Renal Ca2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Journal of Clinical Investigation

• Publication date

  2003-12-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1172/JCI19826PMID 14679186PMCID PMC297001
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Calpain-mediated AQP2 proteolysis in inner medullary collecting duct.

  2003cited by this paper
• Homo‐ and heterotetrameric architecture of the epithelial Ca2+ channels TRPV5 and TRPV6

  2003cited by this paper
• In vivo Studies of the Genetically Modified Mouse Kidney

  2003influential reference
• Molecular mechanisms of primary hypercalciuria.

  2003cited by this paper
• Modulation of renal Ca2+ transport protein genes by dietary Ca2+ and 1,25‐dihydroxyvitamin D3 in 25hydroxyvitamin D3‐1α‐hydroxylase knockout mice

  2002influential reference
• Molecular mechanism of active Ca2+ reabsorption in the distal nephron.

  2002influential reference
• CaT1 manifests the pore properties of the calcium-release-activated calcium channel

  2001cited by this paper
• Duodenal calcium absorption in vitamin D receptor–knockout mice: Functional and molecular aspects

  2001cited by this paper
• Effects of long-term administration of vitamin D3 analogs to mice.

  2000cited by this paper
• Analysis of nanoliter samples of electrolytes using a flow-through microfluorometer.

  2000cited by this paper
• The role of calbindin and 1,25dihydroxyvitamin D3 in the kidney.

  2000cited by this paper
• Molecular Cloning and Characterization of a Channel-like Transporter Mediating Intestinal Calcium Absorption*

  1999cited by this paper
• Developmental expression of ROMK in rat kidney.

  1999cited by this paper
• Developmental expression of ROMK in rat kidney.

  1999cited by this paper
• Molecular Identification of the Apical Ca2+Channel in 1,25-Dihydroxyvitamin D3-responsive Epithelia*

  1999cited by this paper
• Deficient T cell fate specification in mice with an induced inactivation of Notch1.

  1999cited by this paper
• Stone prevention: why so little progress?*

  1998cited by this paper
• Quantification of Bone Microarchitecture with the Structure Model Index.

  1997cited by this paper
• A new method for the model‐independent assessment of thickness in three‐dimensional images

  1997cited by this paper
• Apical extracellular calcium/polyvalent cation-sensing receptor regulates vasopressin-elicited water permeability in rat kidney inner medullary collecting duct.

  1997cited by this paper
• Early death due to defective neonatal lung liquid clearance in alpha-ENaC-deficient mice.

  1996cited by this paper
• Efficient in vivo manipulation of mouse genomic sequences at the zygote stage.

  1996cited by this paper
• Quantification of connectivity in cancellous bone, with special emphasis on 3-D reconstructions.

  1993cited by this paper
• Urinary volume in children with urolithiasis.

  1989cited by this paper
• Bone histomorphometry: standardization of nomenclature, symbols and units (summary of proposed system).

  1988cited by this paper
• Measurement of True Calcium Absorption in Premature Infants Using Intravenous 46Ca and Oral 44Ca

  1988cited by this paper
• Tartrate-resistant acid phosphatase in bone and cartilage following decalcification and cold-embedding in plastic.

  1987cited by this paper
• Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee.

  1987cited by this paper
• Bone histomorphometry: Standardization of nomenclature, symbols, and units: Report of the asbmr histomorphometry nomenclature committee

  1987cited by this paper
• Disappearance of calcium and other electrolytes from microvolume samples.

  1982cited by this paper

• Amino acids critical for lipid/s-interaction at the lipid-water-interface of TRPV5/TRPV6 remain different during vertebrate radiation: Relevance in cancer, bone disorders and other pathophysiologies.

  2025cites this paper
• The role of transient receptor potential channels in chronic kidney disease-mineral and bone disorder

  2025cites this paper
• Physiological functions and pharmacological targeting of transient receptor potential channels

  2025cites this paper
• ADAMTS16 and TRPV5: New targets of Zhenwu decoction on renal fibrosis investigated by chemomics and transcriptomics.

  2025cites this paper
• Genetic Insights Into Nephrolithiasis and Renal Cancer Predisposition: Precision Medicine in Genes, Diagnosis, and Therapy.

  2025cites this paper
• Kidney-specific claudin-2 deficiency leads to medullary nephrocalcinosis in mice

  2025cites this paper
• Transient Receptor Potential channels (TRP) in GtoPdb v.2025.4

  2025cites this paper
• Advances in the Study for Modulators of Transient Receptor Potential Vanilloid (TRPV) Channel Family.

  2025cites this paper
• Bone Metabolism Defects in Children With Idiopathic Hypercalciuria: An Update

  2025cites this paper
• The role of calcium ions and the transient receptor potential vanilloid (TRPV) channel in bone remodelling and orthodontic tooth movement

  2025cites this paper
• Yak milk inhibits osteoclast differentiation by suppressing TRPV5 expression.

