Mitochondrial density determines the cellular sensitivity to cisplatin-induced cell death.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  American Journal of Physiology - Cell Physiology

• Publication date

  2005-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1152/AJPCELL.00265.2005PMID 16107504
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Adaptations in metabolic capacity of rat soleus after paralysis.

  2004cited by this paper
• Minocycline Up-regulates Bcl-2 and Protects against Cell Death in Mitochondria*

  2004cited by this paper
• Edaravone Inhibits Acute Renal Injury and Cyst Formation in Cisplatin-Treated Rat Kidney

  2004cited by this paper
• Mitochondrial generation of reactive oxygen species and its role in aerobic life.

  2003cited by this paper
• Cellular responses to H(2)O(2) and bleomycin-induced oxidative stress in L6C5 rat myoblasts.

  2003cited by this paper
• Tissue mRNA expression of the rat UDP-glucuronosyltransferase gene family.

  2003cited by this paper
• A role for mitochondrial enzymes in inherited neoplasia and beyond

  2003cited by this paper
• Reduced endocytosis and altered lysosome function in cisplatin-resistant cell lines

  2003cited by this paper
• Mitochondrial permeability transition: a common pathway to necrosis and apoptosis.

  2003cited by this paper
• Cisplatin Induces Endoplasmic Reticulum Stress and Nucleus-independent Apoptotic Signaling*

  2003cited by this paper
• Cisplatin induces apoptosis in LLC-PK1 cells via activation of mitochondrial pathways.

  2002cited by this paper
• Characterization of a novel metabolic strategy used by drug‐resistant tumor cells

  2002cited by this paper
• Suppression of human tumor cell proliferation through mitochondrial targeting

  2002cited by this paper
• L-Carnitine inhibits cisplatin-induced injury of the kidney and small intestine.

  2002cited by this paper
• Management of Oxidative Stress by Heme Oxygenase-1 in Cisplatin-induced Toxicity in Renal Tubular Cells

  2002cited by this paper
• Mitochondria as targets for established and novel anti-cancer agents.

  2001cited by this paper
• c-Myc down-regulation increases susceptibility to cisplatin through reactive oxygen species-mediated apoptosis in M14 human melanoma cells.

  2001cited by this paper
• Cytochrome C Maintains Mitochondrial Transmembrane Potential and Atp Generation after Outer Mitochondrial Membrane Permeabilization during the Apoptotic Process

  2001cited by this paper
• Evidence supporting a role for mitochondrial respiration in apoptosis induction by the synthetic retinoid CD437.

  2001cited by this paper
• Mechanisms of resistance to cisplatin.

  2001cited by this paper
• Ultrastructural morphology and localisation of cisplatin-induced platinum-DNA adducts in a cisplatin-sensitive and -resistant human small cell lung cancer cell line using electron microscopy.

  2001cited by this paper
• Targeting superoxide dismutase to renal proximal tubule cells inhibits mitochondrial injury and renal dysfunction inuduced by cisplatin.

  2001cited by this paper
• The biochemistry of apoptosis

  2000cited by this paper
• Dominant negative myostatin produces hypertrophy without hyperplasia in muscle

  2000cited by this paper
• Mitochondrial DNA depletion causes morphological changes in the mitochondrial reticulum of cultured human cells

  2000cited by this paper
• Mitochondrial control of cell death

  2000cited by this paper
• Mitochondria as the central control point of apoptosis.

  2000cited by this paper
• Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue.

  2000cited by this paper
• Repair of DNA damage in mitochondria.

  1999cited by this paper
• The mitochondrial permeability transition pore and its role in cell death.

  1999cited by this paper
• Mitochondrial DNA determines the cellular response to cancer therapeutic agents

  1999cited by this paper
• 1,25-Dihydroxyvitamin D3 enhances the susceptibility of breast cancer cells to doxorubicin-induced oxidative damage.

  1999cited by this paper
• Cisplatin impairs fluid and electrolyte absorption in rat small intestine: a role for 5-hydroxytryptamine

  1999cited by this paper
• Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer.

