Corticosteroid Therapy, Vitamin D Status, and Inflammatory Cytokine Profile in the HIV-Tuberculosis Immune Reconstitution Inflammatory Syndrome

Vitamin D deficiency is common in human immunodeficiency virus–tuberculosis coinfected patients in Cape Town. Those who develop tuberculosis-immune reconstitution inflammatory syndrome have a further reduction in circulating 25-hydroxyvitamin D levels 2 weeks into combined antiretroviral therapy with a concomitant increase in inflammatory cytokines and chemokines.

• Publication year

  2012

• Venue

  Clinical Infectious Diseases

• Publication date

  2012-06-19

• Fields of study

  Medicine

• Identifiers
  DOI 10.1093/cid/cis577PMID 22715179PMCID 3436923
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2010cited by this paper
• Dissection of regenerating T-Cell responses against tuberculosis in HIV-infected adults sensitized by Mycobacterium tuberculosis.

  2009cited by this paper
• Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings.

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  2008cited by this paper
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  2008cited by this paper
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  2007cited by this paper
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• Global tuberculosis control report.

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  1999cited by this paper
• Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety.

  1999cited by this paper
• Vitamin D deficiency.

  1979cited by this paper

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