The Caspase Inhibitor IDN-6556 Attenuates Hepatic Injury and Fibrosis in the Bile Duct Ligated Mouse

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Journal of Pharmacology and Experimental Therapeutics

• Publication date

  2004-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0168-8278(04)90022-0PMID 14617689
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• First clinical trial of a novel caspase inhibitor: anti-apoptotic caspase inhibitor, IDN-6556, improves liver enzymes.

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  2003influential reference
• Apoptotic Body Engulfment by a Human Stellate Cell Line Is Profibrogenic

  2003influential reference
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  2003cited by this paper
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• Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis.

  2003influential reference
• The Role of the Macrophage in Apoptosis: Hunter, Gatherer, and Regulator

  2002cited by this paper
• Mechanisms of caspase activation and inhibition during apoptosis.

  2002cited by this paper
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  2002cited by this paper
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  2002influential reference
• Death receptor-mediated apoptosis and the liver.

  2002cited by this paper
• Burden of liver disease in the United States: Summary of a workshop

  2002cited by this paper
• Inflammation in response to hepatocellular apoptosis

  2002cited by this paper
• Production of proinflammatory cytokines by resident tissue macrophages after phagocytosis of apoptotic cells.

  2001cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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• Anti-Fas Induces Hepatic Chemokines and Promotes Inflammation by an NF-κB-independent, Caspase-3-dependent Pathway*

  2001influential reference
• Molecular Regulation of Hepatic Fibrosis, an Integrated Cellular Response to Tissue Injury*

  2000cited by this paper
• The biochemistry of apoptosis

  2000cited by this paper
• Quantitative grading of rat esophageal carcinogenesis using computer-assisted image tile analysis.

  2000cited by this paper
• Hepatocyte apoptosis after bile duct ligation in the mouse involves Fas.

  1999influential reference
• Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors.

  1998cited by this paper
• Chemokines--chemotactic cytokines that mediate inflammation.

  1998cited by this paper
• Parenchymal cell apoptosis as a signal for sinusoidal sequestration and transendothelial migration of neutrophils in murine models of endotoxin and fas‐antibody–induced liver injury

  1998influential reference
• Regulation of the proinflammatory effects of Fas ligand (CD95L).

  1998cited by this paper
• Caspases: key mediators of apoptosis.

  1998cited by this paper
• Death receptors: signaling and modulation.

  1998cited by this paper
• Caspases: enemies within.

  1998cited by this paper
• Activation of caspase 3 (CPP32)-like proteases is essential for TNF-alpha-induced hepatic parenchymal cell apoptosis and neutrophil-mediated necrosis in a murine endotoxin shock model.

  1998influential reference
• Caspase 1-independent IL-1β release and inflammation induced by the apoptosis inducer Fas ligand

  1998cited by this paper
• Adenovirus‐mediated expression of cytokine‐induced neutrophil chemoattractant in rat liver induces a neutrophilic hepatitis

  1997cited by this paper
• Differential Induction of Apoptosis by Fas–Fas Ligand Interactions in Human Monocytes and Macrophages

  1997cited by this paper
• Digital Image Analysis

  1995cited by this paper
• Digital image analysis.

  1995cited by this paper
• Lethal effect of the anti-Fas antibody in mice

  1993cited by this paper

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  2020cites this paper
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  2020cites this paper
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