Role of voltage-gated calcium channels in ascending pain pathways.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Brain Research Reviews

• Publication date

  2009-04-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.brainresrev.2008.12.021PMID 19162069PMCID PMC2692704
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• T-type Ca2+ channels as therapeutic targets in the nervous system.

  2008cited by this paper
• A Blocker of N- and T-type Voltage-Gated Calcium Channels Attenuates Ethanol-Induced Intoxication, Place Preference, Self-Administration, and Reinstatement

  2008cited by this paper
• Upregulation of the T-type calcium current in small rat sensory neurons after chronic constrictive injury of the sciatic nerve.

  2008cited by this paper
• Attenuated pain responses in mice lacking CaV3.2 T‐type channels

  2007cited by this paper
• The Cav2.3 calcium channel antagonist SNX‐482 reduces dorsal horn neuronal responses in a rat model of chronic neuropathic pain

  2007cited by this paper
• Differential Role of N-Type Calcium Channel Splice Isoforms in Pain

  2007cited by this paper
• Cell-Specific Alterations of T-Type Calcium Current in Painful Diabetic Neuropathy Enhance Excitability of Sensory Neurons

  2007cited by this paper
• Neuronal calcium channels: splicing for optimal performance.

  2007cited by this paper
• Reducing Agents Sensitize C-Type Nociceptors by Relieving High-Affinity Zinc Inhibition of T-Type Calcium Channels

  2007influential reference
• Alternative splicing controls G protein–dependent inhibition of N-type calcium channels in nociceptors

  2007cited by this paper
• χ-Conotoxin and Tricyclic Antidepressant Interactions at the Norepinephrine Transporter Define a New Transporter Model*

  2007cited by this paper
• Noradrenergic pain modulation.

  2006cited by this paper
• Alternative splicing in the C‐terminus of CaV2.2 controls expression and gating of N‐type calcium channels

  2006cited by this paper
• Differential effects of endogenous cysteine analogs on peripheral thermal nociception in intact rats

  2006cited by this paper
• The role of T-type calcium channels in peripheral and central pain processing.

  2006cited by this paper
• Contributions of T-type calcium channels to the pathophysiology of pain signaling

  2006cited by this paper
• Targeting chronic and neuropathic pain: The N-type calcium channel comes of age

  2005influential reference
• Silencing of the Cav3.2 T‐type calcium channel gene in sensory neurons demonstrates its major role in nociception

  2005cited by this paper
• Neuronal proteins custom designed by alternative splicing.

  2005cited by this paper
• Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain.

  2005cited by this paper
• The antihyperalgesic effects of the T-type calcium channel blockers ethosuximide, trimethadione, and mibefradil.

  2005cited by this paper
• The Endogenous Redox Agent L-Cysteine Induces T-Type Ca2+ Channel-Dependent Sensitization of a Novel Subpopulation of Rat Peripheral Nociceptors

  2005cited by this paper
• Neuropathic pain: drug targets for current and future interventions.

  2004cited by this paper
• Cell-specific alternative splicing increases calcium channel current density in the pain pathway.

  2004cited by this paper
• Targeting Ca2+ channels to treat pain: T-type versus N-type.

  2004cited by this paper
• Ethosuximide reverses paclitaxel‐ and vincristine‐induced painful peripheral neuropathy

  2004cited by this paper
• Deletion of N-Type Calcium Channels Alters Ethanol Reward and Reduces Ethanol Consumption in Mice

  2004cited by this paper
• Intrathecal ziconotide in the treatment of refractory pain in patients with cancer or AIDS: a randomized controlled trial.

  2004influential reference
• Pathophysiology of pain

  2004cited by this paper
• An update on electrophysiological studies in neuropathy

  2003cited by this paper
• Reversal of experimental neuropathic pain by T‐type calcium channel blockers

  2003cited by this paper
• Mechanical and thermal antinociception in rats following systemic administration of mibefradil, a T-type calcium channel blocker.

  2002cited by this paper
• Chronic pain and medullary descending facilitation.

