Pentylenetetrazole induced changes in zebrafish behavior, neural activity and c-fos expression.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Neuroscience

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.NEUROSCIENCE.2004.11.031PMID 15730879
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• NMDA receptor alterations in neurons from pediatric cortical dysplasia tissue.

  2004cited by this paper
• In vitro formation of a secondary epileptogenic mirror focus by interhippocampal propagation of seizures

  2003cited by this paper
• cDNA profiling of epileptogenesis in the rat brain

  2003cited by this paper
• Do preclinical seizure models preselect certain adverse effects of antiepileptic drugs.

  2002cited by this paper
• From Zebrafish to human: modular medical models.

  2002cited by this paper
• Animal models of epilepsy for the development of antiepileptogenic and disease-modifying drugs. A comparison of the pharmacology of kindling and post-status epilepticus models of temporal lobe epilepsy.

  2002cited by this paper
• The emerging power of chemical genetics.

  2002cited by this paper
• Targeted "knockdown" of channel expression in vivo with an antisense morpholino oligonucleotide.

  2002cited by this paper
• Genetic suppression of seizure susceptibility in Drosophila.

  2001cited by this paper
• EthoVision: A versatile video tracking system for automation of behavioral experiments

  2001cited by this paper
• Modeling Human Epilepsies in Mice

  2001cited by this paper
• Overview of the Current Animal Models for Human Seizure and Epileptic Disorders.

  2001cited by this paper
• Blockade of Neuronal Activity During Hippocampal Development Produces a Chronic Focal Epilepsy in the Rat

  2000cited by this paper
• Harnessing the power of forward genetics--analysis of neuronal diversity and patterning in the zebrafish retina.

  2000cited by this paper
• Zebrafish: a model system for the study of human disease.

  2000cited by this paper
• Modifications of seizure susceptibility in Drosophila.

  2000cited by this paper
• Spatial and temporal relationships between C-Fos expression and kindling of audiogenic seizures in Wistar rats.

  1999cited by this paper
• Focal epileptogenesis in a rat model of polymicrogyria.

  1999cited by this paper
• Selective changes in single cell GABAA receptor subunit expression and function in temporal lobe epilepsy

  1998cited by this paper
• Antiepileptic drug development

  1998cited by this paper
• Defective "pacemaker" current (Ih) in a zebrafish mutant with a slow heart rate.

  1997cited by this paper
• Dentate Granule Cell Neurogenesis Is Increased by Seizures and Contributes to Aberrant Network Reorganization in the Adult Rat Hippocampus

  1997cited by this paper
• Zinc-Induced Collapse of Augmented Inhibition by GABA in a Temporal Lobe Epilepsy Model

  1996cited by this paper
• Mutations disrupting the ordering and topographic mapping of axons in the retinotectal projection of the zebrafish, Danio rerio.

  1996cited by this paper
• The zebrafish book : a guide for the laboratory use of zebrafish (Danio rerio)

  1995cited by this paper
• Seizures and failures in the giant fiber pathway of Drosophila bang- sensitive paralytic mutants

  1995cited by this paper
• Pentylenetetrazol‐Induced Seizures Decrease γ‐Aminobutyric Acid‐Mediated Recurrent Inhibition and Enhance Adenosine‐Mediated Depression

  1994cited by this paper
• Long-term changes in neocortical activity after chemical kindling with systemic pentylenetetrazole: an in vitro study.

  1994cited by this paper
• Topiramate: Preclinical Evaluation of a Structurally Novel Anticonvulsant

  1994cited by this paper
• Localized excitatory synaptic interactions mediate the sustained depolarization of electrographic seizures in developing hippocampus

  1993cited by this paper
• Circuit Mechanisms of Seizures in the Pilocarpine Model of Chronic Epilepsy: Cell Loss and Mossy Fiber Sprouting

  1993cited by this paper
• Excitatory amino acid antagonists and pentylenetetrazol-induced seizures during ontogenesis

  1991cited by this paper
• Epileptogenic effect of hypoxia in the immature rodent brain

  1991cited by this paper
• Resistance of the immature hippocampus to seizure-induced synaptic reorganization.

  1991cited by this paper
• Excitatory amino acid antagonists and pentylenetetrazol-induced seizures during ontogenesis. I. The effects of 2-amino-7-phosphonoheptanoate.

