Molecular Cytogenetics: Genomic Imbalances in Colorectal Cancer and their Clinical Impact

Chromosomal aberrations play a dominant role in colorectal carcinogenesis. The application of fluorescence in situ hybridization (FISH) based techniques such as comparative genomic hybridization (CGH) and spectral karyotyping (SKY) revealed that colorectal carcinomas are characterized by a specific pattern of chromosomal imbalances which sequentially accumulate during cancer progression. This review aims to summarize molecular cytogenetic studies, provides a background on the functional relevance of chromosomal aberrations for colorectal cancer progression and discusses their potential clinical impact.

• Publication year

  2006

• Venue

  Cellular Oncology

• Publication date

  2006-07-05

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1155/2006/173815PMID 16823176PMCID 4615150
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The order of genetic events associated with colorectal cancer progression inferred from meta‐analysis of copy number changes

  2006cited by this paper
• Genome-wide differences between microsatellite stable and unstable colorectal tumors.

  2006cited by this paper
• Relationship of gene expression and chromosomal abnormalities in colorectal cancer.

  2006cited by this paper
• Aneuploidy-dependent massive deregulation of the cellular transcriptome and apparent divergence of the Wnt/beta-catenin signaling pathway in human rectal carcinomas.

  2006cited by this paper
• Epidermal growth factor receptor inhibitors in colorectal cancer: it's time to get back on target.

  2005cited by this paper
• The distinctive nature of HER2-positive breast cancers.

  2005cited by this paper
• Targeting signal transduction pathways in colorectal cancer--more than skin deep.

  2005cited by this paper
• Systemic therapy for colorectal cancer.

  2005cited by this paper
• Array-CGH analysis of microsatellite-stable, near-diploid bowel cancers and comparison with other types of colorectal carcinoma

  2005cited by this paper
• [Systemic therapy for colorectal cancer].

  2005cited by this paper
• Fractional Genomic Alteration Detected by Array-Based Comparative Genomic Hybridization Independently Predicts Survival after Hepatic Resection for Metastatic Colorectal Cancer

  2005cited by this paper
• Increased epidermal growth factor receptor gene copy number detected by fluorescence in situ hybridization associates with increased sensitivity to gefitinib in patients with bronchioloalveolar carcinoma subtypes: a Southwest Oncology Group Study.

  2005cited by this paper
• Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study.

  2005cited by this paper
• A substantial proportion of microsatellite‐unstable colon tumors carry TP53 mutations while not showing chromosomal instability

  2005cited by this paper
• Critical update and emerging trends in epidermal growth factor receptor targeting in cancer.

  2005cited by this paper
• Wavelet transformations of tumor expression profiles reveals a pervasive genome-wide imprinting of aneuploidy on the cancer transcriptome.

  2005cited by this paper
• Chromosomal instability in flat adenomas and carcinomas of the colon

  2005cited by this paper
• Role of genomic markers in colorectal cancer treatment.

  2005cited by this paper
• Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry.

  2005cited by this paper
• Chromosomal Alterations in Lung Metastases of Colorectal Carcinomas: Associations with Tissue Specific Tumor Dissemination

  2005cited by this paper
• Chromosome alterations in colorectal cancer in Thai patients.

  2005cited by this paper
• Involvement of cyclin D3 in liver metastasis of colorectal cancer, revealed by genome-wide copy-number analysis

  2005cited by this paper
• Chromosomes and Cancer, Boveri Revisited

  2005cited by this paper
• The Chromosomal Basis of Cancer

  2005cited by this paper
• DNA Copy Number Changes at 8q11–24 in Metastasized Colorectal Cancer

  2005cited by this paper
• Effectiveness of gene expression profiling for response prediction of rectal adenocarcinomas to preoperative chemoradiotherapy.

