The Interaction of APOBEC3G with Human Immunodeficiency Virus Type 1 Nucleocapsid Inhibits tRNA3Lys Annealing to Viral RNA

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Journal of Virology

• Publication date

  2007-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/JVI.00162-07PMID 17670826PMCID PMC2045548
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Stoichiometry of the antiviral protein APOBEC3G in HIV-1 virions.

  2007cited by this paper
• Uracil DNA Glycosylase Is Dispensable for Human Immunodeficiency Virus Type 1 Replication and Does Not Contribute to the Antiviral Effects of the Cytidine Deaminase Apobec3G

  2006cited by this paper
• Antiviral Potency of APOBEC Proteins Does Not Correlate with Cytidine Deamination

  2006cited by this paper
• Innate cellular defenses of APOBEC3 cytidine deaminases and viral counter-defenses

  2006cited by this paper
• Inhibition of \batchmode \documentclass[fleqn,10pt,legalpaper]{article} \usepackage{amssymb} \usepackage{amsfonts} \usepackage{amsmath} \pagestyle{empty} \begin{document} \(\mathrm{tRNA}_{3}^{\mathrm{Lys}}\) \end{document}-Primed Reverse Transcription by Human APOBEC3G during Human Immunodeficiency

  2006cited by this paper
• Role and Mechanism of Action of the APOBEC3 Family of Antiretroviral Resistance Factors

  2006cited by this paper
• High-molecular-mass APOBEC3G complexes restrict Alu retrotransposition

  2006cited by this paper
• Biochemical Activities of Highly Purified, Catalytically Active Human APOBEC3G: Correlation with Antiviral Effect

  2006cited by this paper
• QUAKING KH Domain Proteins as Regulators of Glial Cell Fate and Myelination

  2005cited by this paper
• Viral RNA Is Required for the Association of APOBEC3G with Human Immunodeficiency Virus Type 1 Nucleoprotein Complexes

  2005cited by this paper
• Antiviral function of APOBEC3G can be dissociated from cytidine deaminase activity.

  2005cited by this paper
• Functional domains of APOBEC3G required for antiviral activity

  2004cited by this paper
• Conservation of a Stepwise, Energy-Sensitive Pathway Involving HP68 for Assembly of Primate Lentivirus Capsids in Cells

  2004cited by this paper
• The stoichiometry of Gag protein in HIV-1

  2004cited by this paper
• Specific packaging of APOBEC3G into HIV-1 virions is mediated by the nucleocapsid domain of the gag polyprotein precursor.

  2004cited by this paper
• The Interaction between HIV-1 Gag and APOBEC3G*

  2004cited by this paper
• APOBEC3G Incorporation into Human Immunodeficiency Virus Type 1 Particles

  2004cited by this paper
• Single-strand specificity of APOBEC3G accounts for minus-strand deamination of the HIV genome

  2004cited by this paper
• Vif Overcomes the Innate Antiviral Activity of APOBEC3G by Promoting Its Degradation in the Ubiquitin-Proteasome Pathway*

  2004cited by this paper
• APOBEC3G Is Incorporated into Virus-like Particles by a Direct Interaction with HIV-1 Gag Nucleocapsid Protein*

  2004influential reference
• The selective packaging and annealing of primer tRNALys3 in HIV-1.

  2004cited by this paper
• Mechanistic insights into the kinetics of HIV-1 nucleocapsid protein-facilitated tRNA annealing to the primer binding site.

  2004cited by this paper
• Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts

  2003influential reference
• Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif.

  2003cited by this paper
• The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA

  2003cited by this paper
• DNA deamination mediates innate immunity to retroviral infection.

  2003cited by this paper
• The Human Immunodeficiency Virus Type 1 Vif Protein Reduces Intracellular Expression and Inhibits Packaging of APOBEC3G (CEM15), a Cellular Inhibitor of Virus Infectivity

  2003cited by this paper
• Electron tomography analysis of envelope glycoprotein trimers on HIV and simian immunodeficiency virus virions

  2003cited by this paper
• Hypermutation of HIV-1 DNA in the Absence of the Vif Protein

  2003cited by this paper
• Induction of APOBEC3G Ubiquitination and Degradation by an HIV-1 Vif-Cul5-SCF Complex

  2003cited by this paper
• HIV-1 Vif blocks the antiviral activity of APOBEC3G by impairing both its translation and intracellular stability.

  2003cited by this paper
• Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein

  2002cited by this paper
• An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22.

