Evidence for cAMP-independent mechanisms mediating the effects of adrenomedullin, a new inotropic peptide.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Circulation

• Publication date

  1998-03-24

• Fields of study

  Medicine

• Identifiers
  DOI 10.1161/01.CIR.97.11.1062PMID 9531253
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Adrenomedullin stimulates cAMP accumulation and inhibits atrial natriuretic peptide gene expression in cardiomyocytes.

  1997cited by this paper
• Direct cardiac and vascular actions of adrenomedullin in conscious sheep

  1997cited by this paper
• Intravascular and interstitial degradation of bradykinin in isolated perfused rat heart

  1997cited by this paper
• Negative inotropic effect of adrenomedullin in isolated adult rabbit cardiac ventricular myocytes.

  1997cited by this paper
• Negative Inotropic Effect of Adrenomedullin in Isolated Adult Rabbit Cardiac Ventricular Myocytes

  1997cited by this paper
• Adrenomedullin augments inducible nitric oxide synthase expression in cytokine-stimulated cardiac myocytes.

  1996cited by this paper
• Stretch-induced increase in atrial natriuretic peptide secretion is blocked by thapsigargin.

  1996cited by this paper
• Inotropic effect of adrenomedullin in the isolated perfused rat heart.

  1996cited by this paper
• Adrenomedullin.

  1996cited by this paper
• Effect of gadolinium on stretch‐induced changes in contraction and intracellularly recorded action‐ and afterpotentials of rat isolated atrium

  1996cited by this paper
• Distribution and characterization of rat immunoreactive proadrenomedullin N-terminal 20 peptide (PAMP) and the augmented cardiac PAMP in spontaneously hypertensive rat.

  1996cited by this paper
• Plasma adrenomedullin concentration in patients with heart failure.

  1996cited by this paper
• Adrenomedullin: A newly discovered hormone controlling fluid and electrolyte homeostasis.

  1996influential reference
• Cardiac secretion of adrenomedullin in human heart failure.

  1996cited by this paper
• Specific binding sites for proadrenomedullin N-terminal 20 peptide (PAMP) in the rat.

  1996cited by this paper
• An abundant and specific binding site for the novel vasodilator adrenomedullin in the rat.

  1995cited by this paper
• A novel vasoactive peptide, adrenomedullin, inhibits pituitary adrenocorticotropin release.

  1995cited by this paper
• Effects of vasoactive substances and cAMP related compounds on adrenomedullin production in cultured vascular smooth muscle cells

  1995cited by this paper
• Adrenomedullin suppresses mitogenesis in rat mesangial cells via cAMP pathway.

  1995cited by this paper
• Elevation of circulating and ventricular adrenomedullin in human congestive heart failure.

  1995cited by this paper
• Cloning and Expression of cDNA Encoding a Rat Adrenomedullin Receptor (*)

  1995cited by this paper
• Cardiovascular actions of adrenomedullin in conscious sheep.

  1995cited by this paper
• Adrenomedullin Stimulates Two Signal Transduction Pathways, cAMP Accumulation and Ca2+ Mobilization, in Bovine Aortic Endothelial Cells (*)

  1995cited by this paper
• Regulation of InsP3-induced contractions by myoplasmic calcium in permeabilized atrial muscle.

  1995cited by this paper
• Protein kinase C and lipid signaling for sustained cellular responses

  1995cited by this paper
• Vasodilative effect of adrenomedullin in isolated arteries of the dog.

  1995cited by this paper
• Increased plasma levels of adrenomedullin in patients with heart failure.

  1995cited by this paper
• Block of stretch‐activated atrial natriuretic peptide secretion by gadolinium in isolated rat atrium.

  1994cited by this paper
• Vascular effects of halothane and isoflurane: cGMP dependent and independent actions.

  1994cited by this paper
• Specific receptors for adrenomedullin in cultured rat vascular smooth muscle cells

  1994cited by this paper
• Adrenomedullin mediates vasodilation via CGRP1 receptors.

