The struggle for iron – a metal at the host–pathogen interface

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Cellular Microbiology

• Publication date

  2010-12-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1111/j.1462-5822.2010.01529.xPMID 20964797
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Intracellular Mycobacterium avium intersect transferrin in the Rab11(+) recycling endocytic pathway and avoid lipocalin 2 trafficking to the lysosomal pathway.

  2010cited by this paper
• Iron Traffics in Circulation Bound to a Siderocalin (Ngal)-Catechol Complex

  2010cited by this paper
• Differential regulation of iron homeostasis during human macrophage polarized activation

  2010cited by this paper
• Serum ferritin is derived primarily from macrophages through a nonclassical secretory pathway.

  2010cited by this paper
• Hepcidin messenger RNA expression in human lymphocytes

  2010cited by this paper
• Iron homeostasis and the inflammatory response.

  2010cited by this paper
• Two to tango: regulation of Mammalian iron metabolism.

  2010influential reference
• Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice.

  2010cited by this paper
• A mammalian siderophore synthesized by an enzyme with a bacterial homolog involved in enterobactin production.

  2010cited by this paper
• Modulation of iron homeostasis in macrophages by bacterial intracellular pathogens

  2010influential reference
• Increased Iron Stores Correlate with Worse Disease Outcomes in a Mouse Model of Schistosomiasis Infection

  2010cited by this paper
• Lipocalin-2 resistance confers an advantage to Salmonella enterica serotype Typhimurium for growth and survival in the inflamed intestine.

  2009cited by this paper
• Toll-like receptors mediate induction of hepcidin in mice infected with Borrelia burgdorferi.

  2009cited by this paper
• Mucosal Lipocalin 2 Has Pro-Inflammatory and Iron-Sequestering Effects in Response to Bacterial Enterobactin

  2009cited by this paper
• Role of STAT1, NF‐κB, and C/EBPβ in the macrophage transcriptional regulation of hepcidin by mycobacterial infection and IFN‐γ

  2009cited by this paper
• Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in mice.

  2009cited by this paper
• Absence of functional Hfe protects mice from invasive Salmonella enterica serovar Typhimurium infection via induction of lipocalin-2.

  2009cited by this paper
• Ferritin functions as a proinflammatory cytokine via iron‐independent protein kinase C zeta/nuclear factor kappaB–regulated signaling in rat hepatic stellate cells

  2009cited by this paper
• Nramp1 promotes efficient macrophage recycling of iron following erythrophagocytosis in vivo

  2009cited by this paper
• The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression.

  2008cited by this paper
• Iron‐depletion limits intracellular bacterial growth in macrophages

  2008influential reference
• Increased Susceptibility to Mycobacterium avium in Hemochromatosis Protein HFE-Deficient Mice

  2008cited by this paper
• Autocrine formation of hepcidin induces iron retention in human monocytes.

  2008cited by this paper
• Hfe acts in hepatocytes to prevent hemochromatosis.

  2008cited by this paper
• Leishmania donovani depletes labile iron pool to exploit iron uptake capacity of macrophage for its intracellular growth

  2008cited by this paper
• Effects of the Aspergillus fumigatus siderophore systems on the regulation of macrophage immune effector pathways and iron homeostasis.

  2008cited by this paper
• Nramp1 expression by dendritic cells modulates inflammatory responses during Salmonella Typhimurium infection

  2008cited by this paper
• Nramp1‐functionality increases iNOS expression via repression of IL‐10 formation

  2008influential reference
• Modulation of macrophage iron transport by Nramp1 (Slc11a1).

  2008cited by this paper
• Intracellular microbes and haemophagocytosis

  2008cited by this paper
• Heme oxygenase-1 is an anti-inflammatory host factor that promotes murine plasmodium liver infection.

  2008cited by this paper
• Biosynthesis and IroC‐dependent export of the siderophore salmochelin are essential for virulence of Salmonella enterica serovar Typhimurium

  2008cited by this paper
• Role of iron homeostasis in trypanosomiasis-associated anemia.

  2008cited by this paper
• The iron export protein ferroportin 1 is differentially expressed in mouse macrophage populations and is present in the mycobacterial‐containing phagosome

  2008cited by this paper
• Iron overload and immunity.

  2007cited by this paper
• The iron chelator deferasirox protects mice from mucormycosis through iron starvation.

  2007cited by this paper
• Characterization of Heme as Activator of Toll-like Receptor 4*

  2007cited by this paper
• The co‐ordinated regulation of iron homeostasis in murine macrophages limits the availability of iron for intracellular Salmonella typhimurium

  2007influential reference
• Expression and localization of hepcidin in macrophages: a role in host defense against tuberculosis

  2007cited by this paper
• CD163‐expressing monocytes constitute an endotoxin‐sensitive Hb clearance compartment within the vascular system

  2007cited by this paper
• The role of ferritins in the physiology of Salmonella enterica sv. Typhimurium: a unique role for ferritin B in iron‐sulphur cluster repair and virulence

  2007cited by this paper
• Iron acquisition within host cells and the pathogenicity of Leishmania

  2007cited by this paper
• TLR4-dependent hepcidin expression by myeloid cells in response to bacterial pathogens.

  2006cited by this paper
• The Iron Efflux Protein Ferroportin Regulates the Intracellular Growth of Salmonella enterica

  2006cited by this paper
• Ferroportin‐mediated mobilization of ferritin iron precedes ferritin degradation by the proteasome

  2006cited by this paper
• Mycobacterium tuberculosis gene expression profiling within the context of protein networks.

