Kozak sequence polymorphism of the glycoprotein (GP) Ibalpha gene is a major determinant of the plasma membrane levels of the platelet GP Ib-IX-V complex.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Blood

• Publication date

  1999-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1182/BLOOD.V94.1.186.413K19_186_191PMID 10381512
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Systematic screening for genetic polymorphism in human platelet glycoprotein Ibalpha

  2007cited by this paper
• A common genetic polymorphism (46 C to T substitution) in the 5'-untranslated region of the coagulation factor XII gene is associated with low translation efficiency and decrease in plasma factor XII level.

  1998cited by this paper
• Pathophysiology of Platelet Thrombin Receptors

  1997cited by this paper
• Bernard-Soulier syndrome caused by a dinucleotide deletion and reading frameshift in the region encoding the glycoprotein Ib alpha transmembrane domain.

  1997cited by this paper
• Platelet activation: new aspects.

  1996cited by this paper
• Identification of Essential GATA and Ets Binding Motifs within the Promoter of the Platelet Glycoprotein Ibα Gene (*)

  1995cited by this paper
• The platelet glycoprotein Ib-IX complex.

  1994cited by this paper
• The Platelet Cytoskeleton

  1993cited by this paper
• On the role of the platelet membrane skeleton in mediating signal transduction. Association of GP IIb-IIIa, pp60c-src, pp62c-yes, and the p21ras GTPase-activating protein with the membrane skeleton.

  1993cited by this paper
• Polymorphysm of human glycoprotein Ibα results from a variable number of tandem repeats of a 13-amino acid sequence in the mucin-like macroglycopeptide region

  1992cited by this paper
• Efficient plasma membrane expression of a functional platelet glycoprotein Ib-IX complex requires the presence of its three subunits.

  1992cited by this paper
• Tumor necrosis factor-alpha modulation of glycoprotein Ib alpha expression in human endothelial and erythroleukemia cells.

  1992cited by this paper
• Polymorphism of human glycoprotein Ib alpha results from a variable number of tandem repeats of a 13-amino acid sequence in the mucin-like macroglycopeptide region. Structure/function implications.

  1992cited by this paper
• At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells.

  1987cited by this paper
• Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes.

  1986cited by this paper
• Point mutations close to the AUG initiator codon affect the efficiency of translation of rat preproinsulin in vivo

  1984cited by this paper
• Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes.

  1981cited by this paper

• Kv3.3 Expression Enhanced by a Novel Variant in the Kozak Sequence of KCNC3

  2024cites this paper
• An Exploratory Study Using Next-Generation Sequencing to Identify Prothrombotic Variants in Patients with Cerebral Vein Thrombosis

  2023cites this paper
• A non-coding variant in the Kozak sequence of RARS2 strongly decreases protein levels and causes pontocerebellar hypoplasia

  2023cites this paper
• Reprogramming translation for gene therapy.

  2021cites this paper
• An analysis of the Kozak consensus in retinal genes and its relevance to gene therapy

  2021cites this paper
• Enhancing the biotransformation efficiency of human CYP17A1 in Pichia pastoris by co-expressing CPR and glucose-6-phosphate dehydrogenase simultaneously

  2021cites this paper
• A Review of Design Considerations for Hemocompatibility within Microfluidic Systems

  2020cites this paper
• Casein composition and differential translational efficiency of casein transcripts in donkey's milk.

  2019cites this paper
• Identification of llama KRTAP7-1 and KRTAP8-1 fiber genes and polymorphism screening

  2019cites this paper
• Myocardial infarction before and after the age of 45: Possible role of platelet receptor polymorphisms.

  2018cites this paper
• [The association of hemostasis system genes with the development of ischemic stroke in patients under the age of 50 years].

  2018cites this paper
• Platelet Polymorphisms: Still a Long Way to Go

  2018cites this paper
• Active ribosome profiling with RiboLace

  2017cites this paper
• 19 – Investigation of a Thrombotic Tendency

  2017cites this paper
• Platelet genomics: the role of platelet size and number in health and disease

  2017cites this paper
• Gene Regulation of Platelet Function

  2017cites this paper
• Influence of genetic variations in platelet glycoproteins and eNOS in the development of arterial ischaemia of lower limbs in type 2 diabetes mellitus patients.

  2016cites this paper
• Comparison of the gene encoding, and the predicted amino acid composition of, platelet membrane receptor subunit glycoprotein Ibα in members of the family Felidae.

  2016cites this paper
• Aspirin Resistance Resistance In Vitro to Low-Dose Aspirin Is Associated With Platelet PlA 1 ( GP IIIa ) Polymorphism But Not With C 807 T ( GP Ia / IIa ) and C-5 T Kozak ( GP Ib ) Polymorphisms

  2016cites this paper
• Common genetic variants in platelet surface receptors and its association with ischemic stroke.