  2025cites this paper
• The Genistein Supply and Elemental Composition of Rat Kidneys in an Induced Breast Cancer Model

  2025cites this paper
• Ghrelin enhances tubular magnesium absorption in the kidney

  2024cites this paper
• Biology of calcium homeostasis regulation in intestine and kidney

  2024cites this paper
• Functions of TRPs in retinal tissue in physiological and pathological conditions

  2024cites this paper
• Urinary Acidification Does Not Explain the Absence of Nephrocalcinosis in a Mouse Model of Familial Hypomagnesaemia with Hypercalciuria and Nephrocalcinosis (FHHNC)

  2024influential citation
• Calmodulin regulates TRPV5 intracellular trafficking and plasma membrane abundance

  2024cites this paper
• Paracellular Transport and Renal Tubule Calcium Handling

  2024cites this paper
• Calcium signalling and transport in the kidney

  2024cites this paper
• Between a Rock and a Short Place—The Impact of Nephrolithiasis on Skeletal Growth and Development Across the Lifespan

  2024cites this paper
• A successful conclusion to the long search for TRPV5 pathogenic variants in monogenic hypercalciuria

  2024cites this paper
• TRPV Channels in Osteoarthritis: A Comprehensive Review

  2024influential citation
• Decreased calcium permeability caused by biallelic TRPV5 mutation leads to autosomal recessive renal calcium-wasting hypercalciuria

  2024cites this paper
• Alterations in the microenvironment and the effects produced of TRPV5 in osteoporosis

  2023cites this paper
• Effects of parathyroid hormone on renal tubular calcium and phosphate handling

  2023cites this paper
• Biochemistry and pathophysiology of the Transient Potential Receptor Vanilloid 6 (TRPV6) calcium channel.

  2023cites this paper
• Enriched Single-Nucleus RNA-Sequencing reveals unique attributes of distal convoluted tubule cells

  2023cites this paper
• Structural mechanism of TRPV5 inhibition by econazole.

  2023cites this paper
• Kidney stones, hypercalciuria, and recent insights into proximal tubule calcium reabsorption

  2023cites this paper
• Integrative genome-wide analyses identify novel loci associated with kidney stones and provide insights into its genetic architecture

  2023cites this paper
• Yak milk promotes renal calcium reabsorption in mice with osteoporosis via the regulation of TRPV5.

  2023cites this paper
• Furosemide rescues hypercalciuria in familial hypomagnesaemia with hypercalciuria and nephrocalcinosis model

  2023cites this paper
• Influence of glycoprotein MUC1 on trafficking of the Ca2+-selective ion channels, TRPV5 and TRPV6, and on in vivo calcium homeostasis

  2023cites this paper
• Mesenchymal cell TRPM7 expression is required for bone formation via the regulation of chondrogenesis.

  2022cites this paper
• Structural Studies Of Trpv5 Modulation

  2022cites this paper
• Intracellular Helix-Loop-Helix Domain Modulates Inactivation Kinetics of Mammalian TRPV5 and TRPV6 Channels

  2022cites this paper
• The importance of kidney calcium handling in the homeostasis of extracellular fluid calcium

  2022cites this paper
• What structures did, and did not, reveal about the function of the epithelial Ca2+ channels TRPV5 and TRPV6.

  2022cites this paper
• Influence of MUC1 on trafficking of TRPV5 and TRPV6 and in vivo Ca2+ homeostasis

  2022cites this paper
• Structural basis of TRPV5 regulation by physiological and pathophysiological modulators

  2022cites this paper
• Title: Jealous protons sour another happy marriage; the story of how TRPV5 and PI(4,5)P2 split up.

  2022cites this paper
• Calcium Selective Channel TRPV6: Structure, Function, and Implications in Health and Disease.

  2022cites this paper
• Renal calcium and magnesium handling in Gitelman syndrome.

  2022influential citation
• Disrupted placental vitamin D metabolism and calcium signaling in gestational diabetes and pre-eclampsia patients

  2022cites this paper
• Calcium, phosphate, PTH, vitamin D, and FGF-23 in CKD-mineral and bone disorder

  2022cites this paper
• Regulation of Aging and Longevity by Ion Channels and Transporters

  2022cites this paper
• Association of TRPV5, CASR, and CALCR genetic variants with kidney stone disease susceptibility in Egyptians through main effects and gene–gene interactions

  2022cites this paper
• Renal Mechanisms for Hypercalciuria Induced by Metabolic Acidosis

  2022cites this paper
• FAM111A is dispensable for electrolyte homeostasis in mice

  2022cites this paper
• Gentamicin Inhibits Ca2+ Channel TRPV5 and Induces Calciuresis Independent of the Calcium-Sensing Receptor–Claudin-14 Pathway

  2022cites this paper
• Molecular mechanisms altering tubular calcium reabsorption

  2021cites this paper
• Role of the TRP Channels in Pancreatic Ductal Adenocarcinoma Development and Progression

  2021cites this paper
• Membrane Transport Proteins in Osteoclasts: The Ins and Outs

  2021cites this paper
• Renal vascular TRP channels

  2021cites this paper
• Oxoglaucine mediates Ca2+ influx and activates autophagy to alleviate osteoarthritis through the TRPV5/calmodulin/CAMK‐II pathway

  2021cites this paper
• Cellular and molecular mechanotransduction in bone

  2021cites this paper
• How Many Cell Types Are in the Kidney and What Do They Do?