  2006cited by this paper
• Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury.

  2006cited by this paper
• Genome Watch: Enemies within

  2005influential reference
• Siderocalin (Lcn 2) also binds carboxymycobactins, potentially defending against mycobacterial infections through iron sequestration.

  2005cited by this paper
• Iron release from macrophages after erythrophagocytosis is up-regulated by ferroportin 1 overexpression and down-regulated by hepcidin.

  2005cited by this paper
• Identification of the receptor scavenging hemopexin-heme complexes.

  2005cited by this paper
• Modification of iron regulation by the inflammatory response.

  2005influential reference
• Anemia of chronic disease.

  2005cited by this paper
• Siderophore Biosynthesis But Not Reductive Iron Assimilation Is Essential for Aspergillus fumigatus Virulence

  2004cited by this paper
• The Ferritin-Like Dps Protein Is Required for Salmonella enterica Serovar Typhimurium Oxidative Stress Resistance and Virulence

  2004cited by this paper
• Neisseria meningitidis accelerates ferritin degradation in host epithelial cells to yield an essential iron source

  2004cited by this paper
• Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron

  2004cited by this paper
• Ferritin heavy chain upregulation by NF-kappaB inhibits TNFalpha-induced apoptosis by suppressing reactive oxygen species.

  2004influential reference
• Ferritin Heavy Chain Upregulation by NF- B Inhibits TNF -Induced Apoptosis by Suppressing Reactive Oxygen Species

  2004influential reference
• CD163: a regulated hemoglobin scavenger receptor with a role in the anti‐inflammatory response

  2004cited by this paper
• IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin.

  2004cited by this paper
• Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization

  2004cited by this paper
• Iron sequestration by human lactoferrin stimulates P. aeruginosa surface motility and blocks biofilm formation

  2004cited by this paper
• Lactoferrin: Role in iron homeostasis and host defense against microbial infection

  2004cited by this paper
• Cytokine-mediated regulation of iron transport in human monocytic cells.

  2003cited by this paper
• Pathways for the regulation of interferon‐γ‐inducible genes by iron in human monocytic cells

  2003cited by this paper
• Mycobacterium's arrest of phagosome maturation in macrophages requires Rab5 activity and accessibility to iron.

  2003cited by this paper
• Pathways for the regulation of interferon-gamma-inducible genes by iron in human monocytic cells.

  2003influential reference
• JunB inhibits proliferation and transformation in B-lymphoid cells.

  2003influential reference
• Host–pathogen interactions: Host resistance factor Nramp1 up-regulates the expression of Salmonella pathogenicity island-2 virulence genes

  2002cited by this paper
• Iron Chelation Via Deferoxamine Exacerbates Experimental Salmonellosis Via Inhibition of the Nicotinamide Adenine Dinucleotide Phosphate Oxidase-Dependent Respiratory Burst

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• Correction of the Iron Overload Defect in β-2-Microglobulin Knockout Mice by Lactoferrin Abolishes Their Increased Susceptibility to Tuberculosis

  2002cited by this paper
• Iron and immunity: a double‐edged sword

  2002influential reference
• Regulation of ferritin genes and protein.

  2002cited by this paper
• Regulation of Reticuloendothelial Iron Transporter MTP1 (Slc11a3) by Inflammation*

  2002cited by this paper
• The labile iron pool: characterization, measurement, and participation in cellular processes(1).

  2002cited by this paper
• Intraphagosomal Mycobacterium tuberculosis Acquires Iron from Both Extracellular Transferrin and Intracellular Iron Pools

  2002influential reference
• Divalent-metal transport by NRAMP proteins at the interface of host-pathogen interactions.

  2001cited by this paper
• Infection with Mycobacterium aviumDifferentially Regulates the Expression of Iron Transport Protein mRNA in Murine Peritoneal Macrophages

  2001cited by this paper
• SLC11A1 (formerly NRAMP1) and disease resistance

  2001cited by this paper
• Interferon gamma induces enterocyte resistance against infection by the intracellular pathogen Cryptosporidium parvum.

  2001influential reference
• Modulation of intramacrophage iron metabolism during microbial cell invasion.

  2000cited by this paper
• Natural Resistance to Intracellular Infections

  2000cited by this paper
• Hemoglobin Endocytosis in Leishmania Is Mediated through a 46-kDa Protein Located in the Flagellar Pocket*

  1999cited by this paper
• Iron overload alters innate and T helper cell responses to Candida albicans in mice.

  1997cited by this paper
• Hemoglobin metabolism in the malaria parasite Plasmodium falciparum.

  1997cited by this paper
• Iron regulates nitric oxide synthase activity by controlling nuclear transcription

  1994cited by this paper
• Response of Leishmania chagasi promastigotes to oxidant stress

  1994cited by this paper
• Iron overload in Africa. Interaction between a gene and dietary iron content.

  1992cited by this paper
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  1991cited by this paper
• Interferon gamma-activated human monocytes downregulate transferrin receptors and inhibit the intracellular multiplication of Legionella pneumophila by limiting the availability of iron.

  1989cited by this paper

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• Group A streptococcal PerR coordinates iron and zinc homeostasis through Dpr, aiding in bacterial fitness during endothelial cell infection

  2026cites this paper
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