  2016cites this paper
• Glycoprotein Ibα Kozak polymorphism in patients presenting with early-onset acute coronary syndrome

  2016cites this paper
• Association between polymorphisms of platelet membrane glycoprotein Ibα and risk of coronary heart disease in Han Chinese, Henan, China.

  2015cites this paper
• The pharmacogenetic control of antiplatelet response: candidate genes and CYP2C19

  2015cites this paper
• [The molecular mechanisms of platelets activation in patients with cerebrovascular disease].

  2015cites this paper
• Relationships of glycoproteins IIb-IIIa and Ib content with mean platelet volume and their genetic polymorphisms

  2014cites this paper
• Genetic risk factors of atherothrombosis.

  2014cites this paper
• Mean platelet volume: Interrelation with platelet aggregation activity and glycoprotein IIb-IIIa and Ib expression levels

  2014cites this paper
• The role of coagulation factor XII in fibrin clot formation and fibrinolysis

  2014cites this paper
• Quantitative analysis of mammalian translation initiation sites by FACS-seq

  2014cites this paper
• Spectrum of the Mutations in Bernard–Soulier Syndrome

  2014influential citation
• GPIb VNTR C/C genotype may predict embolic events in infective endocarditis.

  2013cites this paper
• Inherited disorders of platelets: membrane glycoprotein disorders.

  2013cites this paper
• Genetic variation of platelet function and pharmacology: An update of current knowledge

  2013cites this paper
• Common Genetic Determinants of Coagulation and Fibrinolysis

  2013cites this paper
• arterial thrombus formation in men Role of 4 platelet membrane glycoprotein polymorphisms on experimental

  2013cites this paper
• Willebrand Disease (VWD) type 1 pedigrees An association of candidate gene haplotypes and bleeding severity in Von

  2013cites this paper
• therapy for coronary heart disease in postmenopausal women taking hormone and VI on the risk α Effect of genetic variations in platelet glycoproteins Ib

  2013cites this paper
• A Novel Finding

  2013cites this paper
• Pharmacogenomics and Personalized Medicine of the Antiplatelet Drugs

  2013cites this paper
• Hemostasis and Thrombosis

  2013cites this paper
• The contribution of platelet glycoproteins (GPIa C807T and GPIba C-5T) and cyclooxygenase 2 (COX-2G-765C) polymorphisms to platelet response in patients treated with aspirin.

  2013cites this paper
• Glycoprotein Ib-alpha Kozak polymorphism in ischemic stroke

  2012cites this paper
• Pharmacogenetics of the antiplatelet effect of aspirin.

  2012cites this paper
• Platelet adhesion to decorin but not collagen I correlates with the integrin α2 dimorphism E534K, the basis of the human platelet alloantigen (HPA)-5 system

  2012cites this paper
• Genetic variants that affect platelet function

  2012cites this paper
• The impact of platelet membrane glycoprotein Ib alpha and Ia/IIa polymorphisms on the risk of thrombosis in the antiphospholipid syndrome.

  2012cites this paper
• Role of Kozak sequence polymorphism of platelet glycoprotein Iba as a risk factor for CAD after PCI

  2011cites this paper
• Individual variability in the disposition of and response to clopidogrel: pharmacogenomics and beyond.

  2011cites this paper
• Platelet-type Von Willebrand disease: three decades in the life of a rare bleeding disorder.

  2011cites this paper
• Platelet receptor gain-of-function single nucleotide polymorphisms in carotid and vertebral stenosis patients

  2011cites this paper
• Impact of COX-2 rs5275 and rs20417 and GPIIIa rs5918 polymorphisms on 90-day ischemic stroke functional outcome: a novel finding.

  2011cites this paper
• Regulatory genetic variation in the Flavin-containing monooxygenase 1 gene (FMO1) : detection and functional consequences

  2011cites this paper
• Novel Insights into Genetics of Arterial Thrombosis

  2011cites this paper
• Recent therapeutic approaches to platelet activation in coronary artery disease.

  2010cites this paper
• The genetics of normal platelet reactivity.

  2010cites this paper
• GPIbα-selective activation of platelets induces platelet signaling events comparable to GPVI activation events

  2010cites this paper
• Novel Mutation in Bernard-Soulier Syndrome

  2010cites this paper
• A functional analysis of G23A polymorphism and the alternative splicing in the expression of the XPA gene

  2010cites this paper
• Antithrombotic drug therapy in cardiovascular disease

  2010cites this paper
• The Genetics of Thrombosis

  2010cites this paper
• Platelet glycoprotein Ibα gene polymorphism and massive or submassive pulmonary embolism

  2009cites this paper
• Genetics of platelet reactivity in normal, healthy individuals

  2009cites this paper
• A functional genomics approach reveals novel quantitative trait loci associated with platelet signaling pathways.