  1994cited by this paper
• Adrenomedullin stimulates cyclic AMP formation in rat vascular smooth muscle cells.

  1994cited by this paper
• Identification and hypotensive activity of proadrenomedullin N‐terminal 20 peptide (PAMP)

  1994cited by this paper
• Distribution and characterization of immunoreactive rat adrenomedullin in tissue and plasma

  1994cited by this paper
• Distribution and characterization of immunoreactive adrenomedullin in human tissue and plasma

  1994cited by this paper
• Molecular cloning and biological activities of rat adrenomedullin, a hypotensive peptide.

  1993cited by this paper
• Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma.

  1993influential reference
• Inositol trisphosphate and calcium signalling

  1993cited by this paper
• Mechanisms of atrial and brain natriuretic peptide release from rat ventricular myocardium: effect of stretching.

  1993cited by this paper
• Inositol 1,4,5-trisphosphate receptor expression in cardiac myocytes

  1993cited by this paper
• Pharmacology of protein kinase inhibitors.

  1992cited by this paper
• Atrial natriuretic peptide: synthesis, release, and metabolism.

  1992cited by this paper
• The impact of single cell voltage clamp on the understanding of the cardiac ventricular action potential.

  1992cited by this paper
• Abnormal intracellular modulation of calcium as a major cause of cardiac contractile dysfunction.

  1991cited by this paper
• Thapsigargin inhibits the sarcoplasmic or endoplasmic reticulum Ca-ATPase family of calcium pumps.

  1991cited by this paper
• Characterization of positive inotropic effect of endothelin on mammalian ventricular myocardium.

  1991cited by this paper
• Staurosporine, a protein kinase C inhibitor, inhibits atrial natriuretic peptide secretion induced by sarafotoxin, endothelin and phorbol ester.

  1991cited by this paper
• Endothelin enhances the contractile responsiveness of adult rat ventricular myocytes to calcium by a pertussis toxin-sensitive pathway.

  1990cited by this paper
• Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells.

  1990cited by this paper
• Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

  1990cited by this paper
• The first demonstration of CGRP-immunoreactive fibers in canine hearts: coronary vasodilator, inotropic and chronotropic effects of CGRP in canine isolated, blood-perfused heart preparations.

  1989cited by this paper
• Positive Inotropic Effect of Calcitonin Gene‐Related Peptide Mediated by Cyclic AMP in Guinea Pig Heart

  1988cited by this paper
• Effect of atenolol and pindolol on the phorbol ester‐induced coronary vasoconstriction in the isolated perfused heart of the rat

  1988cited by this paper
• Tumor‐Promoting Phorbol Esters Inhibit Cardiac Functions and Induce Redistribution of Protein Kinase C in Perfused Beating Rat Heart

  1987cited by this paper
• Ryanodine modifies conductance and gating behavior of single Ca2+ release channel.

  1987cited by this paper
• Human alpha- and beta-CGRP and rat alpha-CGRP are coronary vasodilators in the rat.

  1986cited by this paper
• Ryanodine activation and inhibition of the Ca2+ release channel of sarcoplasmic reticulum.

  1986cited by this paper
• Human α- and β-CGRP and rat α-CGRP are coronary vasodilators in the rat

  1986cited by this paper
• Atrial natriuretic polypeptides (ANP): rat atria store high molecular weight precursor but secrete processed peptides of 25-35 amino acids.

  1985cited by this paper
• Diltiazem. A review of its pharmacological properties and therapeutic efficacy.

  1985cited by this paper
• Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum.

  1983influential reference
• Involvement of cAMP-dependent protein kinase in the regulation of heart contractile force.

  1977cited by this paper
• Dissociation of the Inotropic from the Glycogenolytic Effect of Epinephrine in the Isolated Rat Heart

  1965cited by this paper

• Bio‐Adrenomedullin Predicts Death and Major Adverse Cardiovascular Events in Cardiac Amyloidosis: A Cross‐Continental Multicenter Study

  2025cites this paper
• Association of mid-regional pro-adrenomedullin with office and 24-h ambulatory blood pressure in a Swiss general population sample

  2024cites this paper
• Biomarkers in cardiogenic shock: old pals, new friends

  2024cites this paper
• Clinical Potential of Adrenomedullin Signaling in the Cardiovascular System.

