Uridine and its nucleotides: biological actions, therapeutic potentials.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  TIPS - Trends in Pharmacological Sciences

• Publication date

  1999-05-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/S0165-6147(99)01298-5PMID 10354618
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Erythrocyte Cdp-Choline Accumulation in Haemolytic Anaemia and Renal Failure (Rf)

  1998cited by this paper
• High resolution 1H NMR spectroscopic studies on dynamic biochemical processes in incubated human seminal fluid samples.

  1998cited by this paper
• Direct Demonstration of Mechanically Induced Release of Cellular UTP and Its Implication for Uridine Nucleotide Receptor Activation*

  1997cited by this paper
• Modulation of 5-fluorouracil in mice using uridine diphosphoglucose.

  1997cited by this paper
• Release, metabolism and interconversion of adenine and uridine nucleotides: implications for G protein-coupled P2 receptor agonist selectivity.

  1997cited by this paper
• Developmental disorder associated with increased cellular nucleotidase activity.

  1997cited by this paper
• Ecto-nucleotidases in isolated intact rat vagi, nodose ganglia, and superior cervical ganglia.

  1997cited by this paper
• Investigation of receptors responsive to pyrimidines.

  1997cited by this paper
• Erythrocyte CDP-choline accumulation in haemolytic anaemia and renal failure (RF).

  1997cited by this paper
• Potential signalling roles for UTP and UDP: sources, regulation and release of uracil nucleotides.

  1997cited by this paper
• Nucleotide receptors in the nervous system. An abundant component using diverse transduction mechanisms.

  1997cited by this paper
• Phase I trial of PN401, an oral prodrug of uridine, to prevent toxicity from fluorouracil in patients with advanced cancer.

  1997cited by this paper
• Human seminal plasma soluble 5'-nucleotidase: regulatory aspects of the dephosphorylation of nucleoside 5'-monophosphates.

  1997cited by this paper
• Acute safety and effects on mucociliary clearance of aerosolized uridine 5'-triphosphate +/- amiloride in normal human adults.

  1996cited by this paper
• N3-phenacyluridine, a novel hypnotic compound, interacts with the benzodiazepine receptor.

  1996cited by this paper
• Strategic proposals for predicting drug-drug interactions during new drug development: based on sixteen deaths caused by interactions of the new antiviral sorivudine with 5-fluorouracil prodrugs.

  1996cited by this paper
• Pyrimidines and CNS regulation.

  1996cited by this paper
• Cloning and Functional Expression of a Human Uridine Nucleotide Receptor (*)

  1995cited by this paper
• Structure‐activity relationship of a pyrimidine receptor in the rat isolated superior cervical ganglion

  1995cited by this paper
• Diagnostic analysis, clinical importance and molecular basis of dihydropyrimidine dehydrogenase deficiency.

  1995cited by this paper
• UTP‐ and ATP‐triggered transmitter release from rat sympathetic neurones via separate receptors

  1995cited by this paper
• Uridine reduces rotation induced by L-dopa and methamphetamine in 6-OHDA-treated rats.

  1995cited by this paper
• The increase in the intracellular Ca2+ concentration induced by mechanical stimulation is propagated via release of pyrophosphorylated nucleotides in mammary epithelial cells

  1994cited by this paper
• Physiological concentrations of purines and pyrimidines

  1994cited by this paper
• Action of purine and pyrimidine nucleotides on the rat superior cervical ganglion

  1993cited by this paper
• Uridine and Stimulant-Induced Motor Activity

  1993cited by this paper
• Anti-human immunodeficiency virus type 1 therapy and peripheral neuropathy: prevention of 2',3'-dideoxycytidine toxicity in PC12 cells, a neuronal model, by uridine and pyruvate.

  1993cited by this paper
• Effects of uridine in the treatment of diabetic neuropathy: an electrophysiological study

  1992cited by this paper
• URIDINE‐HALOPERIDOL IN THE TREATMENT OF SCHIZOPHRENIA: PRELIMINARY RESULT

  1992cited by this paper
• Clinical and pharmacologic study of orally administered uridine.

  1991cited by this paper
• Uridine, xanthine and urate concentrations in prostatic fluid and seminal plasma of patients with prostatitis.

  1991cited by this paper
• Disturbances of cerebral purine and pyrimidine metabolism in young children with chronic renal failure.

  1991cited by this paper
• Activation by extracellular nucleotides of chloride secretion in the airway epithelia of patients with cystic fibrosis.

  1991cited by this paper
• [Pyrimidine derivatives: their psychotropic properties and the molecular mechanisms of their central action].