  1990cited by this paper
• Effects of pentetrazol on neuronal activity and on extracellular calcium concentration in rat hippocampal slices.

  1990cited by this paper
• Stable lines of transgenic zebrafish exhibit reproducible patterns of transgene expression.

  1990cited by this paper
• Comparison of the Anticonvulsant Activities of Ethosuximide, Valproate, and a New Anticonvulsant, Thiobutyrolactone

  1989cited by this paper
• Self-sustaining limbic status epilepticus induced by 'continuous' hippocampal stimulation: electrographic and behavioral characteristics.

  1989cited by this paper
• Potassium-induced spontaneous electrographic seizures in the rat hippocampal slice.

  1988cited by this paper
• Synaptic reorganization in the hippocampus induced by abnormal functional activity.

  1988cited by this paper
• The Hippocampal Slice

  1987cited by this paper
• Kindling stimulation induces c-fos protein(s) in granule cells of the rat dentate gyrus

  1987cited by this paper
• The functional anatomy and pathology of lithium-pilocarpine and high-dose pilocarpine seizures.

  1987cited by this paper
• Mapping patterns of c-fos expression in the central nervous system after seizure.

  1987cited by this paper
• Anterior thalamic mediation of generalized pentylenetetrazol seizures.

  1986cited by this paper
• Effects of Antiepileptic Drugs on Pentylenetetrazole‐Induced Epileptiform Activity in the In Vitro Hippocampus

  1986cited by this paper
• Comparative Anticonvulsant Activity and Neurotoxicity of Felbamate and Four Prototype Antiepileptic Drugs in Mice and Rats

  1986cited by this paper
• Intracellular study of human epileptic cortex: in vitro maintenance of epileptiform activity?

  1984cited by this paper
• Mechanisms underlying interictal-ictal transitions.

  1983cited by this paper
• Mechanisms of neocortical epileptogenesis in vitro.

  1982cited by this paper
• Kainic acid‐induced limbic seizures

  1981cited by this paper
• Human epileptic neurons studied in vitro.

  1981cited by this paper
• Mutations affecting segment number and polarity in Drosophila

  1980cited by this paper
• Quantitative evaluation of the actions of anticonvulsants against different chemical convulsants.

  1979cited by this paper
• Quantitative evaluation of the actions of anticonvulsants against different chemical convulsants.

  1979cited by this paper
• Antiepileptic Drug Development: II. Anticonvulsant Drug Screening

  1978cited by this paper
• Antiepileptic Drug Development: I. History and a Program for Progress

  1978cited by this paper
• The Hippocampal Slice: A System for Studying the Pharmacology of Seizures and for Screening Anticonvulsant Drugs

  1977cited by this paper
• Modification of seizure activity by electrical stimulation. II. Motor seizure.

  1972cited by this paper
• Epilepsy and Related Disorders

  1961cited by this paper
• Epilepsy and Related Disorders

  1961cited by this paper
• The Management of Pain

  1954cited by this paper

• Planarian behavioral screening is a useful invertebrate model for evaluating seizurogenic chemicals.

  2026cites this paper
• Estradiol modulates neuronal network hyperexcitability in select NDD risk genes

  2026cites this paper
• Modelling Chemically-induced Seizures in Zebrafish: A Holistic Review of Current Research Applications

  2026cites this paper
• Proceedings from ERN EpiCARE "BEYOND SEIZURES" meeting, Aalesund, Norway, May the 27th. Advancing holistic care for rare and complex epilepsies in adults.

  2026cites this paper
• Potential Effect of Belladonna in the Management of Convulsions in Zebrafish (Danio rerio) and In Silico Mechanistic Approach.

  2026cites this paper
• Myelin sheaths in the central nervous system can withstand damage and dynamically remodel.

  2026cites this paper
• Genetic Diseases of Fucosylation: Insights from Model Organisms

  2025cites this paper
• Zebrafish-based assessment of luteolin’s potential in modulating seizure responses

  2025cites this paper
• Fentanyl and Alcohol Co-Exposure Induce Robust, Sustained Hyperlocomotion and Neural Circuit Disruption in Larval Zebrafish

  2025cites this paper
• Combination of Zonisamide and α-Tocopherol in Pentylenetetrazol Induced Seizures using Zebra fish as Alternative Model

  2025cites this paper
• The Anticonvulsant Effects of Different Cannabis Extracts in a Zebrafish Model of Epilepsy

  2025cites this paper
• Conservation of human NMDA receptor subunits and disease variants in zebrafish

  2025cites this paper
• Towards Better and More Valid Zebrafish Models of Alzheimer's Disease: A Scientific Tribute to Prof. Mikhail I. Aghajanov

  2025cites this paper
• Automated detection of complex zebrafish seizure behavior at scale

  2025cites this paper
• Diverse species of animal models in epilepsy research: Progress and perspectives.