  2002cited by this paper
• Subtle Alterations of the Native Zinc Finger Structures Have Dramatic Effects on the Nucleic Acid Chaperone Activity of Human Immunodeficiency Virus Type 1 Nucleocapsid Protein

  2002cited by this paper
• HIV-1 nucleocapsid protein zinc finger structures induce tRNA(Lys,3) structural changes but are not critical for primer/template annealing.

  2001cited by this paper
• Roles of Pr 55 gag and NCp 7 in tRNA 3 Lys Genomic Placement and the Initiation Step of Reverse Transcription in Human Immunodeficiency Virus Type 1

  2000cited by this paper
• In Vitro Studies on tRNA Annealing and Reverse Transcription with Mutant HIV-1 RNA Templates*

  2000cited by this paper
• Roles of Pr55gag and NCp7 in tRNA3Lys Genomic Placement and the Initiation Step of Reverse Transcription in Human Immunodeficiency Virus Type 1

  2000cited by this paper
• Roles of Pr55(gag) and NCp7 in tRNA(3)(Lys) genomic placement and the initiation step of reverse transcription in human immunodeficiency virus type 1.

  2000cited by this paper
• The Human Immunodeficiency Virus Type 1 Gag Polyprotein Has Nucleic Acid Chaperone Activity: Possible Role in Dimerization of Genomic RNA and Placement of tRNA on the Primer Binding Site

  1999influential reference
• Coupled Integration of Human Immunodeficiency Virus Type 1 cDNA Ends by Purified Integrase In Vitro: Stimulation by the Viral Nucleocapsid Protein

  1999cited by this paper
• The Role of Pr55gag in the Annealing of tRNA3Lys to Human Immunodeficiency Virus Type 1 Genomic RNA

  1999cited by this paper
• An Endogenous Inhibitor of Human Immunodeficiency Virus in Human Lymphocytes Is Overcome by the Viral Vif Protein

  1998cited by this paper
• Role of Vif in human immunodeficiency virus type 1 reverse transcription

  1996cited by this paper
• Effects of modifying the tRNA(3Lys) anticodon on the initiation of human immunodeficiency virus type 1 reverse transcription

  1996cited by this paper
• Initiation of reverse transcription of HIV-1: secondary structure of the HIV-1 RNA/tRNA(3Lys) (template/primer).

  1995cited by this paper
• Initiation of Reverse Transcripion of HIV-1: Secondary Structure of the HIV-1 RNA/tRNA|rlmbopopnbop|Lys|clobop|3 (Template/Primer) Complex

  1995cited by this paper
• Analysis of the nucleic acid annealing activities of nucleocapsid protein from HIV-1

  1995influential reference
• Comparison of deoxyoligonucleotide and tRNA(Lys-3) as primers in an endogenous human immunodeficiency virus-1 in vitro reverse transcription/template-switching reaction.

  1994cited by this paper
• Identification of tRNAs incorporated into wild-type and mutant human immunodeficiency virus type 1

  1993cited by this paper
• Role of vif in replication of human immunodeficiency virus type 1 in CD4+ T lymphocytes

  1992cited by this paper
• Viral RNA annealing activities of human immunodeficiency virus type 1 nucleocapsid protein require only peptide domains outside the zinc fingers.

  1992influential reference
• The HIV A (sor) gene product is essential for virus infectivity

  1987influential reference
• The sor gene of HIV-1 is required for efficient virus transmission in vitro.

  1987influential reference
• Reactions at the termini of tRNA with T4 RNA ligase.

  1978cited by this paper

• [Genetic diversity of Vif protein in human immunodeficiency virus type 1 variants (Retroviridae: Orthoretrovirinae: Lentivirus: Human immunodeficiency virus-1) that circulated in the Moscow region in 2019-2020].

  2025cites this paper
• Viral infection, APOBEC3 dysregulation, and cancer

  2024cites this paper
• Potent dual block to HIV-1 infection using lentiviral vectors expressing fusion inhibitor peptide mC46- and Vif-resistant APOBEC3G

  2023cites this paper
• APOBEC3B drives PKR-mediated translation shutdown and protects stress granules in response to viral infection

  2023cites this paper
• Murine leukemia virus resists producer cell APOBEC3A by its Glycosylated Gag but not target cell APOBEC3A.