  1990cited by this paper
• Different effect of benzylacyclouridine on the toxic and therapeutic effects of azidothymidine in mice

  1990cited by this paper
• Different effect of benzylacyclouridine on the toxic and therapeutic effects of azidothymidine in mice.

  1990cited by this paper
• Benzylacyclouridine reverses azidothymidine-induced marrow suppression without impairment of anti-human immunodeficiency virus activity.

  1990cited by this paper
• Involvement of pyrimidinoceptors in the regulation of cell functions by uridine and by uracil nucleotides.

  1989cited by this paper
• Effects of chronic treatment with uridine on striatal dopamine release and dopamine related behaviours in the absence or the presence of chronic treatment with haloperidol.

  1989cited by this paper
• Uridine-induced hypothermia in mice and rats in relation to plasma and tissue levels of uridine and its metabolites

  1988cited by this paper
• Chronic uridine treatment reduces the level of [3H]spiperone-labelled dopamine receptors and enhances their turnover rate in striatum of young rats: relationship to dopamine-dependent behaviours.

  1988cited by this paper
• Effect of Pyrimidine Nucleosides on Body Temperatures of Man and Rabbit in Relation to Pharmacokinetic Data

  1987cited by this paper
• Clinical and pharmacokinetic studies of prolonged administration of high dose uridine intended for rescue from 5 fluorouracil toxicity

  1986cited by this paper
• Clinical and pharmacokinetic studies of prolonged administration of high-dose uridine intended for rescue from 5-FU toxicity.

  1986cited by this paper
• Intravenous uridine treatment antagonizes hypoglycaemia-induced reduction in brain somatostatin-like immunoreactivity.

  1986cited by this paper
• Interaction Between Uridine and GABA‐Mediated Inhibitory Transmission: Studies In Vivo and In Vitro

  1985cited by this paper
• Sperm motility and interactions among seminal uridine, xanthine, urate, and ATPase in fertile and infertile men.

  1985cited by this paper
• Cerebral endogenous substrate utilization during the recovery period after profound hypoglycemia

  1984cited by this paper
• Phase I and pharmacokinetic studies of high-dose uridine intended for rescue from 5-fluorouracil toxicity.

  1984cited by this paper
• Orotate uptake and metabolism by human erythrocytes.

  1984cited by this paper
• Uridine as an active component of sleep-promoting substance: its effects on nocturnal sleep in rats.

  1984cited by this paper
• Uridine, xanthine, and urate contents in human seminal plasma.

  1984cited by this paper
• Selective accumulation of cytosol CDP-choline as an isolated erythrocyte defect in chronic hemolysis.

  1983cited by this paper
• Effect of glutamine and nucleosides on prolactin secretion in the rat.

  1983cited by this paper
• Interaction of uridine with GABA binding sites in cerebellar membranes of the rat

  1983cited by this paper
• [Observations on the therapeutic usefulness of uridine in epilepsy].

  1975cited by this paper
• Hereditary hemolytic anemia with human erythrocyte pyrimidine 5'-nucleotidase deficiency.

  1974cited by this paper
• Purine metabolism in normal and thioguanine-resistant neuroblastoma.

  1973cited by this paper
• Hormonal regulation of uridine diphosphatase during spermatogenesis in the rat.

  1972cited by this paper
• Adenine-, guanine- and uridine-5'-phosphonucleotides in blood platelets and storage organelles of various species.

  1971cited by this paper
• CYTIDINE AND URIDINE REQUIREMENT OF THE BRAIN * †

  1956cited by this paper

• Integrated metabolomics and machine learning identify potential biomarkers and metabolism-related targets for MASLD in older adults.

  2026cites this paper
• Multitarget Mechanisms of (‒)‒Epigallocatechin-3-Gallate Against MRSA: From SraP L-Lectin Targeting to Synergistic Antibiotic Effects

  2026cites this paper
• Vitamin deficiencies and Alzheimer's disease: evidence and implications for supplementation.

  2026cites this paper
• De Novo Hepatic Pyrimidine Synthesis Regulates Systemic Energy Homeostasis

  2025cites this paper
• Characterization of the nucleoside monophosphate kinase from Thermus thermophilus phage p23-45 and its application in the biosynthesis of deoxynucleoside triphosphates.

  2025cites this paper
• Multi-omics profiling reveals distinct pathogenic mechanisms in Hunner and non-Hunner interstitial cystitis subtypes

  2025cites this paper
• Direct deoxygenative arylation of saccharides via phosphorus-assisted C−OH bond activation

  2025cites this paper
• Regioselective N1-ribosylation of hydantoin: synthesis and properties of the first contracted uridine analog.