  2025cites this paper
• Beyond Impaired GABAergic Signaling: Inflammation and Metabolic Dysfunction in Genetic Epilepsy Induced by GABRG2 Mutation

  2025cites this paper
• Early death and neuronal abnormalities in depdc5 loss-of-function mosaic zebrafish models

  2025cites this paper
• Altered motor activity and social behavior in zebrafish lacking the Hcn2b ion channel.

  2025cites this paper
• GABA A α4 is expressed in cerebrospinal fluid-contacting neurons and regulates swim behavior in developing zebrafish

  2025cites this paper
• Conservation of human NMDA receptor subunits and disease variants in zebrafish

  2025cites this paper
• α-Asaronol, a Low-Toxicity α-Asarone Metabolite, Suppresses Seizures in Zebrafish Dravet Syndrome via Positive Modulation of GABAA Receptors and LDH Inhibition.

  2025cites this paper
• Permethrin induces epileptic susceptibility via activation of Na+ channels and rise in glutamate

  2025cites this paper
• Behavioral and Biochemical Insights into the Therapeutic Potential of Mitocurcumin in a Zebrafish–Pentylenetetrazole (PTZ) Epilepsy Model

  2025cites this paper
• Voltage-Gated Sodium Channel Dysfunction in Epilepsy: Zebrafish Models for Therapeutics

  2025cites this paper
• Effects of two different peptides on pentylenetetrazole-induced seizures in larval zebrafish

  2025influential citation
• PAC‐FOS: A novel translational concordance framework identifies preclinical seizure models with highest predictive validity for clinical focal onset seizures

  2025cites this paper
• A multielectrode array reveals therapeutic potential of translocator protein ligands in a zebrafish model of Dravet syndrome

  2025cites this paper
• Validating the antiseizure effects of vitexin and related flavone glycosides in zebrafish

  2025cites this paper
• kcnb1 loss of function in zebrafish causes neurodevelopmental and epileptic disorders associated with γ‐aminobutyric acid dysregulation

  2025influential citation
• Multi-behavioral fingerprints can identify potential modes of action for neuroactive environmental chemicals.

  2025cites this paper
• A Zebrafish Seizure Model of cblX Syndrome Reveals a Dose-Dependent Response to mTor Inhibition

  2025cites this paper
• Zebrafish mecp2 null-mutation increases anxiety and cortisol levels but no change in adult social preference and larval chemically-induced hyperlocomotion

  2025cites this paper
• Complex network analysis of zebrafish locomotion based on time series and visibility graphs.

  2025cites this paper
• Multifaceted role of galanin in brain excitability

  2025cites this paper
• Nanofibers Derived Self-Assembled Liposomes of α-lipoic acid Mitigates Pentylenetetrazol-Induced Seizures in Zebrafish Larvae

  2025cites this paper
• Discovery of Novel Antiepileptic Agents Targeting the α1β2γ2 GABAA Receptor.

  2025cites this paper
• β-Asaronol, the Neuroactive Component of Acorus tatarinowii: Mitigating Seizures with Minimal Developmental Risk in Dravet Syndrome.

  2025cites this paper
• Linalool and trans-nerolidol prevent pentylenetetrazole-induced seizures in adult zebrafish

  2025cites this paper
• Zebrafish models of developmental epileptic encephalopathy accurately reflect clinical electrographic biomarkers

  2025cites this paper
• Design and Development of Sulfonamide-Chalcones as Antiepileptic Candidates: Computational and Zebrafish-Based Validation Approaches

  2025cites this paper
• Kv2.1-Kv6.4 subunits deficiency impairs inhibitory signaling and visual circuit dynamics in zebrafish

  2025cites this paper
• Does Microplastic Ingestion Affect Cognition and Brain Gene Expression in Zebrafish, Danio rerio ?