  2023cites this paper
• Mid-Regional Proadrenomedullin in COVID-19—May It Act as a Predictor of Prolonged Cardiovascular Complications?

  2023cites this paper
• Immunomodulatory Role of Neuropeptides in the Cornea

  2022cites this paper
• Mid-Regional Proadrenomedullin as a New Biomarker of Kidney and Cardiovascular Diseases—Is It the Future?

  2021cites this paper
• Adrenomedullin Inhibits Osmotic Water Permeability in Rat Inner Medullary Collecting Ducts

  2020cites this paper
• Adrenomedullin: Continuing to explore cardioprotection

  2019cites this paper
• Adrenomedullin as a Protein with Multifunctional Behavior and Effects in Various Organs and Tissues

  2019cites this paper
• Cardiac Remodeling: Endothelial Cells Have More to Say Than Just NO

  2018cites this paper
• Evaluation of Biological Activity Exerted by an Aza-bicyclocarboxylic acid Derivative using Anischemia-Reperfusion Injury Model

  2018cites this paper
• Novel biomarkers for the monitoring of chronic heart failure

  2017cites this paper
• Adrenomedullin regulates intestinal physiology and pathophysiology.

  2016cites this paper
• Cohort of estrogen-induced microRNAs regulate adrenomedullin expression.

  2016cites this paper
• Hemodynamic effects of doxycycline combined with adrenomedullin during acute pulmonary embolism-induced pulmonary hypertension

  2016cites this paper
• regulation of atrial stretch response Key roles of endothelin-1 and p38 MAPK in the

  2016cites this paper
• Cardiac Biomarkers in the Identification of Future Risk in Chronic Obstructive Pulmonary Disease.

  2016cites this paper
• Efeitos da adrenomodulina no tratamento da hipertensão pulmonar induzida por microesferas em ovinos

  2015cites this paper
• Adrenomedullin induces pulmonary vasodilation but does not attenuate pulmonary hypertension in a sheep model of acute pulmonary embolism.

  2015cites this paper
• Adrenomedullin in Vascular Endothelial Injury and Combination Therapy: Time for a New Paradigm.

  2015cites this paper
• myocardium: comparison to atrial natriuretic peptide Gene expression of adrenomedullin in failing

  2015cites this paper
• Effect of Different Peptides

  2015cites this paper
• Design and synthesis of new dihydrotestosterone derivative with positive inotropic activity.

  2015cites this paper
• Effect of adrenomedullin over-expression in the cardiovascular system during development and disease

  2015cites this paper
• Effect of vasoactive peptides in Tetrahymena: chemotactic activities of adrenomedullin, proadrenomedullin N-terminal 20 peptide (PAMP) and calcitonin gene-related peptide (CGRP)

  2015cites this paper
• Characterization of apela, a novel endogenous ligand of apelin receptor, in the adult heart

  2015cites this paper
• Activity Induced by a Naphthalene-Prazosin Derivative on Ischemia/Reperfusion Injury in Rats

  2014cites this paper
• Caracterización de un modelo de colitis en ratones knockout inducibles para adrenomedulina

  2014cites this paper
• Adrenomedullin and tumour microenvironment

  2014cites this paper
• Endogenous α‐calcitonin‐gene‐related peptide promotes exercise‐induced, physiological heart hypertrophy in mice

  2014cites this paper
• Protective effects of intermedin on cardiovascular, pulmonary and renal diseases: comparison with adrenomedullin and CGRP.

  2013cites this paper
• Glucagon-like peptide-1 reduces contractile function and fails to boost glucose utilization in normal hearts in the presence of fatty acids.

  2013cites this paper
• Vasoactive peptides and the pathogenesis of pulmonary hypertension: role and potential therapeutic application.