  2025cites this paper
• The Role of Uridine in Health and Disease

  2025cites this paper
• Use of fecal microbiome to understand the impact of housing conditions on metabolic stress responses in farmed saltwater crocodiles (Crocodylus porosus)

  2025cites this paper
• Uridine-cytidine kinase 2 is correlated with immune, DNA damage repair and promotion of cancer stemness in pan-cancer

  2025cites this paper
• Verification of the mechanism of uridine in promoting neural regeneration via network pharmacology and molecular docking

  2025cites this paper
• Combining Untargeted Metabolomics and High-Throughput Sequencing to Explore the Dynamics of Small-Molecular Metabolites in the Fermentation Stage of Inner Mongolian Cheese.

  2025cites this paper
• Lycium barbarum polysaccharide suppresses uridine induced malignant progression of lung adenocarcinoma via UPP1 regulation

  2025cites this paper
• Uridine depletion impairs CD8⁺ T cell antitumor activity through N-glycosylation.

  2025cites this paper
• Production of pyrimidine nucleosides in microbial systems via metabolic engineering: Theoretical analysis research and prospects.

  2024cites this paper
• Exploration of TCM syndrome types of the material basis and risk prediction of Wilson disease liver fibrosis based on 1H NMR metabolomics.

  2024cites this paper
• Chemical constituents of açai berry pulp (Euterpe oleracea Mart.) by LC-UV-BPSU/NMR and LC-UV-SPE/NMR

  2024cites this paper
• The Protective Effect of Uridine in a Rotenone-Induced Model of Parkinson’s Disease: The Role of the Mitochondrial ATP-Dependent Potassium Channel

  2024cites this paper
• Pharmacological targets of SGLT2 inhibition on prostate cancer mediated by circulating metabolites: a drug-target Mendelian randomization study

  2024cites this paper
• Lowback Pain Management with a Combination of Uridine Triphosphate, Cytidine Monophosphate, and Hydroxocobalamin: A Systematic Review and Meta-Analysis

  2024cites this paper
• p53 activation enhances the sensitivity of non-small cell lung cancer to the combination of SH003 and docetaxel by inhibiting de novo pyrimidine synthesis

  2024cites this paper
• DHA-enriched phosphatidylserine ameliorates cyclophosphamide-induced liver injury via regulating the gut-liver axis.

  2024cites this paper
• Molybdenum inhibited the growth of Phytophthora nicotiana and improved the resistance of Nicotiana tabacum L. against tobacco black shank.

  2024cites this paper
• Tratamento da dor lombar com uma combinação de trifosfato de uridina, monofosfato de citidina e hidroxicobalamina: Uma revisão sistemática e metanálise

  2024cites this paper
• Uridine-mediated Activation of the Keap1-Nrf2 Pathway for Alleviating Sepsis-induced Acute Lung Injury

  2024cites this paper
• The Host Protein CAD Regulates the Replication of FMDV through the Function of Pyrimidines’ De Novo Synthesis

  2023cites this paper
• In Vitro, In Silico, and In Vivo Studies of Cardamine hirsuta Linn as a Potential Antidiabetic Agent in a Rat Model

  2023cites this paper
• Effects of the Long-Term Administration of Uridine on the Functioning of Rat Liver Mitochondria in Hyperthyroidism

  2023cites this paper
• Circulating uridine dynamically and adaptively regulates food intake in humans

  2023cites this paper
• Ormosianines A-P, Structurally Diverse Quinolizidine Alkaloids with AChE Inhibitory Effects from Ormosia yunnanensis.

  2023cites this paper
• Uridine Alleviates Sepsis-Induced Acute Lung Injury by Inhibiting Ferroptosis of Macrophage

  2023cites this paper
• Transcriptomic and Metabolomic Profiling Uncovers Response Mechanisms of Alicyclobacillus acidoterrestris DSM 3922T to Acid Stress

  2023cites this paper
• In Silico Pharmacokinetics, Molecular Docking and Molecular Dynamics Simulation Studies of Nucleoside Analogs for Drug Discovery- A Mini Review.

