HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Nature Cell Biology

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/ncb2008PMID 20023648
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• HCLK2 Is Required for Activity of the DNA Damage Response Kinase ATR*

  2009cited by this paper
• The DNA-damage response in human biology and disease

  2009cited by this paper
• RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins.

  2009cited by this paper
• The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage.

  2009cited by this paper
• A Tribute to Arthur Kornberg 1918–2007

  2008cited by this paper
• Noncanonical E2 Variant-Independent Function of UBC13 in Promoting Checkpoint Protein Assembly

  2008cited by this paper
• Orchestration of the DNA-Damage Response by the RNF8 Ubiquitin Ligase

  2007cited by this paper
• Tel2 regulates the stability of PI3K-related protein kinases.

  2007cited by this paper
• RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly.

  2007cited by this paper
• RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins.

  2007cited by this paper
• ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage

  2007cited by this paper
• A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination.

  2007cited by this paper
• DNA damage checkpoints: from initiation to recovery or adaptation.

  2007cited by this paper
• Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage

  2007cited by this paper
• Ubc13/Rnf8ユビキチンリガーゼはDNS損傷に反応してRap80/Abraxas/Brca1/Brca1/Brcc36複合体のフォーカス形成を制御する

  2007cited by this paper
• Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress.

  2006cited by this paper
• Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks

  2006cited by this paper
• The RING finger protein RNF8 recruits UBC13 for lysine 63‐based self polyubiquitylation

  2006cited by this paper
• Genome organization, function, and imprinting in Prader-Willi and Angelman syndromes.

  2001cited by this paper
• N-Terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8.

  2001cited by this paper
• The FHA domain is a modular phosphopeptide recognition motif.

  1999cited by this paper
• The ancestral gene for transcribed, low-copy repeats in the Prader-Willi/Angelman region encodes a large protein implicated in protein trafficking, which is deficient in mice with neuromuscular and spermiogenic abnormalities.

  1999cited by this paper
• A very large protein with diverse functional motifs is deficient in rjs (runty, jerky, sterile) mice.

  1998cited by this paper
• Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels.

  1996cited by this paper

• The mutual regulation of SOX12 and RNF168 modulates cisplatin resistance in esophageal squamous cell carcinoma cells by regulating DNA damage repair

  2026cites this paper
• Long-term exposure to silica nanoparticles induces DNA damage by activating ferritinophagy in the lungs.

  2026cites this paper
• Hypoxia Increases Cardiac Proteasomal Activity and Differentially Modulates Cullin-RING E3 Ligases in the Naked Mole-Rat Heterocephalus glaber

  2026cites this paper
• Integrative Machine Learning Model for Overall Survival Prediction in Breast Cancer Using Clinical and Transcriptomic Data

  2025cites this paper
• Radiation-induced nuclear translocation of NPRL2 hijacks E3 ubiquitin ligases to enhance DNA repair via the AMPK/WDR24 axis, contributing to CRC radioresistance

  2025cites this paper
• Multiomic integration reveals subtype-specific predictors of neoadjuvant treatment response in breast cancer

  2025cites this paper
• Mechanistic insights into the iron–sulfur cluster-dependent interaction of the autophagy receptor NCOA4 with the E3 ligase HERC2

  2025cites this paper
• HERC2 as a Potential Biomarker for Prognosis and Response to Bevacizumab in Ovarian Cancer: A Bioinformatics Approach

  2025cites this paper
• DNA repair and inflammatory response genes play a central role in protecting patients with long-standing type 1 diabetes from vascular complications.

  2025cites this paper
• Crucian carp HERC7 is an RNA binding protein that selectively targets IRF7 mRNA to downregulate IFN response.

  2025cites this paper
• RIDDLE syndrome ring finger protein 168 deficiency in a 9-month-old boy from Jazan, Saudi Arabia

  2024cites this paper
• The Role of Ubiquitination in Osteosarcoma Development and Therapies

  2024cites this paper
• New Discoveries on Protein Recruitment and Regulation during the Early Stages of the DNA Damage Response Pathways

  2024cites this paper
• SUMO and the DNA damage response

  2024cites this paper
• The disordered negatively charged C‐terminus of the large HECT E3 ubiquitin ligase HERC2 provides structural and thermal stability to the HECT C‐lobe

  2024cites this paper
• Whole Exome Sequencing Reveals Clustering of Variants of Known Vitiligo Genes in Multiplex Consanguineous Pakistani Families

  2023cites this paper
• SRSF1 is essential for primary follicle development by regulating granulosa cell survival via mRNA alternative splicing

  2023cites this paper
• Mechanisms of Ferritinophagy and Ferroptosis in Diseases

  2023cites this paper
• HIC1 interacts with FOXP3 multi protein complex: novel pleiotropic mechanisms to regulate human regulatory T cell differentiation and function.

  2023cites this paper
• Ferritinophagy in the etiopathogenic mechanism of related diseases.

