R. Chapin

A multi-institutional study benchmarking the zebrafish developmental assay for prediction of embryotoxic plasma concentrations from rat embryo-fetal development studies.
201932 citationsauthor #4
Chapter 17 – Male Reproductive System
20189 citationsauthor #2
Predictivity of Nonclinical Male Reproductive Findings for Human Effects.
20184 citationsauthor #3
Use of Rat Primary Mesenteric Cells for the Prediction of PDE4 Inhibitor Drug-Induced Vascular Injury
20170 citationsauthor #2
Effects of the Janus Kinase Inhibitor, Tofacitinib, on Testicular Leydig Cell Hyperplasia and Adenoma in Rats, and on Prolactin Signaling in Cultured Primary Rat Leydig Cells
20179 citationsauthor #1
Lost in translation: The search for an in vitro screen for spermatogenic toxicity.
201624 citationsauthor #1
Nonclinical Models for Neonatal Pediatric Drug Development
20161 citationsauthor #6
Goldilocks' Determination of What New In Vivo Data are "Just Right" for Different Common Drug Development Scenarios, Part 1.
20167 citationsauthor #2
Alternative Models of Developmental and Reproductive Toxicity in Pharmaceutical Risk Assessment and the 3Rs.
201662 citationsauthor #2
Age-related testicular toxicity of mGluR5 negative allosteric modulators appears to be unrelated to testis drug transporter maturity.
20151 citationsauthor #4
CHAPTER 12:Safety Considerations for Epigenetic Mechanisms as Drug Targets: Are Existing Toxicology Studies Fit for Purpose?
20153 citationsauthor #3
Reproductive toxicities of methoxychlor based on estrogenic properties of the compound and its estrogenic metabolite, hydroxyphenyltrichloroethane.
201418 citationsauthor #2
Primary cell cultures for understanding rat epididymal inflammation.
20145 citationsauthor #1
More than just hormones: H295R cells as predictors of reproductive toxicity.
201428 citationsauthor #3
Exposure-based validation list for developmental toxicity screening assays.
201454 citationsauthor #4
Testicular and epididymal toxicity: Pathogenesis and potential mechanisms of toxicity
20148 citationsauthor #2
Reproductive System, Male
201415 citationsauthor #1
Summary of the HESI consortium studies exploring circulating inhibin B as a potential biomarker of testis damage in the rat.
201311 citationsauthor #1
Assuring safety without animal testing: the case for the human testis in vitro.
201314 citationsauthor #1
Review Article Introduction to the HESI-Sponsored Inhibin Consortium
20130 citationsauthor #1
Evidence-based toxicology for the 21st century: opportunities and challenges.
201352 citationsauthor #7
In vitro testicular toxicity models: opportunities for advancement via biomedical engineering techniques.
201332 citationsauthor #5
Male Reproductive System
2013167 citationsauthor #2
The inhibin B response in male rats treated with two drug candidates.
20133 citationsauthor #1
Analytic evaluation of a human ELISA kit for measurement of inhibin B in rat samples.
201314 citationsauthor #6
Introduction to the HESI-sponsored inhibin consortium.
20131 citationsauthor #1
SOT Symposium Highlight: Translatable Indicators of Testicular Toxicity: Inhibin B, MicroRNAs, and Sperm Signatures.
201316 citationsauthor #6
Comparative assessment of the timing of sexual maturation in male Wistar Han and Sprague-Dawley rats.
201347 citationsauthor #3
Testing strategies for embryo-fetal toxicity of human pharmaceuticals. Animal models vs. in vitro approaches: a workshop report.
201241 citationsauthor #2
Assessment of Circulating Hormones in Regulatory Toxicity Studies II. Male Reproductive Hormones
201240 citationsauthor #1
Isoflurane reduces motile sperm counts in the Sprague-Dawley rat
201215 citationsauthor #3
Society of Toxicologic Pathology Position Paper: Review Series: Assessment of Circulating Hormones in Nonclinical Toxicity Studies: General Concepts and Considerations
201217 citationsauthor #3
Not a walk in the park: the ECVAM whole embryo culture model challenged with pharmaceuticals and attempted improvements with random forest design.
