions

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• CD4+ T Cells

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