  2005cited by this paper
• Genetic changes and clonality relationship between primary colorectal cancers and their pulmonary metastases—An analysis by comparative genomic hybridization

  2005cited by this paper
• Deletion at chromosome band 20p12.1 in colorectal cancer revealed by high resolution array comparative genomic hybridization

  2005cited by this paper
• Epidermal growth factor receptor expression and gene amplification in colorectal carcinoma: an immunohistochemical and chromogenic in situ hybridization study

  2005cited by this paper
• Extending the frontiers of surgical therapy for hepatic colorectal metastases: is there a limit?

  2005cited by this paper
• Centromeric chromosomal translocations show tissue-specific differences between squamous cell carcinomas and adenocarcinomas

  2005cited by this paper
• Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor.

  2004cited by this paper
• Cancer genes and the pathways they control

  2004cited by this paper
• Chromosomal alterations during lymphatic and liver metastasis formation of colorectal cancer.

  2004cited by this paper
• The Impact of Molecular Pathology in Oncology: The Clinician’s Perspective

  2004cited by this paper
• Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer.

  2004cited by this paper
• Tumor karyotype predicts clinical outcome in colorectal cancer patients.

  2004cited by this paper
• Immunohistochemical Detection of EGFR in Paraffin-embedded Tumor Tissues

  2004cited by this paper
• Genomic heterogeneity and instability in colorectal cancer: spectral karyotyping, glutathione transferase-Ml and ras.

  2004cited by this paper
• The tethered configuration of the EGF receptor extracellular domain exerts only a limited control of receptor function.

  2004cited by this paper
• Chromosomal Instability, Aneuploidy, and Gene Mutations in Human Sporadic Colorectal Adenomas

  2004cited by this paper
• Detection of chromosome aberrations in the human interphase nucleus by visualization of specific target DNAs with radioactive and non-radioactive in situ hybridization techniques: diagnosis of trisomy 18 with probe L1.84

  2004cited by this paper
• Identification of novel prognosticators of outcome in squamous cell carcinoma of the head and neck.

  2004cited by this paper
• Carcinogen-induced colon tumors in mice are chromosomally stable and are characterized by low-level microsatellite instability

  2004cited by this paper
• Genetic and pathologic significance of 1p, 17p, and 18q aneusomy and the ERBB2 gene in colorectal cancer and related normal colonic mucosa.

  2004cited by this paper
• Genetic evolution in colon cancer KM12 cells and metastatic derivates

  2004cited by this paper
• Overexpression of E2F-1 in Lung and Liver Metastases of Human Colon Cancer is Associated with Gene Amplification

  2004cited by this paper
• Cytogenetics--in color and digitized.

  2004cited by this paper
• High-resolution analysis of DNA copy number alterations in colorectal cancer by array-based comparative genomic hybridization.

  2004cited by this paper
• Genome characteristics of primary carcinomas, local recurrences, carcinomatoses, and liver metastases from colorectal cancer patients

  2004cited by this paper
• Prognostic relevance of 20q13 gains in sporadic colorectal cancers: a FISH analysis

  2004cited by this paper
• Aneuploidy and cancer

  2004cited by this paper
• Genome signatures of colon carcinoma cell lines.

  2004cited by this paper
• Chromosome Transfer Induced Aneuploidy Results in Complex Dysregulation of the Cellular Transcriptome in Immortalized and Cancer Cells

  2004cited by this paper
• Array Comparative Genomic Hybridization Analysis of Colorectal Cancer Cell Lines and Primary Carcinomas

  2004cited by this paper
• Gene expression profiles predict complete pathologic response to neoadjuvant paclitaxel and fluorouracil, doxorubicin, and cyclophosphamide chemotherapy in breast cancer.

  2004cited by this paper
• Genetic profiling of colorectal cancer liver metastases by combined comparative genomic hybridization and G‐banding analysis

  2003cited by this paper
• Gain of chromosome 8q23-24 is a predictive marker for lymph node positivity in colorectal cancer.

