HIV-1 tuberculosis-associated immune reconstitution inflammatory syndrome

Patients co-infected with HIV-1 and tuberculosis (TB) are at risk of developing TB-associated immune reconstitution inflammatory syndrome (TB-IRIS) following commencement of antiretroviral therapy (ART). TB-IRIS is characterized by transient but severe localized or systemic inflammatory reactions against Mycobacterium tuberculosis antigens. Here, we review the risk factors and clinical management of TB-IRIS, as well as the roles played by different aspects of the immune response in contributing to TB-IRIS pathogenesis.

• Publication year

  2015

• Venue

  Seminars in Immunopathology

• Publication date

  2015-09-30

• Fields of study

  Medicine

• Identifiers
  DOI 10.1007/s00281-015-0532-2PMID 26423994PMCID 4779131
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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