  2021cites this paper
• Degradation-Independent Inhibition of APOBEC3G by the HIV-1 Vif Protein

  2021cites this paper
• Human APOBEC3 Variations and Viral Infection

  2021cites this paper
• Deaminase-Independent Mode of Antiretroviral Action in Human and Mouse APOBEC3 Proteins

  2020cites this paper
• The nucleic acid chaperone activity of the HIV-1 Gag polyprotein is boosted by its cellular partner RPL7: a kinetic study

  2020cites this paper
• How HIV-1 Gag Manipulates Its Host Cell Proteins: A Focus on Interactors of the Nucleocapsid Domain

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• Interplay between Intrinsic and Innate Immunity during HIV Infection

  2019cites this paper
• Effects of APOBEC3-Induced Mutations on HIV-1 Expression and Latency

  2019cites this paper
• Biochemical analysis of the catalytic activity of HIV-1 restriction factor SAMHD1

  2019cites this paper
• Host Restriction Factors and Human Immunodeficiency Virus (HIV-1): A Dynamic Interplay Involving All Phases of the Viral Life Cycle.

  2018cites this paper
• Viral subversion of APOBEC3s: Lessons for anti-tumor immunity and tumor immunotherapy

  2018cites this paper
• The role of Gag in HIV-1 DNA synthesis and sensitivity to reverse transcriptase inhibitor drugs

  2018cites this paper
• Post-entry restriction factors of SIVcpz

  2018cites this paper
• Human APOBEC3G Prevents Emergence of Infectious Endogenous Retrovirus in Mice

  2018cites this paper
• Evasion of adaptive immunity by HIV through the action of host APOBEC3G/F enzymes

  2017cites this paper
• DNA mutagenic activity and capacity for HIV-1 restriction of the cytidine deaminase APOBEC3G depend on whether DNA or RNA binds to tyrosine 315

  2017cites this paper
• 7 Retroviral Host Cell Factors : TRIM 5 , APOBEC 3 G and Cyclophilins

  2017cites this paper
• CBFß and HIV Infection.

  2017cites this paper
• Are Evolution and the Intracellular Innate Immune System Key Determinants in HIV Transmission?

  2017cites this paper
• Identification and characterization of loop7 motif and its role in regulating biological function of human APOBEC3G through molecular modeling and biological assay

  2017cites this paper
• STUDIES ON THE MECHANISMS OF ANTI-HIV-1 FUNCTIONS OF APOBEC3F AND APOBEC3G

  2017cites this paper
• A chimeric human APOBEC3A protein with a three amino acid insertion confers differential HIV-1 and adeno-associated virus restriction.

  2016cites this paper
• APOBEC3G-Mediated G-to-A Hypermutation of the HIV-1 Genome: The Missing Link in Antiviral Molecular Mechanisms

  2016cites this paper
• Requirements for nucleocapsid-mediated regulation of reverse transcription during the late steps of HIV-1 assembly

  2016cites this paper
• Lysine Acetylation and Small Molecule Epigenetic Inhibition Reveal Novel Mechanisms Controlling Cellular Susceptibility to HIV-1 Infection

  2016cites this paper
• Exploiting tRNAs to Boost Virulence

  2016cites this paper
• Role of Host Proteins in HIV-1 Early Replication

  2016cites this paper
• Functional characterization of Vif proteins from HIV-1 infected patients with different APOBEC3G haplotypes

  2016cites this paper
• Minimal Contribution of APOBEC3-Induced G-to-A Hypermutation to HIV-1 Recombination and Genetic Variation

  2016cites this paper
• Restriction Factors in HIV-1 Disease Progression.

  2015cites this paper
• Identification of a Novel HIV-1 Inhibitor Targeting Vif-dependent Degradation of Human APOBEC3G Protein*

  2015cites this paper
• In virio SHAPE analysis of tRNALys3 annealing to HIV-1 genomic RNA in wild type and protease-deficient virus

  2015cites this paper
• Role of the Ebolavirus Glycoprotein in Countering Tetherin During Viral Budding

  2015cites this paper
• RNA-binding residues in the N-terminus of APOBEC3G influence its DNA sequence specificity and retrovirus restriction efficiency.

  2015cites this paper
• Redoxal, an inhibitor of de novo pyrimidine biosynthesis, augments APOBEC3G antiviral activity against human immunodeficiency virus type 1.

  2015cites this paper
• Incorporation of Mouse APOBEC3 into Murine Leukemia Virus Virions Decreases the Activity and Fidelity of Reverse Transcriptase

  2014cites this paper
• The multifaceted roles of RNA binding in APOBEC cytidine deaminase functions

  2014cites this paper
• Suppression of APOBEC3-mediated restriction of HIV-1 by Vif

  2014cites this paper
• The assembly of Vif ubiquitin E3 ligase for APOBEC3 degradation

  2014cites this paper
• Multiple APOBEC3 restriction factors for HIV-1 and one Vif to rule them all.

  2014cites this paper
• Cellular HIV-1 inhibition by truncated old world primate APOBEC3A proteins lacking a complete deaminase domain.

