The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage

The CHD4 helicase is identified as a new component of the genome surveillance machinery in a proteomic screen for factors enriched on chromatin after ionizing radiation (see also related paper by Smeenk et al. in this issue).

• Publication year

  2010

• Venue

  Journal of Cell Biology

• Publication date

  2010-09-06

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1083/jcb.200912135PMID 20805324PMCID 2935572
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The NuRD chromatin–remodeling complex regulates signaling and repair of DNA damage

  2010cited by this paper
• The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage.

  2009influential reference
• RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins.

  2009influential reference
• Crosstalk between histone modifications during the DNA damage response.

  2009cited by this paper
• The DNA-damage response in human biology and disease

  2009cited by this paper
• Aging-related chromatin defects via loss of the NURD complex

  2009cited by this paper
• Heterochromatic Genome Stability Requires Regulators of Histone H3 K9 Methylation

  2009cited by this paper
• MBD3, a Component of the NuRD Complex, Facilitates Chromatin Alteration and Deposition of Epigenetic Marks

  2008cited by this paper
• Ubc13/Rnf8ユビキチンリガーゼはDNS損傷に反応してRap80/Abraxas/Brca1/Brca1/Brcc36複合体のフォーカス形成を制御する

  2007cited by this paper
• The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks

  2007influential reference
• RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly.

  2007influential reference
• RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins.

  2007influential reference
• ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage

  2007influential reference
• Orchestration of the DNA-Damage Response by the RNF8 Ubiquitin Ligase

  2007influential reference
• The impact of a negligent G2/M checkpoint on genomic instability and cancer induction

  2007cited by this paper
• DNA damage checkpoints: from initiation to recovery or adaptation.

  2007cited by this paper
• Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage

  2007influential reference
• Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks

  2006influential reference
• Identification of conserved pathways of DNA-damage response and radiation protection by genome-wide RNAi.

  2006cited by this paper
• Adaptation to the ionizing radiation-induced G2 checkpoint occurs in human cells and depends on checkpoint kinase 1 and Polo-like kinase 1 kinases.

  2006cited by this paper
• gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes.

  2006cited by this paper
• Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress.

  2006cited by this paper
• MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks.

  2005cited by this paper
• Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway.

  2004cited by this paper
• Checking on DNA damage in S phase

  2004cited by this paper
• H2AX: the histone guardian of the genome.

  2004cited by this paper
• Cell-cycle checkpoints and cancer

  2004cited by this paper
• Mi-2/NuRD: multiple complexes for many purposes.

  2004cited by this paper
• Mdc1 couples DNA double‐strand break recognition by Nbs1 with its H2AX‐dependent chromatin retention

  2004cited by this paper
• Inhibition of Chk1 by CEP-3891 Accelerates Mitotic Nuclear Fragmentation in Response to Ionizing Radiation

  2004cited by this paper
• Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage

  2003influential reference
• Distinct modes of deregulation of the proto-oncogenic Cdc25A phosphatase in human breast cancer cell lines

  2003cited by this paper
• Mass spectrometry-based proteomics

  2003cited by this paper
• The DNA damage-dependent intra–S phase checkpoint is regulated by parallel pathways

  2002cited by this paper
• Stable Isotope Labeling by Amino Acids in Cell Culture, SILAC, as a Simple and Accurate Approach to Expression Proteomics*

  2002cited by this paper
• Rapid destruction of human Cdc25A in response to DNA damage.

  2000cited by this paper
• Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4.

  1999influential reference
• NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities.

  1998cited by this paper
• The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities.

  1998cited by this paper
• Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex

  1998cited by this paper
• A multiple subunit Mi-2 histone deacetylase from Xenopus laevis cofractionates with an associated Snf2 superfamily ATPase.

  1998cited by this paper
• The human heat-shock protein family. Expression of a novel heat-inducible HSP70 (HSP70B') and isolation of its cDNA and genomic DNA.

