Progesterone and its derivatives are neuroprotective agents in experimental diabetic neuropathy: a multimodal analysis.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Neuroscience

• Publication date

  2007-02-23

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/J.NEUROSCIENCE.2006.11.014PMID 17187935
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Influence of streptozotocin-induced diabetes and insulin treatment on the pituitary-testicular axis during sexual maturation in rats.

  2012cited by this paper
• Expression of Hypothalamic KiSS-1 System and Rescue of Defective Gonadotropic Responses by Kisspeptin in Streptozotocin-Induced Diabetic Male Rats

  2006cited by this paper
• Sexual function and endocrine profile in fertile women with type 1 diabetes.

  2006cited by this paper
• Neuroendocrine control of the gonadotropic function of the hypophysis in experimental diabetes

  2006cited by this paper
• Sex‐dimorphic effects of progesterone and its reduced metabolites on gene expression of myelin proteins by rat Schwann cells

  2006cited by this paper
• Neuroactive steroids prevent peripheral myelin alterations induced by diabetes.

  2006cited by this paper
• Vascular risk factors and diabetic neuropathy.

  2005cited by this paper
• Effect of streptozotocin-induced diabetes on the gene expression and biological activity of 3beta-hydroxysteroid dehydrogenase in the rat spinal cord.

  2005cited by this paper
• Ro5-4864, a synthetic ligand of peripheral benzodiazepine receptor, reduces aging-associated myelin degeneration in the sciatic nerve of male rats.

  2005cited by this paper
• Glia-neuron crosstalk in the neuroprotective mechanisms of sex steroid hormones.

  2005cited by this paper
• Insulin alone increases hypothalamo-pituitary-adrenal activity, and diabetes lowers peak stress responses.

  2005cited by this paper
• Gonadal steroid modulation of the diabetes (db/db) mutation-induced hyperlipometabolic, hypogonadal syndrome: restoration of female reproductive tract cytochemical and structural indices.

  2005cited by this paper
• Intraepidermal nerve fiber density in rat foot pad: neuropathologic–neurophysiologic correlation

  2005cited by this paper
• Impact of neuropathic pain on the gene expression and activity of cytochrome P450side-chain-cleavage in sensory neural networks

  2004cited by this paper
• Erythropoietin both protects from and reverses experimental diabetic neuropathy.

  2004cited by this paper
• Effect of oestrogen plus progestin on the incidence of diabetes in postmenopausal women: results from the Women’s Health Initiative Hormone Trial

  2004cited by this paper
• Niemann–Pick type C disease involves disrupted neurosteroidogenesis and responds to allopregnanolone

  2004cited by this paper
• Experimental cisplatin neuronopathy in rats and the effect of retinoic acid administration

  2004cited by this paper
• Progesterone and its derivatives dihydroprogesterone and tetrahydroprogesterone reduce myelin fiber morphological abnormalities and myelin fiber loss in the sciatic nerve of aged rats.

  2003cited by this paper
• Neurosteroid modulation of GABAA receptors.

  2003cited by this paper
• Restorative effects of neurotrophin treatment on diabetes-induced cutaneous axon loss in mice.

  2003cited by this paper
• Therapeutic administration of progesterone antagonist in a model of Charcot-Marie-Tooth disease (CMT-1A)

  2003cited by this paper
• Steroid hormones and neurosteroids in normal and pathological aging of the nervous system.

  2003cited by this paper
• Progesterone in gestational diabetes mellitus: guilty or not guilty?

  2003cited by this paper
• Mifepristone (RU 38486) influences expression of glycoprotein Po and morphological parameters at the level of rat sciatic nerve: in vivo observations.

  2003cited by this paper
• Disease mechanisms in inherited neuropathies

  2003cited by this paper
• Axonal swellings predict the degeneration of epidermal nerve fibers in painful neuropathies

  2003cited by this paper
• Aromatase: a neuroprotective enzyme.

  2003cited by this paper
• Steroids in adult men with type 1 diabetes: a tendency to hypogonadism.

  2003cited by this paper
• Cellular Basis for Progesterone Neuroprotection in the Injured Spinal Cord

  2002cited by this paper
• Progesterone receptor knockout mice have an improved glucose homeostasis secondary to β-cell proliferation

  2002cited by this paper
• Diabetes impairs hypothalamo-pituitary-adrenal (HPA) responses to hypoglycemia, and insulin treatment normalizes HPA but not epinephrine responses.

  2002cited by this paper
• Effect of treatment of diabetic rats with dehydroepiandrosterone on vascular and neural function.

