JAK1 Activates STAT3 Activity in Non-Small–Cell Lung Cancer Cells and IL-6 Neutralizing Antibodies Can Suppress JAK1-STAT3 Signaling

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Molecular Cancer Therapeutics

• Publication date

  2011-01-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/1535-7163.MCT-10-0502PMID 21216930PMCID PMC4084653
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Using iTRAQ combined with tandem affinity purification to enhance low-abundance proteins associated with somatically mutated EGFR core complexes in lung cancer.

  2011cited by this paper
• TGF-β IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer

  2010cited by this paper
• A chemical and phosphoproteomic characterization of dasatinib action in lung cancer

  2010cited by this paper
• The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors.

  2009cited by this paper
• JAK kinases overexpression promotes in vitro cell transformation

  2008cited by this paper
• Autocrine IL-6 signaling: a key event in tumorigenesis?

  2008cited by this paper
• Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity

  2008influential reference
• Cancer Statistics, 2008

  2008cited by this paper
• Signaling networks assembled by oncogenic EGFR and c-Met

  2008cited by this paper
• Activation state EGFR and STAT-3 as prognostic markers in resected non-small cell lung cancer.

  2007cited by this paper
• Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas.

  2007influential reference
• Abrogation of Signal Transducer and Activator of Transcription 3 Reactivation after Src Kinase Inhibition Results in Synergistic Antitumor Effects

  2007cited by this paper
• The JAK-STAT Signaling Pathway: Input and Output Integration1

  2007influential reference
• Autocrine IL-6-induced Stat3 activation contributes to the pathogenesis of lung adenocarcinoma and malignant pleural effusion

  2006cited by this paper
• Inhibition of interleukin-6 with CNTO328, an anti-interleukin-6 monoclonal antibody, inhibits conversion of androgen-dependent prostate cancer to an androgen-independent phenotype in orchiectomized mice.

  2006cited by this paper
• Signal transducer and activator of transcription 3 is required for the oncogenic effects of non-small-cell lung cancer-associated mutations of the epidermal growth factor receptor.

  2006influential reference
• Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival.

  2006cited by this paper
• Autocrine interleukin-6/interleukin-6 receptor stimulation in non-small-cell lung cancer.

  2006cited by this paper
• Oncogenic Transformation by Inhibitor-Sensitive and -Resistant EGFR Mutants

  2005cited by this paper
• Micronutrient Sprinkles to Control Childhood Anaemia

  2005cited by this paper
• Epithelial to mesenchymal transition is a determinant of sensitivity of non-small-cell lung carcinoma cell lines and xenografts to epidermal growth factor receptor inhibition.

  2005cited by this paper
• High expression of ErbB family members and their ligands in lung adenocarcinomas that are sensitive to inhibition of epidermal growth factor receptor.

  2005cited by this paper
• Acquired Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib Is Associated with a Second Mutation in the EGFR Kinase Domain

  2005cited by this paper
• Mechanisms of Disease: insights into the emerging role of signal transducers and activators of transcription in cancer

  2005cited by this paper
• Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells

  2005cited by this paper
• Activated Epidermal Growth Factor Receptor–Stat-3 Signaling Promotes Tumor Survival In vivo in Non–Small Cell Lung Cancer

  2005cited by this paper
• The STATs of cancer — new molecular targets come of age

  2004cited by this paper
• Targeted anti-interleukin-6 monoclonal antibody therapy for cancer: a review of the rationale and clinical evidence.

  2003cited by this paper
• Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cells

  2003influential reference
• The pyrido[2,3-d]pyrimidine derivative PD180970 inhibits p210Bcr-Abl tyrosine kinase and induces apoptosis of K562 leukemic cells.

  2000cited by this paper
• Requirement for Ras/Rac1-Mediated p38 and c-Jun N-Terminal Kinase Signaling in Stat3 Transcriptional Activity Induced by the Src Oncoprotein

  1999cited by this paper
• Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway.

  1998influential reference
• Stat3 Activation by Src Induces Specific Gene Regulation and Is Required for Cell Transformation

  1998influential reference
• Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice.

  1998cited by this paper
• Demonstration of an interferon γ-dependent tumor surveillance system in immunocompetent mice

  1998cited by this paper
• Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3.

  1997cited by this paper
• In vitro activation of Stat3 by epidermal growth factor receptor kinase.

  1996cited by this paper
• Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation.

  1995cited by this paper

• Targeting PLK1 potentiates the antitumor efficacy of EGFR-TKIs through inhibiting the JAK1/STAT3 pathway

  2026cites this paper
• Intracellular Oxidant Levels Are Crucial for Cell Survival and JAK/STAT Signaling in Classical Hodgkin’s Lymphoma

  2026cites this paper
• The role of cytokines in shaping the future of Cancer immunotherapy.