  1990cited by this paper

• CHD4 Ensures Bovine Early Embryogenesis by Restricting Developmental Gene Expression and Maintaining BRG1 Expression

  2026cites this paper
• CD276 immature glycosylation drives colorectal cancer aggressiveness and T cell mediated immune escape

  2026cites this paper
• How histone modifications influence cellular radiosensitivity: Pharmaceutically targeting epigenetic regulators as a promising avenue to overcome radioresistance

  2025cites this paper
• Chromatin Remodulator CHD4: A Potential Target for Cancer Interception

  2025cites this paper
• CHD6 has poly(ADP-ribose)- and DNA-binding domains and regulates PARP1/2-trapping inhibitor sensitivity via abasic site repair

  2025cites this paper
• Precision proteogenomics reveals pan-cancer impact of germline variants.

  2025cites this paper
• CHD4 Drives Gastric Cancer Metastasis via MYH9/GSK3β/β-Catenin Axis and WNT/EMT Pathway Activation.

  2025cites this paper
• A novel mutant allele of Mta3 in the mouse: genetic analysis of roles in immunity and androgen biology.

  2025cites this paper
• Serum-Based Proteomic Approach to Identify Clinical Biomarkers of Radiation Exposure

  2025cites this paper
• Protein–Protein Interactions in Base Excision Repair

  2025cites this paper
• A novel CHD4-CTCF regulatory axis drives key developmental programs and transitions in male germ cells

  2025cites this paper
• YBX1 promotes homologous recombination and resistance to platinum-induced stress in ovarian cancer by recognizing m5C modification.

  2024cites this paper
• CHD4 acts as a prognostic factor and drives radioresistance in HPV negative HNSCC

  2024cites this paper
• NEAT1 promotes genome stability via m6A methylation-dependent regulation of CHD4

  2024cites this paper
• Validating Radiosensitivity with Pre-Exposure Differential Gene Expression in Peripheral Blood Predicting Survival and Non-Survival in a Second Irradiated Rhesus Macaque Cohort

  2024cites this paper
• The GATAD2B-NuRD complex drives DNA:RNA hybrid-dependent chromatin boundary formation upon DNA damage

  2024cites this paper
• VGLL3 modulates chemosensitivity through promoting DNA double-strand break repair

  2024cites this paper
• HJURP is recruited to double-strand break sites and facilitates DNA repair by promoting chromatin reorganization

  2024cites this paper
• Proteomic analysis reveals mechanisms underlying increased efficacy of bleomycin by photochemical internalization in bladder cancer cells.

  2023cites this paper
• RepairSwitch: simultaneous functional assessment of homologous recombination vs end joining DNA repair pathways in living cells

  2023cites this paper
• The chromatin remodeler CHD4 sustains Ewing Sarcoma cell survival by controlling global chromatin architecture.

  2023cites this paper
• Evaluation of large language models for discovery of gene set function

  2023cites this paper
• The epigenetic factor CHD4 contributes to metastasis by regulating the EZH2/β-catenin axis and acts as a therapeutic target in ovarian cancer

  2023cites this paper
• CHD4 is recruited by GATA4 and NKX2-5 to repress noncardiac gene programs in the developing heart

  2022cites this paper
• CHD4 promotes acquired chemoresistance and tumor progression by activating the MEK/ERK axis.

  2022cites this paper
• Lysine Crotonylation: An Emerging Player in DNA Damage Response

  2022cites this paper
• DNA Double Strand Break Repair and Its Control by Nucleosome Remodeling

  2022cites this paper
• OGG1 in Lung—More than Base Excision Repair

  2022cites this paper
• Privileged Scaffolds Targeting Bromodomain-containing Protein 4.

  2022cites this paper
• CDYL1-dependent decrease in lysine crotonylation at DNA double-strand break sites functionally uncouples transcriptional silencing and repair.

  2022cites this paper
• Mouse Chd4-NURD is required for neonatal spermatogonia survival and normal gonad development

  2022cites this paper
• Epstein-Barr virus protein BKRF4 restricts nucleosome assembly to suppress host antiviral responses

  2022cites this paper
• Regulation of RAD51 at the Transcriptional and Functional Levels: What Prospects for Cancer Therapy?