  1999cited by this paper
• Cytochrome c-mediated Apoptosis in Cells Lacking Mitochondrial DNA

  1999cited by this paper
• Functional F1-ATPase Essential in Maintaining Growth and Membrane Potential of Human Mitochondrial DNA-depleted ρ° Cells*

  1998cited by this paper
• Functional F1-ATPase essential in maintaining growth and membrane potential of human mitochondrial DNA-depleted rho degrees cells.

  1998cited by this paper
• Role of mitochondria in oxidative stress and ageing.

  1998cited by this paper
• Mitochondria and apoptosis.

  1998cited by this paper
• Mitochondria in neuromuscular disorders.

  1998cited by this paper
• Preferential formation and decreased removal of cisplatin-DNA adducts in Chinese hamster ovary cell mitochondrial DNA as compared to nuclear DNA.

  1997cited by this paper
• Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress.

  1997cited by this paper
• Role of reactive oxygen species in cis-dichlorodiammineplatinum-induced cytotoxicity on bladder cancer cells.

  1997cited by this paper
• Cisplatin-induced nephrotoxicity in porcine proximal tubular cells: mitochondrial dysfunction by inhibition of complexes I to IV of the respiratory chain.

  1997cited by this paper
• Isolation of human cell lines lacking mitochondrial DNA.

  1996cited by this paper
• Mechanisms of death induced by cisplatin in proximal tubular epithelial cells: apoptosis vs. necrosis.

  1996cited by this paper
• Mitochondria: beyond oxidative phosphorylation.

  1995cited by this paper
• Cisplatin generates superoxide anion by interaction with DNA in a cell-free system.

  1994cited by this paper
• Evidence that mitochondrial respiration is a source of potentially toxic oxygen free radicals in intact rabbit hearts subjected to ischemia and reflow.

  1993cited by this paper
• Favorable long-term survival following induction chemotherapy with cisplatin, fluorouracil, and leucovorin and concomitant chemoradiotherapy for locally advanced head and neck cancer.

  1992cited by this paper
• Molecular analysis of the muscle pathology associated with mitochondrial DNA deletions

  1992cited by this paper
• Acute gastroduodenal mucosal injury after cisplatin plus etoposide chemotherapy. Clinical and endoscopic study.

  1991cited by this paper
• Distinct genomic copy number in mitochondria of different mammalian organs

  1990cited by this paper
• Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation.

  1989cited by this paper
• Mitochondrial alterations in cisplatin-induced acute renal failure.

  1986cited by this paper
• Cisplatin: Synthesis, antitumour activity and mechanism of action

  1985cited by this paper
• Sequence and organization of the human mitochondrial genome

  1981cited by this paper
• Human Myopathy with Giant Abnormal Mitochondria

  1964cited by this paper

• TRPM2 Channel Involvement in the Hesperidin-Mediated Potentiation of Cisplatin’s Antitumor Action in Laryngeal Carcinoma Cells

  2026cites this paper
• An Adverse Outcome Pathway for DNA adduct formation leading to kidney failure.

  2025cites this paper
• Evaluation of Ototoxic Effects of Cisplatin in a Rat Model: A Dose–Response Study

  2025cites this paper
• Effect of Long-Term Cisplatin Exposure on the Proliferative Potential of Immortalized Renal Progenitor Cells

  2024cites this paper
• Renal Glutathione: Dual roles as antioxidant protector and bioactivation promoter.

  2024cites this paper
• Efficacy of Quercetin and Quercetin Loaded Chitosan Nanoparticles Against Cisplatin-Induced Renal and Testicular Toxicity via Attenuation of Oxidative Stress, Inflammation, and Apoptosis

  2024cites this paper
• An integrated view of cisplatin-induced nephrotoxicity, hepatotoxicity, and cardiotoxicity: characteristics, common molecular mechanisms, and current clinical management

  2024cites this paper
• Evaluation of Herbal Composite for Activity Against Anti-cancer Drug-induced Nephrotoxicity in Wistar Rats

  2024cites this paper
• Distinctive characteristics of extracellular vesicles from feline adipose and placenta stromal cells unveil potential for regenerative medicine in cats.

  2024influential citation
• Mitochondrial dysfunction decreases cisplatin sensitivity in gastric cancer cells through upregulation of integrated stress response and mitokine GDF15

  2023cites this paper
• The Role for AVE0991 (MAS-Receptor Angiotensin II (1-7) Agonist) in Reducing Cisplatin-Induced Acute Kidney Injury on C57BL/6 Mice

  2023cites this paper
• A new perspective in the prevention and treatment of antitumor therapy-related cardiotoxicity: Intestinal microecology.