  2023cites this paper
• Neuroprotective Mechanisms of Amylin Receptor Activation, Not Antagonism, in the APP/PS1 Mouse Model of Alzheimer’s Disease

  2023cites this paper
• HIC1 interacts with FOXP3 multi protein complex: a novel mechanism to regulate human regulatory T cell differentiation and function

  2023cites this paper
• Oxidative-Stress-Associated Proteostasis Disturbances and Increased DNA Damage in the Hippocampal Granule Cells of the Ts65Dn Model of Down Syndrome

  2022cites this paper
• Probing protein ubiquitination in live cells

  2022cites this paper
• Evaluation of Personalized Skincare Through in-silico Gene Interactive Networks and Cellular Responses to UVR and Oxidative Stress

  2022cites this paper
• Chromatin Ubiquitination Guides DNA Double Strand Break Signaling and Repair

  2022cites this paper
• LncRNA CTBP1-DT-encoded microprotein DDUP sustains DNA damage response signalling to trigger dual DNA repair mechanisms

  2022cites this paper
• Genetic diagnosis in Sudanese and Tunisian families with syndromic intellectual disability through exome sequencing

  2022cites this paper
• NCOA4 links iron bioavailability to DNA metabolism.

  2022cites this paper
• Multifaceted regulation and functions of 53BP1 in NHEJ-mediated DSB repair (Review)

  2022cites this paper
• Prognostic and therapeutic value of somatic mutations in diffuse large B-cell lymphoma: A systematic review.

  2021cites this paper
• Genetic alterations associated with malignant transformation of sporadic vestibular schwannoma

  2021cites this paper
• Damsel in distress calling on her knights: Illuminating the pioneering role of E3 ubiquitin ligases in guarding the genome integrity.

  2021cites this paper
• HERC2 inactivation abrogates nucleolar localization of RecQ helicases BLM and WRN

  2021cites this paper
• Molecular Drivers of Developmental Arrest in the Human Preimplantation Embryo: A Systematic Review and Critical Analysis Leading to Mapping Future Research

  2021cites this paper
• ASPM promotes homologous recombination-mediated DNA repair by safeguarding BRCA1 stability

  2021cites this paper
• A comprehensive phenotypic CRISPR-Cas9 screen of the ubiquitin pathway uncovers roles of ubiquitin ligases in mitosis.

  2021cites this paper
• Historical perspective and progress on protein ubiquitination at glutamatergic synapses.

  2021cites this paper
• HERC2 inactivation abrogates nucleolar localization of RecQ helicases BLM and WRN

  2021cites this paper
• Circadian Rhythm of NER and ATR Pathways

  2021cites this paper
• Exploring the Roles of HERC2 and the NEDD4L HECT E3 Ubiquitin Ligase Subfamily in p53 Signaling and the DNA Damage Response

  2021influential citation
• Regulation of Histone Ubiquitination in Response to DNA Double Strand Breaks

  2020cites this paper
• Exome Sequencing Revealed Mutations in ADAT3 and HERC2 Genes in two Sudanese Families with Syndromic Mental Retardation

  2020cites this paper
• HECT E3 ubiquitin ligases – emerging insights into their biological roles and disease relevance

  2020cites this paper
• RNF168-Mediated Ubiquitin Signaling Inhibits the Viability of BRCA1-Null Cancers

  2020cites this paper
• The Role of Posttranslational Modifications in DNA Repair

  2020cites this paper
• E2 ubiquitin-conjugating enzyme UBE2L6 promotes Senecavirus A proliferation by stabilizing the viral RNA polymerase

  2020cites this paper
• From quality control to neurodegeneration : regulation of autophagy and the DNA damage response by ubiquitin-modifying enzymes

  2020cites this paper
• ATM-mediated DNA double-strand break response facilitated oncolytic Newcastle disease virus replication and promoted syncytium formation in tumor cells

  2020cites this paper
• RNF8 has both KU-dependent and independent roles in chromosomal break repair

  2020cites this paper
• HERC Ubiquitin Ligases in Cancer

  2020influential citation
• Novel loss-of-function mutation in HERC2 is associated with severe developmental delay and paediatric lethality

  2020cites this paper
• RNA-seq analysis of galaninergic neurons from ventrolateral preoptic nucleus identifies expression changes between sleep and wake

  2019cites this paper
• Activation and Regulation of the ALKBH3-ASCC Alkylation Repair Pathway

  2019cites this paper
• DNA Repair

  2019cites this paper
• Beyond reversal: ubiquitin and ubiquitin-like proteases and the orchestration of the DNA double strand break repair response

  2019cites this paper
• New Aspects of HECT-E3 Ligases in Cell Senescence and Cell Death of Plants

  2019cites this paper
• SUMOylation homeostasis in tumorigenesis.

  2019cites this paper
• Investigation of Cell-Type-Specific Effects and Synergistic Interactions Between Genes in Duplication 15q Syndrome

  2019cites this paper
• Cell Type-Specific Methylome-wide Association Studies Implicate Neurotrophin and Innate Immune Signaling in Major Depressive Disorder.