  2013cites this paper
• New biomarkers and heart failure

  2013cites this paper
• Review Article — Special issue: Heart Failure

  2013cites this paper
• Myocardial effect of Intermedin in hypertrophic heart: mechanisms and involvement of endothelial dysfunction

  2013cites this paper
• Cellular signalling of adrenomedullin regulating endothelial barrier function and granulocyte extravasation

  2012cites this paper
• Biomarkers in heart failure.

  2012cites this paper
• An ontogenic study of adrenomedullin gene expression in the rat lung, adrenal, kidney, and heart

  2012cites this paper
• Intermedin elicits a negative inotropic effect in rat papillary muscles mediated by endothelial-derived nitric oxide.

  2012cites this paper
• Adrenomedullin as a Growth and Cell Fate Regulatory Factor for Adult Neural Stem Cells

  2012cites this paper
• The Relationships Between Plasma Adrenomedullin and Endothelin-1 Concentrations and Doppler Echocardiographic Indices of Left Ventricular Function During Static Exercise in Healthy Men

  2012cites this paper
• Actualidades farmacológicas en el tratamiento de la insuficiencia cardiaca crónica

  2012cites this paper
• Evidence for a functional adrenomedullin signaling pathway in the mouse retina

  2012cites this paper
• Role of adrenomedullin in the growth and differentiation of stem and progenitor cells.

  2012cites this paper
• Neural Stem Cells in the Adult Brain: From Benchside to Clinic

  2012cites this paper
• Adrenomedullin-epinephrine cotreatment enhances cardiac output and left ventricular function by energetically neutral mechanisms.

  2012cites this paper
• Cardiovascular and hormonal responses to static handgrip in young and older healthy men

  2011cites this paper
• Actividad inotrópica inducida por el derivado carbamacepina-alquino en un modelo de corazón aislado y perfundido a flujo constante

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• Key roles of endothelin-1 and p38 MAPK in the regulation of atrial stretch response.

  2011cites this paper
• Hemodynamic, Hormonal, and Renal Actions of Adrenomedullin-5 in Normal Conscious Sheep

  2011cites this paper
• Valor pronóstico de la cistacina C como biomarcador en insuficiencia cardiaca crónica agudizada con función sistólica preservada y su relación con otros factores pronósticos clínicos

  2011cites this paper
• Cardiac biomarkers in the critically ill.

  2011cites this paper
• [Inotropic activity induced by carbamazepine-alkyne derivative in an isolated heart model and perfused to constant flow].

  2011cites this paper
• Characterization of signaling mechanisms regulating cardiac contractility

  2011cites this paper
• Inhibition of the adrenomedullin/nitric oxide signaling pathway in early diabetic retinopathy

  2011cites this paper
• Role of reactive oxygen species in the regulation of cardiac contractility.

  2011cites this paper
• Aldosterone antisecretagogue and antihypertensive actions of adrenomedullin in patients with primary aldosteronism

  2010cites this paper
• Biomarkers of Cardiac Injury

  2010cites this paper
• Regulation of Kinin Receptor Expression in Heart Failure with a Focus on Vascular Endothelium

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• Adrenomedullin 2 attenuates the pressor but not adrenal responses to angiotensin II in conscious sheep.

  2010cites this paper
• Hemodynamic and hormonal effects of exogenous adrenomedullin administration in humans and relationship to insulin resistance

  2010cites this paper
• A novel p38 MAPK target dyxin is rapidly induced by mechanical load in the heart

  2010cites this paper
• The Role of Endogenous Peptides ( Apelin , Adrenomedullin ) in the Regulation of Cardiac

  2010influential citation
• PEPTIDERGIC REGULATION OF CARDIAC CONTRACTILITY : ROLE OF PROLACTIN-RELEASING PEPTIDE AND ENDOTHELIN-1 Ph

  2010cites this paper
• Effects of adrenomedullin on systolic and diastolic myocardial function.

  2009cites this paper
• Adrenomedullin reduces intestinal epithelial permeability in vivo and in vitro.