  2003cited by this paper
• Chromosome aberrations in solid tumors

  2003cited by this paper
• Establishment of a colonic adenoma cell line (GEKI-2): spectral karyotype analysis and functional characterization

  2003cited by this paper
• Numerical abnormalities of chromosomes 17 and 18 in sporadic colorectal cancer: Incidence and correlation with clinical and biological findings and the prognosis of the disease

  2003cited by this paper
• Mutations of APC, K-ras, and p53 are associated with specific chromosomal aberrations in colorectal adenocarcinomas.

  2003cited by this paper
• The significance of unstable chromosomes in colorectal cancer

  2003cited by this paper
• Chromosomal imbalances in the colorectal carcinomas with microsatellite instability.

  2003cited by this paper
• Analysis of colorectal tumor progression by microdissection and comparative genomic hybridization

  2003cited by this paper
• Multistep Carcinogenesis: A Chain Reaction of Aneuploidizations

  2003cited by this paper
• Genetic imbalances with impact on survival in colorectal cancer patients

  2003cited by this paper
• Recurrent genetic alterations in 26 colorectal carcinomas and 21 adenomas from Chinese patients.

  2003cited by this paper
• Distinct chromosomal imbalances in nonpolypoid and polypoid colorectal adenomas indicate different genetic pathways in the development of colorectal neoplasms.

  2003cited by this paper
• Gene expression profiling for the prediction of therapeutic response to docetaxel in patients with breast cancer.

  2003cited by this paper
• The sigmoidal curve of cancer

  2003cited by this paper
• Microarray analysis reveals a major direct role of DNA copy number alteration in the transcriptional program of human breast tumors

  2002cited by this paper
• Spectral karyotype analysis of colon cancer cell lines of the tumor suppressor and mutator pathway

  2002cited by this paper
• Silence of chromosomal amplifications in colon cancer.

  2002cited by this paper
• The colorectal adenoma–carcinoma sequence

  2002cited by this paper
• Impact of DNA amplification on gene expression patterns in breast cancer.

  2002cited by this paper
• Stable karyotypes in epithelial cancer cell lines despite high rates of ongoing structural and numerical chromosomal instability.

  2002cited by this paper
• Incidence of chromosomal imbalances in advanced colorectal carcinomas and their metastases

  2002cited by this paper
• Mammary tumors in mice conditionally mutant for Brca1 exhibit gross genomic instability and centrosome amplification yet display a recurring distribution of genomic imbalances that is similar to human breast cancer

  2002cited by this paper
• c-erbB-2 in breast cancer: development of a clinically useful marker.

  2002cited by this paper
• Colorectal adenoma to carcinoma progression follows multiple pathways of chromosomal instability.

  2002cited by this paper
• Felix Mitelman: Database of chromosome aberrations in cancer

  2002cited by this paper
• Debate Surges Over the Origins of Genomic Defects in Cancer

  2002cited by this paper
• Chromosomal aberrations in colorectal cancers and liver metastases analyzed by comparative genomic hybridization

  2001cited by this paper
• Evaluation of myc and chromosome 8 copy number in colorectal cancer using interphase cytogenetics.

  2001cited by this paper
• Refining multimodal therapy for rectal cancer.

  2001cited by this paper
• Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia.

  2001cited by this paper
• Prognostic significance of recurrent chromosomal aberrations detected by comparative genomic hybridization in sporadic colorectal cancer

  2001cited by this paper
• Colorectal cancer genomics: evidence for multiple genotypes which influence survival

  2001cited by this paper
• Assessments of clonal composition of colorectal adenomas by FISH analysis of chromosomes 1, 7, 13 and 20

  2001cited by this paper
• Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome.

  2001cited by this paper
• Differences in 20q13.2 Copy Number between Colorectal Cancers with and without Liver Metastasis

  2001cited by this paper
• Genetic changes in colorectal carcinoma tumors with liver metastases analyzed by comparative genomic hybridization and DNA ploidy

  2001cited by this paper
• Early-onset colorectal cancer with stable microsatellite DNA and near-diploid chromosomes

  2001cited by this paper
• DNA amplification and chromosomal translocations are accompanied by chromosomal instability: analysis of seven human colon cancer cell lines by comparative genomic hybridization and spectral karyotyping.