  2002cited by this paper
• Progesterone neuroprotection in the Wobbler mouse, a genetic model of spinal cord motor neuron disease.

  2002cited by this paper
• Role of the Schwann cell in diabetic neuropathy.

  2002cited by this paper
• IMPAIRED TESTICULAR FUNCTION IN RATS WITH DIET-INDUCED HYPERCHOLESTEROLEMIA AND/OR STREPTOZOTOCIN-INDUCED DIABETES MELLITUS

  2001cited by this paper
• Neuroactive steroids and peripheral myelin proteins.

  2001cited by this paper
• Color Subtractive–Computer-assisted Image Analysis for Quantification of Cutaneous Nerves in a Diabetic Mouse Model

  2001cited by this paper
• Formation and effects of neuroactive steroids in the central and peripheral nervous system.

  2001cited by this paper
• Function of tetraspan proteins in the myelin sheath.

  2000cited by this paper
• The action of steroid hormones on peripheral myelin proteins: A possible new tool for the rebuilding of myelin?

  2000cited by this paper
• Quantification of neurosteroids in rat plasma and brain following swim stress and allopregnanolone administration using negative chemical ionization gas chromatography/mass spectrometry.

  2000cited by this paper
• Diabetic neuropathies

  2000cited by this paper
• Diabetic neuropathy – a continuing enigma

  2000cited by this paper
• Protection of Sensory Function and Antihyperalgesic Properties of a Prosaposin-derived Peptide in Diabetic Rats

  2000cited by this paper
• Neurophysiological changes in the central and peripheral nervous system of streptozotocin-diabetic rats. Course of development and effects of insulin treatment.

  1999cited by this paper
• Painful sensory neuropathy

  1999cited by this paper
• Progesterone derivatives are able to influence peripheral myelin protein 22 and P0 gene expression: Possible mechanisms of action

  1999cited by this paper
• Gestational and ovarian sex steroid antinociception: synergy between spinal κ and δ opioid systems

  1998cited by this paper
• Progesterone Stimulates the Activity of the Promoters of Peripheral Myelin Protein‐22 and Protein Zero Genes in Schwann Cells

  1998cited by this paper
• Age-induced decrease of glycoprotein Po and myelin basic protein gene expression in the rat sciatic nerve. Repair by steroid derivatives.

  1998cited by this paper
• Basal concentrations of various steroids in the nonobese diabetic (NOD) mouse and effect of immobilization stress.

  1998cited by this paper
• Gestational and ovarian sex steroid antinociception: synergy between spinal kappa and delta opioid systems.

  1998cited by this paper
• Effects of hypoxia and severity of diabetes on Na,K-ATPase activity and arachidonoyl-containing glycerophospholipid molecular species in nerve from streptozotocin diabetic rats.

  1997cited by this paper
• Involvement of spinal cord δ opiate receptors in the antinociception of gestation and its hormonal simulation

  1997cited by this paper
• Dietary fatty acids in the management of diabetes mellitus.

  1997cited by this paper
• Nerve structural defects in diabetic neuropathy: do animals exhibit similar changes?

  1997cited by this paper
• Progesterone synthesis and myelin formation by Schwann cells.

  1995cited by this paper
• The relationship of vascular changes to metabolic factors in diabetes mellitus and their role in the development of peripheral nerve complications.

  1994cited by this paper
• Decrease of nerve Na+,K(+)-ATPase activity in the pathogenesis of human diabetic neuropathy.

  1993cited by this paper
• The effect of diabetes on sexual behavior and reproductive tract function in male rats.

  1993cited by this paper
• Disturbance of neuroendocrine regulation of sexual behavior of male rats with streptozotocin diabetes

  1993cited by this paper
• Streptozotocin-induced experimental diabetes causes a time-dependent inhibition of growth and steroidogenic capacity of rat adrenal zona glomerulosa

  1990cited by this paper
• Morphology and functional responses of isolated zona glomerulosa cells of streptozotocin-induced diabetic rats.

  1990cited by this paper
• Pathogenesis of diabetic neuropathy: role of altered phosphoinositide metabolism.

  1989cited by this paper
• ATPase Activity Defects in Alloxan-Induced Diabetic Sciatic Nerve Recovered by Ganglioside Treatment

  1988cited by this paper
• Nerve glucose, fructose, sorbitol, myo-inositol, and fiber degeneration and regeneration in diabetic neuropathy.

  1988cited by this paper
• Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.