  2023cites this paper
• MicroRNAs Involved in Intrinsic Apoptotic Pathway during Cisplatin-Induced Nephrotoxicity: Potential Use of Natural Products against DDP-Induced Apoptosis

  2022cites this paper
• Effects of Pantothenic Acid on Growth Performance, Oxidative Stress, and Lipid Content in High-Fat-Fed Megalobrama amblycephala

  2022cites this paper
• Unexpected Enhancement of Cytotoxicity of Cisplatin in a Rat Kidney Proximal Tubular Cell Line Overexpressing Mitochondrial Glutathione Transport Activity

  2022cites this paper
• Ameliorative impacts of polymeric and metallic nanoparticles on cisplatin-induced nephrotoxicity: a 2011–2022 review

  2022cites this paper
• Decreased kidney mitochondrial content and PGC-1α following repeated low-dose cisplatin-induced kidney injury.

  2022cites this paper
• Based on network pharmacology and molecular docking to explore the protective effect of Epimedii Folium extract on cisplatin-induced intestinal injury in mice

  2022cites this paper
• Adipose Tissue-Mesenchymal Stem Cells Improve Cisplatin-Induced Cardiotoxicity in Rats Via Modulating Apoptosis, Oxidative Stress, Inflammation, and Angiogenesis

  2022cites this paper
• Icariin exhibits protective effects on cisplatin-induced cardiotoxicity via ROS-mediated oxidative stress injury in vivo and in vitro.

  2022cites this paper
• Cisplatin induces lung cell cilia disruption and lung damage via oxidative stress.

  2021cites this paper
• Unveiling Metabolic Vulnerability and Plasticity of Human Osteosarcoma Stem and Differentiated Cells to Improve Cancer Therapy

  2021cites this paper
• Mitochondrial Superoxide Dismutase in Cisplatin-Induced Kidney Injury

  2021cites this paper
• The Effect of Curcumin Nanoparticles on Cisplatin-Induced Cardiotoxicity in Male Wistar Albino Rats

  2021cites this paper
• Epigenetic Mechanisms Involved in Cisplatin-Induced Nephrotoxicity: An Update

  2021cites this paper
• New Alkoxy- Analogues of Epoxyeicosatrienoic Acids Attenuate Cisplatin Nephrotoxicity In Vitro via Reduction of Mitochondrial Dysfunction, Oxidative Stress, Mitogen-Activated Protein Kinase Signaling, and Caspase Activation.

  2021cites this paper
• Toxic Effect of Platinum Compounds: Molecular Mechanisms of Toxicity

  2021cites this paper
• Mitochondrial Transplantation: Is It a Feasible Therapy to Prevent the Cardiorenal Side Effects of Cisplatin?

  2021cites this paper
• Cisplatin-induced nephrotoxicity in children: what is the best protective strategy?

  2020cites this paper
• The Role of Mitochondria in Drug-Induced Kidney Injury

  2020cites this paper
• 5-aza-2′-Deoxycytidine Induces a RIG-I-Related Innate Immune Response by Modulating Mitochondria Stress in Neuroblastoma

  2020cites this paper
• Exploiting Cancer Cells Metabolic Adaptability to Enhance Therapy Response in Cancer.

  2020cites this paper
• Cisplatin Suppresses Proliferation of Ovarian Cancer Cells through Inhibition Akt and Modulation MAPK Pathways

  2020cites this paper
• Links between cancer metabolism and cisplatin resistance.

  2020cites this paper
• The Effect of Adipose Derived Stem Cells versus Platelet Rich Plasma in Ameliorating Cisplatin-Induced Injury on The Submandibular Salivary Gland.”A Comparative Histological Study”.

  2020cites this paper
• Carotenoid metabolism in mitochondrial function

  2020cites this paper
• mtDNA mutations in cancer

  2020cites this paper
• Vernonia cinerea regenerates tubular epithelial cells in cisplatin induced nephrotoxicity in cancer bearing mice without affecting antitumor activity

  2020cites this paper
• Role of the mitochondrial stress response in human cancer progression

  2020cites this paper
• The influence of ginger administration on cisplatin-induced cardiotoxicity in rat: Light and electron microscopic study.

