Chapter 11 Essential Myosin Light Chains Regulate Myosin Function and Muscle Contraction

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• Publication year

  2016

• Venue

  Unknown venue

• Publication date

  2016-11-15

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1201/9781315364674-12
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Detection of mutations in symptomatic patients with hypertrophic cardiomyopathy in Taiwan.

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• Amplitude of the actomyosin power stroke depends strongly on the isoform of the myosin essential light chain

  2015cited by this paper
• Molecular mechanism regulating myosin and cardiac functions by ELC.

  2014cited by this paper
• Distinct interactions between actin and essential myosin light chain isoforms.

  2014cited by this paper
• Discrete effects of A57G-myosin essential light chain mutation associated with familial hypertrophic cardiomyopathy.

  2013cited by this paper
• Infantile Hypertrophic Cardiomyopathy Associated with a Novel MYL3 Mutation

  2013cited by this paper
• Characterizations of myosin essential light chain’s N-terminal truncation mutant Δ43 in transgenic mouse papillary muscles by using tension transients in response to sinusoidal length alterations

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• Mutations of ventricular essential myosin light chain disturb myosin binding and sarcomeric sorting.

  2012cited by this paper
• Decreased Rate of CSF Leakage Associated with Complete Reconstruction of Suboccipital Cranial Defects

  2012cited by this paper
• Modification of Interface between Regulatory and Essential Light Chains Hampers Phosphorylation-dependent Activation of Smooth Muscle Myosin*

  2012cited by this paper
• A Novel Myosin Essential Light Chain Mutation Causes Hypertrophic Cardiomyopathy with Late Onset and Low Expressivity

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• Ischemia/reperfusion‐induced myosin light chain 1 phosphorylation increases its degradation by matrix metalloproteinase 2

  2012cited by this paper
• Structural and functional aspects of the myosin essential light chain in cardiac muscle contraction

  2011cited by this paper
• Human essential myosin light chain isoforms revealed distinct myosin binding, sarcomeric sorting, and inotropic activity.

  2011cited by this paper
• Genetic basis of end‐stage hypertrophic cardiomyopathy

  2011cited by this paper
• Rapid detection of genetic variants in hypertrophic cardiomyopathy by custom DNA resequencing array in clinical practice

  2011cited by this paper
• A Single Serine in the Carboxyl Terminus of Cardiac Essential Myosin Light Chain-1 Controls Cardiomyocyte Contractility In Vivo

  2009cited by this paper
• Cardiomyopathy mutations reveal variable region of myosin converter as major element of cross-bridge compliance.

  2009cited by this paper
• Single-molecule measurement of the stiffness of the rigor myosin head.

  2008cited by this paper
• The elastic properties of the structurally characterized myosin II S2 subdomain: a molecular dynamics and normal mode analysis.

  2008cited by this paper
• Prevalence of Sarcomere Protein Gene Mutations in Preadolescent Children With Hypertrophic Cardiomyopathy

  2008cited by this paper
• Stiffness and fraction of Myosin motors responsible for active force in permeabilized muscle fibers from rabbit psoas.

  2007cited by this paper
• Modulation of muscle contraction by a cell-permeable peptide

  2007cited by this paper
• Evidence for an interaction between the SH3 domain and the N-terminal extension of the essential light chain in class II myosins.

  2007cited by this paper
• Skeletal muscle performance determined by modulation of number of myosin motors rather than motor force or stroke size.

  2007cited by this paper
• Molecular modeling of the myosin-S1(A1) isoform.

  2007cited by this paper
• Functional Characterization of the Amino-Terminal Region of Myosin-2

  2006cited by this paper
• Two independent mechanical events in the interaction cycle of skeletal muscle myosin with actin.

  2006cited by this paper
• Minigenes encoding N‐terminal domains of human cardiac myosin light chain‐1 improve heart function of transgenic rats

  2006cited by this paper
• Regulation of the human atrial myosin light chain 1 promoter by Ca2+‐calmodulin‐dependent signaling pathways

  2005cited by this paper
• The molecular mechanism of muscle contraction.

  2005cited by this paper
• Human atrial myosin light chain 1 expression attenuates heart failure.