  2025cites this paper
• Threonyl-tRNA synthetase activates STAT3 by a nontranslational mechanism

  2025cites this paper
• Dual Drug Nanoformulations for Non-Small Cell Lung Cancer Therapeutics: A Systematic Review

  2025cites this paper
• Integrative multi-omics machine learning reveals novel driver genes associations in lung adenocarcinoma.

  2025cites this paper
• PARPs in tumor immunology: Signal transduction and combination therapy for the future

  2025cites this paper
• Tumor-intrinsic interferon signaling drives pancreatic cancer resistance to tumor mucin1-targeted CAR T cell therapy

  2025cites this paper
• Exploring the effect and mechanism of fucoidan on liver cancer depending on network pharmacology and experimental verification

  2025cites this paper
• Decoding the hepatic fibrosis-hepatocellular carcinoma axis: from mechanisms to therapeutic opportunities

  2025cites this paper
• Cardiomyocyte-derived YOD1 promotes pathological cardiac hypertrophy by deubiquitinating and stabilizing STAT3

  2025cites this paper
• From EGFR mutations to STAT30-driven resistance in NSCLC: Biomarkers and multi-modal treatment approach.

  2025cites this paper
• Insights into IL-6/JAK/STAT3 signaling in the tumor microenvironment: Implications for cancer therapy.

  2025cites this paper
• FGFR3-TACC3 fusion gene promotes glioblastoma malignant progression through the activation of STAT3 signaling pathway

  2025cites this paper
• Perspectives on the α5 nicotinic acetylcholine receptor in lung cancer progression

  2025cites this paper
• Synthesis of peiminine derivatives and its effect on A549 lung cancer‐bearing mice

  2024cites this paper
• Boosting immune responses in lung tumor immune microenvironment: A comprehensive review of strategies and adjuvants

  2024cites this paper
• Elevated type I interferon signaling defines the proliferative advantage of ARF and p53 mutant tumor cells

  2024cites this paper
• Interleukin-6 serves as a critical factor in various cancer progression and therapy

  2024cites this paper
• Synthesis, Antiproliferative Activity and Molecular Docking Analysis of Both Enantiomerically Pure Decursin Derivatives as Anticancer Agents.

  2024cites this paper
• Equivocating and Deliberating on the Probability of COVID-19 Infection Serving as a Risk Factor for Lung Cancer and Common Molecular Pathways Serving as a Link

  2024cites this paper
• CTDSPL2 promotes the progression of non-small lung cancer through PI3K/AKT signaling via JAK1

  2024cites this paper
• An intrinsic purine metabolite AICAR blocks lung tumour growth by targeting oncoprotein mucin 1

  2023cites this paper
• Cellular Senescence as a Brake or Accelerator for Oncogenic Transformation and Role in Lymphatic Metastasis

  2023cites this paper
• Intersection of Inflammation and Senescence in the Aging Lung Stem Cell Niche

  2022cites this paper
• Maintaining structural and functional homeostasis of the Drosophila respiratory epithelia requires stress-modulated JAK/STAT activity

  2022cites this paper
• lncRNA MSC-AS1/miRNA-429 Axis Mediates Growth and Metastasis of Nasopharyngeal Carcinoma via JAK1/STAT3 Signaling Pathway

  2022cites this paper
• Central Roles of STAT3-Mediated Signals in Onset and Development of Cancers: Tumorigenesis and Immunosurveillance

  2022cites this paper
• Systematic analysis of IL-6 as a predictive biomarker and desensitizer of immunotherapy responses in patients with non-small cell lung cancer

  2022cites this paper
• Cutting the umbilical cord: Cancer stem cell-targeted therapeutics.

  2022cites this paper
• STAT3 pathway in cancers: Past, present, and future

  2022cites this paper
• The Role of Tumor Inflammatory Microenvironment in Lung Cancer

  2021cites this paper
• Computational Analysis of Drug Resistance Network in Lung Adenocarcinoma.