  2021cites this paper
• CHD4 regulates platinum sensitivity through MDR1 expression in ovarian cancer: A potential role of CHD4 inhibition as a combination therapy with platinum agents

  2021cites this paper
• Chromatin remodeler CHD8 governs hematopoietic stem/progenitor survival by regulating ATM-mediated P53 protein stability.

  2021cites this paper
• Few-shot learning creates predictive models of drug response that translate from high-throughput screens to individual patients

  2021cites this paper
• CHD4 is recruited by GATA4 and NKX2-5 silencers to repress non-cardiac gene programs in the developing heart

  2021cites this paper
• The chromatin remodelling factor Chd7 protects auditory neurons and sensory hair cells from stress-induced degeneration

  2021cites this paper
• 1 CHD 4-NURD controls mouse neonate spermatogonia survival

  2021influential citation
• Role of Chromatin Architecture in Plant Stress Responses: An Update

  2021cites this paper
• Nucleotide excision repair leaves a mark on chromatin: DNA damage detection in nucleosomes

  2021cites this paper
• Chromatin, nuclear organization and genome stability in mammals

  2021cites this paper
• Nucleosome-CHD4 chromatin remodeler structure maps human disease mutations

  2020cites this paper
• SIRT6 coordinates with CHD4 to promote chromatin relaxation and DNA repair

  2020cites this paper
• Upregulation of Phosphatase 1 Nuclear-Targeting Subunit (PNUTS) Is an Independent Predictor of Poor Prognosis in Prostate Cancer

  2020cites this paper
• Knockdown of circ_0006528 Suppresses Cell Proliferation, Migration, Invasion, and Adriamycin Chemoresistance via Regulating the miR-1236-3p/CHD4 Axis in Breast Cancer.

  2020cites this paper
• The Chromatin Response to Double-Strand DNA Breaks and Their Repair

  2020cites this paper
• Mouse CHD4-NURD is required for spermatogonia survival and normal meiotic progression

  2019cites this paper
• CHD4-NURD controls spermatogonia survival and differentiation

  2019cites this paper
• Over-Expression of CHD4 Is an Independent Biomarker of Poor Prognosis in Patients with Rectal Cancers Receiving Concurrent Chemoradiotherapy

  2019cites this paper
• CHD4 is essential for transcriptional repression and lineage progression in B lymphopoiesis

  2019cites this paper
• Nucleosome-CHD4 chromatin remodeller structure explains human disease mutations

  2019cites this paper
• The Functions of DNA Damage Factor RNF8 in the Pathogenesis and Progression of Cancer

  2019cites this paper
• CHD4 regulates the DNA damage response and RAD51 expression in glioblastoma

  2019cites this paper
• Molecular Genetics of Endometrial Carcinoma.

  2019cites this paper
• The Tale of CHD4 in DNA Damage Response and Chemotherapeutic Response

  2019cites this paper
• USP11 acts as a histone deubiquitinase functioning in chromatin reorganization during DNA repair

  2019cites this paper
• NAD+ consumption by PARP1 in response to DNA damage triggers metabolic shift critical for damaged cell survival

  2019cites this paper
• PHF6 promotes non‐homologous end joining and G2 checkpoint recovery

  2019cites this paper
• The CHD6 chromatin remodeler is an oxidative DNA damage response factor

  2019cites this paper
• The effects of stress on avian gene expression and microbiomes

  2019cites this paper
• CHD 4 mutations promote endometrial cancer stemness by activating TGF-beta signaling

  2018cites this paper
• Biphasic recruitment of TRF2 to DNA damage sites promotes non-sister chromatid homologous recombination repair

  2018cites this paper
• Parent and offspring genotypes influence gene expression in early life

  2018cites this paper
• Leveraging Epigenetics to Enhance the Cellular Response to Chemotherapies and Improve Tumor Immunogenicity

  2018cites this paper
• CHD4 mutations promote endometrial cancer stemness by activating TGF-beta signaling.