  2021cites this paper
• Effects and mechanisms of microenvironmental acidosis on osteoclast biology.

  2021cites this paper
• The genetics of kidney stone disease and nephrocalcinosis

  2021cites this paper
• Inherited Disorders of Renal Calcium Handling

  2021cites this paper
• "ADPKD-omics":Determinants of Cyclic AMP Levels in Renal Epithelial Cells.

  2021cites this paper
• Modeling Distal Convoluted Tubule (Patho)Physiology: An Overview of Past Developments and an Outlook Toward the Future

  2021cites this paper
• Beyond Hot and Spicy: TRPV Channels and their Pharmacological Modulation.

  2021cites this paper
• Structure and function of the calcium‐selective TRP channel TRPV6

  2020cites this paper
• Transglutaminase 2 as a novel target in chronic kidney disease - Methods, mechanisms and pharmacological inhibition.

  2020cites this paper
• 1,25(OH)2 vitamin D3 stimulates active phosphate transport but not paracellular phosphate absorption in mouse intestine

  2020cites this paper
• The Role of Ca2+-NFATc1 Signaling and Its Modulation on Osteoclastogenesis

  2020cites this paper
• Genetics of kidney stone disease

  2020cites this paper
• Vitamin D gene regulation

  2020cites this paper
• NME/NM23/NDPK and Histidine Phosphorylation

  2020cites this paper
• G protein-coupled pH-sensing receptor OGR1 and metabolic acidosis-induced hypercalciuria.

  2020cites this paper
• The molecular actions of parathyroid hormone/parathyroid hormone–related protein receptor type 1 and their implications

  2020cites this paper
• The sense of urinary flow in kidney physiology

  2020cites this paper
• Cinacalcet for the Treatment of Humoral Hypercalcemia of Malignancy: An Introductory Case Report with a Pathophysiologic and Therapeutic Review

  2020cites this paper
• TRP Channels in Renal Epithelia

  2020cites this paper
• Genetics of Mechanoreceptor Evolution and Development

  2020cites this paper
• Ionomycin ameliorates hypophosphatasia via rescuing alkaline phosphatase deficiency-mediated L-type Ca2+ channel internalization in mesenchymal stem cells

  2020cites this paper
• Vitamin D in The Regulation of Osteoclasts

  2020cites this paper
• Genetic Basis of Aerobically Supported Voluntary Exercise: Results from a Selection Experiment with House Mice

  2020cites this paper
• Evolutionary analyses reveal independent origins of gene repertoires and structural motifs associated to fast inactivation in calcium-selective TRPV channels

  2020cites this paper
• Vitamin D and Bone.

  2019cites this paper
• Identifying genetic loci for metabolic disorders affecting the renal tract

  2019cites this paper
• Acid-Base Status Determines the Renal Expression of Ca and Mg Transport Proteins

  2019cites this paper
• The use of LP533401 as a therapeutic option for renal osteodystrophy affects, renal calcium handling, vitamin D metabolism, and bone health in uremic rats

  2019influential citation
• Ionomycin Ameliorates Hypophosphatasia via Rescuing Alkaline Phosphatase Deficiency-mediated L-type Ca2+ Channel Internalization in Mesenchymal Stem Cells

  2019cites this paper
• Animal Models of Phosphorus Homeostasis

  2019cites this paper
• Association of TRPV5 gene polymorphism with calcium urolithiasis: a case–control study from West Bengal, India

  2019cites this paper
• Pharmacological Npt2a Inhibition Causes Phosphaturia and Reduces Plasma Phosphate in Mice with Normal and Reduced Kidney Function.

  2019cites this paper
• Phosphorylated claudin-16 interacts with Trpv5 and regulates transcellular calcium transport in the kidney

  2019cites this paper
• Enhanced remedial effects for vitamin D3 and calcium co-supplementation against pre-existing lead nephrotoxicity in mice: The roles of renal calcium homeostatic molecules.

  2019cites this paper
• Ion Channels and Bone Homeostasis Imbalance

  2019cites this paper
• Renal Tubular Acidosis.

  2019cites this paper
• Learning Physiology From Inherited Kidney Disorders.

  2019cites this paper
• TRPV5 in renal tubular calcium handling and its potential relevance for nephrolithiasis.

  2019cites this paper
• Association between single nucleotide polymorphism (rs4252424) in TRPV5 calcium channel gene and lead poisoning in Chinese workers

  2019cites this paper
• Evolutionary analyses reveal independent origins of gene repertoires and structural motifs associated to fast inactivation in calcium-selective TRPV channels

  2019cites this paper
• Structure-based characterization of novel TRPV5 inhibitors

  2019cites this paper
• Chapter 21 – Calbindin-D28K and Calbindin-D9K and the Epithelial Calcium Channels TRPV5 and TRPV6

  2018cites this paper
• Polycystin-1 dysfunction impairs electrolyte and water handling in a renal precystic mouse model for ADPKD.

  2018cites this paper
• Claudins and nephrolithiasis

  2018cites this paper