Structure of Functionally Activated Small Ribosomal Subunit at 3.3 Å Resolution

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Cell

• Publication date

  2000-09-01

• Fields of study

  Biology, Materials Science

• Identifiers
  DOI 10.1016/S0092-8674(00)00084-2
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Structure of the S15,S6,S18-rRNA complex: assembly of the 30S ribosome central domain.

  2000influential reference
• Solution structure of the E. coli 70S ribosome at 11.5 A resolution.

  2000influential reference
• Using a targeted chemical nuclease to elucidate conformational changes in the E. coli 30S ribosomal subunit.

  2000cited by this paper
• Crystal structure of the S15–rRNA complex

  2000cited by this paper
• Identification of Selected Ribosomal Components in Crystallographic Maps of Prokaryotic Ribosomal Subunits at Medium Resolution

  2000cited by this paper
• Genetic and Biochemical Manipulations of the Small Ribosomal Subunit from Thermus thermophilus HB8

  2000cited by this paper
• A ratchet-like inter-subunit reorganization of the ribosome during translocation

  2000cited by this paper
• Large-scale movement of elongation factor G and extensive conformational change of the ribosome during translocation.

  2000cited by this paper
• Efficient anisotropic refinement of macromolecular structures using FFT.

  1999cited by this paper
• Major groove binding of the tRNA/mRNA complex to the 16 S ribosomal RNA decoding site.

  1999cited by this paper
• Solution structure of the ribosomal protein S19 from Thermus thermophilus.

  1999cited by this paper
• Structure and structural variations of the Escherichia coli 30 S ribosomal subunit as revealed by three-dimensional cryo-electron microscopy.

  1999influential reference
• X-ray crystal structures of 70S ribosome functional complexes.

  1999influential reference
• Metal compounds as tools for the construction and the interpretation of medium-resolution maps of ribosomal particles.

  1999cited by this paper
• Placement of protein and RNA structures into a 5 Å-resolution map of the 50S ribosomal subunit

  1999influential reference
• The small ribosomal subunit from Thermus thermophilus at 4.5 A resolution: pattern fittings and the identification of a functional site.

  1999cited by this paper
• Directed hydroxyl radical probing of 16S rRNA in the ribosome: spatial proximity of RNA elements of the 3' and 5' domains.

  1999cited by this paper
• The Database of Ribosomal Cross-links: an update

  1999influential reference
• Major rearrangements in the 70S ribosomal 3D structure caused by a conformational switch in 16S ribosomal RNA

  1999influential reference
• A detailed view of a ribosomal active site: the structure of the L11-RNA complex.

  1999cited by this paper
• Structure of a bacterial 30S ribosomal subunit at 5.5 Å resolution

  1999influential reference
• Elucidating the medium-resolution structure of ribosomal particles: an interplay between electron cryo-microscopy and X-ray crystallograhy.

  1999influential reference
• Crystal structure of a conserved ribosomal protein-RNA complex.

  1999cited by this paper
• Specific mutations in a viral RNA pseudoknot drastically change ribosomal frameshifting efficiency.

  1999cited by this paper
• Regions of 16S ribosomal RNA proximal to transfer RNA bound at the P-site of Escherichia coli ribosomes.

  1998cited by this paper
• A common motif organizes the structure of multi-helix loops in 16 S and 23 S ribosomal RNAs.

  1998cited by this paper
• Paromomycin binding induces a local conformational change in the A-site of 16 S rRNA.

  1998cited by this paper
• Ribosomal protein structures: insights into the architecture, machinery and evolution of the ribosome.

  1998influential reference
• The Database of Ribosomal Cross links (DRC)

  1998cited by this paper
• Mapping the position of translational elongation factor EF-G in the ribosome by directed hydroxyl radical probing.

  1998cited by this paper
• Base complementarity in helix 2 of the central pseudoknot in 16S rRNA is essential for ribosome functioning.

  1998cited by this paper
• Crystallography & NMR system: A new software suite for macromolecular structure determination.

  1998cited by this paper
• Directed hydroxyl radical probing of 16S ribosomal RNA in ribosomes containing Fe(II) tethered to ribosomal protein S20.

  1998cited by this paper
• Ribosomes and translation.

