S100A4, a Mediator of Metastasis*

The transition from benign tumor growth to malignancy is manifested by the ability of tumor cells to traverse tissue barriers and invade surrounding tissues. The traversal of basement membrane barriers is thought to be the critical event in the initiation of themetastatic cascade and, as described by the three-step hypothesis of metastasis, involves attachment to the extracellular matrix, local proteolysis, and subsequentmigration (1). In recent years, a number of specific genes have been identified, the expressions of which correlate with tumorigenesis and/or metastatic potential. S100A4 is a member of the S100 family of calcium-binding proteins that is directly involved in tumor metastasis. This report reviews the animal and cellular studies implicating S100A4 in the establishment of the metastatic phenotype and examines the biochemical properties of S100A4 that are relevant to its role as a metastasis factor.

• Publication year

  2006

• Venue

  Journal of Biological Chemistry

• Publication date

  2006-01-13

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1074/jbc.R500017200PMID 16243835
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2005cited by this paper
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  2005cited by this paper
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  2005cited by this paper
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  2005cited by this paper
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  2005cited by this paper
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  2005cited by this paper
• Functional Significance of Metastasis-inducing S100A4(Mts1) in Tumor-Stroma Interplay*

  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2002cited by this paper
• Calcium coordination studies of the metastatic Mts1 protein.

  2002cited by this paper
• Prognostic significance of S100A4 expression in gallbladder cancer.

  2002cited by this paper
• Liprin β1, a Member of the Family of LAR Transmembrane Tyrosine Phosphatase-interacting Proteins, Is a New Target for the Metastasis-associated Protein S100A4 (Mts1)*

  2002cited by this paper
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  2002cited by this paper
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  2002cited by this paper
• Solution structure of human Mts1 (S100A4) as determined by NMR spectroscopy.

  2002cited by this paper
• Methionine Aminopeptidase 2 Is a New Target for the Metastasis-associated Protein, S100A4*

  2002cited by this paper
• S100 proteins: structure, functions and pathology.

  2002cited by this paper
• Solution NMR structure of S100B bound to the high-affinity target peptide TRTK-12.

  2002cited by this paper
• The metastasis-associated Mts1(S100A4) protein could act as an angiogenic factor

  2001cited by this paper
• Inhibition of p53 Transcriptional Activity by the S100B Calcium-binding Protein*

  2001cited by this paper
• Tumor Suppressor p53 Protein Is a New Target for the Metastasis-associated Mts1/S100A4 Protein

  2001cited by this paper
• Characterization of Sp1, AP-1, CBF and KRC binding sites and minisatellite DNA as functional elements of the metastasis-associated mts1/S100A4 gene intronic enhancer.

  2001cited by this paper
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  2001cited by this paper
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  2001cited by this paper
• Heterocomplex formation between metastasis‐related protein S100A4 (Mts1) and S100A1 as revealed by the yeast two‐hybrid system

  2000cited by this paper
• Structure of the negative regulatory domain of p53 bound to S100B(ββ)

  2000cited by this paper
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  2000cited by this paper
• Calcium: The Molecular Basis of Calcium Action in Biology and Medicine

  2000cited by this paper
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  2000cited by this paper
• Comparison of the metastasis‐inducing protein S100A4 (p9ka) with other prognostic markers in human breast cancer

  2000cited by this paper
• Inverse expression of S100A4 and E-cadherin is associated with metastatic potential in gastric cancer.

  2000cited by this paper
• Interaction in Vivo and in Vitro of the Metastasis-inducing S100 Protein, S100A4 (p9Ka) with S100A1*

  2000cited by this paper
• S100A6 and S100A11 Are Specific Targets of the Calcium- and Zinc-binding S100B Protein in Vivo *

  2000cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
• Differential Reactivity of the RatS100A4(p9Ka) Gene to Sodium Bisulfite Is Associated with Differential Levels of the S100A4 (p9Ka) mRNA in Rat Mammary Epithelial Cells*

  1999cited by this paper
• Differential reactivity of the rat S100A4(p9Ka) gene to sodium bisulfite is associated with differential levels of the S100A4 (p9Ka) mRNA in rat mammary epithelial cells.

  1999cited by this paper
• A change-in-hand mechanism for S100 signalling.

  1998cited by this paper
• Metastasis-associated Mts1 (S100A4) Protein Modulates Protein Kinase C Phosphorylation of the Heavy Chain of Nonmuscle Myosin*

  1998cited by this paper
• Spectral studies on the calcium‐binding properties of Mts1 protein and its interaction with target protein

  1997cited by this paper
• Expression of the metastasis‐associated mts1 gene during mouse development

  1997cited by this paper
• Effect of Mts1 on the structure and activity of nonmuscle myosin II.

  1997cited by this paper
• A κB-related Binding Site Is an Integral Part of the mts1 Gene Composite Enhancer Element Located in the First Intron of the Gene*

  1997cited by this paper
• Expression of antisense RNA to S100A4 gene encoding an S100-related calcium-binding protein suppresses metastatic potential of high-metastatic Lewis lung carcinoma cells

  1997cited by this paper
• Oligomerization state of S100B at nanomolar concentration determined by large‐zone analytical gel filtration chromatography

  1997cited by this paper
• Effect of mts1 (S100A4) expression on the progression of human breast cancer cells

  1996cited by this paper
• Novel AP-1 binding site created by DNA-methylation.

  1996cited by this paper
• Metastasis-related mts1 gene.

  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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  1993cited by this paper
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  1993cited by this paper
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  1993cited by this paper
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  1993cited by this paper
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  1992cited by this paper
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  1992cited by this paper
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  1992cited by this paper
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  1992cited by this paper
• Characterization of the tumor suppressor protein p53 as a protein kinase C substrate and a S100b-binding protein.

  1992cited by this paper
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  1992cited by this paper
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  1989cited by this paper
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  1989cited by this paper
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  1988cited by this paper
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  1988cited by this paper
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  1988cited by this paper
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  1987cited by this paper
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  1987cited by this paper
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  1983cited by this paper
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  1965cited by this paper

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