  2019cites this paper
• Peptidomic analysis of blastocyst culture medium and the effect of peptide derived from blastocyst culture medium on blastocyst formation and viability

  2019cites this paper
• Regulation of the MDM2‐p53 pathway by the ubiquitin ligase HERC2

  2019cites this paper
• Chromatin control in double strand break repair.

  2019cites this paper
• HERC2 regulates RPA2 by mediating ATR-induced Ser33 phosphorylation and ubiquitin-dependent degradation

  2019cites this paper
• Open source bioimage informatics tools for the analysis of DNA damage and associated biomarkers

  2019cites this paper
• Homologous Recombination-Mediated DNA Repair and Implications for Clinical Treatment of Repair Defective Cancers.

  2019cites this paper
• HERCing: Structural and Functional Relevance of the Large HERC Ubiquitin Ligases

  2019cites this paper
• Processes that Regulate the Ubiquitination of Chromatin and Chromatin-Associated Proteins

  2019cites this paper
• NudC-like protein 2 restrains centriole amplification by stabilizing HERC2

  2019cites this paper
• HERC2 promotes BLM and WRN to suppress G-quadruplex DNA

  2018cites this paper
• HERC2 Facilitates BLM and WRN Helicase Complex Interaction with RPA to Suppress G-Quadruplex DNA.

  2018cites this paper
• Gene expression imputation identifies candidate genes and susceptibility loci associated with cutaneous squamous cell carcinoma

  2018cites this paper
• Ferritinophagy/ferroptosis: Iron‐related newcomers in human diseases

  2018cites this paper
• Rare Genetic Diseases with Defects in DNA Repair: Opportunities and Challenges in Orphan Drug Development for Targeted Cancer Therapy

  2018cites this paper
• Investigations into the spatial distribution of γH2AX around a DNA double-strand break and the analysis of double-strand break mobility

  2018cites this paper
• The Role of Nuclear Architecture in DNA Repair

  2018influential citation
• Network Analysis of UBE3A/E6AP-Associated Proteins Provides Connections to Several Distinct Cellular Processes.

  2018cites this paper
• Cell-type-specific methylome-wide association studies implicate neurodegenerative processes and neuroimmune communication in major depressive disorder

  2018cites this paper
• PHOPSPHORYLATION AND UBIQUITIN MODIFICATION AT DNA DAMAGE SITES IN RESPONSE TO DOUBLE-STRAND BREAKS

  2017cites this paper
• Using genetics to predict patient response to platinum-based chemotherapy

  2017cites this paper
• Identification of Factors Involved in the DNA Repair Phase of B Cell Class Switch Recombination

  2017cites this paper
• Enzyme–substrate relationships in the ubiquitin system: approaches for identifying substrates of ubiquitin ligases

  2017cites this paper
• Differences in bone structure and unloading-induced bone loss between C57BL/6N and C57BL/6J mice

  2017cites this paper
• Molecular Basis for K63-Linked Ubiquitination Processes in Double-Strand DNA Break Repair: A Focus on Kinetics and Dynamics.

  2017cites this paper
• Inference on the Genetic Basis of Eye and Skin Color in an Admixed Population via Bayesian Linear Mixed Models

  2017cites this paper
• E3 ubiquitin ligases in cancer and implications for therapies

  2017cites this paper
• RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain

  2017cites this paper
• Ubiquitin-like modifications in the DNA damage response.

  2017cites this paper
• Associations of OCA2-HERC2 SNPs and haplotypes with human pigmentation characteristics in the Brazilian population.

  2017cites this paper
• Epigenetic mechanisms involved in the cellular response to DNA damage processed by Base Excision Repair

  2017cites this paper
• Tumors overexpressing RNF168 show altered DNA repair and responses to genotoxic treatments, genomic instability and resistance to proteotoxic stress

  2017cites this paper
• DNA Damage-inducing Compounds: Unraveling their Pleiotropic Effects Using High Throughput Sequencing.

  2017cites this paper
• Eukaryotic DNA damage responses: Homologous recombination factors and ubiquitin modification.

  2017cites this paper
• Centrosomal MCM7 strengthens the Cep68-VHL interaction and excessive MCM7 leads to centrosome splitting resulting from increase in Cep68 ubiquitination and proteasomal degradation.

  2017cites this paper
• SUMO in the DNA Double-Stranded Break Response: Similarities, Differences, and Cooperation with Ubiquitin.

  2017cites this paper
• NCOA4 Deficiency Impairs Systemic Iron Homeostasis.

  2016cites this paper
• A Genome-scale RNA Interference Screen Identifies Novel Regulators of DNA Double-strand Break Repair

  2016cites this paper
• Breast cancer predisposition gene brca1, pathogenic c61g mutation in mice: synthetic viability in DNA repair and tumour development

  2016influential citation
• Writers, Readers, and Erasers of Histone Ubiquitylation in DNA Double-Strand Break Repair

  2016cites this paper
• Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers

  2016cites this paper