Phosphatase inhibitor-1-deficient mice are protected from catecholamine-induced arrhythmias and myocardial hypertrophy.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Cardiovascular Research

• Publication date

  2008-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/cvr/cvn208PMID 18689792
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A GRK5 polymorphism that inhibits β-adrenergic receptor signaling is protective in heart failure

  2008cited by this paper
• β-adrenergic signaling in heart failure—adapt or die

  2008cited by this paper
• the Stimulatory Effects of Protein Kinase A-Signaling in Cardiac Myocytes

  2007cited by this paper
• β-Adrenergic Enhancement of Sarcoplasmic Reticulum Calcium Leak in Cardiac Myocytes Is Mediated by Calcium/Calmodulin-Dependent Protein Kinase

  2007cited by this paper
• Phosphorylation of human inhibitor-1 at Ser67 and/or Thr75 attenuates stimulatory effects of protein kinase A signaling in cardiac myocytes.

  2007cited by this paper
• Long‐term β‐adrenergic stimulation leads to downregulation of protein phosphatase inhibitor‐1 in the heart

  2007cited by this paper
• Beta-adrenergic enhancement of sarcoplasmic reticulum calcium leak in cardiac myocytes is mediated by calcium/calmodulin-dependent protein kinase.

  2007cited by this paper
• Intact &bgr;-Adrenergic Response and Unmodified Progression Toward Heart Failure in Mice With Genetic Ablation of a Major Protein Kinase A Phosphorylation Site in the Cardiac Ryanodine Receptor

  2007cited by this paper
• Molecular Determinants of Altered Ca2+ Handling in Human Chronic Atrial Fibrillation

  2006cited by this paper
• The MLCK-mediated alpha1-adrenergic inotropic effect in atrial myocardium is negatively modulated by PKCepsilon signaling.

  2006cited by this paper
• Inhibition of protein phosphatase 1 by inhibitor‐2 gene delivery ameliorates heart failure progression in genetic cardiomyopathy

  2006cited by this paper
• Role of calcineurin and protein phosphatase-2A in the regulation of phosphatase inhibitor-1 in cardiac myocytes.

  2006cited by this paper
• The MLCK‐mediated α1‐adrenergic inotropic effect in atrial myocardium is negatively modulated by PKCɛ signaling

  2006cited by this paper
• Enhancement of Cardiac Function and Suppression of Heart Failure Progression By Inhibition of Protein Phosphatase 1

  2005cited by this paper
• Enhanced cardiac function in mice overexpressing protein phosphatase Inhibitor-2.

  2005cited by this paper
• Strain-dependent beta-adrenergic receptor function influences myocardial responses to isoproterenol stimulation in mice.

  2005cited by this paper
• Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias.

  2005cited by this paper
• The Inhibitor-1 C Terminus Facilitates Hormonal Regulation of Cellular Protein Phosphatase-1

  2004cited by this paper
• Ca2+/Calmodulin-Dependent Protein Kinase II Phosphorylation Regulates the Cardiac Ryanodine Receptor

  2004cited by this paper
• PKC-α regulates cardiac contractility and propensity toward heart failure

  2004cited by this paper
• PKC-alpha regulates cardiac contractility and propensity toward heart failure.

  2004cited by this paper
• Decreased protein and phosphorylation level of the protein phosphatase inhibitor-1 in failing human hearts.

  2004cited by this paper
• Evidence for protein phosphatase inhibitor‐1 playing an amplifier role in β‐adrenergic signaling in cardiac myocytes

  2003cited by this paper
• What Is the Role of &bgr;-Adrenergic Signaling in Heart Failure?

  2003cited by this paper
• Type 1 Phosphatase, a Negative Regulator of Cardiac Function

  2002cited by this paper
• Cyclic nucleotide-gated ion channels.

  2002cited by this paper
• Adenylyl Cyclase Increases Survival in Cardiomyopathy

  2002cited by this paper
• Dilated Cardiomyopathy and Sudden Death Resulting From Constitutive Activation of Protein Kinase A

  2001cited by this paper
• The Muscle-specific Protein Phosphatase PP1G/RGL(GM) Is Essential for Activation of Glycogen Synthase by Exercise*

  2001cited by this paper
• Protein Phosphatase-1 Regulation in the Induction of Long-Term Potentiation: Heterogeneous Molecular Mechanisms

  2000cited by this paper
• Effects of serine/threonine protein phosphatases on ion channels in excitable membranes.

  2000cited by this paper
• PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts.

  2000cited by this paper
• Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy.

  1999cited by this paper
• Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice.