  2001cited by this paper
• Spectral karyotyping suggests additional subsets of colorectal cancers characterized by pattern of chromosome rearrangement

  2001cited by this paper
• Comprehensive copy number and gene expression profiling of the 17q23 amplicon in human breast cancer

  2001cited by this paper
• New therapies, new directions: advances in the systemic treatment of metastatic colorectal cancer.

  2001cited by this paper
• Spectral karyotyping of the human colon cancer cell lines SW480 and SW620.

  2000cited by this paper
• Differences in 20q13.2 copy number between colorectal cancers with and without liver metastasis.

  2000cited by this paper

• Use of peptide nucleic acid probe to determine telomere dynamics in improving chromosome analysis in genetic toxicology studies.

  2024cites this paper
• Meta-Analytic Operation of Threshold-independent Filtering (MOTiF) reveals sub-threshold genomic robustness in trisomy: The Jörmungandr Effect.

  2023cites this paper
• Genomic profiling of sporadic liver metastatic colorectal cancer.

  2020cites this paper
• Single Chromosome Aneuploidy Induces Genome-Wide Perturbation of Nuclear Organization and Gene Expression

  2019cites this paper
• Single‐cell genetic analysis of clonal dynamics in colorectal adenomas indicates CDX2 gain as a predictor of recurrence

  2018cites this paper
• A functional CNVR_3425.1 damping lincRNA FENDRR increases lifetime risk of lung cancer and COPD in Chinese

  2018cites this paper
• Chromosomal Aberrations Associated with Sequential Steps of the Metastatic Cascade in Colorectal Cancer Patients.

  2018cites this paper
• EXOSC4 functions as a potential oncogene in development and progression of colorectal cancer

  2018cites this paper
• The role of LINE-1 methylation in predicting survival among colorectal cancer patients: a meta-analysis

  2017cites this paper
• Novel mouse model recapitulates genome and transcriptome alterations in human colorectal carcinomas

  2017cites this paper
• Comparison of Results between Cytogenetic Technique and Molecular Genetic Technique in Colorectal Carcinoma Patients

  2017cites this paper
• Associations between novel genetic variants in the promoter region of MALAT1 and risk of colorectal cancer

  2017cites this paper
• Global and chromosome-specific consequences of aneuploidy in Saccharomyces cerevisiae

  2016cites this paper
• Chromosome-Specific and Global Effects of Aneuploidy in Saccharomyces cerevisiae

  2016cites this paper
• Genetic traits for hematogeneous tumor cell dissemination in cancer patients

  2016cites this paper
• Copy number alterations and allelic ratio in relation to recurrence of rectal cancer

  2015cites this paper
• Patterns of Chromosomal Aberrations in Solid Tumors.

  2015cites this paper
• In vitro combined treatment with cetuximab and trastuzumab inhibits growth of colon cancer cells

  2014cites this paper
• An essential microRNA maturing microprocessor complex component DGCR8 is up-regulated in colorectal carcinomas

  2013cites this paper
• A Genome-Wide Study of Cytogenetic Changes in Colorectal Cancer Using SNP Microarrays: Opportunities for Future Personalized Treatment

  2012cites this paper
• Estudio farmacogenético del cáncer colorrectal

  2012cites this paper
• The molecular basis of chemoradiosensitivity in rectal cancer:implications for personalized therapies

  2012cites this paper
• A new whole genome amplification method for studying clonal evolution patterns in malignant colorectal polyps

  2012cites this paper
• The consequences of chromosomal aneuploidy on the transcriptome of cancer cells.

  2012cites this paper
• Effects of the miR-143/-145 microRNA cluster on the colon cancer proteome and transcriptome.

  2012cites this paper
• Expression of the ribonucleases Drosha, Dicer, and Ago2 in colorectal carcinomas

  2011cites this paper
• Genome and transcriptome profiles of CD133-positive colorectal cancer cells.

  2011cites this paper
• Cytogenetic analysis of tumor clonality.