  2019cites this paper
• Cisplatin Toxicity in Children with Malignancy

  2019cites this paper
• Mitochondrial Involvement in Cisplatin Resistance

  2019cites this paper
• Regulation of mitochondrial biosynthesis and function by dietary carbohydrate levels and lipid sources in juvenile blunt snout bream Megalobrama amblycephala.

  2019cites this paper
• Benfotiamine, a Lipid-Soluble Analog of Vitamin B1, Improves the Mitochondrial Biogenesis and Function in Blunt Snout Bream (Megalobrama amblycephala) Fed High-Carbohydrate Diets by Promoting the AMPK/PGC-1β/NRF-1 Axis

  2018cites this paper
• Possible Prophylactic Role of Querctine on Cisplatin-Induced Myocardial Toxicity in Adult Male Albino Rat: Histological and Immunohistochemical Study

  2018cites this paper
• Cisplatin nephrotoxicity: a review of the literature

  2018cites this paper
• Comprehensive review on how platinum- and taxane-based chemotherapy of ovarian cancer affects biology of normal cells

  2018cites this paper
• Aristolochic acid I determine the phenotype and activation of macrophages in acute and chronic kidney disease

  2018cites this paper
• Low Ctr1p, due to lack of Sco1p results in lowered cisplatin uptake and mediates insensitivity of rho0 yeast to cisplatin.

  2018cites this paper
• Mitochondrial NADP+-dependent isocitrate dehydrogenase deficiency increases cisplatin-induced oxidative damage in the kidney tubule cells

  2018cites this paper
• Oxidized fish oil injury stress in Megalobrama amblycephala: Evaluated by growth, intestinal physiology, and transcriptome‐based PI3K‐Akt/NF‐&kgr;B/TCR inflammatory signaling

  2018cites this paper
• Bioenergetics of acquired cisplatin resistant H1299 non-small cell lung cancer and P31 mesothelioma cells

  2017cites this paper
• L-thyroxine modifies nephrotoxicity by regulating the apoptotic pathway: The possible role of CD38/ADP-ribosyl cyclase-mediated calcium mobilization

  2017cites this paper
• Evidence for a morphologically distinct and functionally robust cell type in the proximal tubules of human kidney

  2017cites this paper
• Berberine attenuates oxidative stress and hepatocytes apoptosis via protecting mitochondria in blunt snout bream Megalobrama amblycephala fed high-fat diets

  2017cites this paper
• Acetyl-l-carnitine partially prevents benzene-induced hematotoxicity and oxidative stress in C3H/He mice.

  2017cites this paper
• Linking metabolic reprogramming to therapy resistance in cancer.

  2017cites this paper
• Common Chemical Inductors of Replication Stress: Focus on Cell-Based Studies

  2017cites this paper
• Mitochondrial dysfunction and prostate cancer racial disparities among American men.

  2017cites this paper
• Effects of thymoquinone against cisplatin-induced cardiac injury in rats.

  2016cites this paper
• Studies on renal progenitor cells and kidney cancer

  2016cites this paper
• Minimal systems analysis of mitochondria-dependent apoptosis induced by cisplatin

  2016cites this paper
• Drug induced mitochondrial dysfunction: Mechanisms and adverse clinical consequences.

  2016cites this paper
• A Comprehensive Review on the Genetic Regulation of Cisplatin-induced Nephrotoxicity

  2016cites this paper
• The effect of hyperthermia on liver histology, oxidative stress and disease resistance of the Wuchang bream, Megalobrama amblycephala.

  2016cites this paper
• Species Diversity Regarding the Presence of Proximal Tubular Progenitor Cells of the Kidney

  2016cites this paper
• Mitochondrial Mutagenesis in Cancer

  2016cites this paper
• Modulation of PKC signaling and induction of apoptosis through suppression of reactive oxygen species and tumor necrosis factor receptor 1 (TNFR1): key role of quercetin in cancer prevention

  2015cites this paper
• Anticarcinogenic action of quercetin by downregulation of phosphatidylinositol 3-kinase (PI3K) and protein kinase C (PKC) via induction of p53 in hepatocellular carcinoma (HepG2) cell line

  2015cites this paper
• The ability of mannitol to decrease cisplatin-induced nephrotoxicity in children: real or not?