  1999cited by this paper
• Gating of CaMKII by cAMP-regulated protein phosphatase activity during LTP.

  1998cited by this paper
• Cardiomyopathy induced by cardiac Gs alpha overexpression.

  1997cited by this paper
• Multiple structural elements define the specificity of recombinant human inhibitor-1 as a protein phosphatase-1 inhibitor.

  1996influential reference
• Effects of xylazine and ketamine on epinephrine-induced arrhythmia in the dog.

  1987cited by this paper
• Decreased catecholamine sensitivity and beta-adrenergic-receptor density in failing human hearts.

  1982cited by this paper

• Isoproterenol induced cardiac hypertrophy: A comparison of three doses and two delivery methods in C57BL/6J mice

  2024cites this paper
• Chronic isoprenaline/phenylephrine vs. exclusive isoprenaline stimulation in mice: critical contribution of alpha1-adrenoceptors to early cardiac stress responses

  2022cites this paper
• Function and regulation of phosphatase 1 in healthy and diseased heart.

  2021cites this paper
• Molecular noise filtering in the β-adrenergic signaling network by phospholamban pentamers

  2021cites this paper
• Diminished PLK2 Induces Cardiac Fibrosis and Promotes Atrial Fibrillation

  2021cites this paper
• Serine-threonine protein phosphatase regulation of Cx43 dephosphorylation in arrhythmogenic disorders.

  2021cites this paper
• Adaptive versus maladaptive cardiac remodelling in response to sustained β-adrenergic stimulation in a new ‘ISO on/off model’

  2021cites this paper
• Genetic Deletion of Polo-Like Kinase 2 Induces a Pro-Fibrotic Pulmonary Phenotype

  2021cites this paper
• Three Cases of Karoshi Without the Typical Pathomorphological Features of Cardiovascular/Cerebrovascular Disease.

  2020cites this paper
• Molecular Noise-Filtering in the β-adrenergic Signaling Network by Phospholamban Pentamers

  2020cites this paper
• Modeling atrial fibrosis in vitro—Generation and characterization of a novel human atrial fibroblast cell line

  2020cites this paper
• Repurposing mesalazine against cardiac fibrosis in vitro

  2020cites this paper
• Inhibitor 1 of Protein Phosphatase 1 Regulates Ca2+/Calmodulin-Dependent Protein Kinase II to Alleviate Oxidative Stress in Hypoxia-Reoxygenation Injury of Cardiomyocytes

  2019cites this paper
• Protein Phosphatase 1 Inhibitor-1 Mediates the cAMP-Dependent Stimulation of the Renal NaCl Cotransporter.

  2019cites this paper
• A mathematical model for β1-adrenergic regulation of the mouse ventricular myocyte contraction.

  2019cites this paper
• Role of β-adrenergic signaling in masseter muscle

  2019cites this paper
• Potential targets of gene therapy in the treatment of heart failure

  2018cites this paper
• AAV-9 mediated phosphatase-1 inhibitor-1 overexpression improves cardiac contractility in unchallenged mice but is deleterious in pressure-overload

  2018cites this paper
• Rearrangement of the Protein Phosphatase 1 Interactome During Heart Failure Progression

  2018cites this paper
• Hypoxia-induced epigenetic silencing of polo-like kinase 2 promotes fibrosis in atrial fibrillation

  2018cites this paper
• Inhibiting the Inhibitors, PTP1B as a Therapeutic Target in Myocardial Infarction

  2018cites this paper
• Chronic β-adrenergic stimulation reverses depressed Ca handling in mice overexpressing inhibitor-2 of protein phosphatase 1.

  2018cites this paper
• Activation of protein phosphatase 1 by a selective phosphatase disrupting peptide reduces sarcoplasmic reticulum Ca2+ leak in human heart failure

  2018cites this paper
• Functions and therapeutic potential of protein phosphatase 1: Insights from mouse genetics

  2018cites this paper
• Phosphodiesterase 2 Protects Against Catecholamine-Induced Arrhythmia and Preserves Contractile Function After Myocardial Infarction

  2017cites this paper
• Chronic loss of inhibitor-1 diminishes cardiac RyR2 phosphorylation despite exaggerated CaMKII activity

  2017cites this paper
• Nucleoside Diphosphate Kinase-C Suppresses cAMP Formation in Human Heart Failure

  2017cites this paper
• The p21‐activated kinase 1 (Pak1) signalling pathway in cardiac disease: from mechanistic study to therapeutic exploration

  2017influential citation
• Raf kinase inhibitor protein: lessons of a better way for β‐adrenergic receptor activation in the heart

  2017influential citation
• Regulating the regulator: Insights into the cardiac protein phosphatase 1 interactome.