  1997cited by this paper
• A new model for the three-dimensional folding of Escherichia coli 16 S ribosomal RNA. III. The topography of the functional centre.

  1997cited by this paper
• Streptomycin binds to the decoding center of 16 S ribosomal RNA.

  1997cited by this paper
• Visualization of elongation factor Tu on the Escherichia coli ribosome

  1997cited by this paper
• Crystal structure of the nucleosome core particle at 2.8 Å resolution

  1997cited by this paper
• Electron-density map interpretation.

  1997cited by this paper
• A new model for the three-dimensional folding of Escherichia coli 16 S ribosomal RNA. I. Fitting the RNA to a 3D electron microscopic map at 20 A.

  1997cited by this paper
• A conformational switch in Escherichia coli 16S ribosomal RNA during decoding of messenger RNA.

  1997cited by this paper
• [20] Processing of X-ray diffraction data collected in oscillation mode.

  1997cited by this paper
• [27] Maximum-likelihood heavy-atom parameter refinement for multiple isomorphous replacement and multiwavelength anomalous diffraction methods.

  1997cited by this paper
• Methods used in the structure determination of bovine mitochondrial F1 ATPase.

  1996influential reference
• A model of protein synthesis based on cryo-electron microscopy of the E. coli ribosome

  1995cited by this paper
• Purine functional groups in essential residues of the hairpin ribozyme required for catalytic cleavage of RNA.

  1995cited by this paper
• The 70S Escherichia coli ribosome at 23 A resolution: fitting the ribosomal RNA.

  1995cited by this paper
• The CCP4 suite: programs for protein crystallography.

  1994cited by this paper
• Purification and characterization of the 30S ribosomal proteins from the bacterium Thermus thermophilus.

  1994cited by this paper
• The conformation of the sarcin/ricin loop from 28S ribosomal RNA.

  1993cited by this paper
• Ribosome activity and modification of 16S RNA are influenced by deletion of ribosomal protein S20

  1993cited by this paper
• An accuracy center in the ribosome conserved over 2 billion years.

  1993cited by this paper
• Immunoelectron microscopic localization of ribosomal proteins BS8, BS9, BS20, BL3 and BL21 on the surface of 30S and 50S subunits from Bacillus stearothermophilus.

  1993cited by this paper
• Isolation and characterization of a new ribosomal protein from the thermophilic eubacteria, Thermus thermophilus, T. aquaticus and T. flavus.

  1993cited by this paper
• Three widely separated positions in the 16S RNA lie in or close to the ribosomal decoding region; a site‐directed cross‐linking study with mRNA analogues.

  1992cited by this paper
• The location of mRNA in the ribosomal 30S initiation complex; site‐directed cross‐linking of mRNA analogues carrying several photo‐reactive labels simultaneously on either side of the AUG start codon.

  1991cited by this paper
• A functional pseudoknot in 16S ribosomal RNA.

  1991cited by this paper
• The Ribosome : structure, function, and evolution

  1990cited by this paper
• Escherichia coli 30S mutants lacking protein S20 are defective in translation initiation.

  1990cited by this paper
• Probing the assembly of the 3' major domain of 16 S rRNA. Interactions involving ribosomal proteins S2, S3, S10, S13 and S14.

  1988cited by this paper
• Identification of a cross-link in the Escherichia coli ribosomal protein pair S13-S19 at the amino acid level.

  1988influential reference
• Nucleotide sequence of Thermus thermophilus HB8 gene coding 16S rRNA.

  1988cited by this paper
• Three-dimensional image reconstruction from ordered arrays of 70S ribosomes.

  1987cited by this paper
• Ribosome Structure, Function, and Evolution: Mapping Ribosomal RNA, Proteins, and Functional Sites in Three Dimensions

  1986cited by this paper
• Structure, Function, and Genetics of Ribosomes

  1986cited by this paper
• Immuno Electron Microscopy on Escherichia coli Ribosomes

  1986cited by this paper
• The primary structure of protein S5 from the small subunit of the Escherichia coli ribosome

  1978cited by this paper
• Inactivation and reactivation of ribosomal subunits: amino acyl-transfer RNA binding activity of the 30 s subunit of Escherichia coli.

  1971cited by this paper
• Crystal Structure

  year unknowncited by this paper

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• Orchestrating ribosomal RNA folding during ribosome assembly

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