  2009cites this paper
• Effects of long-term intravenous administration of adrenomedullin (AM) plus hANP therapy in acute decompensated heart failure: a pilot study.

  2009cites this paper
• Effects of proadrenomedullin N-terminal 20 peptide and calcitonin on isolated perfused rat hearts.

  2009cites this paper
• Cirrhotic cardiomyopathy

  2009cites this paper
• Relationships between plasma adrenomedullin concentration and systolic time intervals during static handgrip in patients with heart failure

  2009influential citation
• Effects of proadrenomedullin N-terminal 20 peptide and calcitonin on isolated perfused rat hearts İzole perfüze siçan kalpleri üzerinde proadrenomedullin N-terminal 20 peptit ve kalsitonin'in etkileri

  2009cites this paper
• [Pyr1]Apelin-13 Identified as the Predominant Apelin Isoform in the Human Heart: Vasoactive Mechanisms and Inotropic Action in Disease

  2009cites this paper
• ST2 and adrenomedullin in heart failure.

  2009cites this paper
• Intermedin (adrenomedullin‐2): a novel counter‐regulatory peptide in the cardiovascular and renal systems

  2008cites this paper
• Adaptive or maladaptive response to adenoviral adrenomedullin gene transfer is context‐dependent in the heart

  2008cites this paper
• Direct cardiac actions of erythropoietin (EPO): effects on cardiac contractility, BNP secretion and ischaemia/reperfusion injury.

  2008cites this paper
• Adrenomedullin enhances baroreceptor reflex response via cAMP/PKA signaling in nucleus tractus solitarii of rats.

  2008cites this paper
• Functionally Opposing Roles of Extracellular Signal-Regulated Kinase 1/2 and p38 Mitogen-Activated Protein Kinase in the Regulation of Cardiac Contractility

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• Adrenomedullin and endothelial barrier function

  2007cites this paper
• Adrenomedullin is a novel adipokine: adrenomedullin in adipocytes and adipose tissues.

  2007cites this paper
• Cardiovascular Regulation: Basic Considerations

  2007cites this paper
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  2007cites this paper
• Adrenomedullin in the Treatment of Cardiovascular Dysfunction and Sepsis

  2007cites this paper
• Exogenous adrenomedullin prevents and reverses hypodynamic circulation and pulmonary hypertension in ovine endotoxaemia.

  2007cites this paper
• Role of vasoactive factors in animal models of pressure and volume overload induced hypertrophy

  2007cites this paper
• Adrenomedullin Gene Expression and Peptide Levels in the Heart and Blood Vessels of Streptozotocin-diabetic Rats

  2007cites this paper
• Hemodynamic, hormonal, and renal actions of adrenomedullin-2 in normal conscious sheep.

  2006cites this paper
• DIABETES AND NATRIURETIC SUBSTANCES

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• Effect of adrenergic blockade on plasma adrenomedullin concentration during static handgrip in patients with heart failure

  2006cites this paper
• Pathophysiologic and therapeutic implications of adrenomedullin in cardiovascular disorders.

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• Therapeutic Potential of Adrenomedullin for Pulmonary Hypertension

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• Intermedin (adrenomedullin-2) enhances cardiac contractile function via a protein kinase C- and protein kinase A-dependent pathway in murine ventricular myocytes.

  2006cites this paper
• myocytes A-dependent pathway in murine ventricular protein contractile function via a protein kinase C- and Intermedin (adrenomedullin-2) enhances cardiac

  2006cites this paper
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  2006cites this paper
• Role of vasoactive factors in animal models of pressure and volume overload induced hypertrophy

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• Gs and Gi coupling of adrenomedullin in adult rat ventricular myocytes.

  2006cites this paper
• Die Wirkung von Adrenomedullin auf die Kontraktilität des Rattenherzens

  2005cites this paper
• Protective effects of intermedin/adrenomedullin2 on ischemia/reperfusion injury in isolated rat hearts.

  2005cites this paper