Role of the Interleukin 10 Family of Cytokines in Patients With Immune Reconstitution Inflammatory Syndrome Associated With HIV Infection and Tuberculosis

Background.  The interleukin 10 (IL-10) family comprises cytokines structurally related to IL-10 that share signaling receptors that have conserved signaling cascades. The immunopathogenesis of immune reconstitution inflammatory syndrome (IRIS) in patients with human immunodeficiency virus (HIV) infection and tuberculosis remains incompletely understood. We hypothesized that a deficiency of IL-10 and its homologs may contribute to the immunopathology of IRIS in these patients. Methods. We performed a case-control analysis involving patients with HIV infection and tuberculosis who had IRIS at clinical presentation (tuberculosis-IRIS) and similar patients with HIV infection and tuberculosis who did not develop tuberculosis-IRIS (non-IRIS). Peripheral blood mononuclear cells (PBMCs) were cultured in the presence or absence of heat-killed Mycobacterium tuberculosis for 6 and 24 hours. Messenger RNA was analyzed by quantitative reverse transcription polymerase chain reaction analysis. Cytokine concentrations in serum were also determined. Results. Cultures of PBMCs stimulated with M. tuberculosis for 24 hours yielded higher IL-10 and interleukin 22 (IL-22) transcript levels for tuberculosis-IRIS patients, compared with non-IRIS patients. Analysis of corresponding serum samples showed significantly higher concentrations of IL-10 and IL-22 in tuberculosis-IRIS patients, compared with non-IRIS patients. Conclusions. IL-10 and IL-22 were differentially induced in PBMCs from tuberculosis-IRIS patients after in vitro stimulation, and higher concentrations of their corresponding proteins were detected in serum (in vivo). The higher levels of IL-10 observed in this study may represent a compensatory antiinflammatory response during tuberculosis-IRIS. The elevated levels of IL-22 suggest an association between this cytokine and immunopathology during tuberculosis-IRIS.

• Publication year

  2013

• Venue

  Journal of Infectious Diseases

• Publication date

  2013-01-09

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/infdis/jit002PMID 23303806PMCID 3583273
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Immune reconstitution inflammatory syndrome: the trouble with immunity when you had none

  2012cited by this paper
• Corticosteroid Therapy, Vitamin D Status, and Inflammatory Cytokine Profile in the HIV-Tuberculosis Immune Reconstitution Inflammatory Syndrome

  2012cited by this paper
• Corticosteroid-modulated immune activation in the tuberculosis immune reconstitution inflammatory syndrome.

  2012cited by this paper
• Predominance of interleukin-22 over interleukin-17 at the site of disease in human tuberculosis

  2011cited by this paper
• TLR2-induced cytokine responses may characterize HIV-infected patients experiencing mycobacterial immune restoration disease

  2011cited by this paper
• [Immune reconstitution inflammatory syndrome].

  2011cited by this paper
• Evaluation of Paradoxical TB-Associated IRIS With the Use of Standardized Case Definitions For Resource-Limited Settings

  2010cited by this paper
• The regulation of IL-10 production by immune cells

  2010cited by this paper
• Hypercytokinaemia accompanies HIV–tuberculosis immune reconstitution inflammatory syndrome

  2010cited by this paper
• Enhanced protection to Mycobacterium tuberculosis infection in IL-10-deficient mice is accompanied by early and enhanced Th1 responses in the lung

  2010cited by this paper
• Validation of a published case definition for tuberculosis-associated immune reconstitution inflammatory syndrome

  2010cited by this paper
• Fatal unmasking tuberculosis immune reconstitution disease with bronchiolitis obliterans organizing pneumonia: the role of macrophages.

  2009cited by this paper
• Tuberculosis-associated immune reconstitution inflammatory syndrome and unmasking of tuberculosis by antiretroviral therapy.

  2009cited by this paper
• Novel relationship between tuberculosis immune reconstitution inflammatory syndrome and antitubercular drug resistance.

  2009cited by this paper
• Clinical case definition and manifestations of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome

  2009cited by this paper
• Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings.

  2008cited by this paper
• Type 1 helper T cells and FoxP3-positive T cells in HIV-tuberculosis-associated immune reconstitution inflammatory syndrome.

  2008cited by this paper
• Distinct, Specific IL-17- and IL-22-Producing CD4+ T Cell Subsets Contribute to the Human Anti-Mycobacterial Immune Response1

  2008cited by this paper
• The extended IL-10 superfamily: IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, IL-28, and IL-29.

  2008cited by this paper
• The two faces of interleukin 10 in human infectious diseases.

  2006influential reference
• Is there an interaction between interleukin-10 and interleukin-22?

  2005cited by this paper
• IL-22 increases the innate immunity of tissues.

  2004cited by this paper
• Immune restoration disease after antiretroviral therapy

  2004cited by this paper
• of Tissues

  2003cited by this paper
• The immune reconstitution inflammatory syndrome.

  2003cited by this paper
• Serum cytokine concentrations do not parallel Mycobacterium tuberculosis-induced cytokine production in patients with tuberculosis.

  2003cited by this paper
• The interleukin-10 family of cytokines.