  2021cites this paper
• Studies in lung cancer cytokine proteomics: a review

  2021cites this paper
• FGFR leads to sustained activation of STAT3 to mediate resistance to EGFR-TKIs treatment

  2021influential citation
• Long non-coding RNA LEISA promotes progression of lung adenocarcinoma via enhancing interaction between STAT3 and IL-6 promoter

  2021cites this paper
• Multicellular Effects of STAT3 in Non-small Cell Lung Cancer: Mechanistic Insights and Therapeutic Opportunities

  2021cites this paper
• A phase 1b study of erlotinib and momelotinib for the treatment of EGFR-mutated, tyrosine kinase inhibitor-naive metastatic non-small cell lung cancer

  2021cites this paper
• The deubiquitinase USP16 functions as an oncogenic factor in K-RAS-driven lung tumorigenesis

  2021cites this paper
• Interleukin polymorphisms and protein levels associated with lung cancer susceptibility and phenotypes

  2021cites this paper
• MicroRNAs: Harbingers and shapers of periodontal inflammation.

  2021cites this paper
• Myristoylation-mediated phase separation of EZH2 compartmentalizes STAT3 to promote lung cancer growth.

  2021cites this paper
• cacy of combination treatment using YHO-1701 , an orally active STAT 3 inhibitor , with molecular-targeted agents on cancer cell lines

  2020cites this paper
• Efficacy of combination treatment using YHO-1701, an orally active STAT3 inhibitor, with molecular-targeted agents on cancer cell lines

  2020cites this paper
• Saikosaponin D inhibits proliferation and induces apoptosis of non-small cell lung cancer cells by inhibiting the STAT3 pathway

  2020cites this paper
• Balanced JAK/STAT signaling is critical to maintain the functional and structural integrity of the Drosophila respiratory epithelium

  2020cites this paper
• Reduced expression of CYLD promotes cell survival and inflammation in gefitinib-treated NSCLC PC-9 cells: targeting CYLD may be beneficial for acquired resistance to gefitinib therapy.

  2020cites this paper
• Alkynyl Benzoxazines and Dihydroquinazolines as Cysteine Targeting Covalent Warheads and Their Application in Identification of Selective Irreversible Kinase Inhibitors.

  2020cites this paper
• Porphyromonas gingivalis Inhibition of MicroRNA-205-5p Expression Modulates Proinflammatory Cytokines in Gingival Epithelial Cells

  2020cites this paper
• MiR-30c-5p inhibits high glucose-induced EMT and renal fibrogenesis by down-regulation of JAK1 in diabetic nephropathy.

  2020cites this paper
• Unphosphorylated STAT3 in heterochromatin formation and tumor suppression in lung cancer

  2020cites this paper
• Osteopontin accelerates the development and metastasis of bladder cancer via activating JAK1/STAT1 pathway

  2020cites this paper
• PRR34‐AS1 overexpression promotes protection of propofol pretreatment against ischemia/reperfusion injury in a mouse model after total knee arthroplasty via blockade of the JAK1‐dependent JAK‐STAT signaling pathway

  2020cites this paper
• Unmasking senescence: context-dependent effects of SASP in cancer

  2019cites this paper
• Evolution in medicinal chemistry of sorafenib derivatives for hepatocellular carcinoma.

  2019cites this paper
• Characterization of epidermal growth factor receptor (EGFR) P848L, an unusual EGFR variant present in lung cancer patients, in a murine Ba/F3 model

  2019cites this paper
• Long noncoding RNA PART1 promotes progression of non‐small cell lung cancer cells via JAK‐STAT signaling pathway

  2019cites this paper
• JAK–STAT inhibition impairs K‐RAS‐driven lung adenocarcinoma progression

  2019cites this paper
• ARHGAP15 regulates lung cancer cell proliferation and metastasis via the STAT3 pathway.

  2019cites this paper
• Association of Variants in IL6-Related Genes with Lung Cancer Risk in Moroccan Population

  2019cites this paper
• STAT3 Activation and Oncogenesis in Lymphoma

  2019cites this paper
• Gigantol Targets Cancer Stem Cells and Destabilizes Tumors via the Suppression of the PI3K/AKT and JAK/STAT Pathways in Ectopic Lung Cancer Xenografts

  2019cites this paper
• VEGFR2 survival and mitotic signaling depends on joint activation of associated C3ar1/C5ar1 and IL-6R–gp130

  2019cites this paper
• Long noncoding RNA CHRF exacerbates IL‐6‐induced inflammatory damages by downregulating microRNA‐146a in ATDC5 cells

  2019cites this paper
• Janus kinase JAK1 maintains the ovarian reserve of primordial follicles in the mouse ovary

  2018cites this paper
• A Graphical Model of Smoking-Induced Global Instability in Lung Cancer

  2018cites this paper
• Molecular cross‐talk of IL‐6 in tumors and new progress in combined therapy

  2018cites this paper
• IRF9 and unphosphorylated STAT2 cooperate with NF-κB to drive IL6 expression