  2023cites this paper
• Metabolomic Analysis of Exosomes Derived from Lung Cancer Cell Line H460 Treated with SH003 and Docetaxel

  2022cites this paper
• The Effect of Uridine on the State of Skeletal Muscles and the Functioning of Mitochondria in Duchenne Dystrophy

  2022cites this paper
• Uridine relieves MSCs and chondrocyte senescence in vitvo and exhibits the potential to treat osteoarthritis in vivo

  2022cites this paper
• Uridine-Derived 4-Aminophenyl 1-Thioglucosides: DFT Optimized FMO, ADME, and Antiviral Activities Study

  2022cites this paper
• Effect of Chronic Treatment with Uridine on Cardiac Mitochondrial Dysfunction in the C57BL/6 Mouse Model of High-Fat Diet–Streptozotocin-Induced Diabetes

  2022cites this paper
• Identification of Major Antioxidant Compounds from the Edible Mushroom Basidiomycetes-X (Echigoshirayukidake).

  2022cites this paper
• Adipocyte purinergic receptors activated by uracil nucleotides as obesity and type 2 diabetes targets.

  2022cites this paper
• Integrated Metabolomics and Proteomics Analysis of Urine in a Mouse Model of Posttraumatic Stress Disorder

  2022cites this paper
• Intestinal aging is alleviated by uridine via regulating inflammation and oxidative stress in vivo and in vitro

  2022cites this paper
• Azoxystrobin Induces Apoptosis and Cell Cycle Arrest in Human Leukemia Cells Independent of p53 Expression

  2022cites this paper
• Metabolite, protein, and tissue dysfunction associated with COVID-19 disease severity

  2021cites this paper
• Uridine treatment prevents myocardial injury in rat models of acute ischemia and ischemia/reperfusion by activating the mitochondrial ATP-dependent potassium channel

  2021cites this paper
• Ectonucleotidases in Inflammation, Immunity, and Cancer

  2021cites this paper
• Uridine and pyruvate protect T cells’ proliferative capacity from mitochondrial toxic antibiotics: a clinical pilot study

  2021cites this paper
• Hydrogen Peroxide Affects Growth of S. aureus Through Downregulation of Genes Involved in Pyrimidine Biosynthesis

  2021cites this paper
• Uridine in twelve pure solvents: Equilibrium solubility, thermodynamic analysis and molecular simulation

  2021cites this paper
• Uridine attenuates obesity, ameliorates hepatic lipid accumulation and modifies the gut microbiota composition in mice fed with a high-fat diet.

  2021cites this paper
• Metabolic Alterations in Preneoplastic Development Revealed by Untargeted Metabolomic Analysis

  2021cites this paper
• INVESTIGATION OF THE COMBINED INJECTION SOLUTION ‘NEURONUCLEOS’ ACTIVE COMPONENTS STABILITY AND COMPATIBILITY

  2021cites this paper
• Adipokines and Adipose Tissue-Related Metabolites, Nuts and Cardiovascular Disease

  2020cites this paper
• Dynamic Alterations of Brain Injury, Functional Recovery, and Metabolites Profile after Cerebral Ischemia/Reperfusion in Rats Contributes to Potential Biomarkers

  2020cites this paper
• Uridine natural products: Challenging targets and inspiration for novel small molecule inhibitors.

  2020cites this paper
• Modulating pyrimidine ribonucleotide levels for the treatment of cancer

  2020influential citation
• Uridine Metabolism and Its Role in Glucose, Lipid, and Amino Acid Homeostasis

  2020cites this paper
• Bcl-2 family proteins, beyond the veil.

  2020cites this paper
• Purines and Pyrimidines: Metabolism, Function and Potential as therapeutic options in neurodegenerative diseases.

  2020cites this paper
• β-Cyanuryl Ribose, β-Barbituryl Ribose, and 6-Azauridine as Uridine Mimetics

  2020cites this paper
• Material basis, effect, and mechanism of ethanol extract of Pinellia ternata tubers on oxidative stress-induced cell senescence.

  2020cites this paper
• Uridine‐cytidine kinase 2 (UCK2): A potential diagnostic and prognostic biomarker for lung cancer

  2019cites this paper
• Human vitreous concentrations of citicoline following topical application of citicoline 2% ophthalmic solution

  2019cites this paper
• Identification of disordered metabolic networks in postpartum dairy cows with left displacement of the abomasum through integrated metabolomics and pathway analyses

  2019cites this paper
• Local and systemic metabolic alterations in brain, plasma, and liver of rats in response to aging and ischemic stroke, as detected by nuclear magnetic resonance (NMR) spectroscopy.

  2019cites this paper
• Meal for Two: Human Cytomegalovirus-Induced Activation of Cellular Metabolism

  2019cites this paper
• Uridine‐cytidine kinase 2 upregulation predicts poor prognosis of hepatocellular carcinoma and is associated with cancer aggressiveness

  2019cites this paper
• Combined small molecule and loss-of-function screen uncovers estrogen receptor alpha and CAD as host factors for HDV infection and antiviral targets

  2019cites this paper
• Uridine dynamic administration affects circadian variations in lipid metabolisms in the liver of high-fat-diet-fed mice

  2019cites this paper
• Beyond adiponectin and leptin: adipose tissue-derived mediators of inter-organ communication

  2019cites this paper
• Involvement of the uridine cytidine kinase 2 enzyme in cancer cell death: A molecular crosstalk between the enzyme and cellular apoptosis induction.

