AAV-mediated gene transfer of pigment epithelium-derived factor inhibits choroidal neovascularization.

K. Mori,P. Gehlbach,Satoru Yamamoto,E. Duh,D. Zack,Quihong Li,K. Berns,B. Raisler,W. Hauswirth,P. Campochiaro

Published 2002 in Investigative Ophthalmology and Visual Science

ABSTRACT

No abstract is available for this paper.

PUBLICATION RECORD

Publication year
2002
Venue
Investigative Ophthalmology and Visual Science
Publication date
2002-06-01
Fields of study
Biology, Medicine
Identifiers
PMID 12037010
External record
Open on Semantic Scholar
Source metadata
Semantic Scholar, PubMed

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REFERENCES

Intraocular adenoviral vector-mediated gene transfer in proliferative retinopathies.
2002cited by this paper
Pigment epithelium‐derived factor inhibits retinal and choroidal neovascularization
2001cited by this paper
Prevention of ischemia-induced retinopathy by the natural ocular antiangiogenic agent pigment epithelium-derived factor
2001cited by this paper
Inhibition of choroidal neovascularization by intravenous injection of adenoviral vectors expressing secretable endostatin.
2001cited by this paper
Quantitative image analysis of laser-induced choroidal neovascularization in rat.
2000cited by this paper
VEGF is major stimulator in model of choroidal neovascularization.
2000cited by this paper
Retinal degeneration is slowed in transgenic rats by AAV-mediated delivery of FGF-2.
2000cited by this paper
Pigment Epithelium-Derived Factor Supports Normal Development of Photoreceptor Neurons and Opsin Expression after Retinal Pigment Epithelium Removal
2000cited by this paper
Blockade of vascular endothelial cell growth factor receptor signaling is sufficient to completely prevent retinal neovascularization.
2000cited by this paper
Pigment epithelium‐derived factor protects cultured retinal neurons against hydrogen peroxide‐induced cell death
1999cited by this paper
Pigment epithelium-derived factor (PEDF) protects motor neurons from chronic glutamate-mediated neurodegeneration.
1999cited by this paper
Stable transgene expression in rod photoreceptors after recombinant adeno-associated virus-mediated gene transfer to monkey retina.
1999cited by this paper
Pigment epithelium-derived factor: a potent inhibitor of angiogenesis.
1999cited by this paper
Neuroprotection by pigment epithelial‐derived factor against glutamate toxicity in developing primary hippocampal neurons
1999cited by this paper
Pigment epithelium‐derived factor promotes the survival and differentiation of developing spinal motor neurons
1999cited by this paper
Antiangiogenic activity of the cleaved conformation of the serpin antithrombin.
1999cited by this paper
Dramatic inhibition of retinal and choroidal neovascularization by oral administration of a kinase inhibitor.
1999cited by this paper
Pigment epithelium‐derived factor (PEDF) differentially protects immature but not mature cerebellar granule cells against apoptotic cell death
1998cited by this paper
Evolution of neovascularization in mice with overexpression of vascular endothelial growth factor in photoreceptors.
1998cited by this paper
Targeted disruption of the FGF2 gene does not prevent choroidal neovascularization in a murine model.
1998cited by this paper
Endostatin: an endogenous inhibitor of angiogenesis and tumor growth.
1997cited by this paper
A "humanized" green fluorescent protein cDNA adapted for high-level expression in mammalian cells
1996cited by this paper
Pigment Epithelium‐Derived Factor Is a Survival Factor for Cerebellar Granule Cells in Culture
1995cited by this paper
Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma.
1994cited by this paper
Pigment epithelium-derived factor: neurotrophic activity and identification as a member of the serine protease inhibitor gene family.
1993cited by this paper
PEDF: a pigment epithelium-derived factor with potent neuronal differentiative activity.
1991cited by this paper
Inhibition of angiogenesis by recombinant human platelet factor-4 and related peptides.
1990cited by this paper
A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin.
1990cited by this paper

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