  2002cited by this paper
• Cutting Edge: Immune Cells as Sources and Targets of the IL-10 Family Members?

  2002influential reference
• Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor.

  2000cited by this paper
• IL‐10 in HIV infection: increasing serum IL‐10 levels with disease progression—down‐regulatory effect of potent anti‐retroviral therapy

  1999cited by this paper
• The Interleukin-10 Signal Transduction Pathway and Regulation of Gene Expression in Mononuclear Phagocytes

  1999cited by this paper
• Enhanced interleukin-10 production in response to Mycobacterium avium products in mononuclear cells from patients with human immunodeficiency virus infection.

  1998influential reference

• The Crosstalk Between HIV-TB Co-Infection and Associated Resistance in the Indian Population

  2024cites this paper
• Lymph node tuberculosis‐associated paradoxical immune reconstitution inflammatory syndrome in a non‐HIV patient: Case report and review of literature

  2024cites this paper
• Cryptococcal Immune Reconstitution Inflammatory Syndrome: From Clinical Studies to Animal Experiments

  2022cites this paper
• Aberrant cytokine milieu and signaling affect immune cell phenotypes and functions in tuberculosis pathology: What can we learn from this phenomenon for application to inflammatory syndromes?

  2021cites this paper
• Tuberculosis IRIS: Pathogenesis, Presentation, and Management across the Spectrum of Disease

  2020cites this paper
• CD4+ T cell cytokine responses to the DAR-901 booster vaccine in BCG-primed adults: A randomized, placebo-controlled trial

  2019cites this paper
• Attenuation of macrophage IL-10 responses by HIV-1

  2019cites this paper
• Chronic Disseminated Candidiasis During Hematological Maligancies: An Immune Reconstitution Inflammatory Syndrome with Expansion of Pathogen-Specific TH1 T Cells.

  2019influential citation
• SEKRESI IFN-? DAN IL-10 SETELAH STIMULASI ANTIGEN FUSI ESAT-6-CFP-10 (EC610) PADA PENDERITA TB AKTIF DAN TB LATEN

  2019cites this paper
• Th1/Th2细胞因子及淋巴细胞亚群在成人淋巴瘤相关噬血细胞性淋巴组织细胞增多症中的表达及临床意义

  2019cites this paper
• Immune reconstitution inflammatory syndrome in non‐HIV immunosuppressed patients

  2018cites this paper
• Diminished circulating plasma and elevated lymph node culture supernatant levels of IL‐10 family cytokines in tuberculous lymphadenitis

  2018cites this paper
• Striking the right immunological balance prevents progression of tuberculosis

  2017cites this paper
• The Goldilocks model of immune symbiosis with Mycobacteria and Candida colonizers.

  2017cites this paper
• Novel role for IL-22 in protection during chronic Mycobacterium tuberculosis HN878 infection

  2017cites this paper
• Neutrophil Activation and Enhanced Release of Granule Products in HIV-TB Immune Reconstitution Inflammatory Syndrome

  2017cites this paper
• Confusion in the Study of Immune Reconstitution Inflammatory Syndrome

  2017cites this paper
• The effect of Kefir on The Immune Response of Healthy Volunteers In Vitro

  2017cites this paper
• Preventing Paradoxical Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome in High-Risk Patients: Protocol of a Randomized Placebo-Controlled Trial of Prednisone (PredART Trial)

  2016cites this paper
• Interleukin-10 Family and Tuberculosis: An Old Story Renewed

  2016cites this paper
• Interleukin 27 R regulates CD 4 + T cell phenotype and impacts protective immunity during Mycobacterium tuberculosis infection

  2015cites this paper
• Role of cytokines and other factors involved in the Mycobacterium tuberculosis infection

  2015cites this paper
• TB-IRIS, T-cell activation, and remodeling of the T-cell compartment in highly immunosuppressed HIV-infected patients with TB

  2015cites this paper
• Interleukin 27R regulates CD4+ T cell phenotype and impacts protective immunity during Mycobacterium tuberculosis infection

  2015cites this paper
• Immune reconstitution inflammatory syndrome in HIV-infected patients

  2015cites this paper
• HIV-1 tuberculosis-associated immune reconstitution inflammatory syndrome

  2015cites this paper
• Biomarkers of CD 4 + T-cell activation as risk factors for tuberculosis-associated immune reconstitution inflammatory syndrome

  2014cites this paper
• OMIP-022: Comprehensive assessment of antigen-specific human T-cell functionality and memory

  2014cites this paper
• Biomarkers of CD4+ T-cell activation as risk factors for tuberculosis-associated immune reconstitution inflammatory syndrome

  2014cites this paper
• TB-IRIS and remodelling of the T-cell compartment in highly immunosuppressed HIV+ patients with TB

  2014cites this paper
• Immune Reconstitution Disorders in Patients With HIV Infection: From Pathogenesis to Prevention and Treatment

  2014cites this paper
• Immune restoration after antiretroviral therapy: the pitfalls of hasty or incomplete repairs

  2013cites this paper
• The immunopathogenesis of the HIV tuberculosis immune reconstitution inflammatory syndrome

  2013cites this paper