  2009cites this paper
• Compromised ITAM‐based platelet receptor function in a patient with immune thrombocytopenic purpura

  2008cites this paper
• Genetic polymorphisms for the study of multifactorial stroke

  2008cites this paper
• Platelet GPIbalpha, GPIV and vWF polymorphisms and fatal pre-hospital MI among middle-aged men.

  2008cites this paper
• Pharmacogenetics of bone treatments: the VDR and ERalpha gene story.

  2008cites this paper
• A case of Bernard-Soulier Syndrome due to a homozygous four bases deletion (TGAG) of GPIbα gene: Lack of GPIbα but absence of bleeding

  2008cites this paper
• Polymorphisms of Platelet Membrane Glycoproteins

  2008cites this paper
• Platelet GPIbα, GPIV and vWF polymorphisms and fatal pre-hospital MI among middle-aged men

  2008cites this paper
• Lack of association between aspirin responsiveness and seven candidate gene haplotypes in patients with symptomatic vascular disease

  2008cites this paper
• Polymorphisms in Platelet Glycoprotein 1bα and Factor VII and Risk of Ischemic Stroke: A Meta-Analysis

  2008cites this paper
• 17 – Investigación de la tendencia trombótica

  2008cites this paper
• Platelet functional implications of glycoprotein Ibα polymorphisms in African Americans

  2007cites this paper
• Bone mass pharmacogenetics and ethnic health implications.

  2007cites this paper
• Platelet glycoprotein polymorphisms: risk, in vivo expression and severity of atherothrombotic stroke in Chinese.

  2007cites this paper
• Effect of genetic variations in platelet glycoproteins Ibalpha and VI on the risk for coronary heart disease events in postmenopausal women taking hormone therapy.

  2007cites this paper
• Platelet glycoprotein VI‐related clinical defects

  2007influential citation
• Exploratory aspirin resistance trial in healthy Japanese volunteers (J-ART) using platelet aggregation as a measure of thrombogenicity

  2007cites this paper
• CHAPTER 14 – Platelet Polymorphisms

  2007cites this paper
• Role of CD36 in Platelet Function

  2007cites this paper
• Bone mass pharmacogenetics and ethnic health implications Mini-review

  2007cites this paper
• Platelet glycoprotein Ibα polymorphisms and function evaluated by the platelet function analyzer PFA-100 in patients with lupus anticoagulant: the association with thromboembolic disease

  2007cites this paper
• Genetic characterization of patients with Bernard-Soulier syndrome and their relatives from Southern Iran

  2007cites this paper
• [Predictors of intracardiac thrombosis in patients with atrial fibrillation: factors of hemostasis, markers of inflammation, and genetic factors].

  2007cites this paper
• Association between Platelet Glycoprotein Ib‐α and Myocardial Infarction

  2006cites this paper
• Seven haemostatic gene polymorphisms in coronary disease: meta-analysis of 66,155 cases and 91,307 controls.

  2006cites this paper
• Efficient expression of a transgene in platelets using simian immunodeficiency virus‐based vector harboring glycoprotein Ibα promoter: in vivo model for platelet‐targeting gene therapy

  2006cites this paper
• Molecular Mechanisms of Prothrombotic Risk Due to Genetic Variations in Platelet Genes: Enhanced Outside-In Signaling Through the Pro33 Variant of Integrin β3

  2006cites this paper
• Role of five platelet membrane glycoprotein polymorphisms in branch retinal vein occlusion

  2006cites this paper
• An association of candidate gene haplotypes and bleeding severity in von Willebrand disease type 2A, 2B, and 2M pedigrees

  2006cites this paper
• Thrombotic Vascular Disease

  2005cites this paper
• Genetics of Platelet Glycoprotein Receptors: Risk of Thrombotic Events and Pharmacogenetic Implications

  2005cites this paper
• Turkish population data on the factor XIII Val34Leu,glycoprotein (GP)Ibα Kozak and P‐selectin glycoprotein ligand 1 (PSGL‐1) loci

  2005cites this paper
• The snake venom protein botrocetin acts as a biological brace to promote dysfunctional platelet aggregation

  2005cites this paper
• Co‐inheritance of the Hb Sun Prairie mutation with a point mutation at 5′‐UTR in the eastern Indian population

  2005cites this paper
• Platelet Function Studies

  2005cites this paper
• Pathobiology and cell interactions of platelets in diabetes

  2005cites this paper
• Blood platelet reactivity and its pharmacological modulation in (people with) diabetes mellitus.

  2005cites this paper
• Genetic factors underlying differential blood platelet sensitivity to inhibitors.

  2005cites this paper