  2005cited by this paper
• Functional characterization of the human atrial essential myosin light chain (hALC-1) in a transgenic rat model

  2004cited by this paper
• Myosin light chain isoforms modify force-generating ability of cardiac myosin by changing the kinetics of actin-myosin interaction.

  2003cited by this paper
• Hypertrophic cardiomyopathy:a paradigm for myocardial energy depletion.

  2003cited by this paper
• Ca2+ binding to myosin regulatory light chain affects the conformation of the N-terminus of essential light chain and its binding to actin.

  2003cited by this paper
• Hypertrophic Cardiomyopathy: Distribution of Disease Genes, Spectrum of Mutations, and Implications for a Molecular Diagnosis Strategy

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• Shortening velocity and myosin heavy- and light-chain isoform mRNA in rabbit arterial smooth muscle cells.

  2002cited by this paper
• The inhibitory region of troponin-I alters the ability of F-actin to interact with different segments of myosin.

  2002cited by this paper
• Myosin Light Chain Mutation Causes Autosomal Recessive Cardiomyopathy With Mid-Cavitary Hypertrophy and Restrictive Physiology

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• Mutation of the myosin converter domain alters cross-bridge elasticity

  2002cited by this paper
• The power stroke causes changes in the orientation and mobility of the termini of essential light chain 1 of myosin.

  2001cited by this paper
• Proteomic Analysis of Pharmacologically Preconditioned Cardiomyocytes Reveals Novel Phosphorylation of Myosin Light Chain 1

  2001cited by this paper
• Different expressivity of a ventricular essential myosin light chain gene Ala57Gly mutation in familial hypertrophic cardiomyopathy.

  2001cited by this paper
• In Vivo Analysis of an Essential Myosin Light Chain Mutation Linked to Familial Hypertrophic Cardiomyopathy

  2000cited by this paper
• Size and Charge Requirements for Kinetic Modulation and Actin Binding by Alkali 1-type Myosin Essential Light Chains*

  1999cited by this paper
• Remodeling of the hypertrophied human myocardium by cardiac bHLH transcription factors

  1999cited by this paper
• Forced Expression of Essential Myosin Light Chain Isoforms Demonstrates Their Role in Smooth Muscle Force Production*

  1999cited by this paper
• The stiffness of rabbit skeletal actomyosin cross-bridges determined with an optical tweezers transducer.

  1998cited by this paper
• Myosin Essential Light Chain Isoforms Modulate the Velocity of Shortening Propelled by Nonphosphorylated Cross-bridges*

  1998cited by this paper
• Functional significance of cardiac myosin essential light chain isoform switching in transgenic mice.

  1998cited by this paper
• Elastic bending and active tilting of myosin heads during muscle contraction

  1998cited by this paper
• Changes in essential myosin light chain isoform expression provide a molecular basis for isometric force regulation in the failing human heart.

  1997cited by this paper
• The neck region of the myosin motor domain acts as a lever arm to generate movement.

  1996cited by this paper
• Regulation of human heart contractility by essential myosin light chain isoforms.

  1996cited by this paper
• Protein-protein interactions in the rigor actomyosin complex.

  1996cited by this paper
• Contraction kinetics and myosin isoform composition in smooth muscle from hypertrophied rat urinary bladder

  1996cited by this paper
• An Essential Myosin Light Chain Peptide Induces Supramaximal Stimulation of Cardiac Myofibrillar ATPase Activity*

  1996cited by this paper
• Mutations in either the essential or regulatory light chains of myosin are associated with a rare myopathy in human heart and skeletal muscle

  1996cited by this paper
• The role of the skeletal muscle myosin light chains N‐terminal fragments

  1995cited by this paper
• Target sequence recognition by the calmodulin superfamily: implications from light chain binding to the regulatory domain of scallop myosin.

  1995cited by this paper
• Myosin light chain-actin interaction regulates cardiac contractility.

  1995cited by this paper
• Proline-rich sequences that bind to Src homology 3 domains with individual specificities.

  1995cited by this paper
• Structure of the regulatory domain of scallop myosin at 2.8 Ä resolution

  1994cited by this paper
• The essential light chain is required for full force production by skeletal muscle myosin.

  1994cited by this paper
• Binding of the amino-terminal region of myosin alkali 1 light chain to actin and its effect on actin-myosin interaction.

  1994cited by this paper
• Regulation of scallop myosin by the regulatory light chain depends on a single glycine residue.