  2002cited by this paper
• The novel N‐type calcium channel blocker, AM336, produces potent dose‐dependent antinociception after intrathecal dosing in rats and inhibits substance P release in rat spinal cord slices

  2002cited by this paper
• Two new classes of conopeptides inhibit the α1-adrenoceptor and noradrenaline transporter

  2001influential reference
• Pharmacology of opioid and nonopioid analgesics in chronic pain states.

  2001influential reference
• Effects of ethosuximide, a T-type Ca(2+) channel blocker, on dorsal horn neuronal responses in rats.

  2001cited by this paper
• Suppression of inflammatory and neuropathic pain symptoms in mice lacking the N‐type Ca2+ channel

  2001influential reference
• Molecular mechanisms of nociception

  2001cited by this paper
• Differential nociceptive responses in mice lacking the alpha(1B) subunit of N-type Ca(2+) channels.

  2001cited by this paper
• Redox modulation of T-type calcium channels in rat peripheral nociceptors.

  2001cited by this paper
• Low-voltage-activated calcium current does not regulate the firing behavior in paired mechanosensory neurons with different adaptation properties.

  2000cited by this paper
• Altered pain responses in mice lacking alpha 1E subunit of the voltage-dependent Ca2+ channel.

  2000cited by this paper
• Altered pain responses in mice lacking α1E subunit of the voltage-dependent Ca2+ channel

  2000cited by this paper
• Novel ω-Conotoxins from Conus catus Discriminate among Neuronal Calcium Channel Subtypes*

  2000cited by this paper
• Enhanced excitability of sensory neurons in rats with cutaneous hyperalgesia produced by chronic compression of the dorsal root ganglion.

  1999cited by this paper
• Mechanical and thermal hyperalgesia and ectopic neuronal discharge after chronic compression of dorsal root ganglia.

  1999cited by this paper
• Determinants of the G protein-dependent opioid modulation of neuronal calcium channels.

  1996cited by this paper
• Abnormal spontaneous activity and responses to norepinephrine in dissociated dorsal root ganglion cells after chronic nerve constriction

  1996cited by this paper
• Effect of continuous intrathecal infusion of &ohgr;‐conopeptides, N‐type calcium‐channel blockers, on behavior and antinociception in the formalin and hot‐plate tests in rats

  1995cited by this paper
• Clinical relevance of defects in signalling pathways.

  1995cited by this paper
• Modulation of activity in dorsal root ganglion neurons by sympathetic activation in nerve-injured rats.

  1994cited by this paper
• Onset of a painful peripheral neuropathy in rat: a partial and differential deafferentation and spontaneous discharge in A beta and A delta primary afferent neurons.

  1992cited by this paper

• Acute Intravenous Astaxanthin Administration Modulates Hyperexcitability in Rat Nociceptive Secondary Sensory Neurons Induced by Inflammation

  2026cites this paper
• Shaping the Action Potential in Dorsal Root and Trigeminal Ganglia Neurons: Relevance to Pain Mechanisms

  2026cites this paper
• Intraneural delivery of CBD3A6K-RhB via PEG-PLGA nanoparticles for neuropathic pain therapy.

  2026cites this paper
• Cav3.2 channels modulate allodynia but TRP channels are the primary mediators in prenatal valproic acid-induced sensory dysfunction.

  2025cites this paper
• Astaxanthin Alleviates Inflammatory Mechanical Hyperalgesia by Reducing Hyperexcitability of Trigeminal Nociceptive Secondary Neurons: Potential as an NSAID Alternative

  2025influential citation
• Systemic Administration of the Phytochemical, Myricetin, Attenuates the Excitability of Rat Nociceptive Secondary Trigeminal Neurons

  2025cites this paper
• Voltage-Gated Calcium Channels Play a Central Role in Caenorhabditis elegans Response to Noxious Heat

  2025cites this paper
• An orally bioavailable MrgprX1-positive allosteric modulator alleviates certain neuropathic pain-related behaviors in humanized mice.