  2018cites this paper
• Retracted: MicroRNA‐520a‐3p suppresses epithelial–mesenchymal transition, invasion, and migration of papillary thyroid carcinoma cells via the JAK1‐mediated JAK/STAT signaling pathway

  2018cites this paper
• 8 Interleukin-6 in the Breast Tumor Microenvironment

  2018cites this paper
• Discover prognostic RNAs through identifying lncRNA-miRNA-mRNA triplets in lung squamous cell carcinoma

  2017cites this paper
• Understanding and targeting resistance mechanisms in NSCLC

  2017cites this paper
• 8-Bromo-7-methoxychrysin-blocked STAT3/Twist axis inhibits the stemness of cancer stem cell-like cell originated from SMMC-7721 cells

  2017cites this paper
• Tumour-associated macrophages activate migration and STAT3 in pancreatic ductal adenocarcinoma cells in co-cultures.

  2017cites this paper
• Adenocarcinoma of the lung: an exploration of the relationships between histopathology, molecular pathology and inflammatory markers and their relationship to patient outcomes

  2017influential citation
• Gr upSM Interleukin-6 as a Therapeutic Target on Human Cancer

  2017cites this paper
• Genetic predisposition to lung adenocarcinoma among never-smoking Chinese with different epidermal growth factor receptor mutation status.

  2017cites this paper
• CGI-99 promotes breast cancer metastasis via autocrine interleukin-6 signaling

  2017cites this paper
• Prolonged inflammatory microenvironment is crucial for pro-neoplastic growth and genome instability: a detailed review

  2017cites this paper
• B1, a novel HDAC inhibitor, induces apoptosis through the regulation of STAT3 and NF-κB

  2017cites this paper
• Protease Serine S1 Family Member 8 (PRSS8) Inhibits Tumor Growth In Vitro and In Vivo in Human Non-Small Cell Lung Cancer

  2017cites this paper
• EGFR and KRAS mutations do not enrich for the activation of IL-6, JAK1 or phosphorylated STAT3 in resected lung adenocarcinoma

  2017cites this paper
• LARP1 is regulated by the XIST/miR-374a axis and functions as an oncogene in non-small cell lung carcinoma.

  2017cites this paper
• Repositioning Bazedoxifene as a novel IL-6/GP130 signaling antagonist for human rhabdomyosarcoma therapy

  2017cites this paper
• Siltuximab and hematologic malignancies. A focus in non Hodgkin lymphoma

  2017cites this paper
• LARP 1 is regulated by the XIST / miR-374 a axis and functions as an oncogene in non-small cell lung carcinoma

  2017cites this paper
• Breaking the crosstalk of the cellular tumorigenic network: Hypothesis for addressing resistances to targeted therapies in advanced NSCLC

  2017cites this paper
• Oncogene driver mutations and copy number variation as markers for predicting drug resistance and disease outcome in NSCLC

  2017cites this paper
• An Approach to Breast Cancer Immunotherapy: The Apoptotic Activity of Recombinant Anti‐Interleukin‐6 Monoclonal Antibodies in Intact Tumour Microenvironment of Breast Carcinoma

  2016cites this paper
• JAK2 inhibition sensitizes resistant EGFR-mutant lung adenocarcinoma to tyrosine kinase inhibitors

  2016cites this paper
• Chitosan-hyaluronan based 3D co-culture platform for studying the crosstalk of lung cancer cells and mesenchymal stem cells.

  2016cites this paper
• EGFR gene deregulation mechanisms in lung adenocarcinoma: A molecular review.

  2016cites this paper
• Immunotherapeutic Approach to Breast Cancer: The Anti-Tumor Effect of Anti-IL-6 Monoclonal Antibodies in Malignant Mammary Tumor Implanted-Mice.

  2016cites this paper
• Diabetes-associated dysregulated cytokines and cancer.

  2016cites this paper
• Effect of Small Molecule Inhibitor Fisetin over Proliferation of Human Non-Small Cell Pulmonary Carcinoma

  2016cites this paper
• inflammation from emphysema in gp130 mutant mice Deregulated Stat3 signaling dissociates pulmonary

  2016cites this paper
• Cambiamenti nell'espressione genica in un sistema di co-coltura di fibroblasti umani e cellule di osteosarcoma: il ruolo del microambiente

  2016cites this paper
• Migration Suppression of Small Cell Lung Cancer by Polysaccharides from Nostoc commune Vaucher.

  2016cites this paper
• IL6 Trans-signaling Promotes KRAS-Driven Lung Carcinogenesis.

  2016cites this paper
• Investigation of JAKs/STAT‐3 in lipopolysaccharide‐induced intestinal epithelial cells

  2016cites this paper