  1994cited by this paper
• Unloaded shortening velocity and myosin heavy chain and alkali light chain isoform composition in rat skeletal muscle fibres.

  1994cited by this paper
• Skeletal muscle myosin light chains are essential for physiological speeds of shortening

  1993cited by this paper
• Function of skeletal muscle myosin heavy and light chain isoforms by an in vitro motility assay.

  1993cited by this paper
• An insert of seven amino acids confers functional differences between smooth muscle myosins from the intestines and vasculature.

  1993cited by this paper
• Three-dimensional structure of myosin subfragment-1: a molecular motor.

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  1993cited by this paper
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• Role of 17-kDa essential light chain isoforms of aorta smooth muscle myosin.

  1992cited by this paper
• Factors affecting movement of F-actin filaments propelled by skeletal muscle heavy meromyosin.

  1992cited by this paper
• Correlation between isoform composition of the 17 kDa myosin light chain and maximal shortening velocity in smooth muscle

  1991cited by this paper
• Expression of ventricular myosin subunits in the atria of children with congenital heart malformations.

  1991cited by this paper
• Human embryonic/atrial myosin alkali light chain gene: characterization, sequence, and chromosomal location.

  1990cited by this paper
• Myosin step size. Estimation from slow sliding movement of actin over low densities of heavy meromyosin.

  1990cited by this paper
• Phosphorylation and thiophosphorylation by myosin light chain kinase: different effects on mechanical properties of chemically skinned ventricular fibers from the pig.

  1990cited by this paper
• Evolution of EF-hand calcium-modulated proteins. I. Relationships based on amino acid sequences

  1990cited by this paper
• Nucleotide and deduced amino acid sequence of cDNAs encoding two isoforms for the 17,000 dalton myosin light chain in bovine aortic smooth muscle.

  1990cited by this paper
• Human ventricular/slow twitch myosin alkali light chain gene characterization, sequence, and chromosomal location.

  1989cited by this paper
• The alkali light chains of human smooth and nonmuscle myosins are encoded by a single gene. Tissue-specific expression by alternative splicing pathways.

  1989cited by this paper
• Different phosphorylation patterns of cardiac myosin light chains using ATP and ATP gamma S as substrates.

  1988cited by this paper
• Variations in contractile properties of rabbit single muscle fibres in relation to troponin T isoforms and myosin light chains.

  1988cited by this paper
• Myosin alkali light chain and heavy chain variations correlate with altered shortening velocity of isolated skeletal muscle fibers.

  1988cited by this paper
• Nonmuscle and smooth muscle myosin light chain mRNAs are generated from a single gene by the tissue-specific alternative RNA splicing.

  1987cited by this paper
• Evidence that the N-terminal region of A1-light chain of myosin interacts directly with the C-terminal region of actin. A proton magnetic resonance study.

  1987cited by this paper
• Cardiac myosin light and heavy chain isotypes in tetralogy of Fallot.

  1986cited by this paper
• Stability and substructure of cardiac myosin subfragment 1 and isolation and properties of its heavy-chain subunit.

  1986cited by this paper
• Isoforms of myosin and actin in human, monkey and rat myometrium. Comparison of pregnant and non-pregnant uterus proteins.

  1986cited by this paper
• Differential binding of rabbit fast muscle myosin light chain isoenzymes to regulated actin

  1985cited by this paper
• The myosin alkali light chain proteins and their genes.

  1985cited by this paper
• ADP dissociation from actomyosin subfragment 1 is sufficiently slow to limit the unloaded shortening velocity in vertebrate muscle.

  1985cited by this paper
• Myosin isoenzymes in human hypertrophic hearts. Shift in atrial myosin heavy chains and in ventricular myosin light chains.

  1984cited by this paper
• Interaction of isozymes of myosin subfragment 1 with actin: effect of ionic strength and nucleotide.

  1984cited by this paper
• Fast skeletal muscle myosin light chains 1 and 3 are produced from a single gene by a combined process of differential RNA transcription and splicing.

  1984cited by this paper
• Alternative transcription and two modes of splicing result in two myosin light chains from one gene

  1984cited by this paper

• The SZS is an efficient statistical method to identify regulated splicing events in droplet-based RNA sequencing

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