  2025cites this paper
• Dioxopiperidinamide Derivative SKT-36 Alleviates scopolamine-induced Cognitive and Neurobehavioral Impairments in an In-vivo Zebrafish Model.

  2025cites this paper
• Rapid antiepileptic activity identification of isopimpinellin using a multi-model of epilepsy based on behavior-biomarker-BBB screening pipeline.

  2025cites this paper
• Comparing Human Annotation and Machine Learning Models for Optimizing Zebrafish Behavioral Classification in Seizure Analysis.

  2025cites this paper
• Ergolide Regulates Microglial Activation and Inflammatory-Mediated Dysfunction: A Role for the Cysteinyl Leukotriene Pathway

  2025cites this paper
• Towards zebrafish model applications in drug discovery targeting central nervous system diseases and neurotoxicity assessment.

  2025cites this paper
• A coral-derived neuropeptide suppresses pentylenetetrazol (PTZ)-induced epileptic seizures and improves recognition memory deficits by modulating NPY-Y1R

  2025cites this paper
• Evaluation of Safety and Efficacy of Cuprum metallicum in Zebrafish and Mouse Models as a Potential Drug Candidate for the Management of Seizures.

  2025cites this paper
• A larval zebrafish model of traumatic brain injury: optimizing the dose of neurotrauma for discovery of treatments and aetiology

  2025cites this paper
• 2,3,4-Trihydroxybenzophenone-induced cardiac and neurological toxicity: Heart-brain interaction mediated by regulation of pgam1a and pgk1 involved in glycolysis and gluconeogenesis in zebrafish.

  2025cites this paper
• Whole-Brain Mapping in Adult Zebrafish and Identification of the Functional Brain Network Underlying the Novel Tank Test

  2025cites this paper
• Modulation of NMDA receptor signaling and zinc chelation prevent seizure-like events in a zebrafish model of SLC13A5 epilepsy

  2025cites this paper
• Broad Vitamin B6-Related Metabolic Disturbances in a Zebrafish Model of Hypophosphatasia (TNSALP-Deficiency)

  2025cites this paper
• Effects of Polydatin on Pentylenetetrazol-Induced Seizures in Zebrafish Larvae

  2025cites this paper
• Guardian of Excitability: Multifaceted Role of Galanin in Whole Brain Excitability

  2025cites this paper
• Planarian behavioral screening is a useful invertebrate model for evaluating seizurogenic chemicals

  2025influential citation
• Perfluorooctanesulfonic acid (PFOS) antagonizes gamma-aminobutyric acid (GABA) receptors in larval zebrafish and mammalian models

  2025cites this paper
• Machine learning enables high-throughput, low-replicate screening for novel anti-seizure targets and compounds using combined movement and calcium fluorescence in larval zebrafish.

  2025cites this paper
• 2024 International Academy of Toxicologic Pathology (IATP) Satellite Symposium: New Approach Methodologies (NAMs) for Neurotoxicity Assessment and Regulatory Perspectives

  2025cites this paper
• Temporal Dynamics of c-Fos Expression in a Zebrafish Larva Model of Pentylenetetrazole-Induced Seizures

  2025cites this paper
• Targeting MMP-9 activation after early-life seizures reduces seizure susceptibility and memory deficits in a larval zebrafish model.

  2025influential citation
• Testing of putative antiseizure medications in a preclinical Dravet syndrome zebrafish model.

  2024cites this paper
• Chemical profiling, anticonvulsant and anxiolytic effects of the smoke constituents isolated from Leonotis leonurus (L.) R.Br.

  2024cites this paper
• Effects of baicalin pre-treatment on pentylenetetrazole-induced seizures: Insights from zebrafish larvae locomotor behavior and neuronal calcium imaging.

  2024cites this paper
• Vertebrates on a Chip: Noninvasive Electrical and Optical Mapping of Whole Brain Activity Associated with Pharmacological Treatments.

  2024cites this paper
• Developing Peripheral Biochemical Biomarkers of Brain Disorders: Insights from Zebrafish Models

  2024cites this paper
• Ethanolic valeriana officinalis extracts and valerenic acid delay pentylenetetrazole-induced seizures in adult zebrafish (Danio rerio): interactions with GABAa, glutamate, and adenosine receptors

  2024cites this paper
• Berberine and hesperidin prevent the memory consolidation impairment induced by pentylenotetrazole in zebrafish.