  1987cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper
• Printed in U.S.A. Copyright © 2001 by The Endocrine Society Molecular Regulation of the Hypothalamo-Pituitary- Adrenal Axis in Streptozotocin-Induced Diabetes: Effects of Insulin Treatment

  year unknowncited by this paper
• 0163-769X/04/$20.00/0 Endocrine Reviews 25(4):612–628 Printed in U.S.A. Copyright © 2004 by The Endocrine Society doi: 10.1210/er.2003-0019 Oxidative Stress in the Pathogenesis of

  year unknowncited by this paper

• Synthesis of a New Bioconjugate Steroid Pyridinium Salt Derived from Allopregnanolone Acetate

  2025cites this paper
• Synthetic Derivates of Progesterone Ameliorate Scopolamine-Induced Cognitive Deficits in Animal Models: Antioxidant, Enzyme Inhibitory, Molecular Docking and Behavioral Correlates

  2025cites this paper
• The neuroprotective effects of progesterone against peripheral neuropathy: a systematic review of non-clinical studies

  2024influential citation
• Modulatory role of neurosteroidogenesis in the spinal cord during peripheral nerve injury-induced chronic pain.

  2024cites this paper
• Chondroitin sulfate proteoglycans mRNA expression and degradation in the zebra finch following traumatic brain injury.

  2024cites this paper
• Allopregnanolone pleiotropic action in neurons and astrocytes: calcium signaling as a unifying mechanism

  2023cites this paper
• Evaluation of the serum level of estrogen, progesterone, prolactin, and testosterone in patients with trigeminal neuralgia compared to a healthy population

  2023cites this paper
• Sigma-1 receptors and progesterone metabolizing enzymes in nociceptive sensory neurons of the female rat trigeminal ganglia: A neural substrate for the antinociceptive actions of progesterone

  2022cites this paper
• Surgical Procedures Required for Measurement Reduce Nerve Conduction Velocity: An In Vivo and In Vitro Comparative Study

  2022cites this paper
• Gut Inflammation Induced by Finasteride Withdrawal: Therapeutic Effect of Allopregnanolone in Adult Male Rats

  2022cites this paper
• New horizons of biomaterials in treatment of nerve damage in diabetes mellitus: A translational prospective review

  2022cites this paper
• Protective assessment of progesterone and its receptor on experimental diabetic neuropathy: Antioxidant and anti‐inflammatory effects

  2022cites this paper
• Therapeutic potential of progesterone in spinal cord injury‐induced neuropathic pain: At the crossroads between neuroinflammation and N‐methyl‐D‐aspartate receptor

  2022cites this paper
• Effects of progesterone on T-type-Ca2+-channel expression in Purkinje cells

  2022cites this paper
• Evaluation the Serum Level of Sex Hormones in Patients With Trigeminal Neuralgia

  2021cites this paper
• Effects of combined chronic progesterone administration and forced exercise on behavioral pain responses in the neuropathic pain model of chronic constriction injury in rats

  2021cites this paper
• Protective effects of oxytocin and progesterone on paclitaxel-induced neuropathy in rats

  2021cites this paper
• Allopregnanolone: An overview on its synthesis and effects

  2021cites this paper
• Progesterone and Allopregnanolone Neuroprotective Effects in the Wobbler Mouse Model of Amyotrophic Lateral Sclerosis

  2021cites this paper
• Combined effect of chronic progesterone administration with compulsive exercise on prevention of TNF-α production and abnormal electrophysiological responses of sciatic nerve in Chronic Constriction injury pain model in rat

  2021cites this paper
• Sex differences in neuroimmune and glial mechanisms of pain.

  2021cites this paper
• بررسی اثرات پیشگیریکننده تجویز مزمن پروژسترون توأم با ورزش اجباری بر پاسخهای الکتروفیزیولوژیک عصب سیاتیک و میزان سرمی فاکتور التهابی TNF-α در درد نوروپاتیک ناشی از فشردگی مزمن عصب در موش صحرایی

  2021cites this paper
• Genomic and Non-genomic Action of Neurosteroids in the Peripheral Nervous System

  2020influential citation
• Sex differences in steroid levels and steroidogenesis in the nervous system: physiopathological role.

  2020influential citation
• Progesterone receptor-mediated actions and the treatment of central nervous system disorders: an up-date of the known and the challenge of the unknown.

  2020cites this paper
• Progesterone and Allopregnanolone Rapidly Attenuate Estrogen-Associated Mechanical Allodynia in Rats with Persistent Temporomandibular Joint Inflammation

  2020cites this paper
• Convergent pathological and ultrasound features in hereditary syndromic and non‐syndromic minifascicular neuropathy related to DHH

  2020cites this paper
• Physiopathological role of the enzymatic complex 5α-reductase and 3α/β- hydroxysteroid oxidoreductase in the generation of progesterone and testosterone neuroactive metabolites.