  2025cites this paper
• Spinal activation of TRPV1-mediated attenuation of a chemoreflex: Potential mechanism of action linking TRPV1 activation with modulation of CaV2.2 channels.

  2025cites this paper
• Functional coupling between peripheral nociceptor terminals in vivo is enhanced during acute inflammation.

  2025cites this paper
• Degradation of voltage-gated calcium channels: mechanisms and applications in neurological and cardiovascular diseases

  2025cites this paper
• Myricetin Attenuates Hyperexcitability of Trigeminal Nociceptive Second-Order Neurons in Inflammatory Hyperalgesia: Celecoxib-like Effects

  2025cites this paper
• The Increased Activity of CaV3.2 Channels Contributes to Nociceptors’ Hyperexcitability and Chronic Neuropathic Pain Following Spinal Cord Injury in Mice

  2025cites this paper
• Pregabalin for Neuropathic Pain in Post-radiotherapy Head and Neck Cancer Patients: A Retrospective Study and Review of the Literature

  2024cites this paper
• Cell-type specific methylation changes in the newborn child associated to obstetric pain relief

  2024cites this paper
• Suppression of the Excitability of Nociceptive Secondary Sensory Neurons Following Systemic Administration of Astaxanthin in Rats

  2024cites this paper
• Expression of Acid-Sensing Ion Channel 3 in Afferents Averts Long-Term Sensitization and the Development of Visceral Pain

  2024cites this paper
• A comprehensive review on ziconotide

  2024cites this paper
• Functional Sexual Dimorphism in Human Nociceptors

  2023cites this paper
• Neuropathic pain; what we know and what we should do about it

  2023cites this paper
• N-type calcium channel blockers: a new approach towards the treatment of chronic neuropathic pain

  2023cites this paper
• T-type calcium channel modulation by hydrogen sulfide in neuropathic pain conditions

  2023cites this paper
• Plant-derived natural products targeting ion channels for pain

  2023cites this paper
• Neuropathic Pain: Mechanisms, Sex Differences, and Potential Therapies for a Global Problem.

  2023cites this paper
• Advances in the Treatment of Diabetic Peripheral Neuropathy

  2023cites this paper
• Targeted Therapy for Orofacial Pain: A Novel Perspective for Precision Medicine

  2023cites this paper
• Inhibitory effects of linalool, an essential oil component of lavender, on nociceptive TRPA1 and voltage-gated Ca2+ channels in mouse sensory neurons.

  2023cites this paper
• Some Like It Hot: Dynamic Control of Cav2.2 Channels By Chili Peppers

  2022cites this paper
• Progress in the treatment of diabetic peripheral neuropathy.

  2022cites this paper
• Preparation and Functional Identification of a Novel Conotoxin QcMNCL-XIII0.1 from Conus quercinus

  2022cites this paper
• Mechanisms of exercise for diabetic neuropathic pain

  2022cites this paper
• High-voltage long-duration pulsed radiofrequency attenuates neuropathic pain in CCI rats by inhibiting Cav2.2 in spinal dorsal horn and dorsal root ganglion.

  2022cites this paper
• Phα1β is a Promising Neuroprotective Peptide from the Phoneutrianigriventer‘Armed’ Spider

  2022cites this paper
• Pathophysiological Responses to Conotoxin Modulation of Voltage-Gated Ion Currents

  2022cites this paper
• Design of 1,4-Dihydropyridine Hybrid Benzamide Derivatives: Synthesis and Evaluation of Analgesic Activity and Their Molecular Docking Studies

  2022cites this paper
• An Update On Proficiency of Voltage-gated Ion Channel Blockers in the Treatment of Inflammation-associated Diseases.

  2022cites this paper
• Pharmacological and non-pharmacological therapeutic interventions for the treatment of spinal cord injury-induced pain

  2022cites this paper
• Pain-related toxins in scorpion and spider venoms: a face to face with ion channels

  2021cites this paper
• Peripheral Voltage-Gated Cation Channels in Neuropathic Pain and Their Potential as Therapeutic Targets

  2021cites this paper
• Analgesic effects of Phα1β toxin: a review of mechanisms of action involving pain pathways

  2021cites this paper
• Involvement of T-type calcium channels in the mechanism of low dose morphine-induced hyperalgesia in adult male rats.