  2024cites this paper
• Diverse perspectives in zebrafish seizure models: An exploration of chemical inducers

  2024cites this paper
• Anti-seizure Effects and Mechanisms of Berberine: A Systematic Review.

  2024cites this paper
• Behavioral and neurotransmitter changes on antiepileptic drugs treatment in the zebrafish pentylenetetrazol-induced seizure model.

  2024cites this paper
• Using deep learning to quantify neuronal activation from single-cell and spatial transcriptomic data

  2024cites this paper
• Effect of alpelisib, a selective phosphatidylinositol-3-kinase inhibitor, on seizure development in a rat pentylenetetrazole model

  2024cites this paper
• Zebrafish Provide Critical Insights in a Sea of Genes

  2024cites this paper
• Differential inflammation responses determine the variable phenotypes of epilepsy induced by GABRG2 mutations

  2024cites this paper
• Inhibition of Seizure-Like Paroxysms and Toxicity Effects of Securidaca longepedunculata Extracts and Constituents in Zebrafish Danio rerio

  2024cites this paper
• A Zebrafish-Based Platform for High-Throughput Epilepsy Modeling and Drug Screening in F0

  2024influential citation
• Necrostatin-1 as a Potential Anticonvulsant: Insights from Zebrafish Larvae Model of PTZ-Induced Seizures

  2024cites this paper
• Dechorionated zebrafish embryos improve evaluation of nanotoxicity

  2024cites this paper
• Buspirone administration: Influence on growth, spawning, immune response, and stress in female goldfish (Carassius auratus)

  2024cites this paper
• Zebrafish as a Model Organism for Congenital Hydrocephalus: Characteristics and Insights

  2024cites this paper
• Classification of Current Experimental Models of Epilepsy

  2024cites this paper
• Decreased GABA levels during development result in increased connectivity in the larval zebrafish tectum

  2024influential citation
• A Systematic Review of the Anti-seizure and Antiepileptic Effects and Mechanisms of Piperine.

  2024cites this paper
• Effects of two different compounds on seizure suppression using the zebrafish PTZ-seizure model

  2024cites this paper
• Examining perfluorohexane sulfonate (PFHxS) impacts on sensorimotor and circadian rhythm development

  2024cites this paper
• Disrupted development of sensory systems and the cerebellum in a zebrafish ebf3a mutant

  2024cites this paper
• Reconnoitring antiepileptic and anxiolytic effects of Indian herbs: Findings from zebrafish behavioral research

  2024cites this paper
• kcnb1 loss-of-function in zebrafish causes neurodevelopmental and epileptic disorders associated with GABA dysregulation

  2024cites this paper
• VICR: A Novel Software for Unbiased Video and Image Analysis in Scientific Research

  2024influential citation
• AOP-Anchored Transcriptome Analysis Catalogue Accelerates the Discovery of Environmental Toxicants in Zebrafish.

  2024cites this paper
• Long-working-distance high-collection-efficiency three-photon microscopy for in vivo long-term imaging of zebrafish and organoids

  2024cites this paper
• VICR: A novel software for unbiased video and image analysis in scientific research

  2024cites this paper
• Investigation of Peroxisome Proliferator-Activated Receptor Genes as Requirements for Visual Startle Response Hyperactivity in Larval Zebrafish Exposed to Structurally Similar Per- and Polyfluoroalkyl Substances (PFAS)

  2024cites this paper
• "BEHAVIORAL RESCUE: NARINGENIN'S NEUROPROTECTIVE EFFECTS AGAINST PTZ-INDUCED SEIZURES BY MITIGATING OXIDATIVE STRESS AND NEUROINFLAMMATION IN ZEBRAFISH LARVAE"

  2024cites this paper
• A zebrafish-based acoustic motor response (AMR) assay to evaluate chemical-induced developmental neurotoxicity.

  2024cites this paper
• Effects of developmental exposure to arsenic species on behavioral stress responses in larval zebrafish and implications for stress-related disorders.

  2024cites this paper
• Preliminary study on the mechanism of SAHA in the treatment of refractory epilepsy induced by GABRG2(F343L) mutation.

  2024cites this paper
• A larval zebrafish model of TBI: Optimizing the dose of neurotrauma for discovery of treatments and aetiology

  2024influential citation