  2011cites this paper
• Characterization of aneuploid populations with trisomy 7 and 20 derived from diploid human colonic epithelial cells.

  2011cites this paper
• Pharmacogenetic analysis in neoadjuvant chemoradiation for rectal cancer: high incidence of somatic mutations and their relation with response.

  2010cites this paper
• Trifluorothymidine Resistance Is Associated with Decreased Thymidine Kinase and Equilibrative Nucleoside Transporter Expression or Increased Secretory Phospholipase A2

  2010cites this paper
• Hydrophobic Bile Acid-Induced Micronuclei Formation, Mitotic Perturbations, and Decreases in Spindle Checkpoint Proteins: Relevance to Genomic Instability in Colon Carcinogenesis

  2010cites this paper
• Trifluorothymidine resistance is associated with decreased thymidine kinase and equilibrative nucleoside transporter expression or increased secretory phospholipase A 2 Molecular Cancer Therapeutics 9 : 1047-57 , 2010

  2010cites this paper
• Applikation der Comparativen Genomischen Hybridisierung (CGH) zur Vorhersage des Ansprechens von Rektumkarzinomen auf neoadjuvante Radiochemotherapie

  2010cites this paper
• Open Access RESEARCH

  2010cites this paper
• Chromosomal copy number changes of locally advanced rectal cancers treated with preoperative chemoradiotherapy.

  2009cites this paper
• Chromosomal instability in sporadic colorectal cancer

  2009influential citation
• Hydrophobic bile acids, genomic instability, Darwinian selection, and colon carcinogenesis

  2008cites this paper
• Chromosomal breakpoints in primary colon cancer cluster at sites of structural variants in the genome.

  2008cites this paper
• Genetic variants in the 8q24 locus and risk of testicular germ cell tumors

  2008cites this paper
• TGF-β Repressors SnoN and Ski Are Implicated in Human Colorectal Carcinogenesis

  2008cites this paper
• Estudi genètic integral de la regió 4p15 i identificació de PI4K2B i STIM2 com a gens alterats en càncer colorectal

  2008cites this paper
• Cell-cycle and Apoptosis Regulators (p16INK4A, p21CIP1, α-Catenin, Survivin, and hTERT) and Morphometry-Defined MPECs Predict Metachronous Cancer Development in Colorectal Adenoma Patients

  2007cites this paper
• Chromosomale Signaturen und Immunprofile in der Tumorprogression kolorektaler Karzinome

  2007cites this paper
• The 13th Fanconi Anemia Gene Identified: FANCI – Importance of the ‘Fanconi Anemia Pathway’ for Cellular Oncology

  2007cites this paper
• Diagnostic significance of allelic imbalance in cancer.

  2007cites this paper
• Analysis of extended genomic rearrangements in oncological research.

  2007cites this paper
• Gene expression profiling reveals a massive, aneuploidy-dependent transcriptional deregulation and distinct differences between lymph node-negative and lymph node-positive colon carcinomas.

  2007cites this paper
• Artificially Introduced Aneuploid Chromosomes Assume a Conserved Position in Colon Cancer Cells

  2007cites this paper
• Mutant spectra of irradiated CHO AL cells determined with multiple markers analyzed by flow cytometry.

  2007cites this paper
• Genomic imbalances in 5918 malignant epithelial tumors: an explorative meta-analysis of chromosomal CGH data

  2007cites this paper
• Distinct Chromosomal Profiles in Metastasizing and Non-Metastasizing Colorectal Carcinomas

  2006cites this paper
• Positive Colon Carcinomas − Lymph Node Negative and − Distinct Differences between Lymph Node Aneuploidy-Dependent Transcriptional Deregulation and Gene Expression Profiling Reveals a Massive

  2006cites this paper
• At Sites of Structural Variants in the Genome Chromosomal Breakpoints in Primary Colon Cancer Cluster Material Supplementary Cited Articles Citing Articles E-mail Alerts Chromosomal Breakpoints in Primary Colon Cancer Cluster at Sites of Structural Variants in the Genome

  year unknowncites this paper