  2014cites this paper
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  2014cites this paper
• N-Linked Glycosylation Protects Gammaretroviruses against Deamination by APOBEC3 Proteins

  2014cites this paper
• Inhibition of HIV-1 Vif by Pokeweed Antiviral Protein and its Impact on Cellular Immune Defense

  2014cites this paper
• Roles of DNA Damage and its Cellular Response in the Transduction of Human Immunodeficiency Virus-1

  2014cites this paper
• The role of APOBEC3G in acute and early HIV-1 subtype C infection.

  2014cites this paper
• APOBEC3-mediated hypermutation of retroviruses:A defensive tool of the innate immune system

  2014cites this paper
• Transcriptome-Wide Characterization of APOBEC1-Catalyzed RNA Editing Events in Macrophages

  2014cites this paper
• Immunodeficiency Virus Type 1 Annealing to Viral RNA in Human Roles of Gag and NCp7 in Facilitating

  2014cites this paper
• Structure-guided analysis of the human APOBEC3-HIV restrictome.

  2014cites this paper
• Feline restriction factors to lentiviral replication

  2013cites this paper
• APOBEC3 Inhibition of Mouse Mammary Tumor Virus Infection: the Role of Cytidine Deamination versus Inhibition of Reverse Transcription

  2013cites this paper
• Human Immunodeficiency Virus Reverse Transcriptase

  2013cites this paper
• Retroviral Restriction Factor APOBEC3G Delays the Initiation of DNA Synthesis by HIV-1 Reverse Transcriptase

  2013cites this paper
• APOBEC3G-Augmented Stem Cell Therapy to Modulate HIV Replication: A Computational Study

  2013cites this paper
• APOBECs and Their Role in Proviral DNA Synthesis

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• Host restriction factors in retroviral infection: promises in virus-host interaction

  2012cites this paper
• Antiviral Mechanism and Biochemical Basis of the Human APOBEC3 Family

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  2012influential citation
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• Random Mutagenesis MAPPIT Analysis Identifies Binding Sites for Vif and Gag in Both Cytidine Deaminase Domains of Apobec3G

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• The APOBEC3G Deamination Independent Mode of HIV Inhibition

  2012influential citation
• Lentiviral gene therapy for HIV using TRIM-cyclophilin restriction factors

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• Multi-Scale Modeling of HIV Infection in vitro and APOBEC3G-Based Anti-Retroviral Therapy

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• Emerging complexities of APOBEC3G action on immunity and viral fitness during HIV infection and treatment

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• Running Loose or Getting Lost: How HIV-1 Counters and Capitalizes on APOBEC3-Induced Mutagenesis through Its Vif Protein

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• The Cellular Antiviral Protein APOBEC3G Interacts with HIV-1 Reverse Transcriptase and Inhibits Its Function during Viral Replication

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• Aspects of HIV-1 assembly that promote primer tRNA(Lys3) annealing to viral RNA.

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• The APOBEC3G Deamination Independent

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• Direct evidence that RNA inhibits APOBEC3G ssDNA cytidine deaminase activity.

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• APOBEC3G: a double agent in defense.

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• Heat Shock Protein 70 Inhibits HIV-1 Vif-mediated Ubiquitination and Degradation of APOBEC3G*

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• N-Terminal Hemagglutinin Tag Renders Lysine-Deficient APOBEC3G Resistant to HIV-1 Vif-Induced Degradation by Reduced Polyubiquitination

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• Stably Expressed APOBEC3F Has Negligible Antiviral Activity

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• Productive Replication of vif-Chimeric HIV-1 in Feline Cells

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• Identification of Specific Determinants of Human APOBEC3F, APOBEC3C, and APOBEC3DE and African Green Monkey APOBEC3F That Interact with HIV-1 Vif

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• HIV-1 Vif versus the APOBEC3 cytidine deaminases: an intracellular duel between pathogen and host restriction factors.

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• APOBEC3F and APOBEC3G Inhibit HIV-1 DNA Integration by Different Mechanisms (cid:1)

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• Innate Immune Signaling Induces High Levels of TC-specific Deaminase Activity in Primary Monocyte-derived Cells through Expression of APOBEC3A Isoforms*

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• APOBEC3F and APOBEC3G Inhibit HIV-1 DNA Integration by Different Mechanisms

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• through Sublethal Mutagenesis APOBEC3G Contributes to HIV-1 Variation

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• Identification of the Function of the Vpx Protein of Primate Lentiviruses: A Dissertation

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• Restriction of HIV-1 by APOBEC3G is cytidine deaminase-dependent.

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• APOBEC deaminases-mutases with defensive roles for immunity

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