  2018cites this paper
• Double duty: ZMYND8 in the DNA damage response and cancer

  2018cites this paper
• Maintenance of Genome Integrity by Mi2 Homologs CHD-3 and LET-418 in Caenorhabditis elegans

  2018cites this paper
• The IκB kinase complex is a regulator of mRNA stability

  2018cites this paper
• DNA damage-induced dynamic changes in abundance and cytosol-nuclear translocation of proteins involved in translational processes, metabolism, and autophagy

  2018cites this paper
• CDYL1 fosters double-strand break-induced transcription silencing and promotes homology-directed repair

  2018cites this paper
• Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage.

  2018cites this paper
• CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor Suppressor Genes.

  2017cites this paper
• The Molecular Pathology of Serous Endometrial Cancer

  2017cites this paper
• CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality

  2017cites this paper
• Chromodomain-helicase-DNA-binding protein 4: a novel therapeutic target in liver cancer stem cells.

  2017influential citation
• The tale of a tail: histone H4 acetylation and the repair of DNA breaks

  2017cites this paper
• DNA repair goes hip-hop: SMARCA and CHD chromatin remodellers join the break dance

  2017cites this paper
• The NuRD complex‐mediated p21 suppression facilitates chemoresistance in BRCA‐proficient breast cancer

  2017cites this paper
• Meta-analysis of DNA double-strand break response kinetics

  2017cites this paper
• Bromodomain proteins: repairing DNA damage within chromatin

  2017cites this paper
• The role of ubiquitin-dependent segregase p97 (VCP or Cdc48) in chromatin dynamics after DNA double strand breaks

  2017cites this paper
• Precision Molecular Pathology of Uterine Cancer

  2017cites this paper
• Chapter 3 – The Nucleosome Remodeling and Deacetylase Complex in Development and Disease

  2017cites this paper
• CREBBP and p300 lysine acetyl transferases in the DNA damage response

  2017influential citation
• PARP, transcription and chromatin modeling.

  2017cites this paper
• ZMYND 8 Co-localizes with NuRD on Target Genes and Regulates Poly ( ADP-Ribose )-Dependent Recruitment ofGATAD 2 A / NuRD toSitesofDNADamage

  2017influential citation
• The evolving concept of liver cancer stem cells

  2017cites this paper
• Regulation of DNA Repair Mechanisms: How the Chromatin Environment Regulates the DNA Damage Response

  2017cites this paper
• A team of heterochromatin factors collaborates with small RNA pathways to combat repetitive elements and germline stress

  2017cites this paper
• Deterministic Reprogramming of Somatic Cells to Pluripotency via Regulation of Mbd3/NuRD Activity

  2016cites this paper
• Depletion of Histone Demethylase Jarid1A Resulting in Histone Hyperacetylation and Radiation Sensitivity Does Not Affect DNA Double-Strand Break Repair

  2016cites this paper
• ZMYND8 Co-localizes with NuRD on Target Genes and Regulates Poly(ADP-Ribose)-Dependent Recruitment of GATAD2A/NuRD to Sites of DNA Damage.

  2016influential citation
• ZMYND 8 Co-localizes with NuRD on Target Genes and Regulates Poly ( ADP-Ribose )-Dependent Recruitment of GATAD 2 A / NuRD to Sites of DNA Damage Graphical

  2016influential citation
• Helicase CHD4 is an epigenetic coregulator of PAX3-FOXO1 in alveolar rhabdomyosarcoma.

  2016cites this paper
• Antagonizing functions of BARD1 and its alternatively spliced variant BARD1δ in telomere stability

  2016cites this paper
• Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes

  2016cites this paper
• Brg1 Enables Rapid Growth of the Early Embryo by Suppressing Genes That Regulate Apoptosis and Cell Growth Arrest

  2016cites this paper
• Defeating EpCAM+ liver cancer stem cells by targeting chromatin remodeling enzyme CHD4 in human hepatocellular carcinoma

  2016cites this paper
• The multifaceted influence of histone deacetylases on DNA damage signalling and DNA repair

  2016cites this paper