  2019cites this paper
• Serum Metabolomics and Incidence of Atrial Fibrillation (From the Atherosclerosis Risk in Communities [ARIC] Study)

  2019cites this paper
• Discovery of small molecule inhibitors of human uridine-cytidine kinase 2 by high-throughput screening.

  2019cites this paper
• Pot, atom and step economic (PASE) assembly of salicylaldehydes, malononitrile dimer and 4-hydroxypyridine-2(1H)-ones into medicinally relevant 5H-chromeno[2,3-b]pyridine scaffold

  2019cites this paper
• Plasma metabolite changes in dairy cows during parturition identified using untargeted metabolomics.

  2019cites this paper
• Deficiency of perforin and hCNT1, a novel inborn error of pyrimidine metabolism, associated with a rapidly developing lethal phenotype due to multi-organ failure.

  2019cites this paper
• Serum Metabolomics and Incidence of Atrial Fibrillation (from the Atherosclerosis Risk in Communities Study).

  2019cites this paper
• Temporal variations of nucleosides and nucleotides in rabbit milk

  2018cites this paper
• Concise synthesis and antibacterial evaluation of novel 3‐(1,4‐disubstituted‐1,2,3‐triazolyl)uridine nucleosides

  2018cites this paper
• Metabolic engineering of Bacillus subtilis for the co-production of uridine and acetoin

  2018cites this paper
• Integrated Metabolomics and Proteomics Approach To Identify Metabolic Abnormalities in Rats with Dioscorea bulbifera Rhizome-Induced Hepatotoxicity.

  2018cites this paper
• New perspectives on the roles of pyrimidines in the central nervous system

  2018cites this paper
• The role of mitochondrial KATP channel in anti-inflammatory effects of uridine in endotoxemic mice.

  2018cites this paper
• Energetic characterization of a bioactive compound: Uridine

  2018cites this paper
• Metabolomic response of osteosarcoma cells to nanographene oxide-mediated hyperthermia.

  2018cites this paper
• Plasma metabolomics and incidence of atrial fibrillation: the Atherosclerosis Risk in Communities (ARIC) Study

  2018cites this paper
• Capparis spinosa L.: a natural source of pharmaceuticals

  2018cites this paper
• Dependence on the Pyrimidine Biosynthetic Enzyme DHODH Is a Synthetic Lethal Vulnerability in Mutant KRAS-Driven Cancers.

  2018cites this paper
• An adipo-biliary-uridine axis that regulates energy homeostasis

  2017cites this paper
• Discovery and Roles of 2',3'-cAMP in Biological Systems.

  2017cites this paper
• Comparison of human erythrocyte purine nucleotide metabolism and blood purine and pyrimidine degradation product concentrations before and after acute exercise in trained and sedentary subjects

  2017cites this paper
• Systemic and local regulation of experimental arthritis by IFN-α, dendritic cells and uridine

  2017cites this paper
• ‘On-solvent’ new domino reaction of salicylaldehyde, malononitrile and 4-hydroxy-6-methylpyridin-2(1H)-one: fast and efficient approach to medicinally relevant 4-pyridinyl-2-amino-4H-chromene scaffold

  2017cites this paper
• Uridine homeostatic disorder leads to DNA damage and tumorigenesis.

  2016cites this paper
• Associations Between the Serum Metabolome and All-Cause Mortality Among African Americans in the Atherosclerosis Risk in Communities (ARIC) Study.

  2016cites this paper
• The Meiothermus ruber Mrub_2572 gene is an ortholog of the Escherichia coli pyrE b3642 gene and the Meiothermus ruber Mrub_2071 gene is an ortholog of the Escherichia coli pyrF b1281 gene

  2016cites this paper
• Fragment-based drug discovery and mechanistic studies of human thymidylate synthase

  2016cites this paper
• Biochemical characterization of dihydroorotase of Leishmania donovani: Understanding pyrimidine metabolism through its inhibition.

  2016cites this paper
• Effect of the use of combination uridine triphosphate, cytidine monophosphate, and hydroxycobalamin on the recovery of neurosensory disturbance after bilateral sagittal split osteotomy: a randomized, double-blind trial.

  2016cites this paper