201113 citationsauthor #3
Histologic and Cytologic Detection of Endocrine and Reproductive Tract Effects of Exemestane in Female Rats Treated for up to Twenty-eight Days
201115 citationsauthor #5
Incidence and nature of testicular toxicity findings in pharmaceutical development.
201141 citationsauthor #2
Impaired reproduction in adult male, but not female, rats following juvenile treatment with the aromatase inhibitor, exemestane.
201111 citationsauthor #2
Determination of the di-(2-ethylhexyl) phthalate NOAEL for reproductive development in the rat: importance of the retention of extra animals to adulthood.
201067 citationsauthor #4
Sisyphus Lives: Pfizer's Efforts to Tweak and Improve the Embryonic Stem Cell Test (EST)
20100 citationsauthor #1
Maternal-placental insulin-like growth factor (IGF) signaling and its importance to normal embryo-fetal development.
201061 citationsauthor #3
A different approach to validating screening assays for developmental toxicity.
201059 citationsauthor #2
Endless possibilities: stem cells and the vision for toxicology testing in the 21st century.
200965 citationsauthor #1
Inter-laboratory control data for reproductive endpoints required in the OPPTS 870.3800/OECD 416 reproduction and fertility test.
200924 citationsauthor #3
NTP-CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A.
2008531 citationsauthor #1
State of the art in developmental toxicity screening methods and a way forward: a meeting report addressing embryonic stem cells, whole embryo culture, and zebrafish.
200876 citationsauthor #1
Assessment of the Embryonic Stem Cell Test and application and use in the pharmaceutical industry.
2008116 citationsauthor #5
Struggles for equivalence: in vitro developmental toxicity model evolution in pharmaceuticals in 2006.
200728 citationsauthor #1
Syzygy's Enlightenments
20070 citationsauthor #1
In utero exposure to the antiandrogen 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) in relation to anogenital distance in male newborns from Chiapas, México.
200791 citationsauthor #7
In utero exposure to the antiandrogen 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) in relation to anogenital distance in male newborns from Chiapas, México.
200791 citationsauthor #6
Effects of boric acid supplementation on bone histomorphometry, metabolism, and biomechanical properties in aged female F-344 rats
200740 citationsauthor #7
Chronic Ethanol Perturbs Testicular Folate Metabolism and Dietary Folate Deficiency Reduces Sex Hormone Levels in the Yucatan Micropig1
200732 citationsauthor #3
Toxicological highlights.
20070 citationsauthor #1
Introduction to Female Reproductive Physiology and Toxicology Review Series
20071 citationsauthor #1
The effects of dietary boric acid on bone strength in rats
200753 citationsauthor #1
CERHR Expert Panel Report NTP-CERHR Expert Panel update on the reproductive and developmental toxicity of di(2-ethylhexyl) phthalate
20066 citationsauthor #6
Chronic Ethanol Perturbs Testicular Folate Metabolism and Dietary Folate Deficiency 1 Reduces Sex Hormone Levels in the Yucatan Micropig 2 3 Short Title: Chronic Ethanol and Folate Deficiency in Micropigs
20060 citationsauthor #3
NTP-CERHR Expert Panel Update on the Reproductive and Developmental Toxicity of di(2-ethylhexyl) phthalate.
2006228 citationsauthor #6
Developmental toxicology evaluations--issues with including neurotoxicology and immunotoxicology assessments in reproductive toxicology studies.
200541 citationsauthor #2
The effects of feed restriction during organogenesis on embryo-fetal development in the rat.
200515 citationsauthor #3
Male Reproductive Toxicology
20051 citationsauthor #2
Atrazine : Mechanisms of Hormonal Imbalance in Female SD Rats
20052 citationsauthor #1
Effects of feed restriction during organogenesis on embryo-fetal development in rabbit.
200584 citationsauthor #3
Effects of feed restriction on fertility in female rats.