  2016cites this paper
• Cardiac Effects of Attenuating Gsα - Dependent Signaling

  2016cites this paper
• The neglected messengers: Control of cardiac myofilaments by protein phosphatases.

  2016cites this paper
• Role of protein phosphatase inhibitor-1 in cardiac beta adrenergic pathway.

  2016cites this paper
• Regulation of sarcoplasmic reticulum Ca2+ release by serine-threonine phosphatases in the heart.

  2016cites this paper
• Phosphodiesterase 2: anti-adrenergic friend or hypertrophic foe in heart disease?

  2016cites this paper
• Development of phosphatase inhibitor-1 peptides acting as indirect activators of phosphatase 1

  2015cites this paper
• Cardiac-specific deletion of protein phosphatase 1β promotes increased myofilament protein phosphorylation and contractile alterations.

  2015cites this paper
• Up‐regulation of micro‐RNA765 in human failing hearts is associated with post‐transcriptional regulation of protein phosphatase inhibitor‐1 and depressed contractility

  2015cites this paper
• I-1-deficiency negatively impacts survival in a cardiomyopathy mouse model

  2015cites this paper
• Counteracting Protein Kinase Activity in the Heart: The Multiple Roles of Protein Phosphatases

  2015influential citation
• Alterations in the interactome of serine/threonine protein phosphatase type-1 in atrial fibrillation patients.

  2015cites this paper
• Differential PI3K signal transduction in obesity‐associated cardiac hypertrophy and response to ischemia

  2015cites this paper
• Cardiac RKIP induces a beneficial β-adrenoceptor–dependent positive inotropy

  2015cites this paper
• Should we treat heart failure with phosphatase inhibitors? Better to start at the end.

  2015cites this paper
• Melusin protects from cardiac rupture and improves functional remodelling after myocardial infarction.

  2014cites this paper
• A Compartmentalized Mathematical Model of the β1-Adrenergic Signaling System in Mouse Ventricular Myocytes

  2014cites this paper
• Role of RyR2 Phosphorylation in Heart Failure and Arrhythmias: Controversies Around Ryanodine Receptor Phosphorylation in Cardiac Disease

  2014cites this paper
• Guanabenz Interferes with ER Stress and Exerts Protective Effects in Cardiac Myocytes

  2014cites this paper
• Cellular and Molecular Electrophysiology of Atrial Fibrillation Initiation, Maintenance, and Progression

  2014cites this paper
• Prostaglandin E2 does not attenuate adrenergic-induced cardiac contractile response

  2014cites this paper
• Cardiac I-1c overexpression with reengineered AAV improves cardiac function in swine ischemic heart failure.

  2014cites this paper
• Fibrillation Initiation , Maintenance , and Progression

  2014cites this paper
• Paradoxical Effects on Force Generation after Efficient β1-Adrenoceptor Knockdown in Reconstituted Heart Tissue

  2014cites this paper
• Impaired local regulation of ryanodine receptor type 2 by protein phosphatase 1 promotes atrial fibrillation.

  2014cites this paper
• Rescue of cardiac failing and remodelling by inhibition of protein phosphatase 1γ is associated with suppression of the alternative splicing factor‐mediated splicing of Ca2+/calmodulin‐dependent protein kinase δ

  2014cites this paper
• Gene- and Cell-Based Therapy for Cardiovascular Disease

  2014cites this paper
• Actions of NAADP and other agents in cardiac myocytes

  2014cites this paper
• AKAP18: Bidirectional Regulator Of Protein Phosphorylation

  2013cites this paper
• While systolic cardiomyocyte function is preserved, diastolic myocyte function and recovery from acidosis are impaired in CaMKIIδ-KO mice.

  2013cites this paper
• Development of a Colorimetric and a Fluorescence Phosphatase-Inhibitor Assay Suitable for Drug Discovery Approaches

  2013cites this paper
• Phosphodiesterase-2 is up-regulated in human failing hearts and blunts β-adrenergic responses in cardiomyocytes.

  2013cites this paper
• Functional dissection of myosin binding protein C phosphorylation.

  2013cites this paper
• AAV9.I-1c Delivered via Direct Coronary Infusion in a Porcine Model of Heart Failure Improves Contractility and Mitigates Adverse Remodeling

  2013cites this paper
• Novel regulation of cardiac Na pump via phospholemman.