  2020cites this paper
• Evaluation of Biological Activity of Two Steroid Derivatives on Glucose Levels Using a Diabetic Model

  2020cites this paper
• Physiopathological Role of Neuroactive Steroids in the Peripheral Nervous System

  2020cites this paper
• Neurosteroids and Neuropathic Pain Management: basic evidence and therapeutic perspectives.

  2019cites this paper
• Neuroactive steroids, neurosteroidogenesis and sex

  2019cites this paper
• Inhibition of multiple voltage-gated calcium channels may contribute to spinally mediated analgesia by epipregnanolone in a rat model of surgical paw incision

  2019cites this paper
• The role of inflammation and potential use of sex steroids in intracranial aneurysms and subarachnoid hemorrhage

  2018cites this paper
• Neurosteroid Metabolites of Gonadal Steroid Hormones in Neuroprotection: Implications for Sex Differences in Neurodegenerative Disease

  2018cites this paper
• Neurosteroids in Pain Management: A New Perspective on an Old Player

  2018cites this paper
• Allopregnanolone and Progesterone in Experimental Neuropathic Pain: Former and New Insights with a Translational Perspective

  2018cites this paper
• Neuroactive Steroids and Sex-Dimorphic Nervous Damage Induced by Diabetes Mellitus

  2018cites this paper
• Neurosteroid metabolites of testosterone and progesterone differentially inhibit ERK phosphorylation induced by amyloid β in SH-SY5Y cells and primary cortical neurons.

  2018cites this paper
• The regulatory role of Toll-like receptors after ischemic stroke: neurosteroids as TLR modulators with the focus on TLR2/4

  2018cites this paper
• Olive and Its Phenolic Compound as the Promising Neuroprotective Agent

  2018cites this paper
• The Role of Steroids on Brain Function

  2018cites this paper
• Short-term effects of diabetes on neurosteroidogenesis in the rat hippocampus.

  2017cites this paper
• Progesterone modulates diabetes/hyperglycemia-induced changes in the central nervous system and sciatic nerve.

  2017cites this paper
• Neuroactive steroids and diabetic complications in the nervous system.

  2017cites this paper
• Diabetes alters myelin lipid profile in rat cerebral cortex: Protective effects of dihydroprogesterone.

  2017cites this paper
• Sterol regulatory element binding protein‐1C knockout mice show altered neuroactive steroid levels in sciatic nerve

  2017cites this paper
• 5.17 – Effects of Sex Steroids on Damaged Neural Systems

  2017cites this paper
• Quantitative Study of the Effect of Progesterone on the Diabetic Sural Nerves in Rats

  2017cites this paper
• Neurosteroids and their neuroprotective actions

  2017cites this paper
• Protective effects of the neurosteroid allopregnanolone in a mouse model of spontaneous motoneuron degeneration.

  2017cites this paper
• 4′-Chlorodiazepam Protects Mitochondria in T98G Astrocyte Cell Line from Glucose Deprivation

  2017cites this paper
• Diabetes induces mitochondrial dysfunction and alters cholesterol homeostasis and neurosteroidogenesis in the rat cerebral cortex.

  2017cites this paper
• Effect of Progesterone on Cerebral Vasospasm and Neurobehavioral Outcomes in a Rodent Model of Subarachnoid Hemorrhage.

  2017cites this paper
• Neuroactive steroids, nociception and neuropathic pain: A flashback to go forward.

  2016cites this paper
• Dietary withdrawal of phytoestrogens resulted in higher gene expression of 3-beta-HSD and ARO but lower 5-alpha-R-1 in male rats.

  2016cites this paper
• Comparison of Gender Differences in Intracerebral Hemorrhage in a Multi-Ethnic Asian Population

  2016cites this paper
• The antidepressant-like activity of AC-5216, a ligand for 18KDa translocator protein (TSPO), in an animal model of diabetes mellitus

  2016cites this paper
• Middle-Aged Diabetic Females and Males Present Distinct Susceptibility to Alzheimer Disease-like Pathology

  2016cites this paper
• Stroke and Neuroinflamation: Role of Sexual Hormones.

  2016cites this paper
• Levels and actions of neuroactive steroids in the nervous system under physiological and pathological conditions: Sex-specific features.

  2016cites this paper
• Neuroprotective Role of Steroidal Sex Hormones: An Overview

  2016cites this paper
• Motor Nerve Conduction Velocity In Postmenopausal Women with Peripheral Neuropathy.