  2021cites this paper
• Cluster Headache Pathophysiology—A Disorder of Network Excitability?

  2021cites this paper
• Neuromedin B receptor stimulation of Cav3.2 T-type Ca2+ channels in primary sensory neurons mediates peripheral pain hypersensitivity

  2021cites this paper
• Breeding of Cav2.3 deficient mice reveals Mendelian inheritance in contrast to complex inheritance in Cav3.2 null mutant breeding

  2021cites this paper
• Epigenetic modifications in neuropathic pain

  2021cites this paper
• N-type calcium channels control GABAergic transmission in brain areas related to fear and anxiety

  2020cites this paper
• Evaluation of analgesic activity of t type calcium channel blocker (ethosuximide) in animal model of neuropathic pain

  2020cites this paper
• Pain pathways and potential new targets for pain relief

  2020cites this paper
• Evaluation of analgesic activity of levofloxacin in adult albino rats

  2020cites this paper
• Status of peripheral sodium channel blockers for non-addictive pain treatment

  2020cites this paper
• Anti-hypernociceptive and anti-inflammatory effects of JM-20: A novel hybrid neuroprotective compound.

  2020cites this paper
• Molecular Biology of the Nociceptor/Transduction

  2020cites this paper
• Response to pregabalin and progesterone differs in male and female rat models of neuropathic and cancer pain

  2020cites this paper
• Challenges of neuropathic pain: focus on diabetic neuropathy

  2020cites this paper
• NeuroGPU: Accelerating multi-compartment, biophysically detailed neuron simulations on GPUs

  2019cites this paper
• p-Cymene attenuates cancer pain via inhibitory pathways and modulation of calcium currents.

  2019cites this paper
• Inhibition of multiple voltage-gated calcium channels may contribute to spinally mediated analgesia by epipregnanolone in a rat model of surgical paw incision

  2019cites this paper
• Synthesis of some new C2 substituted dihydropyrimidines and their electrophysiological evaluation as L-/T-type calcium channel blockers.

  2019cites this paper
• Targeting the CaVα-CaVβ interaction yields an antagonist of the N-type CaV2.2 channel with broad antinociceptive efficacy.

  2019cites this paper
• Role of Dysregulated Ion Channels in Sensory Neurons in Chronic Kidney Disease-Associated Pruritus

  2019cites this paper
• Involvement of the PKA pathway and inhibition of voltage gated Ca2+ channels in antihyperalgesic activity of Lippia grata/β-cyclodextrin.

  2019cites this paper
• Location and Plasticity of the Sodium Spike Initiation Zone in Nociceptive Terminals In Vivo.

  2019cites this paper
• Chronic kidney disease – associated pruritus is caused 2 by dysregulated ion channels in sensory neurons 3

  2019cites this paper
• Therapeutic benefits of maintaining mitochondrial integrity and calcium homeostasis by forced expression of Hsp27 in chemotherapy-induced peripheral neuropathy.

  2019cites this paper
• Discovering the pharmacodynamics of conolidine and cannabidiol using a cultured neuronal network based workflow

  2019cites this paper
• Psychotropic Drugs for the Management of Chronic Pain and Itch

  2019cites this paper
• Transcriptomics Analysis of Porcine Caudal Dorsal Root Ganglia in Tail Amputated Pigs Shows Long-Term Effects on Many Pain-Associated Genes

  2019cites this paper
• Brain-derived neurotrophic factor stimulation of T-type Ca2+ channels in sensory neurons contributes to increased peripheral pain sensitivity

  2019cites this paper
• Peripheral nerve injury increases contribution of L-type calcium channels to synaptic transmission in spinal lamina II : Role of a 2 d – 1 subunits

  2018cites this paper
• Peripheral nerve injury increases contribution of L-type calcium channels to synaptic transmission in spinal lamina II: Role of α2δ–1 subunits

  2018cites this paper
• Targeting the CaVα-β interaction yields a selective antagonist of the N-type CaV2.2 channel with broad antinociceptive efficacy

  2018cites this paper
• Elucidating the molecular and biophysical determinants that suppress Ca2+-dependent facilitation of Cav2.2 Ca2+ channels

  2018cites this paper
• Fibroblast growth factor type 1 receptor stimulation of T-type Ca2+ channels in sensory neurons requires the phosphatidylinositol 3-kinase and protein kinase A pathways, independently of Akt.