  2013cites this paper
• Identification of a Protein Phosphatase-1/Phospholamban Complex That Is Regulated by cAMP-Dependent Phosphorylation

  2013cites this paper
• Melusin protects from cardiac rupture and improves functional remodelling in mice after myocardial infarction

  2013cites this paper
• Function and regulation of serine/threonine phosphatases in the healthy and diseased heart.

  2013cites this paper
• Impaired local regulation of ryanodine receptor type-2 by protein phosphatase 1 promotes atrial fibrillation

  2013cites this paper
• Adenylyl cyclase 6 deletion increases mortality during sustained β-adrenergic receptor stimulation.

  2013cites this paper
• Modulation of Cardiac Contractility by the Phopholamban/SERCA2a Regulatome

  2012cites this paper
• The relationship between the MMP system, adrenoceptors and phosphoprotein phosphatases

  2012influential citation
• Novel molecular targets for atrial fibrillation therapy

  2012cites this paper
• Proarrhythmic atrial calcium cycling in the diseased heart.

  2012cites this paper
• Targeted Deletion of MicroRNA-22 Promotes Stress-Induced Cardiac Dilation and Contractile Dysfunction

  2012cites this paper
• Development of an in vitro assay system for protein phosphatase inhibitor-1 antagonists

  2012influential citation
• Identification et caractérisation des inhibiteurs de type 2 et 3 de la phosphatase de type 1 chez Plasmodium falciparum

  2012cites this paper
• Altered sarcoplasmic reticulum calcium cycling—targets for heart failure therapy

  2012cites this paper
• Identification of novel drug targets for the treatment of heart failure

  2012cites this paper
• Heart Failure-Inducible Gene Therapy Targeting Protein Phosphatase 1 Prevents Progressive Left Ventricular Remodeling

  2012cites this paper
• Phospholemman‐dependent regulation of the cardiac Na/K‐ATPase activity is modulated by inhibitor‐1 sensitive type‐1 phosphatase

  2011cites this paper
• AKAP Phosphatase Complexes in the Heart

  2011cites this paper
• Gene Therapy Targets in Heart Failure: The Path to Translation

  2011cites this paper
• Impaired β‐adrenergic responsiveness accentuates dysfunctional excitation–contraction coupling in an ovine model of tachypacing‐induced heart failure

  2011cites this paper
• The role of protein phosphatase inhibitor 1 in the initial phase after transverse aortic constriction in a murine model

  2011cites this paper
• The role of protein phosphatase inhibitor 1 in the initial phase after transverse aortic constriction in a murine model

  2011cites this paper
• The ryanodine receptor channel as a molecular motif in atrial fibrillation: pathophysiological and therapeutic implications.

  2011cites this paper
• Generierung und kardiovaskuläre Phänotypisierung einer transgenen Mauslinie, die die Phosphodiesterase-2A unter Kontrolle eines herzspezifischen Promotors überexprimiert

  2011cites this paper
• The Large Isoforms of A-Kinase Anchoring Protein 18 Mediate the Phosphorylation of Inhibitor-1 by Protein Kinase A and the Inhibition of Protein Phosphatase 1 Activity

  2011cites this paper
• Phosphatase-1 inhibitor-1 in physiological and pathological β-adrenoceptor signalling.

  2011influential citation
• MicroRNA-1 and -133 Increase Arrhythmogenesis in Heart Failure by Dissociating Phosphatase Activity from RyR2 Complex

  2011cites this paper
• Multiple Potential Molecular Contributors to Atrial Hypocontractility Caused by Atrial Tachycardia Remodeling in Dogs

  2010cites this paper
• The new HNO donor, 1-nitrosocyclohexyl acetate, increases contractile force in normal and β-adrenergically desensitized ventricular myocytes.

  2010cites this paper
• Differential Cardiac Remodeling in Preload Versus Afterload

  2010cites this paper
• Common MicroRNA Signatures in Cardiac Hypertrophic and Atrophic Remodeling Induced by Changes in Hemodynamic Load

  2010cites this paper
• Expression of active protein phosphatase 1 inhibitor-1 attenuates chronic beta-agonist-induced cardiac apoptosis

  2010cites this paper
• Ryanodine receptor mutations in arrhythmia: The continuing mystery of channel dysfunction

  2010cites this paper
• Role of abnormal sarcoplasmic reticulum function in atrial fibrillation.

  2010cites this paper
• Atrial Ca2+ signaling in atrial fibrillation as an antiarrhythmic drug target

  2010cites this paper
• Phosphatase-1-inhibitor-1: amplifier or attenuator of catecholaminergic stress?

  2010cites this paper
• Beta-adrenergic receptor signaling in the heart: role of CaMKII.

  2010cites this paper