  2015cites this paper
• Mechanism of cisplatin proximal tubule toxicity revealed by integrating transcriptomics, proteomics, metabolomics and biokinetics.

  2015cites this paper
• Oxidative Stress Resistance in Metastatic Prostate Cancer: Renewal by Self-Eating

  2015cites this paper
• How do changes in the mtDNA and mitochondrial dysfunction influence cancer and cancer therapy? Challenges, opportunities and models.

  2015cites this paper
• P53 Contributes to Cisplatin Induced Renal Oxidative Damage via Regulating P66shc and MnSOD

  2015cites this paper
• Canonical and new generation anticancer drugs also target energy metabolism

  2014influential citation
• Exploring the protective role of apocynin, a specific NADPH oxidase inhibitor, in cisplatin-induced cardiotoxicity in rats.

  2014cites this paper
• The protective effect of thiamine pyrophosphate, but not thiamine, against cardiotoxicity induced with cisplatin in rats

  2014cites this paper
• Evidence for a morphologically distinct and functionally robust cell type in the proximal tubules of human kidney.

  2014cites this paper
• Tempol, a Superoxide Dismutase Mimetic Agent, Ameliorates Cisplatin-Induced Nephrotoxicity through Alleviation of Mitochondrial Dysfunction in Mice

  2014cites this paper
• Effect of creatine and pioglitazone on Hk-2 cell line cisplatin nephrotoxicity

  2014cites this paper
• Association of mitochondrial dysfunction with oxidative stress and immune suppression in Blunt Snout Bream Megalobrama amblycephala fed a high-fat diet.

  2014cites this paper
• Effect of free creatine therapy on cisplatin-induced renal damage

  2014cites this paper
• GENETIC AND HISTOLOGICAL STUDIES ON EFFECT OF MESENCHYMAL STEM CELL THERAPY ON EXPERIMENTAL RENAL INJURY INDUCED BY CISPLATIN IN MALE ALBINO RATS

  2014cites this paper
• Mitochondrial DNA haplogroup-dependence of drugs and xenobiotics toxicity

  2014cites this paper
• Evidence Against Protective Role of Sex Hormone Estrogen in Cisplatin-Induced Nephrotoxicity in Ovarectomized Rat Model

  2013cites this paper
• Reduced Mitochondrial DNA Content Associates with Poor Prognosis of Prostate Cancer in African American Men

  2013cites this paper
• Mitochondrial dysfunction mediated cisplatin induced toxicity: modulatory role of curcumin.

  2013cites this paper
• Cisplatin-induced injury of the renal distal convoluted tubule is associated with hypomagnesaemia in mice

  2013cites this paper
• Role of mitochondrial respiration in sensitization of copper-deficient yeast to cisplatin-induced cytotoxicity

  2013cites this paper
• Cisplatin-induced injury of the renal distal convoluted tubule is associated with hypomagnesaemia in mice.

  2013cites this paper
• Cisplatin Induces a Mitochondrial-ROS Response That Contributes to Cytotoxicity Depending on Mitochondrial Redox Status and Bioenergetic Functions

  2013cites this paper
• Platinum compounds in children with cancer: toxicity and clinical management

  2013cites this paper
• Effects of Fennel Essential Oil on Cisplatin-induced Nephrotoxicity in Ovariectomized Rats

  2013cites this paper
• Organelle Cross-Talk in Apoptotic and Survival Pathways

  2012cites this paper
• Harnessing Mitochondria-penetrating Peptides for the Organellar Delivery of Small Molecule Drugs

  2012cites this paper
• Mitochondrial DNA Copy Number Alterations in Human Cancers

  2012cites this paper
• Effects of Cisplatin in Neuroblastoma Rat Cells: Damage to Cellular Organelles

  2012cites this paper
• Computational modeling of apoptotic signaling pathways induced by cisplatin

  2012cites this paper
• Effects of creatine in a rat intestinal model of ischemia/reperfusion injury

  2012cites this paper
• Cisplatin as an Anti-Tumor Drug: Cellular Mechanisms of Activity, Drug Resistance and Induced Side Effects

  2011cites this paper