  2016cites this paper
• Neurosteroidogenesis Today: Novel Targets for Neuroactive Steroid Synthesis and Action and Their Relevance for Translational Research

  2016cites this paper
• Neuroprotective Effect of Progesterone in MPTP-Treated Male Mice

  2015cites this paper
• Involvement of Neuroactive Steroids in Pain, Depression and Anxiety.

  2015cites this paper
• Neuroactive steroids and the peripheral nervous system: An update.

  2015cites this paper
• Natural Variation in Testosterone is Associated With Hypoalgesia in Healthy Women

  2015cites this paper
• Multidisciplinary analysis of biological effects of novel analogs of the neurosteroid allopregnanolone : evidence for a proliferative, neurogenic and neuroprotective action

  2015cites this paper
• Treatment of Pain with Antidepressants

  2015cites this paper
• Progesterone-treatment in a model of Retinitis Pigmentosa: the rd1 mice

  2015cites this paper
• The progesterone receptor agonist Nestorone holds back proinflammatory mediators and neuropathology in the wobbler mouse model of motoneuron degeneration.

  2015cites this paper
• Biogenic Amines and the Amino Acids GABA and Glutamate: Relationships with Pain and Depression.

  2015cites this paper
• Sex-Specific Effects of Progesterone on Early Outcome of Intracerebral Hemorrhage

  2015cites this paper
• Early repeated administration of progesterone improves the recovery of neuropathic pain and modulates spinal 18kDa-translocator protein (TSPO) expression.

  2014cites this paper
• Effects of progesterone on neuropathic pain responses in an experimental animal model for peripheral neuropathy in the rat: a behavioral and electrophysiological study.

  2014cites this paper
• Point process analysis in brain networks of patients with diabetes

  2014cites this paper
• Diabetic neuropathic pain: a role for testosterone metabolites.

  2014cites this paper
• Anti-allodynic and neuroprotective effects of koumine, a Benth alkaloid, in a rat model of diabetic neuropathy.

  2014cites this paper
• Allopregnanolone: state of the art.

  2014cites this paper
• Progesterone reduces the expression of spinal cyclooxygenase‐2 and inducible nitric oxide synthase and prevents allodynia in a rat model of central neuropathic pain

  2014cites this paper
• Gender differences in nerve regeneration after sciatic nerve injury and repair in healthy and in type 2 diabetic Goto-Kakizaki rats

  2014cites this paper
• Levels and actions of progesterone and its metabolites in the nervous system during physiological and pathological conditions.

  2014cites this paper
• Frontiers in therapeutic development of allopregnanolone for Alzheimer’s disease and other neurological disorders

  2014influential citation
• Ozone partially prevents diabetic neuropathy in rats.

  2014cites this paper
• Painful neuropathy: Mechanisms.

  2014cites this paper
• Mechanisms of diabetic neuropathy: Schwann cells.

  2014cites this paper
• Neuroactive steroid treatment modulates myelin lipid profile in diabetic peripheral neuropathy.

  2014cites this paper
• Neurosteroid allopregnanolone attenuates high glucose-induced apoptosis and prevents experimental diabetic neuropathic pain: in vitro and in vivo studies.

  2014cites this paper
• ROLE OF LIVER X RECEPTOR ACTIVATION ON DIABETIC PERIPHERAL NEUROPATHY

  2014cites this paper
• Expression and cellular localization of the classical progesterone receptor in healthy and amyotrophic lateral sclerosis affected spinal cord

  2014cites this paper
• Progesterone Protective Effects in Neurodegeneration and Neuroinflammation

  2013cites this paper
• The effect of progesterone on expression and development of neuropathic pain in a rat model of peripheral neuropathy.

  2013cites this paper
• Neuroprotection by steroids after neurotrauma in organotypic spinal cord cultures: a key role for progesterone receptors and steroidal modulators of GABA(A) receptors.

  2013cites this paper
• Investigations on Alternative Treatment Approaches in the Unilateral 6-OHDA Lesion Rat Model of Parkinson ’ s Disease

  2013cites this paper
• Therapeutic effects of progesterone in animal models of neurological disorders.

  2013cites this paper
• FINALISTA FIDEL PAGÉS MIRAVÉ 2013 Combined estradiol and progesterone: a potentially valuable therapeutic treatment for human ischemic stroke

  2013cites this paper
• Implication du sexe, des hormones gonadiques et de leurs métabolites dans la réponse nociceptive et la perception de la douleur

  2013cites this paper
• The Physiologic Effects of Pain on the Endocrine System

  2013cites this paper
• Reduced epidermal thickness, nerve degeneration and increased pain-related behavior in rats with diabetes type 1 and 2.

  2013cites this paper