200531 citationsauthor #7
NTP-CERHR expert panel report on the reproductive and developmental toxicity of acrylamide.
200565 citationsauthor #5
Off to a good start: the influence of pre- and periconceptional exposures, parental fertility, and nutrition on children's health.
200496 citationsauthor #1
Thyroid hormone, glucocorticoids, and prolactin at the nexus of physiology, reproduction, and toxicology.
200488 citationsauthor #7
Nature is complex: our orchestra seats at the most wonderful show on earth.
200411 citationsauthor #1
Reproductive Assessment by Continuous Breeding: Evolving Study Design and Summaries of Eighty-Eight Studies
20042 citationsauthor #1
Cadmium at a non-toxic dose alters gene expression in mouse testes.
2004101 citationsauthor #3
Boron Supplementation Inhibits the Growth and Local Expression of IGF-1 in Human Prostate Adenocarcinoma (LNCaP) Tumors in Nude Mice
2004108 citationsauthor #2
Male Reproductive Toxicology
200447 citationsauthor #2
Inhibition of the enzymatic activity of prostate‐specific antigen by boric acid and 3‐nitrophenyl boronic acid
200374 citationsauthor #5
Development and maturation of the male reproductive system.
2003134 citationsauthor #2
Our once-in-a-lifetime opportunity.
200320 citationsauthor #1
Critical evaluation of observed adverse effects of endocrine active substances on reproduction and development, the immune system, and the nervous system
200397 citationsauthor #2
Long-term, low-dose lead exposure alters the gonadotropin-releasing hormone system in the male rat.
200287 citationsauthor #6
The pesticide methoxychlor given orally during the perinatal/juvenile period, reduced the spermatogenic potential of males as adults by reducing their Sertoli cell number.
200215 citationsauthor #5
NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-n-octyl phthalate.
2002157 citationsauthor #3
NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-isodecyl phthalate.
200223 citationsauthor #3
The hidden effect of estrogenic/antiandrogenic methoxychlor on spermatogenesis.
200229 citationsauthor #3
NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of butyl benzyl phthalate.
200241 citationsauthor #3
Recommended Approaches for the Evaluation of Testicular and Epididymal Toxicity
2002226 citationsauthor #3
NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di(2-ethylhexyl) phthalate.
2002496 citationsauthor #3
NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-n-butyl phthalate.
2002149 citationsauthor #3
NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-isononyl phthalate.
200286 citationsauthor #3
NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-n-hexyl phthalate.
200231 citationsauthor #3
Neurotoxicological outcomes of perinatal heptachlor exposure in the rat.
200142 citationsauthor #6
Protein Kinase Activity Is Central to Rat Germ Cell Apoptosis Induced by Methoxyacetic Acid
200127 citationsauthor #4
The effects of perinatal tebuconazole exposure on adult neurological, immunological, and reproductive function in rats.
200192 citationsauthor #8
Rat testicular Src: normal distribution and involvement in ethylene glycol monomethyl ether-induced apoptosis.
200036 citationsauthor #3
Prioritization of NTP reproductive toxicants for field studies.
200060 citationsauthor #3
Differential gene expression detected by suppression subtractive hybridization in the ethylene glycol monomethyl ether-induced testicular lesion.
200020 citationsauthor #2
Evaluating the effects of endocrine disruptors on endocrine function during development.
1999221 citationsauthor #2
Normative reproductive indices for male and female adult Sprague-Dawley rats.
199925 citationsauthor #6
The effects of 4-nonylphenol in rats: a multigeneration reproduction study.
1999166 citationsauthor #1
Toxicity of 3,3',4,4'-tetrachloroazoxybenzene in rats and mice.
199920 citationsauthor #5
Toxicity of 3,3',4,4'-tetrachloroazobenzene in rats and mice.
19999 citationsauthor #5
General, reproductive, developmental, and endocrine toxicity of boronated compounds.
1998143 citationsauthor #2
Reproductive endpoints in general toxicity studies: are they predictive?
199829 citationsauthor #1
Reproductive toxicity of methoxychlor in rats
19980 citationsauthor #1

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