  2018cites this paper
• Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides

  2018cites this paper
• CRMP2 and voltage-gated ion channels: potential roles in neuropathic pain

  2018cites this paper
• Recent progress in non-opioid analgesic peptides.

  2018cites this paper
• Melatonin‐mediated inhibition of Cav3.2 T‐type Ca2+ channels induces sensory neuronal hypoexcitability through the novel protein kinase C‐eta isoform

  2018cites this paper
• Matrine inhibits itching by lowering the activity of calcium channel

  2018cites this paper
• Lysophosphatidic Acid and Ion Channels as Molecular Mediators of Pain

  2018cites this paper
• Synergistic antinociception between ZC88, an N‐type voltage‐dependent calcium channel blocker, and ibuprofen in mouse models of visceral and somatic inflammatory pain

  2018cites this paper
• p-Cimeno reduz dor oncológica através da modulação da via de analgesia endógena e correntes de cálcio

  2018cites this paper
• Origins of antidromic activity in sensory afferent fibers and neurogenic inflammation

  2018cites this paper
• Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi

  2017cites this paper
• El receptor α2 adrenérgico de la célula cromafín de la médula adrenal: ¿una nueva diana para el tratamiento del dolor neuropático?

  2017cites this paper
• Regulatory Action of Calcium in Pain Pathway

  2017cites this paper
• Ion channels and neuronal hyperexcitability in chemotherapy-induced peripheral neuropathy

  2017cites this paper
• Introductory Chapter: Pain Relief - From Analgesics to Alternative Therapies

  2017cites this paper
• Cisplatin alters the function and expression of N-type voltage-gated calcium channels in the absence of morphological damage of sensory neurons

  2017cites this paper
• Calcium Signaling: From Physiology to Diseases

  2017cites this paper
• Cisplatin‐induced neuropathic pain is mediated by upregulation of N‐type voltage‐gated calcium channels in dorsal root ganglion neurons

  2017cites this paper
• Challenges to develop novel anti-inflammatory and analgesic drugs.

  2017cites this paper
• Action Potential Broadening in Capsaicin-Sensitive DRG Neurons from Frequency-Dependent Reduction of Kv3 Current

  2017cites this paper
• Comparative pre-emptive analgesic efficacy study of novel antiepileptic agents gabapentin, lamotrigine and topiramate in patients undergoing major surgeries at a tertiary care hospital: a randomized double blind clinical trial

  2017cites this paper
• Synthesis and biological evaluation of novel N3-substituted dihydropyrimidine derivatives as T-type calcium channel blockers and their efficacy as analgesics in mouse models of inflammatory pain.

  2017cites this paper
• Changes in Ionic Conductance Signature of Nociceptive Neurons Underlying Fabry Disease Phenotype

  2017cites this paper
• Developing antibody discovery and recombination technology towards the goal of modulating cation channels

  2016cites this paper
• Sustained relief of ongoing experimental neuropathic pain by a CRMP2 peptide aptamer with low abuse potential

  2016cites this paper
• Comparative Pre-Emptive Analgesic Efficacy Study of Novel Antiepileptic Agents Lamotrigine and Topiramate in Patients Undergoing Major Surgeries at a Tertiary Care Hospital: A Randomized Double Blind Clinical Trial

  2016cites this paper
• Development of a spontaneously active dorsal root ganglia assay using multiwell multielectrode arrays.

  2016influential citation
• Microbial biodiscovery: Exploring venomous animal associated microbes as sources of new chemical diversity

  2016cites this paper